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The map label for this gene is degP [H]

Identifier: 116694114

GI number: 116694114

Start: 181668

End: 183134

Strand: Direct

Name: degP [H]

Synonym: H16_B0159

Alternate gene names: 116694114

Gene position: 181668-183134 (Clockwise)

Preceding gene: 116694111

Following gene: 116694115

Centisome position: 6.24

GC content: 68.58

Gene sequence:

>1467_bases
ATGATGCGCCAGACCATTGCTCGCACGGCCGTTGGTATCGCGGCCCTTGCCGCCCTTGGCGGCGGCTATGCCTATCTGCA
GAGGGAAGTCATCACGCCGGGGTACGCGGCACCTGCGCCAGCCGTCGCGCCAGCGCAGCCGGCGGCCGCCGTGGCCACGC
CGACGGATTTCTCCGGCATCGTGGCACAGTACGGGCCCGCCGTGGTCAATATCAGCGTCACCGCGCGCGCCCAGCGCACC
GCGGCGCAGATGCCCCCGGGCATCGATCCGGACGATCCGCTGTTCCAGTTCTTCAAGCGTTTCGGGCCGCAGTTCCAGGG
TCCGCAAGGCGGCCAGCAGCAACTGGTGCGCGGACTGGGCTCGGGCTTTATCGTGAGCCCGGACGGGCTGATCCTGACCA
ATGCGCACGTCGTCGACGGCGCGCAGGAGGTCACGGTCAAGCTGACCGACCGCCGCGAGTTCAAGGCCAAGGTGCTCGGC
AGCGATCCGCAGACCGACGTGGCCGTGATCCGCATCGACGCCAAGAACCTGCCGGCCGTGCGCCTGGGCGATCCTTCGCA
GGTGCGCGTGGGCGAGCCGGTGCTGGCGATCGGTTCTCCCTACGGCTTCGAGAACACCGTGACCGCGGGCATCGTCAGCG
CCAAGTCGCGCTCGCTGCCGGACGATACCTATGTGCCGTTCATCCAGACCGATGTTGCCGTCAATCCCGGCAACTCGGGC
GGGCCGCTGTTCAACCAGCGCGGCGAGGTGGTCGGCATCAATGCGCAGATCTACAGCCAGACCGGCGGCTACCAGGGCCT
GTCGTTCGCGATCCCGATCGACGTGGCCACCAAGGTGCAGCAGCAGCTGGTGGCGCATGGCAAGGTCACGCGCGGTCGTC
TCGGCATCAGCGTGCAGGAGGTGAACCAGGCGCTTGCACAATCGTTCGGGCTGCCCAAGCCTACTGGTGCGCTGGTCAAC
TCGGTCGAGCCCGACAGCCCGGCCGCGCGCGCTGGCCTGAAGCCTGGCGACGTCATCGTGCAGCTCGACAATGACGTGAT
CGACCATTCGGGCGACCTGCCCGAGCACGTGGCCGATATCAAGCCGGGCACGCAGACCTCGTTGAAGATCATCCGCAAGG
GCCAGCCGATGACGCTGTCGGTGACGGTGGGCACGGCCAGGGACCGGGCCGTCGCACAGAAGGGCGGTGGCAGCGAGGCC
GGTGGCCGGCTGGGGCTGGCGGTGCGCCCGCTCACGCCGGCGGAGAAGCGTGGCAGCGGCATCGACGGCGGTCTGGTGGT
CGAGGACGTGGCCGGCCCCGCCGCGCGCGTCGGCATCCAGCCGGGCGACGTGATCCTGTCGCTCAACGGCACGCCCATCA
GCTCGCCCGAACAGCTCAAGTCGCTGGTATCGAAATCGGGCAAGCAGGTGGCACTGCTGGTGCAGCGCGACGATGCGCGC
ATCTTCATTCCGCTCGACCTGGGCTGA

Upstream 100 bases:

>100_bases
CTGGTGCTGACCCTTAAGTCTGTTTTAAGTCTGGGTCGCTAGCATGACCGTGTCGCGTCGCAAACTGCCGACGCCTGATG
CACAAGGAAAGGAACCACAC

Downstream 100 bases:

>100_bases
TTGCCGCGGGCACGCCAGACTGCCCGCAAGCCGTTAACTGGCAAGGCTTTGCTGCCCGCGCGGGCCGTATACCCCGACGT
ATACCGACACGTATACGAAG

Product: trypsin-like serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MMRQTIARTAVGIAALAALGGGYAYLQREVITPGYAAPAPAVAPAQPAAAVATPTDFSGIVAQYGPAVVNISVTARAQRT
AAQMPPGIDPDDPLFQFFKRFGPQFQGPQGGQQQLVRGLGSGFIVSPDGLILTNAHVVDGAQEVTVKLTDRREFKAKVLG
SDPQTDVAVIRIDAKNLPAVRLGDPSQVRVGEPVLAIGSPYGFENTVTAGIVSAKSRSLPDDTYVPFIQTDVAVNPGNSG
GPLFNQRGEVVGINAQIYSQTGGYQGLSFAIPIDVATKVQQQLVAHGKVTRGRLGISVQEVNQALAQSFGLPKPTGALVN
SVEPDSPAARAGLKPGDVIVQLDNDVIDHSGDLPEHVADIKPGTQTSLKIIRKGQPMTLSVTVGTARDRAVAQKGGGSEA
GGRLGLAVRPLTPAEKRGSGIDGGLVVEDVAGPAARVGIQPGDVILSLNGTPISSPEQLKSLVSKSGKQVALLVQRDDAR
IFIPLDLG

Sequences:

>Translated_488_residues
MMRQTIARTAVGIAALAALGGGYAYLQREVITPGYAAPAPAVAPAQPAAAVATPTDFSGIVAQYGPAVVNISVTARAQRT
AAQMPPGIDPDDPLFQFFKRFGPQFQGPQGGQQQLVRGLGSGFIVSPDGLILTNAHVVDGAQEVTVKLTDRREFKAKVLG
SDPQTDVAVIRIDAKNLPAVRLGDPSQVRVGEPVLAIGSPYGFENTVTAGIVSAKSRSLPDDTYVPFIQTDVAVNPGNSG
GPLFNQRGEVVGINAQIYSQTGGYQGLSFAIPIDVATKVQQQLVAHGKVTRGRLGISVQEVNQALAQSFGLPKPTGALVN
SVEPDSPAARAGLKPGDVIVQLDNDVIDHSGDLPEHVADIKPGTQTSLKIIRKGQPMTLSVTVGTARDRAVAQKGGGSEA
GGRLGLAVRPLTPAEKRGSGIDGGLVVEDVAGPAARVGIQPGDVILSLNGTPISSPEQLKSLVSKSGKQVALLVQRDDAR
IFIPLDLG
>Mature_488_residues
MMRQTIARTAVGIAALAALGGGYAYLQREVITPGYAAPAPAVAPAQPAAAVATPTDFSGIVAQYGPAVVNISVTARAQRT
AAQMPPGIDPDDPLFQFFKRFGPQFQGPQGGQQQLVRGLGSGFIVSPDGLILTNAHVVDGAQEVTVKLTDRREFKAKVLG
SDPQTDVAVIRIDAKNLPAVRLGDPSQVRVGEPVLAIGSPYGFENTVTAGIVSAKSRSLPDDTYVPFIQTDVAVNPGNSG
GPLFNQRGEVVGINAQIYSQTGGYQGLSFAIPIDVATKVQQQLVAHGKVTRGRLGISVQEVNQALAQSFGLPKPTGALVN
SVEPDSPAARAGLKPGDVIVQLDNDVIDHSGDLPEHVADIKPGTQTSLKIIRKGQPMTLSVTVGTARDRAVAQKGGGSEA
GGRLGLAVRPLTPAEKRGSGIDGGLVVEDVAGPAARVGIQPGDVILSLNGTPISSPEQLKSLVSKSGKQVALLVQRDDAR
IFIPLDLG

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=274, Percent_Identity=37.5912408759124, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI7019477, Length=280, Percent_Identity=37.5, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI22129776, Length=264, Percent_Identity=37.5, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI24308541, Length=250, Percent_Identity=36.8, Blast_Score=142, Evalue=7e-34,
Organism=Escherichia coli, GI1786356, Length=372, Percent_Identity=37.9032258064516, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI1789629, Length=461, Percent_Identity=32.7548806941432, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI1789630, Length=277, Percent_Identity=38.9891696750903, Blast_Score=185, Evalue=6e-48,
Organism=Drosophila melanogaster, GI24646839, Length=285, Percent_Identity=35.4385964912281, Blast_Score=148, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 50505; Mature: 50505

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRQTIARTAVGIAALAALGGGYAYLQREVITPGYAAPAPAVAPAQPAAAVATPTDFSGI
CCHHHHHHHHHHHHHHHHHCCCCEEEEHHHCCCCCCCCCCCCCCCCCCCEEECCCCCHHH
VAQYGPAVVNISVTARAQRTAAQMPPGIDPDDPLFQFFKRFGPQFQGPQGGQQQLVRGLG
HHHCCCEEEEEEEEECHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCC
SGFIVSPDGLILTNAHVVDGAQEVTVKLTDRREFKAKVLGSDPQTDVAVIRIDAKNLPAV
CCEEECCCCEEEECCEEECCCEEEEEEEECCCCEEHEECCCCCCCCEEEEEEECCCCCEE
RLGDPSQVRVGEPVLAIGSPYGFENTVTAGIVSAKSRSLPDDTYVPFIQTDVAVNPGNSG
EECCCCCEEECCCEEEECCCCCCCCCHHHHEEECCCCCCCCCCCCCEEEEEEEECCCCCC
GPLFNQRGEVVGINAQIYSQTGGYQGLSFAIPIDVATKVQQQLVAHGKVTRGRLGISVQE
CCCCCCCCCEEEEEEEEEECCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCHHH
VNQALAQSFGLPKPTGALVNSVEPDSPAARAGLKPGDVIVQLDNDVIDHSGDLPEHVADI
HHHHHHHHCCCCCCCHHHHCCCCCCCCHHHCCCCCCCEEEEECCCHHCCCCCCHHHHHHC
KPGTQTSLKIIRKGQPMTLSVTVGTARDRAVAQKGGGSEAGGRLGLAVRPLTPAEKRGSG
CCCCCHHHHHEECCCCEEEEEEECCCCCHHHHHCCCCCCCCCEEEEEEECCCCHHHCCCC
IDGGLVVEDVAGPAARVGIQPGDVILSLNGTPISSPEQLKSLVSKSGKQVALLVQRDDAR
CCCCEEEECCCCCHHEECCCCCCEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEEECCCE
IFIPLDLG
EEEEECCC
>Mature Secondary Structure
MMRQTIARTAVGIAALAALGGGYAYLQREVITPGYAAPAPAVAPAQPAAAVATPTDFSGI
CCHHHHHHHHHHHHHHHHHCCCCEEEEHHHCCCCCCCCCCCCCCCCCCCEEECCCCCHHH
VAQYGPAVVNISVTARAQRTAAQMPPGIDPDDPLFQFFKRFGPQFQGPQGGQQQLVRGLG
HHHCCCEEEEEEEEECHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCC
SGFIVSPDGLILTNAHVVDGAQEVTVKLTDRREFKAKVLGSDPQTDVAVIRIDAKNLPAV
CCEEECCCCEEEECCEEECCCEEEEEEEECCCCEEHEECCCCCCCCEEEEEEECCCCCEE
RLGDPSQVRVGEPVLAIGSPYGFENTVTAGIVSAKSRSLPDDTYVPFIQTDVAVNPGNSG
EECCCCCEEECCCEEEECCCCCCCCCHHHHEEECCCCCCCCCCCCCEEEEEEEECCCCCC
GPLFNQRGEVVGINAQIYSQTGGYQGLSFAIPIDVATKVQQQLVAHGKVTRGRLGISVQE
CCCCCCCCCEEEEEEEEEECCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCHHH
VNQALAQSFGLPKPTGALVNSVEPDSPAARAGLKPGDVIVQLDNDVIDHSGDLPEHVADI
HHHHHHHHCCCCCCCHHHHCCCCCCCCHHHCCCCCCCEEEEECCCHHCCCCCCHHHHHHC
KPGTQTSLKIIRKGQPMTLSVTVGTARDRAVAQKGGGSEAGGRLGLAVRPLTPAEKRGSG
CCCCCHHHHHEECCCCEEEEEEECCCCCHHHHHCCCCCCCCCEEEEEEECCCCHHHCCCC
IDGGLVVEDVAGPAARVGIQPGDVILSLNGTPISSPEQLKSLVSKSGKQVALLVQRDDAR
CCCCEEEECCCCCHHEECCCCCCEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEEECCCE
IFIPLDLG
EEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]