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The map label for this gene is paaF [H]

Identifier: 116690248

GI number: 116690248

Start: 2482640

End: 2483431

Strand: Direct

Name: paaF [H]

Synonym: Bcen2424_2227

Alternate gene names: 116690248

Gene position: 2482640-2483431 (Clockwise)

Preceding gene: 116690246

Following gene: 116690249

Centisome position: 71.26

GC content: 68.69

Gene sequence:

>792_bases
ATGAGTGCTGAACTGCTGGCCTCGCGTCCGCCCGAGAGCGAATCGACGCTCGTCCTCACGCTGTCCAATCCTGGCGCGCG
CAACGCGCTGCATCCCGACATGTACGCGGCGGGCATCGAAGCGCTCGCCACCGCCGAGCGCGATCCGGCGATTCGCGCCG
TCGTGCTGACGGGCGCCGATCGCTTCTTCTGCGCCGGCGGCAACCTGAACCGGCTGCTCGAGAATCGCTCGAAGGATCCG
TCCTTCCAGGCCGACAGCATCGATCAGCTCGCGGCATGGGTCACGGCGATCCGCGCATCGACGAAACCGGTGATCGCGGC
CGTCGAAGGCGCCGCGGCCGGCGCGGGCTTCTCGCTCGCGCTCGCGTGTGACCTGATCGTCGCCGCACACGATGCGAAAT
TCGTGATGTCGTATGCGCGCGTCGGCCTGACGCCCGACGGCGGCGGCTCGTGGTTTCTCGCCCGCGCGCTGCCGCGTGCG
ATCGCGGCCGAAATCCTGTTCGAAGGCAAACCGGTCGCCGCCGAACGCCTGCATGCGCTCGGCGTCGTCAACCGGCTCGC
CGCGCCAGGCACCGCATTGAGCGACGCACTGGCCTGGGCCGACGCACTCGCCGGCATCTCGCCGAATGCGCTCACGCGCA
TCAAGTCGCTGCTCGACGACGCGACCGAGCAACCGCTGGACGCGCACCTCGGCACCGAGCGCGATCATTTCGTCGCGTCG
CTGCATCATGCGGACGGGCTCGAAGGCATCACCGCTTTTCTCGAGAAGCGTCAGCCGCGCTACAAGCGCTGA

Upstream 100 bases:

>100_bases
GTTCGTCACGACAACATTACATCCGCTGCGGCGTCGGCTCTGGCCGTCCGCACGACACACGCGGCGTCGCTGCCGCGCCA
CCCGATGGAGACACGCTCGC

Downstream 100 bases:

>100_bases
TCCACCGCGTCGGACTTCGACCCGACGCCACGCCACCGGGTCCATCCGATACGGCCCGCCGACGCGTACGCCATGTCGGC
GACGCTCTCCGGCCCGCCGT

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MSAELLASRPPESESTLVLTLSNPGARNALHPDMYAAGIEALATAERDPAIRAVVLTGADRFFCAGGNLNRLLENRSKDP
SFQADSIDQLAAWVTAIRASTKPVIAAVEGAAAGAGFSLALACDLIVAAHDAKFVMSYARVGLTPDGGGSWFLARALPRA
IAAEILFEGKPVAAERLHALGVVNRLAAPGTALSDALAWADALAGISPNALTRIKSLLDDATEQPLDAHLGTERDHFVAS
LHHADGLEGITAFLEKRQPRYKR

Sequences:

>Translated_263_residues
MSAELLASRPPESESTLVLTLSNPGARNALHPDMYAAGIEALATAERDPAIRAVVLTGADRFFCAGGNLNRLLENRSKDP
SFQADSIDQLAAWVTAIRASTKPVIAAVEGAAAGAGFSLALACDLIVAAHDAKFVMSYARVGLTPDGGGSWFLARALPRA
IAAEILFEGKPVAAERLHALGVVNRLAAPGTALSDALAWADALAGISPNALTRIKSLLDDATEQPLDAHLGTERDHFVAS
LHHADGLEGITAFLEKRQPRYKR
>Mature_262_residues
SAELLASRPPESESTLVLTLSNPGARNALHPDMYAAGIEALATAERDPAIRAVVLTGADRFFCAGGNLNRLLENRSKDPS
FQADSIDQLAAWVTAIRASTKPVIAAVEGAAAGAGFSLALACDLIVAAHDAKFVMSYARVGLTPDGGGSWFLARALPRAI
AAEILFEGKPVAAERLHALGVVNRLAAPGTALSDALAWADALAGISPNALTRIKSLLDDATEQPLDAHLGTERDHFVASL
HHADGLEGITAFLEKRQPRYKR

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=261, Percent_Identity=31.8007662835249, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI31542718, Length=243, Percent_Identity=28.8065843621399, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI221136756, Length=246, Percent_Identity=25.609756097561, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI221136753, Length=246, Percent_Identity=25.609756097561, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI221307494, Length=246, Percent_Identity=25.609756097561, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI25453481, Length=245, Percent_Identity=25.3061224489796, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI51538573, Length=245, Percent_Identity=25.3061224489796, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4502327, Length=257, Percent_Identity=28.4046692607004, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI116235487, Length=218, Percent_Identity=28.4403669724771, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI4757966, Length=206, Percent_Identity=27.1844660194175, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI51538581, Length=206, Percent_Identity=27.1844660194175, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI4757968, Length=245, Percent_Identity=25.3061224489796, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI49355787, Length=245, Percent_Identity=25.3061224489796, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI70995211, Length=180, Percent_Identity=30, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI260274832, Length=217, Percent_Identity=26.2672811059908, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI45643119, Length=217, Percent_Identity=26.2672811059908, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI260275230, Length=217, Percent_Identity=26.2672811059908, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI20127408, Length=176, Percent_Identity=26.1363636363636, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787659, Length=261, Percent_Identity=36.7816091954023, Blast_Score=141, Evalue=5e-35,
Organism=Escherichia coli, GI221142681, Length=253, Percent_Identity=35.1778656126482, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1787660, Length=254, Percent_Identity=37.7952755905512, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1788597, Length=251, Percent_Identity=31.4741035856574, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI87082183, Length=231, Percent_Identity=28.1385281385281, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17554946, Length=254, Percent_Identity=31.8897637795276, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI25145438, Length=254, Percent_Identity=31.496062992126, Blast_Score=120, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17540714, Length=227, Percent_Identity=26.8722466960352, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17540306, Length=257, Percent_Identity=27.2373540856031, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17536985, Length=257, Percent_Identity=23.7354085603113, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17560910, Length=227, Percent_Identity=27.7533039647577, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17535521, Length=244, Percent_Identity=24.5901639344262, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17549921, Length=244, Percent_Identity=25.8196721311475, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17558304, Length=165, Percent_Identity=26.0606060606061, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI20129971, Length=251, Percent_Identity=31.4741035856574, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24653477, Length=251, Percent_Identity=31.4741035856574, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24653139, Length=250, Percent_Identity=31.2, Blast_Score=110, Evalue=8e-25,
Organism=Drosophila melanogaster, GI19922422, Length=245, Percent_Identity=28.9795918367347, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24654903, Length=243, Percent_Identity=24.2798353909465, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19920382, Length=209, Percent_Identity=28.7081339712919, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21357171, Length=253, Percent_Identity=24.5059288537549, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24650670, Length=198, Percent_Identity=29.2929292929293, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 27634; Mature: 27502

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAELLASRPPESESTLVLTLSNPGARNALHPDMYAAGIEALATAERDPAIRAVVLTGAD
CCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCC
RFFCAGGNLNRLLENRSKDPSFQADSIDQLAAWVTAIRASTKPVIAAVEGAAAGAGFSLA
EEEEECCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHH
LACDLIVAAHDAKFVMSYARVGLTPDGGGSWFLARALPRAIAAEILFEGKPVAAERLHAL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GVVNRLAAPGTALSDALAWADALAGISPNALTRIKSLLDDATEQPLDAHLGTERDHFVAS
HHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHH
LHHADGLEGITAFLEKRQPRYKR
HHHCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SAELLASRPPESESTLVLTLSNPGARNALHPDMYAAGIEALATAERDPAIRAVVLTGAD
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCC
RFFCAGGNLNRLLENRSKDPSFQADSIDQLAAWVTAIRASTKPVIAAVEGAAAGAGFSLA
EEEEECCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHH
LACDLIVAAHDAKFVMSYARVGLTPDGGGSWFLARALPRAIAAEILFEGKPVAAERLHAL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GVVNRLAAPGTALSDALAWADALAGISPNALTRIKSLLDDATEQPLDAHLGTERDHFVAS
HHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHH
LHHADGLEGITAFLEKRQPRYKR
HHHCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]