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The map label for this gene is ilvC [H]

Identifier: 116690284

GI number: 116690284

Start: 2518012

End: 2519028

Strand: Reverse

Name: ilvC [H]

Synonym: Bcen2424_2263

Alternate gene names: 116690284

Gene position: 2519028-2518012 (Counterclockwise)

Preceding gene: 116690285

Following gene: 116690283

Centisome position: 72.3

GC content: 64.21

Gene sequence:

>1017_bases
ATGAACGTTTTCTACGACAAAGACGCTGACCTCTCCCTCATCAAGGGCAAGCAAGTCACGATCATCGGCTACGGCTCGCA
AGGCCATGCACACGCGCTGAACCTGAAGGACAGCGGCGTGAACGTGACGGTCGGCCTGCGCAAGGGCGGCGCGTCGTGGA
GCAAGGCCGAAAACGCCGGCCTGTCGGTCAAGGAAGTCGCGGAAGCGGTGAAGGGCGCGGACGTCGTCATGATGCTGCTG
CCGGACGAGCAGATCGCCGACGTGTACGCGAAGGAAGTCCACGCGAACATCAAGCAGGGCGCGGCGCTCGCATTCGCGCA
CGGCTTTAACGTGCACTACGGCCAGGTGATCCCGCGCGCCGACCTCGACGTGATCATGATCGCGCCGAAGGCGCCGGGCC
ACACCGTGCGCGGCACGTACTCGCAAGGTGGCGGCGTGCCGCACCTGATCGCGGTGGCGCAGAACAAGTCGGGCGCGGCA
CGCGACATCGCGCTGTCGTACGCGGCGGCGAACGGCGGCGGCCGTGCCGGCATCATCGAGACGAACTTCCGTGAAGAAAC
CGAAACCGACCTGTTCGGCGAACAGGCCGTGCTGTGCGGCGGCACCGTCGAGCTGATCAAGGCCGGTTTCGAGACGCTGG
TCGAAGCCGGCTATGCGCCGGAAATGGCGTACTTCGAGTGCCTGCACGAGCTGAAGCTGATCGTCGACCTGATCTACGAA
GGCGGCATCGCGAACATGAACTACTCGATCTCGAACAACGCCGAGTACGGCGAGTACGTGACCGGCCCGCGCGTCGTCAC
GGAAGAGACGAAGAAGGCGATGAAGCAGTGCCTGACCGACATCCAGACGGGCGAGTACGCGAAGAGCTTCATTCTCGAGA
ACAAGGCAGGCGCCCCGACGCTGCAGTCGCGCCGCCGCCTGACGGCCGAGCACCAGATCGAGCAGGTCGGCGCGAAGCTG
CGTGCGATGATGCCGTGGATCGCGAAGAACAAGCTCGTCGACCAGACGAAGAACTAA

Upstream 100 bases:

>100_bases
ACATAGCCAAAGAGGCACGCCGGGTGCGCCGTCATGTCCCGGCCCGCAGTACTCCATCCGAACGAATTATTGAATTTTTT
GAATTAGCGAAGGAACCATC

Downstream 100 bases:

>100_bases
GCACCCCGTGCTGTTCCGGCCCTTCGAGTGGAGGGTCGGCATCAAAAAGCCGTCCGAAGGCAGCAGTGCCCCGGGCGGCT
TTTGTTATGCTACGTGCTTT

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MNVFYDKDADLSLIKGKQVTIIGYGSQGHAHALNLKDSGVNVTVGLRKGGASWSKAENAGLSVKEVAEAVKGADVVMMLL
PDEQIADVYAKEVHANIKQGAALAFAHGFNVHYGQVIPRADLDVIMIAPKAPGHTVRGTYSQGGGVPHLIAVAQNKSGAA
RDIALSYAAANGGGRAGIIETNFREETETDLFGEQAVLCGGTVELIKAGFETLVEAGYAPEMAYFECLHELKLIVDLIYE
GGIANMNYSISNNAEYGEYVTGPRVVTEETKKAMKQCLTDIQTGEYAKSFILENKAGAPTLQSRRRLTAEHQIEQVGAKL
RAMMPWIAKNKLVDQTKN

Sequences:

>Translated_338_residues
MNVFYDKDADLSLIKGKQVTIIGYGSQGHAHALNLKDSGVNVTVGLRKGGASWSKAENAGLSVKEVAEAVKGADVVMMLL
PDEQIADVYAKEVHANIKQGAALAFAHGFNVHYGQVIPRADLDVIMIAPKAPGHTVRGTYSQGGGVPHLIAVAQNKSGAA
RDIALSYAAANGGGRAGIIETNFREETETDLFGEQAVLCGGTVELIKAGFETLVEAGYAPEMAYFECLHELKLIVDLIYE
GGIANMNYSISNNAEYGEYVTGPRVVTEETKKAMKQCLTDIQTGEYAKSFILENKAGAPTLQSRRRLTAEHQIEQVGAKL
RAMMPWIAKNKLVDQTKN
>Mature_338_residues
MNVFYDKDADLSLIKGKQVTIIGYGSQGHAHALNLKDSGVNVTVGLRKGGASWSKAENAGLSVKEVAEAVKGADVVMMLL
PDEQIADVYAKEVHANIKQGAALAFAHGFNVHYGQVIPRADLDVIMIAPKAPGHTVRGTYSQGGGVPHLIAVAQNKSGAA
RDIALSYAAANGGGRAGIIETNFREETETDLFGEQAVLCGGTVELIKAGFETLVEAGYAPEMAYFECLHELKLIVDLIYE
GGIANMNYSISNNAEYGEYVTGPRVVTEETKKAMKQCLTDIQTGEYAKSFILENKAGAPTLQSRRRLTAEHQIEQVGAKL
RAMMPWIAKNKLVDQTKN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=321, Percent_Identity=37.6947040498442, Blast_Score=169, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6323387, Length=285, Percent_Identity=32.9824561403509, Blast_Score=124, Evalue=2e-29,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 36312; Mature: 36312

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVFYDKDADLSLIKGKQVTIIGYGSQGHAHALNLKDSGVNVTVGLRKGGASWSKAENAG
CCCCCCCCCCEEEECCCEEEEEEECCCCCEEEEEECCCCCEEEEEEECCCCCCCHHCCCC
LSVKEVAEAVKGADVVMMLLPDEQIADVYAKEVHANIKQGAALAFAHGFNVHYGQVIPRA
CCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCC
DLDVIMIAPKAPGHTVRGTYSQGGGVPHLIAVAQNKSGAARDIALSYAAANGGGRAGIIE
CCCEEEECCCCCCCCEEECCCCCCCCCEEEEEECCCCCCCHHEEEEEEECCCCCCEEEEE
TNFREETETDLFGEQAVLCGGTVELIKAGFETLVEAGYAPEMAYFECLHELKLIVDLIYE
CCCCCCHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
GGIANMNYSISNNAEYGEYVTGPRVVTEETKKAMKQCLTDIQTGEYAKSFILENKAGAPT
CCCCCEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCC
LQSRRRLTAEHQIEQVGAKLRAMMPWIAKNKLVDQTKN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNVFYDKDADLSLIKGKQVTIIGYGSQGHAHALNLKDSGVNVTVGLRKGGASWSKAENAG
CCCCCCCCCCEEEECCCEEEEEEECCCCCEEEEEECCCCCEEEEEEECCCCCCCHHCCCC
LSVKEVAEAVKGADVVMMLLPDEQIADVYAKEVHANIKQGAALAFAHGFNVHYGQVIPRA
CCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCC
DLDVIMIAPKAPGHTVRGTYSQGGGVPHLIAVAQNKSGAARDIALSYAAANGGGRAGIIE
CCCEEEECCCCCCCCEEECCCCCCCCCEEEEEECCCCCCCHHEEEEEEECCCCCCEEEEE
TNFREETETDLFGEQAVLCGGTVELIKAGFETLVEAGYAPEMAYFECLHELKLIVDLIYE
CCCCCCHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
GGIANMNYSISNNAEYGEYVTGPRVVTEETKKAMKQCLTDIQTGEYAKSFILENKAGAPT
CCCCCEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCC
LQSRRRLTAEHQIEQVGAKLRAMMPWIAKNKLVDQTKN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA