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The map label for this gene is hexR [H]

Identifier: 116690761

GI number: 116690761

Start: 3038259

End: 3039197

Strand: Reverse

Name: hexR [H]

Synonym: Bcen2424_2741

Alternate gene names: 116690761

Gene position: 3039197-3038259 (Counterclockwise)

Preceding gene: 116690764

Following gene: 116690760

Centisome position: 87.24

GC content: 70.93

Gene sequence:

>939_bases
ATGAATACGTCCGCTTCCCCGTCCGCTCCGCCTGCCGCCGAGCCGCATCCGGCTCAGGCCGCCCCGCCGGTCCTCGACAT
CGTCGCGCGGATCGCCGAATGCGCGCCCGAGCTGCGCGAAGCCGAGCGCAAGGTTGCCGCGTTCATCCTCGCCGATCTGG
CGCGCGCCGCGCATGCGAGCATCGGCGCGCTCGCGCGCGACGCGGAGGTCAGCGTCGCGACGGTCACGCGTTTCGCGAAG
GCCGTCGGCTGCCGCGACGTGCGCGAACTGAAGGTGCTCGTCGCGCAGGCGGCGGCCGTCGGTCAGCGTTTCCTGGTGCC
GTCCGACGACGCGCCGGCCGACGACGCGAGCCCCGCATCGATGGTCTACGACGAGATTCGCGTGGCGCTCGCGCACAACC
ACCAGTTGCTGCGCAACACGTCGTTCGACGCGGCGGCCGACCTGCTCGCCGGCGCGAAGATGACGTACGTGTACGGGCAG
GGCGGCGGTTCGACCGCGCTGGCCGACGAGCTGCGCTTCCGGCTCGTGCGTTTCGGCCGGCCGGTCGCGAGCTACCAGGA
CAGCCTGCTGCAACGGATGGTGGCCGCGACGCTGTCGGGCGACACCGTCGTCGTCGCGTTGTCGGTGAGCGGGCGCGTGC
CCGAGCTGCTCGAGAGCTGCCGGCTCGCGAAGCGCTACGGCGCGAAGCTGATCGCGATCACCGCGCCGGCGTCGCCGCTC
GCGAAGCTTGCCGACCACCTGATCCCGGTCGTCGCGTTCGAAACCGATTTCATTTACAAGCCGTCGACCTCGCGCTACGC
GATGATGATGGCGATCGACGTGCTCGTCACCGGCGTCGCGCTGCGGCTCGGCGATGCGGGCCGTGAATCGCTGCGCCGCA
TCAAACACGCGCTCGATGCGCACCGCGGCGGCGGAGACCGTCAACCGGTAGGAGACTGA

Upstream 100 bases:

>100_bases
ACTATGCATTGCACTGAAGTTGACATGCAGATGGTACAGAAAGTAGCATCGGCGCGGTGATGTTATTTAATAACATCCCG
CTTCACACCCTTTTCCGCCG

Downstream 100 bases:

>100_bases
CCATGCATTCGCATCCCGAAGCGGCCGATACGCTGATCGTCGGCGCGCAGTTGTACGACGGCACTGGCGCGCCGCCCGTC
ACGCGCGACGTCGCGATCCG

Product: RpiR family transcriptional regulator

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MNTSASPSAPPAAEPHPAQAAPPVLDIVARIAECAPELREAERKVAAFILADLARAAHASIGALARDAEVSVATVTRFAK
AVGCRDVRELKVLVAQAAAVGQRFLVPSDDAPADDASPASMVYDEIRVALAHNHQLLRNTSFDAAADLLAGAKMTYVYGQ
GGGSTALADELRFRLVRFGRPVASYQDSLLQRMVAATLSGDTVVVALSVSGRVPELLESCRLAKRYGAKLIAITAPASPL
AKLADHLIPVVAFETDFIYKPSTSRYAMMMAIDVLVTGVALRLGDAGRESLRRIKHALDAHRGGGDRQPVGD

Sequences:

>Translated_312_residues
MNTSASPSAPPAAEPHPAQAAPPVLDIVARIAECAPELREAERKVAAFILADLARAAHASIGALARDAEVSVATVTRFAK
AVGCRDVRELKVLVAQAAAVGQRFLVPSDDAPADDASPASMVYDEIRVALAHNHQLLRNTSFDAAADLLAGAKMTYVYGQ
GGGSTALADELRFRLVRFGRPVASYQDSLLQRMVAATLSGDTVVVALSVSGRVPELLESCRLAKRYGAKLIAITAPASPL
AKLADHLIPVVAFETDFIYKPSTSRYAMMMAIDVLVTGVALRLGDAGRESLRRIKHALDAHRGGGDRQPVGD
>Mature_312_residues
MNTSASPSAPPAAEPHPAQAAPPVLDIVARIAECAPELREAERKVAAFILADLARAAHASIGALARDAEVSVATVTRFAK
AVGCRDVRELKVLVAQAAAVGQRFLVPSDDAPADDASPASMVYDEIRVALAHNHQLLRNTSFDAAADLLAGAKMTYVYGQ
GGGSTALADELRFRLVRFGRPVASYQDSLLQRMVAATLSGDTVVVALSVSGRVPELLESCRLAKRYGAKLIAITAPASPL
AKLADHLIPVVAFETDFIYKPSTSRYAMMMAIDVLVTGVALRLGDAGRESLRRIKHALDAHRGGGDRQPVGD

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=281, Percent_Identity=35.2313167259786, Blast_Score=140, Evalue=8e-35,
Organism=Escherichia coli, GI1788767, Length=278, Percent_Identity=26.6187050359712, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI87082369, Length=248, Percent_Identity=26.2096774193548, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 32924; Mature: 32924

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTSASPSAPPAAEPHPAQAAPPVLDIVARIAECAPELREAERKVAAFILADLARAAHAS
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGALARDAEVSVATVTRFAKAVGCRDVRELKVLVAQAAAVGQRFLVPSDDAPADDASPAS
HHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCHHH
MVYDEIRVALAHNHQLLRNTSFDAAADLLAGAKMTYVYGQGGGSTALADELRFRLVRFGR
HHHHHHHHHHHHCHHHHHCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHCC
PVASYQDSLLQRMVAATLSGDTVVVALSVSGRVPELLESCRLAKRYGAKLIAITAPASPL
CHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCEEEEEECCCCHH
AKLADHLIPVVAFETDFIYKPSTSRYAMMMAIDVLVTGVALRLGDAGRESLRRIKHALDA
HHHHHHHHHHHEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
HRGGGDRQPVGD
HCCCCCCCCCCC
>Mature Secondary Structure
MNTSASPSAPPAAEPHPAQAAPPVLDIVARIAECAPELREAERKVAAFILADLARAAHAS
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGALARDAEVSVATVTRFAKAVGCRDVRELKVLVAQAAAVGQRFLVPSDDAPADDASPAS
HHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCHHH
MVYDEIRVALAHNHQLLRNTSFDAAADLLAGAKMTYVYGQGGGSTALADELRFRLVRFGR
HHHHHHHHHHHHCHHHHHCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHCC
PVASYQDSLLQRMVAATLSGDTVVVALSVSGRVPELLESCRLAKRYGAKLIAITAPASPL
CHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCEEEEEECCCCHH
AKLADHLIPVVAFETDFIYKPSTSRYAMMMAIDVLVTGVALRLGDAGRESLRRIKHALDA
HHHHHHHHHHHEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
HRGGGDRQPVGD
HCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]