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The map label for this gene is mrdA [H]

Identifier: 116691131

GI number: 116691131

Start: 3426944

End: 3429241

Strand: Direct

Name: mrdA [H]

Synonym: Bcen2424_3113

Alternate gene names: 116691131

Gene position: 3426944-3429241 (Clockwise)

Preceding gene: 116691130

Following gene: 116691132

Centisome position: 98.37

GC content: 68.93

Gene sequence:

>2298_bases
ATGACCGAATTCAACGACACCCAACAGCAGCTCTCGAGGTTCCGCCTGCGCGTCGCGGCGGCGGGCGTGTTCGTGTTCGT
CTGCTTCGGGCTGCTCGCGAGCCGCTTCTTCTACCTGCAGTTGATGCAGCACGGCAAATACGCGCTGCAGGCCGAGGAAA
ACCGCATCTCGGTCGCGCCGATCGTGCCGAACCGCGGGATCATCACCGACCGCAACGGCGTGATCCTCGCGAAGAACTAC
TCGGCGTACACGCTCGAGATCACGCCGTCGAAGCTCGACGACACGCTCGACAACACGATCGACAAGCTGTCCGAGATCAT
CCCGATCGACGCCCGCGACCGCCGCCGCTTCAAGAAGCTCCAGGAAGACTCGAAGAATTTCGAGAGCCTGCCGATCCGCA
CGCGGCTCACCGACGCCGAAGTCGCGCGCTTCACCGCGCAGCGCTTCCGCTTCCCCGGCGTCGACGTGCGCGCGCGGCTG
TTCCGCCAGTACCCGCTCGGCATGACGGCCGCGCACGTGATCGGCTATATCGGCCGGATCTCGAAGCGCGACCAGGATCG
CATCGACGCGATGAGCGACGACAACGACAGCGACCAGGAGCACTACGATCCGCGCCGCGACGCGAACAACTACAAGGGCA
CCGACTACATCGGCAAGATCGGCGTCGAGCAGAGCTACGAGACCGAGCTGCACGGGCTGACGGGCTTCGAGGAAGTCGAG
GTGACGGCTGGCGGCCGGCCGGTGCGCACGCTGTCGCGCACGCAGGCGACGCCCGGCAACAACCTCGTGCTGTCGCTCGA
CATCGGGCTGCAGCAGGTCGCCGAGCAGGCGTTCGCCGGCAAGCGCGGCGCGCTCGTCGCGATCGAGCCGAAGACGGGCG
ACGTGCTCGCGTTCGTATCGTCGCCGAGCTTCGACCCGAACTCGTTCGTCGACGGCATCGACCAGCAGACCTGGGACGAG
CTGAACAACTCGCCCGACAAGCCGCTCCTGAACCGCCCGCTGCACGGCACCTACCCGCCCGGCTCGACGTACAAGCCGTT
CATGGCGCTCGCGGGCCTCACGCTCGGCAAGCGCACGCCGGGCTGGGGCTTCCAGGACCCGGGCTACTTCACGTTCGGCG
GCCACACGTTCCGCAACGACGTGCGCTCCGGCCAGGGCTGGGTCGACATGAACAAGGCGATCATGGTGTCGAACGACACC
TACTTCTACATGCTCGCGCGCGACCTCGGCGTGAACGCGATCGCGAACTTCATGAAGCCGTTCGGCTTCGGCCAGATCAC
CGGAATCGACATCCAGGGCGAGGCGCGCGGCATCCTGCCATCGACCGACTGGAAGAAGAAGGCGTTCAAGAAGGCCGCGC
AGCAGAAGTGGTTCGACGGCGAGACGATCAGCCTCGGAATCGGCCAGGGCTACAACTCGTTCACGATCCTGCAGCTCGCG
CACGCCACGGCAACGCTCGCGAACAACGGCGTCGTGATGAAGCCTCACCTCGTGAAGGAAGTCGAGGACCCGATCTCGCG
GGCGCGCCACCTGACCGTGCCGAAGGAAAGCGAGGTGATCCCGCTGAAGGCGGCCGACATCGACGTCGTGAAGCGCGGGA
TGGAGAACGTGATCGAGAACCCGTCCGGGACCGCGTACAAGGTGTTCCGCGGCGCGCAGTACCTCGCCGCCGGCAAGACC
GGTACCGCGCAGGTGTTCTCGCTGCAGGGTTCGAACTACAAGGGCCACCTGCTCGCCGAACACCTGCGCGACCACGCGCT
GTTCATCGCGTACGCGCCGGTCGACCATCCGCAGATCGCCGTCGCGCTGGTCGTCGAGAACGGCGGCTGGGGCGCGCAGG
CCGCCGGCCCGATCGCGCGTCGCGTGCTCGACTACTACCTGGTCGAGCGCCAGAACCCGAAGAACGAGGCCGCGGCCGTA
GCCGCCGCGGCGTCGGCGACCGAGCCGGTGAGCGCGCCGGTGGTCGGCGACACGTCGAAGCCGGCCACGATCGCGGCCGG
CTTCACCGCGCTGCCGCAGCCGGTCGTGCCGTCGGCGGCCAGCGCGGCCGAGGCGGCATCGGGTGCGTCGGGTGCGTCGG
GTGCCTTGGGCGCCTCTGGGGCCGCCAGCGCCAGCGCCACCGCGCCGGCCGACGCGAGCGCCGCGGCGCCGATGGCCGCG
AGCCTGCCGCCGATCCGGCGTCCGCACCGGCCGCGCCGGCCCGCCAGCGACGCGCAGCCGGTCGCCGCCGCGCCGCGGGA
CGACAACCATCGTGCGACGGCCCCCGCGAAAGCGGCGGACGCCGGCACCGCTCATTAA

Upstream 100 bases:

>100_bases
CCGGACCGACCTTGAATACCCGCCGCCCCCACGCCCGCCGCGCGCCGCGCTCCGGGGCGGCACCTCGCCCGCGTCCGCGC
GCGGGCCAGATTGCCCTTAA

Downstream 100 bases:

>100_bases
CGGAGAAAGGCATGCAATTCGACAAGCGCGCCTGGCTCGACAAGATCAAGCAGATGTTCGCGGGCTTCGATCGCCCGCTC
GCCCTCATCGTGTTCCTGCT

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 765; Mature: 764

Protein sequence:

>765_residues
MTEFNDTQQQLSRFRLRVAAAGVFVFVCFGLLASRFFYLQLMQHGKYALQAEENRISVAPIVPNRGIITDRNGVILAKNY
SAYTLEITPSKLDDTLDNTIDKLSEIIPIDARDRRRFKKLQEDSKNFESLPIRTRLTDAEVARFTAQRFRFPGVDVRARL
FRQYPLGMTAAHVIGYIGRISKRDQDRIDAMSDDNDSDQEHYDPRRDANNYKGTDYIGKIGVEQSYETELHGLTGFEEVE
VTAGGRPVRTLSRTQATPGNNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKTGDVLAFVSSPSFDPNSFVDGIDQQTWDE
LNNSPDKPLLNRPLHGTYPPGSTYKPFMALAGLTLGKRTPGWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNKAIMVSNDT
YFYMLARDLGVNAIANFMKPFGFGQITGIDIQGEARGILPSTDWKKKAFKKAAQQKWFDGETISLGIGQGYNSFTILQLA
HATATLANNGVVMKPHLVKEVEDPISRARHLTVPKESEVIPLKAADIDVVKRGMENVIENPSGTAYKVFRGAQYLAAGKT
GTAQVFSLQGSNYKGHLLAEHLRDHALFIAYAPVDHPQIAVALVVENGGWGAQAAGPIARRVLDYYLVERQNPKNEAAAV
AAAASATEPVSAPVVGDTSKPATIAAGFTALPQPVVPSAASAAEAASGASGASGALGASGAASASATAPADASAAAPMAA
SLPPIRRPHRPRRPASDAQPVAAAPRDDNHRATAPAKAADAGTAH

Sequences:

>Translated_765_residues
MTEFNDTQQQLSRFRLRVAAAGVFVFVCFGLLASRFFYLQLMQHGKYALQAEENRISVAPIVPNRGIITDRNGVILAKNY
SAYTLEITPSKLDDTLDNTIDKLSEIIPIDARDRRRFKKLQEDSKNFESLPIRTRLTDAEVARFTAQRFRFPGVDVRARL
FRQYPLGMTAAHVIGYIGRISKRDQDRIDAMSDDNDSDQEHYDPRRDANNYKGTDYIGKIGVEQSYETELHGLTGFEEVE
VTAGGRPVRTLSRTQATPGNNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKTGDVLAFVSSPSFDPNSFVDGIDQQTWDE
LNNSPDKPLLNRPLHGTYPPGSTYKPFMALAGLTLGKRTPGWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNKAIMVSNDT
YFYMLARDLGVNAIANFMKPFGFGQITGIDIQGEARGILPSTDWKKKAFKKAAQQKWFDGETISLGIGQGYNSFTILQLA
HATATLANNGVVMKPHLVKEVEDPISRARHLTVPKESEVIPLKAADIDVVKRGMENVIENPSGTAYKVFRGAQYLAAGKT
GTAQVFSLQGSNYKGHLLAEHLRDHALFIAYAPVDHPQIAVALVVENGGWGAQAAGPIARRVLDYYLVERQNPKNEAAAV
AAAASATEPVSAPVVGDTSKPATIAAGFTALPQPVVPSAASAAEAASGASGASGALGASGAASASATAPADASAAAPMAA
SLPPIRRPHRPRRPASDAQPVAAAPRDDNHRATAPAKAADAGTAH
>Mature_764_residues
TEFNDTQQQLSRFRLRVAAAGVFVFVCFGLLASRFFYLQLMQHGKYALQAEENRISVAPIVPNRGIITDRNGVILAKNYS
AYTLEITPSKLDDTLDNTIDKLSEIIPIDARDRRRFKKLQEDSKNFESLPIRTRLTDAEVARFTAQRFRFPGVDVRARLF
RQYPLGMTAAHVIGYIGRISKRDQDRIDAMSDDNDSDQEHYDPRRDANNYKGTDYIGKIGVEQSYETELHGLTGFEEVEV
TAGGRPVRTLSRTQATPGNNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKTGDVLAFVSSPSFDPNSFVDGIDQQTWDEL
NNSPDKPLLNRPLHGTYPPGSTYKPFMALAGLTLGKRTPGWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNKAIMVSNDTY
FYMLARDLGVNAIANFMKPFGFGQITGIDIQGEARGILPSTDWKKKAFKKAAQQKWFDGETISLGIGQGYNSFTILQLAH
ATATLANNGVVMKPHLVKEVEDPISRARHLTVPKESEVIPLKAADIDVVKRGMENVIENPSGTAYKVFRGAQYLAAGKTG
TAQVFSLQGSNYKGHLLAEHLRDHALFIAYAPVDHPQIAVALVVENGGWGAQAAGPIARRVLDYYLVERQNPKNEAAAVA
AAASATEPVSAPVVGDTSKPATIAAGFTALPQPVVPSAASAAEAASGASGASGALGASGAASASATAPADASAAAPMAAS
LPPIRRPHRPRRPASDAQPVAAAPRDDNHRATAPAKAADAGTAH

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=645, Percent_Identity=39.3798449612403, Blast_Score=469, Evalue=1e-133,
Organism=Escherichia coli, GI1786272, Length=629, Percent_Identity=23.5294117647059, Blast_Score=120, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 82543; Mature: 82412

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEFNDTQQQLSRFRLRVAAAGVFVFVCFGLLASRFFYLQLMQHGKYALQAEENRISVAP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEE
IVPNRGIITDRNGVILAKNYSAYTLEITPSKLDDTLDNTIDKLSEIIPIDARDRRRFKKL
ECCCCCEEECCCCEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
QEDSKNFESLPIRTRLTDAEVARFTAQRFRFPGVDVRARLFRQYPLGMTAAHVIGYIGRI
HHHCCCHHCCCCEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
SKRDQDRIDAMSDDNDSDQEHYDPRRDANNYKGTDYIGKIGVEQSYETELHGLTGFEEVE
CCCCHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCHHEECCCCCCHHHHHCCCCCCCEEE
VTAGGRPVRTLSRTQATPGNNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKTGDVLAFVS
EECCCCCHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCCCCCEEEEECCCCCEEEEEC
SPSFDPNSFVDGIDQQTWDELNNSPDKPLLNRPLHGTYPPGSTYKPFMALAGLTLGKRTP
CCCCCCHHHHCCCCHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCCC
GWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNKAIMVSNDTYFYMLARDLGVNAIANFMKP
CCCCCCCCEEEECCHHHHHHHCCCCCEEECCCEEEEECCCEEEEEEHHHCHHHHHHHHCC
FGFGQITGIDIQGEARGILPSTDWKKKAFKKAAQQKWFDGETISLGIGQGYNSFTILQLA
CCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEH
HATATLANNGVVMKPHLVKEVEDPISRARHLTVPKESEVIPLKAADIDVVKRGMENVIEN
HHHHHHCCCCEEECCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHCC
PSGTAYKVFRGAQYLAAGKTGTAQVFSLQGSNYKGHLLAEHLRDHALFIAYAPVDHPQIA
CCCCEEEEECCCEEEECCCCCCEEEEEECCCCCCCHHHHHHHCCCEEEEEECCCCCCCEE
VALVVENGGWGAQAAGPIARRVLDYYLVERQNPKNEAAAVAAAASATEPVSAPVVGDTSK
EEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCC
PATIAAGFTALPQPVVPSAASAAEAASGASGASGALGASGAASASATAPADASAAAPMAA
CCEEECCCHHCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
SLPPIRRPHRPRRPASDAQPVAAAPRDDNHRATAPAKAADAGTAH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TEFNDTQQQLSRFRLRVAAAGVFVFVCFGLLASRFFYLQLMQHGKYALQAEENRISVAP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEE
IVPNRGIITDRNGVILAKNYSAYTLEITPSKLDDTLDNTIDKLSEIIPIDARDRRRFKKL
ECCCCCEEECCCCEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
QEDSKNFESLPIRTRLTDAEVARFTAQRFRFPGVDVRARLFRQYPLGMTAAHVIGYIGRI
HHHCCCHHCCCCEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
SKRDQDRIDAMSDDNDSDQEHYDPRRDANNYKGTDYIGKIGVEQSYETELHGLTGFEEVE
CCCCHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCHHEECCCCCCHHHHHCCCCCCCEEE
VTAGGRPVRTLSRTQATPGNNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKTGDVLAFVS
EECCCCCHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCCCCCEEEEECCCCCEEEEEC
SPSFDPNSFVDGIDQQTWDELNNSPDKPLLNRPLHGTYPPGSTYKPFMALAGLTLGKRTP
CCCCCCHHHHCCCCHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCCC
GWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNKAIMVSNDTYFYMLARDLGVNAIANFMKP
CCCCCCCCEEEECCHHHHHHHCCCCCEEECCCEEEEECCCEEEEEEHHHCHHHHHHHHCC
FGFGQITGIDIQGEARGILPSTDWKKKAFKKAAQQKWFDGETISLGIGQGYNSFTILQLA
CCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEH
HATATLANNGVVMKPHLVKEVEDPISRARHLTVPKESEVIPLKAADIDVVKRGMENVIEN
HHHHHHCCCCEEECCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHCC
PSGTAYKVFRGAQYLAAGKTGTAQVFSLQGSNYKGHLLAEHLRDHALFIAYAPVDHPQIA
CCCCEEEEECCCEEEECCCCCCEEEEEECCCCCCCHHHHHHHCCCEEEEEECCCCCCCEE
VALVVENGGWGAQAAGPIARRVLDYYLVERQNPKNEAAAVAAAASATEPVSAPVVGDTSK
EEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCC
PATIAAGFTALPQPVVPSAASAAEAASGASGASGALGASGAASASATAPADASAAAPMAA
CCEEECCCHHCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
SLPPIRRPHRPRRPASDAQPVAAAPRDDNHRATAPAKAADAGTAH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]