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The map label for this gene is kduD [C]

Identifier: 116690504

GI number: 116690504

Start: 2755985

End: 2756758

Strand: Reverse

Name: kduD [C]

Synonym: Bcen2424_2484

Alternate gene names: 116690504

Gene position: 2756758-2755985 (Counterclockwise)

Preceding gene: 116690505

Following gene: 116690503

Centisome position: 79.13

GC content: 67.18

Gene sequence:

>774_bases
GTGGCAACTCATACGCTCGCAGACAAGGTCGTCCTGATCGCAGGCGGCGCAAAGAACCTCGGCGGCCTGATCGCCCGGGA
CCTGGCGGGCCACGGCGCGAAGGCGGTGGCGATTCACTACAACAGCGCGGCGTCGCAGGCGCAGGCCGAGGAGACGGCTG
CCGCGGTGCGCGCGGCCGGCGCGGAGGCCGCGACGTTCCAGGCGGACCTGACGACGGCCGCCGCGGTCGAGAGGCTGTTC
GACGACGCGAAGCAGCGCTTCGGCAAGATCGACATCGCGATCAACACGGTCGGCAAGGTGCTGAAGAAGCCGTTCACCGA
GATCAGCGAGGCCGAATACGACGAGATGTTCGCGGTCAACAGCAAGTCGGCGTTCTTCTTCATCAAGGAAGCCGGCCGGC
ATCTCGAGGATCACGGCAAGCTCGTCACGCTCGTGACGTCGCTGCTCGGCGCGTTCACGCCGTTCTACGCGGCGTACGAG
GGATCGAAGGCGCCGGTCGAGCACTTCACGCGCGCGGCGTCGAAGGAGTACGGCGCCCGCGGGATCTCGGTGACGGCCGT
CGGGCCGGGCCCGATGGACACGCCGTTCTTCTATCCGGCCGAAGGCGCCGATGCGGTCGCGTATCACAAGACGGCCGCCG
CGCTGTCGCCGTTCAGCAAGACGGGGCTGACCGACATCGAGGACGTCGTGCCGTTCATCCGCCATCTGGTGACCGACGGC
TGGTGGATCACCGGCCAGACGATCCTGATCAACGGCGGCTATACGACCAAGTAA

Upstream 100 bases:

>100_bases
GGATCGGTTTTCTGGATAATCCATCCAGCCGCGGCCGGCTGACCGGCGCGTCGCGCATGCCTACACTCCTAGCTTCGTTC
AACGAAAAAAGGAGTCAACC

Downstream 100 bases:

>100_bases
CCGGGGCGCTTGCCGGCCGCGCGGCGCACCGCACTGGCGCGTTTGCGTGGACAATGGACGGGCGCGCGACCACGAGGCCG
CGCGCCCGTTTTCTCTGTGC

Product: short chain dehydrogenase

Products: @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate!; NADH. [C]

Alternate protein names: ORFC [H]

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MATHTLADKVVLIAGGAKNLGGLIARDLAGHGAKAVAIHYNSAASQAQAEETAAAVRAAGAEAATFQADLTTAAAVERLF
DDAKQRFGKIDIAINTVGKVLKKPFTEISEAEYDEMFAVNSKSAFFFIKEAGRHLEDHGKLVTLVTSLLGAFTPFYAAYE
GSKAPVEHFTRAASKEYGARGISVTAVGPGPMDTPFFYPAEGADAVAYHKTAAALSPFSKTGLTDIEDVVPFIRHLVTDG
WWITGQTILINGGYTTK

Sequences:

>Translated_257_residues
MATHTLADKVVLIAGGAKNLGGLIARDLAGHGAKAVAIHYNSAASQAQAEETAAAVRAAGAEAATFQADLTTAAAVERLF
DDAKQRFGKIDIAINTVGKVLKKPFTEISEAEYDEMFAVNSKSAFFFIKEAGRHLEDHGKLVTLVTSLLGAFTPFYAAYE
GSKAPVEHFTRAASKEYGARGISVTAVGPGPMDTPFFYPAEGADAVAYHKTAAALSPFSKTGLTDIEDVVPFIRHLVTDG
WWITGQTILINGGYTTK
>Mature_256_residues
ATHTLADKVVLIAGGAKNLGGLIARDLAGHGAKAVAIHYNSAASQAQAEETAAAVRAAGAEAATFQADLTTAAAVERLFD
DAKQRFGKIDIAINTVGKVLKKPFTEISEAEYDEMFAVNSKSAFFFIKEAGRHLEDHGKLVTLVTSLLGAFTPFYAAYEG
SKAPVEHFTRAASKEYGARGISVTAVGPGPMDTPFFYPAEGADAVAYHKTAAALSPFSKTGLTDIEDVVPFIRHLVTDGW
WITGQTILINGGYTTK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=265, Percent_Identity=26.4150943396226, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI32483357, Length=259, Percent_Identity=24.7104247104247, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI10190704, Length=255, Percent_Identity=27.4509803921569, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI4758504, Length=211, Percent_Identity=28.9099526066351, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1789208, Length=266, Percent_Identity=27.8195488721804, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1787335, Length=250, Percent_Identity=24.8, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788459, Length=254, Percent_Identity=26.7716535433071, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1790717, Length=196, Percent_Identity=28.0612244897959, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI87082160, Length=195, Percent_Identity=27.1794871794872, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87082100, Length=267, Percent_Identity=26.2172284644195, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI2367365, Length=188, Percent_Identity=27.6595744680851, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789378, Length=192, Percent_Identity=27.0833333333333, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17562910, Length=266, Percent_Identity=28.9473684210526, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17560676, Length=264, Percent_Identity=26.1363636363636, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17538486, Length=261, Percent_Identity=29.5019157088123, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17544670, Length=263, Percent_Identity=27.7566539923954, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17562906, Length=266, Percent_Identity=26.6917293233083, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI193204405, Length=263, Percent_Identity=26.615969581749, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17560332, Length=266, Percent_Identity=28.1954887218045, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17560220, Length=264, Percent_Identity=26.1363636363636, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=264, Percent_Identity=27.2727272727273, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25147288, Length=256, Percent_Identity=25.390625, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17555706, Length=253, Percent_Identity=24.5059288537549, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17565030, Length=266, Percent_Identity=28.1954887218045, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=266, Percent_Identity=25.187969924812, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17563726, Length=264, Percent_Identity=26.1363636363636, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17551412, Length=267, Percent_Identity=25.8426966292135, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17560150, Length=265, Percent_Identity=25.2830188679245, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17564282, Length=199, Percent_Identity=29.6482412060301, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17562904, Length=268, Percent_Identity=24.2537313432836, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24639444, Length=260, Percent_Identity=27.6923076923077, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21355319, Length=265, Percent_Identity=29.4339622641509, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24644339, Length=255, Percent_Identity=26.2745098039216, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI28571526, Length=252, Percent_Identity=28.968253968254, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24643142, Length=255, Percent_Identity=25.4901960784314, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI23397609, Length=188, Percent_Identity=28.7234042553192, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21357041, Length=205, Percent_Identity=27.3170731707317, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.125 [C]

Molecular weight: Translated: 27170; Mature: 27039

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATHTLADKVVLIAGGAKNLGGLIARDLAGHGAKAVAIHYNSAASQAQAEETAAAVRAAG
CCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCC
AEAATFQADLTTAAAVERLFDDAKQRFGKIDIAINTVGKVLKKPFTEISEAEYDEMFAVN
CCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHHHHHHHHHHHHHHHCCHHHHEEEC
SKSAFFFIKEAGRHLEDHGKLVTLVTSLLGAFTPFYAAYEGSKAPVEHFTRAASKEYGAR
CCCEEEEEHHHCCCHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
GISVTAVGPGPMDTPFFYPAEGADAVAYHKTAAALSPFSKTGLTDIEDVVPFIRHLVTDG
CEEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHCCC
WWITGQTILINGGYTTK
EEEECCEEEEECCCCCC
>Mature Secondary Structure 
ATHTLADKVVLIAGGAKNLGGLIARDLAGHGAKAVAIHYNSAASQAQAEETAAAVRAAG
CCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCC
AEAATFQADLTTAAAVERLFDDAKQRFGKIDIAINTVGKVLKKPFTEISEAEYDEMFAVN
CCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHHHHHHHHHHHHHHHCCHHHHEEEC
SKSAFFFIKEAGRHLEDHGKLVTLVTSLLGAFTPFYAAYEGSKAPVEHFTRAASKEYGAR
CCCEEEEEHHHCCCHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
GISVTAVGPGPMDTPFFYPAEGADAVAYHKTAAALSPFSKTGLTDIEDVVPFIRHLVTDG
CEEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHCCC
WWITGQTILINGGYTTK
EEEECCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 15.4 {2-deoxygluconate}} [C]

Substrates: @DEOX03.txt*2-Deoxy-D-Gluconate!; NAD(+) [C]

Specific reaction: @DEOX03.txt*2-Deoxy-D-Gluconate! + NAD(+) = @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate! + NADH. [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8868443 [H]