Click here to switch to the map view.

The map label for this gene is parC [H]

Identifier: 116690379

GI number: 116690379

Start: 2621846

End: 2624167

Strand: Reverse

Name: parC [H]

Synonym: Bcen2424_2359

Alternate gene names: 116690379

Gene position: 2624167-2621846 (Counterclockwise)

Preceding gene: 116690380

Following gene: 116690378

Centisome position: 75.32

GC content: 67.1

Gene sequence:

>2322_bases
ATGGACGACAATACTTCCGATCTCTTTGCCAGCCCCGACGCGCCCGAGAGCGACGCGCTGACGCTCGGCAACTACGCGGA
GCAGGCGTATCTCAGCTACGCGGTCAGCGTCGTGAAGAGCCGCGCGCTGCCCGACGTGTGCGACGGCCAGAAGCCGGTGC
AGCGCCGGATCCTGTTCGCGATGAACGAAATGGGCCTCGGGCCCGACGCGAAGCCGGTGAAGTCGGCACGCGTGGTCGGC
GACGTGCTCGGTAAATACCACCCGCACGGCGACCAGTCGGCATACGACGCGCTCGTGCGGCTCGCGCAGGATTTCTCGCT
GCGCTACCCGCTGATCGACGGGCAGGGCAACTTCGGCTCGCGCGACGGCGACGGCGCGGCGGCGATGCGTTACACGGAAG
CGCGCCTCACGCCGATCGCGAAGCTGCTGCTCGACGAGATCGACCAGGGCACGGTCGACTTCATGCCGAACTACGACGGC
TCGTTCGAGGAGCCGAAGACGCTGCCGAGCCGCATGCCGTTCGTGCTGCTGAACGGCGCGTCGGGCATCGCGGTCGGCCT
CGCCACCGAAATCCCGTCGCACAACCTGCGCGAAGTCGCGGCGGCGGCGGTCGCATTGATCCGCAATCCGAAGCTCACGC
ACGCGGAGCTGATGAACCTGATTCCCGGCCCGGATTTCCCCGGCGGCGGCCAGATCATCTCGAGCGACACCGAAATCGCG
GCGGCGTACGAAACGGGCCGCGGCAGCCTGAAGGTGCGCGCGAAGTGGAAGATCGAGGATCTCGCGCGCGGCCAGTGGCA
GCTCGTCGTCACCGAGCTGCCGCCGAGCACGTCGGGGCAGAAGGTGCTCGAGGAAATCGAGGAACTGACCAACCCGAAGC
TCAAGCTCGGCAAGAAGACGCTGACGCCCGAGCAGCTCAACACGAAGAAGGCGATGCTCGACCTGCTCGACGCGGTGCGC
GACGAGTCGGGCAAGGAAGCCGCGGTGCGGCTCGTGTTCGAGCCGAAGTCGCGCACGATCGACCAGACGGAATTCGTGAA
CACGCTGCTCGCGTACACGAGCCTCGAATCGAACGCGACGCTGAACCTCGTGATGATCGGCGCAGACGGTCGGCCGGGCC
AGAAGGGCCTGCTGACGATCCTCGACGAATGGGTGAAGTTCCGCCAACTGACGATGACGCGCCGGTGCCGCCATCGTCTC
GCGAAGGTCGACGACCGCATCCACATCCTCGAAGGGCGGATGATCGTCTTCCTGAACATCGACGAGGTGATCCGCATCAT
CCGCGAGTCGGACGAGCCGAAGGCCGCGCTGATGAGCGCGTTCGGCCTCAGCGAGCGGCAGGCCGAGGACATCCTCGAAA
TCCGCCTGCGCCAGCTCGCGCGGCTCGAGAAGATCAAGATCGAGAAGGAACTCGACGCGCTGCGCGACGAGAAGGCAAAG
CTCGAGGAACTGCTCGCGAACGAAAGCGCGATGAAGCGGTTGATGATCAAGGAGATCGAGGCCGATGCGAAGCAGTACGG
CGACGATCGCCGCACGCTGATCCAGCAGGAAAAGCGCGCGACGTTCGAGGCGAAGGTGGTCGACGAGCCGGTGACGGTGG
TCGTGTCGCAGAAGGGCTGGGTGCGTGCGCTGAAGGGCCACGGGCTCGATCCGGCCGGCTTCACGTTCAAGGCGGGCGAC
CACCTGTACGCGGCGTTCCAGTGCCGCACGCCGGATCGCCTGATCGCGTGGGGCAGCAGCGGCCGCGTGTATTCGGTCGA
CGTGTCGGTGCTGCCGGGCGGGCGCGGCGACGGCGTGCCGGTCACGTCGCTGATCGAACTCGAATCGGGTTCGCACCTGA
TGCACTACTACGCGGCGCCGGCCGATCAGCAACTGCTGCTCGCGTCGAGCAACGGCTTCGGCTTCCTCGCGAAGGTCGGC
GACATGGTGAGCCGCCTGAAGGCCGGCAAGTCGTTCATGACGATCGATGCGGGTGCGGTGCCGCTCGCGCCGATGCCGGT
GCTGCCGAACGCGACGCAGGTCGCGTGCCTGTCGAGCGGCGGGCGCTTGCTGGTGTTCGGGATGGACGAGATGAAGACGC
TGTCCGGCGGCGGGCGCGGCGTGATCCTGATGGCGCTCGACGACAAGGAAACGCTCGTGCAGGCGCTGGCGATCGATCCG
GCCGGCGTCGTGCTGATCGGCACCGGCCGCGGCGGCAAGCCGCAGGACGACACGCTGTCGTATGCCGGGCTCGCGCCGCA
TATCGGCAAGCGCGCCCGCAAGGGCCGTGCGCCGGACACGAAGCTCAAGGTCGTCAACGAACTGCGTCCGCTGCTCGGCT
GA

Upstream 100 bases:

>100_bases
AAGGGCAACGACGTCGAAGCGGACATTTAAGCGGAGCGTTCCGCGCGGCCGGGCATGACGCCCGGCCCGGCCTCACGCCA
CTTACGAATACGGAATTCAG

Downstream 100 bases:

>100_bases
CGCCGCGCGCTGCGCGGCCGCCCGGATCGTCCGGTTCGGCCGCGATCGACGGCCGAACGTCCGCTTCGGCGGCGTGCGGC
TTTTTCTTGCCGGCGAGGAT

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 773; Mature: 773

Protein sequence:

>773_residues
MDDNTSDLFASPDAPESDALTLGNYAEQAYLSYAVSVVKSRALPDVCDGQKPVQRRILFAMNEMGLGPDAKPVKSARVVG
DVLGKYHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPIAKLLLDEIDQGTVDFMPNYDG
SFEEPKTLPSRMPFVLLNGASGIAVGLATEIPSHNLREVAAAAVALIRNPKLTHAELMNLIPGPDFPGGGQIISSDTEIA
AAYETGRGSLKVRAKWKIEDLARGQWQLVVTELPPSTSGQKVLEEIEELTNPKLKLGKKTLTPEQLNTKKAMLDLLDAVR
DESGKEAAVRLVFEPKSRTIDQTEFVNTLLAYTSLESNATLNLVMIGADGRPGQKGLLTILDEWVKFRQLTMTRRCRHRL
AKVDDRIHILEGRMIVFLNIDEVIRIIRESDEPKAALMSAFGLSERQAEDILEIRLRQLARLEKIKIEKELDALRDEKAK
LEELLANESAMKRLMIKEIEADAKQYGDDRRTLIQQEKRATFEAKVVDEPVTVVVSQKGWVRALKGHGLDPAGFTFKAGD
HLYAAFQCRTPDRLIAWGSSGRVYSVDVSVLPGGRGDGVPVTSLIELESGSHLMHYYAAPADQQLLLASSNGFGFLAKVG
DMVSRLKAGKSFMTIDAGAVPLAPMPVLPNATQVACLSSGGRLLVFGMDEMKTLSGGGRGVILMALDDKETLVQALAIDP
AGVVLIGTGRGGKPQDDTLSYAGLAPHIGKRARKGRAPDTKLKVVNELRPLLG

Sequences:

>Translated_773_residues
MDDNTSDLFASPDAPESDALTLGNYAEQAYLSYAVSVVKSRALPDVCDGQKPVQRRILFAMNEMGLGPDAKPVKSARVVG
DVLGKYHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPIAKLLLDEIDQGTVDFMPNYDG
SFEEPKTLPSRMPFVLLNGASGIAVGLATEIPSHNLREVAAAAVALIRNPKLTHAELMNLIPGPDFPGGGQIISSDTEIA
AAYETGRGSLKVRAKWKIEDLARGQWQLVVTELPPSTSGQKVLEEIEELTNPKLKLGKKTLTPEQLNTKKAMLDLLDAVR
DESGKEAAVRLVFEPKSRTIDQTEFVNTLLAYTSLESNATLNLVMIGADGRPGQKGLLTILDEWVKFRQLTMTRRCRHRL
AKVDDRIHILEGRMIVFLNIDEVIRIIRESDEPKAALMSAFGLSERQAEDILEIRLRQLARLEKIKIEKELDALRDEKAK
LEELLANESAMKRLMIKEIEADAKQYGDDRRTLIQQEKRATFEAKVVDEPVTVVVSQKGWVRALKGHGLDPAGFTFKAGD
HLYAAFQCRTPDRLIAWGSSGRVYSVDVSVLPGGRGDGVPVTSLIELESGSHLMHYYAAPADQQLLLASSNGFGFLAKVG
DMVSRLKAGKSFMTIDAGAVPLAPMPVLPNATQVACLSSGGRLLVFGMDEMKTLSGGGRGVILMALDDKETLVQALAIDP
AGVVLIGTGRGGKPQDDTLSYAGLAPHIGKRARKGRAPDTKLKVVNELRPLLG
>Mature_773_residues
MDDNTSDLFASPDAPESDALTLGNYAEQAYLSYAVSVVKSRALPDVCDGQKPVQRRILFAMNEMGLGPDAKPVKSARVVG
DVLGKYHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPIAKLLLDEIDQGTVDFMPNYDG
SFEEPKTLPSRMPFVLLNGASGIAVGLATEIPSHNLREVAAAAVALIRNPKLTHAELMNLIPGPDFPGGGQIISSDTEIA
AAYETGRGSLKVRAKWKIEDLARGQWQLVVTELPPSTSGQKVLEEIEELTNPKLKLGKKTLTPEQLNTKKAMLDLLDAVR
DESGKEAAVRLVFEPKSRTIDQTEFVNTLLAYTSLESNATLNLVMIGADGRPGQKGLLTILDEWVKFRQLTMTRRCRHRL
AKVDDRIHILEGRMIVFLNIDEVIRIIRESDEPKAALMSAFGLSERQAEDILEIRLRQLARLEKIKIEKELDALRDEKAK
LEELLANESAMKRLMIKEIEADAKQYGDDRRTLIQQEKRATFEAKVVDEPVTVVVSQKGWVRALKGHGLDPAGFTFKAGD
HLYAAFQCRTPDRLIAWGSSGRVYSVDVSVLPGGRGDGVPVTSLIELESGSHLMHYYAAPADQQLLLASSNGFGFLAKVG
DMVSRLKAGKSFMTIDAGAVPLAPMPVLPNATQVACLSSGGRLLVFGMDEMKTLSGGGRGVILMALDDKETLVQALAIDP
AGVVLIGTGRGGKPQDDTLSYAGLAPHIGKRARKGRAPDTKLKVVNELRPLLG

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=275, Percent_Identity=28.7272727272727, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI19913406, Length=187, Percent_Identity=32.620320855615, Blast_Score=90, Evalue=9e-18,
Organism=Escherichia coli, GI1789396, Length=748, Percent_Identity=45.5882352941176, Blast_Score=630, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=768, Percent_Identity=34.1145833333333, Blast_Score=382, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI212645845, Length=393, Percent_Identity=26.4631043256997, Blast_Score=93, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17535065, Length=173, Percent_Identity=35.8381502890173, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI212645657, Length=172, Percent_Identity=33.7209302325581, Blast_Score=82, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI115534553, Length=169, Percent_Identity=32.5443786982249, Blast_Score=80, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6324241, Length=248, Percent_Identity=29.8387096774194, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17136538, Length=256, Percent_Identity=28.515625, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 84145; Mature: 84145

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDNTSDLFASPDAPESDALTLGNYAEQAYLSYAVSVVKSRALPDVCDGQKPVQRRILFA
CCCCCCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
MNEMGLGPDAKPVKSARVVGDVLGKYHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGS
HHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEECCEECCCCCCCC
RDGDGAAAMRYTEARLTPIAKLLLDEIDQGTVDFMPNYDGSFEEPKTLPSRMPFVLLNGA
CCCCCHHHEEEHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECC
SGIAVGLATEIPSHNLREVAAAAVALIRNPKLTHAELMNLIPGPDFPGGGQIISSDTEIA
CCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCEEECCCCEE
AAYETGRGSLKVRAKWKIEDLARGQWQLVVTELPPSTSGQKVLEEIEELTNPKLKLGKKT
EEEECCCCCEEEEEEEEHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEECCCCC
LTPEQLNTKKAMLDLLDAVRDESGKEAAVRLVFEPKSRTIDQTEFVNTLLAYTSLESNAT
CCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCE
LNLVMIGADGRPGQKGLLTILDEWVKFRQLTMTRRCRHRLAKVDDRIHILEGRMIVFLNI
EEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEEEH
DEVIRIIRESDEPKAALMSAFGLSERQAEDILEIRLRQLARLEKIKIEKELDALRDEKAK
HHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEELLANESAMKRLMIKEIEADAKQYGDDRRTLIQQEKRATFEAKVVDEPVTVVVSQKGW
HHHHHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEECCCCEEEEEECCCH
VRALKGHGLDPAGFTFKAGDHLYAAFQCRTPDRLIAWGSSGRVYSVDVSVLPGGRGDGVP
HHHHHCCCCCCCCCEEECCCCEEEEEEECCCCEEEEECCCCEEEEEEEEEECCCCCCCCC
VTSLIELESGSHLMHYYAAPADQQLLLASSNGFGFLAKVGDMVSRLKAGKSFMTIDAGAV
EEEEEEECCCCEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCCC
PLAPMPVLPNATQVACLSSGGRLLVFGMDEMKTLSGGGRGVILMALDDKETLVQALAIDP
CCCCCCCCCCCCEEEEECCCCEEEEEECHHHHHHCCCCCEEEEEEECCHHHHHHHHHCCC
AGVVLIGTGRGGKPQDDTLSYAGLAPHIGKRARKGRAPDTKLKVVNELRPLLG
CCEEEEECCCCCCCCCCCEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MDDNTSDLFASPDAPESDALTLGNYAEQAYLSYAVSVVKSRALPDVCDGQKPVQRRILFA
CCCCCCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
MNEMGLGPDAKPVKSARVVGDVLGKYHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGS
HHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEECCEECCCCCCCC
RDGDGAAAMRYTEARLTPIAKLLLDEIDQGTVDFMPNYDGSFEEPKTLPSRMPFVLLNGA
CCCCCHHHEEEHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECC
SGIAVGLATEIPSHNLREVAAAAVALIRNPKLTHAELMNLIPGPDFPGGGQIISSDTEIA
CCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCEEECCCCEE
AAYETGRGSLKVRAKWKIEDLARGQWQLVVTELPPSTSGQKVLEEIEELTNPKLKLGKKT
EEEECCCCCEEEEEEEEHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEECCCCC
LTPEQLNTKKAMLDLLDAVRDESGKEAAVRLVFEPKSRTIDQTEFVNTLLAYTSLESNAT
CCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCE
LNLVMIGADGRPGQKGLLTILDEWVKFRQLTMTRRCRHRLAKVDDRIHILEGRMIVFLNI
EEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEEEH
DEVIRIIRESDEPKAALMSAFGLSERQAEDILEIRLRQLARLEKIKIEKELDALRDEKAK
HHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEELLANESAMKRLMIKEIEADAKQYGDDRRTLIQQEKRATFEAKVVDEPVTVVVSQKGW
HHHHHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEECCCCEEEEEECCCH
VRALKGHGLDPAGFTFKAGDHLYAAFQCRTPDRLIAWGSSGRVYSVDVSVLPGGRGDGVP
HHHHHCCCCCCCCCEEECCCCEEEEEEECCCCEEEEECCCCEEEEEEEEEECCCCCCCCC
VTSLIELESGSHLMHYYAAPADQQLLLASSNGFGFLAKVGDMVSRLKAGKSFMTIDAGAV
EEEEEEECCCCEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCCC
PLAPMPVLPNATQVACLSSGGRLLVFGMDEMKTLSGGGRGVILMALDDKETLVQALAIDP
CCCCCCCCCCCCEEEEECCCCEEEEEECHHHHHHCCCCCEEEEEEECCHHHHHHHHHCCC
AGVVLIGTGRGGKPQDDTLSYAGLAPHIGKRARKGRAPDTKLKVVNELRPLLG
CCEEEEECCCCCCCCCCCEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7830580 [H]