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The map label for this gene is dctA

Identifier: 116690893

GI number: 116690893

Start: 3173588

End: 3174880

Strand: Reverse

Name: dctA

Synonym: Bcen2424_2873

Alternate gene names: 116690893

Gene position: 3174880-3173588 (Counterclockwise)

Preceding gene: 116690894

Following gene: 116690892

Centisome position: 91.13

GC content: 64.81

Gene sequence:

>1293_bases
GTGAAGAAGAAACCCTTCTACAAAGTGCTCTATGTGCAGGTGATTTTCGCCATCATCGTCGGCGTGATCCTCGGCCACTT
CTACCCATCGATCGCCACCGACATGAAGCCGCTCGGCGACGGGTTCATCAAGCTGATCAAGATGGTGATCGGCCCGATCA
TCTTCTGTACGGTCGTCACCGGCATTGCCGGCATGGAGGACATGAAGAAGGTCGGCCGCGTCGGCGGCAAGGCGCTGCTG
TACTTCGAGATCGTGTCGACCTTCGCGCTGCTGCTCGGCCTCGCGGCCACGCACCTGCTGCGTCCGGGCGTCGGCTTCAA
CATCGATCCGGCGACGCTCGACGGCAAGGCCGTCGCGTCGTACGCGGCCAAGGCGCACGGGCAGTCGACGGTCGACTTCC
TGATGCACATCATCCCGAACACGATGGTCGACGCGTTCGCGCAGGGTGAAATCCTGCAGATCCTGCTGATCGCGCTGCTG
TTCGGCAGCGTGCTCGCGCACCTCGGCGAGCGCGGCAAGGTCGTGACCGACTTCATCGACGGCCTGACGCGCGTGCTGTT
CGGCATCGTGCACATCGTCACGAAGCTGGCCCCGATCGGCGCGTTCGGCGCGATGGCGTTCACGATCGGCAAGTACGGCG
TCGGCTCGCTGGTGCCGCTGCTCAAGCTGATCGGCACGTTCTACCTGACGTCGGTCGTGTTCGTGCTGGTCGTGCTCGGC
GCGATCGCGCGCTTCACCGGCTTCTCGATCATCCGCTTCGTGTCGTACATCAAGGAAGAGCTGCTGATCGTGCTCGGCAC
GAGCTCGTCGGAAGCCGCGCTGCCGCAGCTGATGGAAAAGCTCGAGAAGGCCGGCTGCTCGCGTTCGGTCGTCGGCCTCG
TCGTGCCGACCGGCTACTCGTTCAACCTCGACGGCACCAACATCTACATGACGATGGCCGTGCTGTTCATCGCGCAGGCG
ACCAACATCGAGCTGACGTGGATGCAGCAGCTTACGCTGCTGGCCGTCGCGATGCTGACGTCGAAGGGCGCGAGCGGTGT
GACCGGCGCGGGCTTCATCACGCTGGCCGCGACGCTGGCCGTCGTGCCGACGATCCCGCTGTCGGGCATGGTGCTGATCC
TCGGCATCGACCGCTTCATGAGCGAATGCCGTGCGCTGACCAACATCGTCGGCAACGGCGTGGCCACCGTCGTCGTGTCG
GCCTGGGAGAAGGAGCTCGACCGCAACAAGCTGCGCCAGGCGCTGAAGGGCGGCGGCGAAGTCGCGCCGACCGAGACGAC
GGCCGGCGTCTGA

Upstream 100 bases:

>100_bases
TGCGGCACGGCAGCCGCGCGGGCGAATGCCTTTCCCCTGAGACATTCGCCTGCGCGCGTGACGCCGTTTCCACGGCTCAT
CTACTTCAGCAGGAACCATC

Downstream 100 bases:

>100_bases
CGTCATGAAGGAGCAGGCGGCGGCACCGCCCGCCGGCCGTGCGGCCCGCGGCGGCCGGGGTATCGAGGCGGAGGCCTATG
ACACAATAGGCGATCCGCAT

Product: C4-dicarboxylate transporter DctA

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MKKKPFYKVLYVQVIFAIIVGVILGHFYPSIATDMKPLGDGFIKLIKMVIGPIIFCTVVTGIAGMEDMKKVGRVGGKALL
YFEIVSTFALLLGLAATHLLRPGVGFNIDPATLDGKAVASYAAKAHGQSTVDFLMHIIPNTMVDAFAQGEILQILLIALL
FGSVLAHLGERGKVVTDFIDGLTRVLFGIVHIVTKLAPIGAFGAMAFTIGKYGVGSLVPLLKLIGTFYLTSVVFVLVVLG
AIARFTGFSIIRFVSYIKEELLIVLGTSSSEAALPQLMEKLEKAGCSRSVVGLVVPTGYSFNLDGTNIYMTMAVLFIAQA
TNIELTWMQQLTLLAVAMLTSKGASGVTGAGFITLAATLAVVPTIPLSGMVLILGIDRFMSECRALTNIVGNGVATVVVS
AWEKELDRNKLRQALKGGGEVAPTETTAGV

Sequences:

>Translated_430_residues
MKKKPFYKVLYVQVIFAIIVGVILGHFYPSIATDMKPLGDGFIKLIKMVIGPIIFCTVVTGIAGMEDMKKVGRVGGKALL
YFEIVSTFALLLGLAATHLLRPGVGFNIDPATLDGKAVASYAAKAHGQSTVDFLMHIIPNTMVDAFAQGEILQILLIALL
FGSVLAHLGERGKVVTDFIDGLTRVLFGIVHIVTKLAPIGAFGAMAFTIGKYGVGSLVPLLKLIGTFYLTSVVFVLVVLG
AIARFTGFSIIRFVSYIKEELLIVLGTSSSEAALPQLMEKLEKAGCSRSVVGLVVPTGYSFNLDGTNIYMTMAVLFIAQA
TNIELTWMQQLTLLAVAMLTSKGASGVTGAGFITLAATLAVVPTIPLSGMVLILGIDRFMSECRALTNIVGNGVATVVVS
AWEKELDRNKLRQALKGGGEVAPTETTAGV
>Mature_430_residues
MKKKPFYKVLYVQVIFAIIVGVILGHFYPSIATDMKPLGDGFIKLIKMVIGPIIFCTVVTGIAGMEDMKKVGRVGGKALL
YFEIVSTFALLLGLAATHLLRPGVGFNIDPATLDGKAVASYAAKAHGQSTVDFLMHIIPNTMVDAFAQGEILQILLIALL
FGSVLAHLGERGKVVTDFIDGLTRVLFGIVHIVTKLAPIGAFGAMAFTIGKYGVGSLVPLLKLIGTFYLTSVVFVLVVLG
AIARFTGFSIIRFVSYIKEELLIVLGTSSSEAALPQLMEKLEKAGCSRSVVGLVVPTGYSFNLDGTNIYMTMAVLFIAQA
TNIELTWMQQLTLLAVAMLTSKGASGVTGAGFITLAATLAVVPTIPLSGMVLILGIDRFMSECRALTNIVGNGVATVVVS
AWEKELDRNKLRQALKGGGEVAPTETTAGV

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family

Homologues:

Organism=Homo sapiens, GI169790839, Length=478, Percent_Identity=24.4769874476987, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI4827012, Length=274, Percent_Identity=29.9270072992701, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI21314632, Length=400, Percent_Identity=25.25, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI66773030, Length=408, Percent_Identity=24.5098039215686, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI194239697, Length=492, Percent_Identity=24.390243902439, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI5032093, Length=396, Percent_Identity=27.020202020202, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI223468564, Length=268, Percent_Identity=29.1044776119403, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI223468566, Length=268, Percent_Identity=29.1044776119403, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI262359914, Length=418, Percent_Identity=23.444976076555, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI40254478, Length=277, Percent_Identity=25.9927797833935, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI301601644, Length=166, Percent_Identity=30.1204819277108, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1789947, Length=414, Percent_Identity=62.8019323671498, Blast_Score=538, Evalue=1e-154,
Organism=Escherichia coli, GI1790514, Length=411, Percent_Identity=38.6861313868613, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI1788024, Length=393, Percent_Identity=21.1195928753181, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1789473, Length=323, Percent_Identity=25.077399380805, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17537407, Length=399, Percent_Identity=27.5689223057644, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI193206505, Length=477, Percent_Identity=24.5283018867925, Blast_Score=111, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI71996953, Length=470, Percent_Identity=24.2553191489362, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71983099, Length=449, Percent_Identity=23.8307349665924, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71983106, Length=449, Percent_Identity=23.8307349665924, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI193206654, Length=413, Percent_Identity=23.4866828087167, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17541374, Length=400, Percent_Identity=22.75, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24583025, Length=414, Percent_Identity=23.4299516908213, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI17137668, Length=414, Percent_Identity=23.4299516908213, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24583023, Length=414, Percent_Identity=23.4299516908213, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI281360481, Length=429, Percent_Identity=25.4079254079254, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI281360483, Length=429, Percent_Identity=25.4079254079254, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI17137666, Length=429, Percent_Identity=25.4079254079254, Blast_Score=92, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCTA_BURCA (Q1BT95)

Other databases:

- EMBL:   CP000378
- RefSeq:   YP_622133.1
- ProteinModelPortal:   Q1BT95
- SMR:   Q1BT95
- STRING:   Q1BT95
- GeneID:   4093001
- GenomeReviews:   CP000378_GR
- KEGG:   bcn:Bcen_2259
- eggNOG:   COG1301
- HOGENOM:   HBG739804
- OMA:   ALATDMK
- ProtClustDB:   PRK01663
- BioCyc:   BCEN331271:BCEN_2259-MONOMER
- HAMAP:   MF_01300
- InterPro:   IPR001991
- InterPro:   IPR018107
- PANTHER:   PTHR11958
- PRINTS:   PR00173

Pfam domain/function: PF00375 SDF

EC number: NA

Molecular weight: Translated: 45608; Mature: 45608

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1d0d0f5c)-; HASH(0x1948c844)-; HASH(0x1dcfad78)-; HASH(0x1c09dbf4)-; HASH(0x1e08cafc)-; HASH(0x1dd10b18)-; HASH(0x1d3d3550)-; HASH(0x1dd82aa8)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCH
>Mature Secondary Structure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CCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA