Click here to switch to the map view.

The map label for this gene is pdhR [H]

Identifier: 116694054

GI number: 116694054

Start: 109148

End: 109819

Strand: Direct

Name: pdhR [H]

Synonym: H16_B0094

Alternate gene names: 116694054

Gene position: 109148-109819 (Clockwise)

Preceding gene: 116694049

Following gene: 116694056

Centisome position: 3.75

GC content: 71.73

Gene sequence:

>672_bases
ATGCGCCGGATCGAGACCGCGCTGCTCGACGGCACCTGGCCGCCCGGCACGCGGCTGCCGGCCGAGCGGGTGCTGGCCGG
GCAATACGAGGTGGCGCGCAACACCGTGCGCGAGGCGATCCAGCGCCTGGCCGCGCGCGGCCTGCTGCAGAGCCGGCGCG
GTGCCGGGGTCTACGCCACCGACCAGCTGCGCGCCGGCATTGCCTCGCCCTGGGGCCAGCTGGTGGCCGACCACCCCGCG
CTGCGCGACGACATCCTGGAGTTCCGCCGCGTGCTGGAGGGCGCGACCGCGTATTTTGCGGCGCTGCGCGCGGATGCCGC
TGACGTGAAGCGGATCCGCGCCCTGATGGCCGAGCTGGAACGCGCGCGCGCCGCCGACGACAAGCAGGCAGAGGCCGATG
CCGATGCGCAGCTGCACGACGCCATTGCCCAGGCCTCGCACAACACCATGTTCCTGCACCTGCATACCAGCGTGATCGGC
ATGCTGCGCGAGCACATCACCATCAATGGCACCGGCCTGCGCGAACAGGACGACGGCGCGTCAGACCTGTTGCTGCTGCA
GCATCGCACGCTGTGCGATGCGATTTGCGCGCGCCGCCCGGAAGAGGCGCGCACCGCCATGCAGACCCATATCGACTTCG
TGCGCAGCCGGGTGGAGCAGGACGGCGCCTGA

Upstream 100 bases:

>100_bases
AATCTGCCCGACGACGCGCGCAAGCTCAGGAGCGAGGACACACGGCATGACGGCAGCGGCAGCAAGGCACGGGCGCACCC
GCGGACGCGTGGAGTCGGTC

Downstream 100 bases:

>100_bases
GCAGGCATTGGTCCTACCACCGCCGCGGCGAGCCGGCTGCGGCACTCAGATCAGTCCGGCGCCGGCCAGCTCCCGCTTCA
GGTAGGCATAGAAGATAGGT

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MRRIETALLDGTWPPGTRLPAERVLAGQYEVARNTVREAIQRLAARGLLQSRRGAGVYATDQLRAGIASPWGQLVADHPA
LRDDILEFRRVLEGATAYFAALRADAADVKRIRALMAELERARAADDKQAEADADAQLHDAIAQASHNTMFLHLHTSVIG
MLREHITINGTGLREQDDGASDLLLLQHRTLCDAICARRPEEARTAMQTHIDFVRSRVEQDGA

Sequences:

>Translated_223_residues
MRRIETALLDGTWPPGTRLPAERVLAGQYEVARNTVREAIQRLAARGLLQSRRGAGVYATDQLRAGIASPWGQLVADHPA
LRDDILEFRRVLEGATAYFAALRADAADVKRIRALMAELERARAADDKQAEADADAQLHDAIAQASHNTMFLHLHTSVIG
MLREHITINGTGLREQDDGASDLLLLQHRTLCDAICARRPEEARTAMQTHIDFVRSRVEQDGA
>Mature_223_residues
MRRIETALLDGTWPPGTRLPAERVLAGQYEVARNTVREAIQRLAARGLLQSRRGAGVYATDQLRAGIASPWGQLVADHPA
LRDDILEFRRVLEGATAYFAALRADAADVKRIRALMAELERARAADDKQAEADADAQLHDAIAQASHNTMFLHLHTSVIG
MLREHITINGTGLREQDDGASDLLLLQHRTLCDAICARRPEEARTAMQTHIDFVRSRVEQDGA

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=214, Percent_Identity=40.1869158878505, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1790032, Length=218, Percent_Identity=34.8623853211009, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI1790780, Length=223, Percent_Identity=29.1479820627803, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI48994955, Length=198, Percent_Identity=26.7676767676768, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789353, Length=223, Percent_Identity=27.8026905829596, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI87082208, Length=212, Percent_Identity=27.8301886792453, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1789621, Length=213, Percent_Identity=26.2910798122066, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 24645; Mature: 24645

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRIETALLDGTWPPGTRLPAERVLAGQYEVARNTVREAIQRLAARGLLQSRRGAGVYAT
CCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEH
DQLRAGIASPWGQLVADHPALRDDILEFRRVLEGATAYFAALRADAADVKRIRALMAELE
HHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
RARAADDKQAEADADAQLHDAIAQASHNTMFLHLHTSVIGMLREHITINGTGLREQDDGA
HHHCCCCHHHHCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHEECCCCCCCCCCCCC
SDLLLLQHRTLCDAICARRPEEARTAMQTHIDFVRSRVEQDGA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRRIETALLDGTWPPGTRLPAERVLAGQYEVARNTVREAIQRLAARGLLQSRRGAGVYAT
CCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEH
DQLRAGIASPWGQLVADHPALRDDILEFRRVLEGATAYFAALRADAADVKRIRALMAELE
HHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
RARAADDKQAEADADAQLHDAIAQASHNTMFLHLHTSVIGMLREHITINGTGLREQDDGA
HHHCCCCHHHHCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHEECCCCCCCCCCCCC
SDLLLLQHRTLCDAICARRPEEARTAMQTHIDFVRSRVEQDGA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]