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The map label for this gene is ilvR [H]

Identifier: 116690481

GI number: 116690481

Start: 2732114

End: 2733100

Strand: Reverse

Name: ilvR [H]

Synonym: Bcen2424_2461

Alternate gene names: 116690481

Gene position: 2733100-2732114 (Counterclockwise)

Preceding gene: 116690484

Following gene: 116690480

Centisome position: 78.45

GC content: 70.11

Gene sequence:

>987_bases
ATGGAGTTTCAGTTATCGGATGTCCAATATATTATTTGTCGCTTATTAAGTCGTTTTACGAATGAGTCGAGCATGGCCGA
TCCCACCCCCGACCTGCGCCAGTGGCGCTATTTCGTCACCGTCGCCGACGAGCGCCATTTCGGCCGCGCGGCCGAGCGCC
TGTCGATGACGCAGCCGCCGCTGTCGCAGGCGATTCGCGCGCTGGAGGACGCGCTGGGGGTCGCGCTGTTCGTGCGCACC
AAGCGCTCGGTGGCGCTGACGGCGGTCGGCGCGGCGCTGCTGCCGGACGTGCGCCGGCTGCTGGCGTCGGCCGACGCGCT
GCCGCCGCTCGCGCGGCGGCTCGCACGCGGCGAGGCCGGCTCGCTGTCGCTCGCGTTCGTGTCGACCGCCGACTACGGGC
TCTTGCCGTCGTTGCTGCGTGCGTTCGGCGCGCGCTATCCGCAGGTGCGGCTGCAACTTGCGGAAGCGACGAGCGACGTG
CAGATCGACGAACTCGTCGCCGGGCGCATCGATGCCGGGCTCGTGATTCCACCCGTGCCGCCGCGACACGCGGCCGGGCT
GTCGTACCTGCCGGTGGTGCGCGAACCGCTGGTGGTCGCGATGCCGGCCGGGGCATCCGATGCGCCGGAGGACGCGCCCG
TGCAGCTCGCCGAGGTTGCCGCGTTGCCGCTCGTGATCTTCCCGCGTCGTTTGGCGCCCGGCTTTTATGACATCATTACG
GGCTGCTACGGCGCGGCGGGGGAAACCCCCCACATCGGCCAGGAGGCGATCCAGATGCAGACGATCGTCAGCCTCGTGTC
GGCCGGCATGGGCGTCGCACTGGTGCCGCAATCGCTGCGTAACCTGCGGCGCACCGGCGTGGTCTACCGGCCGCTCGCCG
GCCCTGCGCCGGTCGTCGAGACGGGCCTCGTGTGGCGCACCGGCGACGTGAGCCCCGTGCTCGCCGGCTTCATCGACGTC
GTGCGCGCGCAAGGTCTTGCCGCGTGA

Upstream 100 bases:

>100_bases
TTGCGTGATGTTTTTAGAGCGGCGGTTGTACGACATGGGGAGCTCCATCGTTGTTTTGGCGACGCCGGCGCGACCGGTGC
GCCGGGTGGATCAACCAAGC

Downstream 100 bases:

>100_bases
CGTGAACGATGGCGTGCGCGCCCCGTCCAACGCGCGGTGCCGCACATGTGCGACGGCCGTACCGTATTCGAAAACTTCTT
CGCTAACCCATGATCATTCA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Isoleucine biosynthesis transcriptional activator [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MEFQLSDVQYIICRLLSRFTNESSMADPTPDLRQWRYFVTVADERHFGRAAERLSMTQPPLSQAIRALEDALGVALFVRT
KRSVALTAVGAALLPDVRRLLASADALPPLARRLARGEAGSLSLAFVSTADYGLLPSLLRAFGARYPQVRLQLAEATSDV
QIDELVAGRIDAGLVIPPVPPRHAAGLSYLPVVREPLVVAMPAGASDAPEDAPVQLAEVAALPLVIFPRRLAPGFYDIIT
GCYGAAGETPHIGQEAIQMQTIVSLVSAGMGVALVPQSLRNLRRTGVVYRPLAGPAPVVETGLVWRTGDVSPVLAGFIDV
VRAQGLAA

Sequences:

>Translated_328_residues
MEFQLSDVQYIICRLLSRFTNESSMADPTPDLRQWRYFVTVADERHFGRAAERLSMTQPPLSQAIRALEDALGVALFVRT
KRSVALTAVGAALLPDVRRLLASADALPPLARRLARGEAGSLSLAFVSTADYGLLPSLLRAFGARYPQVRLQLAEATSDV
QIDELVAGRIDAGLVIPPVPPRHAAGLSYLPVVREPLVVAMPAGASDAPEDAPVQLAEVAALPLVIFPRRLAPGFYDIIT
GCYGAAGETPHIGQEAIQMQTIVSLVSAGMGVALVPQSLRNLRRTGVVYRPLAGPAPVVETGLVWRTGDVSPVLAGFIDV
VRAQGLAA
>Mature_328_residues
MEFQLSDVQYIICRLLSRFTNESSMADPTPDLRQWRYFVTVADERHFGRAAERLSMTQPPLSQAIRALEDALGVALFVRT
KRSVALTAVGAALLPDVRRLLASADALPPLARRLARGEAGSLSLAFVSTADYGLLPSLLRAFGARYPQVRLQLAEATSDV
QIDELVAGRIDAGLVIPPVPPRHAAGLSYLPVVREPLVVAMPAGASDAPEDAPVQLAEVAALPLVIFPRRLAPGFYDIIT
GCYGAAGETPHIGQEAIQMQTIVSLVSAGMGVALVPQSLRNLRRTGVVYRPLAGPAPVVETGLVWRTGDVSPVLAGFIDV
VRAQGLAA

Specific function: Positively regulates the expression of the ilvD gene while negatively autoregulating its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=291, Percent_Identity=40.2061855670103, Blast_Score=183, Evalue=1e-47,
Organism=Escherichia coli, GI1788887, Length=296, Percent_Identity=34.7972972972973, Blast_Score=164, Evalue=8e-42,
Organism=Escherichia coli, GI2367136, Length=291, Percent_Identity=33.3333333333333, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1790399, Length=286, Percent_Identity=30.4195804195804, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI145693105, Length=259, Percent_Identity=28.1853281853282, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1787806, Length=295, Percent_Identity=27.1186440677966, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1788748, Length=302, Percent_Identity=29.4701986754967, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI157672245, Length=167, Percent_Identity=35.3293413173653, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788297, Length=253, Percent_Identity=26.8774703557312, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1790208, Length=262, Percent_Identity=29.7709923664122, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1787530, Length=246, Percent_Identity=28.4552845528455, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787589, Length=137, Percent_Identity=37.2262773722628, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI87081904, Length=205, Percent_Identity=31.7073170731707, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788296, Length=228, Percent_Identity=28.9473684210526, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1787601, Length=141, Percent_Identity=29.0780141843972, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI48994962, Length=71, Percent_Identity=46.4788732394366, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786713, Length=121, Percent_Identity=33.8842975206612, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789173, Length=145, Percent_Identity=34.4827586206897, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI87082132, Length=144, Percent_Identity=31.9444444444444, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34969; Mature: 34969

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFQLSDVQYIICRLLSRFTNESSMADPTPDLRQWRYFVTVADERHFGRAAERLSMTQPP
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHEEEEEEEECCHHHHHHHHHHCCCCCC
LSQAIRALEDALGVALFVRTKRSVALTAVGAALLPDVRRLLASADALPPLARRLARGEAG
HHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCC
SLSLAFVSTADYGLLPSLLRAFGARYPQVRLQLAEATSDVQIDELVAGRIDAGLVIPPVP
CEEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCEEECCCC
PRHAAGLSYLPVVREPLVVAMPAGASDAPEDAPVQLAEVAALPLVIFPRRLAPGFYDIIT
CCHHCCCCCHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHEEHHHHCCHHHHHHH
GCYGAAGETPHIGQEAIQMQTIVSLVSAGMGVALVPQSLRNLRRTGVVYRPLAGPAPVVE
HHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEECCCCCCCHHH
TGLVWRTGDVSPVLAGFIDVVRAQGLAA
CCCEEECCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEFQLSDVQYIICRLLSRFTNESSMADPTPDLRQWRYFVTVADERHFGRAAERLSMTQPP
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHEEEEEEEECCHHHHHHHHHHCCCCCC
LSQAIRALEDALGVALFVRTKRSVALTAVGAALLPDVRRLLASADALPPLARRLARGEAG
HHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCC
SLSLAFVSTADYGLLPSLLRAFGARYPQVRLQLAEATSDVQIDELVAGRIDAGLVIPPVP
CEEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCEEECCCC
PRHAAGLSYLPVVREPLVVAMPAGASDAPEDAPVQLAEVAALPLVIFPRRLAPGFYDIIT
CCHHCCCCCHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHEEHHHHCCHHHHHHH
GCYGAAGETPHIGQEAIQMQTIVSLVSAGMGVALVPQSLRNLRRTGVVYRPLAGPAPVVE
HHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEECCCCCCCHHH
TGLVWRTGDVSPVLAGFIDVVRAQGLAA
CCCEEECCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8113165; 11259647 [H]