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The map label for this gene is phr [H]

Identifier: 116690199

GI number: 116690199

Start: 2426528

End: 2428087

Strand: Reverse

Name: phr [H]

Synonym: Bcen2424_2178

Alternate gene names: 116690199

Gene position: 2428087-2426528 (Counterclockwise)

Preceding gene: 116690200

Following gene: 116690196

Centisome position: 69.69

GC content: 72.56

Gene sequence:

>1560_bases
ATGACGGCCGGCGTCGACACCGCGCAGCGCAGCCGCGACAATACGCGTCTCCTTTTGCTTTCGCCATCGAGGTGCCTGCC
CGTGTCTGCCAAGCCGTCCGTTGCTCCCGCGATCGTCTGGTTCCGCGACGATCTGCGCGTGACCGATCAGCCCGCGCTGA
CGCGCGCGGTCGAATCCGGCCGGCCGCTCGTCTGCGTGTTCGTCGACGACACGGGCGCCGGCGCCGGGCCCGCACTCGGC
GGCGCGGCGCGCTGGTGGCTGCACGGGTCGCTGGCCGGGCTCGACGCCGCGCTCGCGCGTCACGACGGGCGCCTGCTGCT
GTTGCGCGGCGACGCACAGCGCGAGATCGAGCGCGTCGTCGGCGACACGGGCGCGGCAGCCGTGTACTGGAACCGCCGCT
ATGCGCAGCCGCAGCGCGACGCGGACGCGGCGCTGAAGGCGTCGCTCAAGGCGCGCGGCGTGACGGTCGAGAGCAGCAAC
GGCAGCCTGCTGAACGAGCCGTGGGAGGTGCTGACGGGCAGCGGCGGCCCGTACCAGGTGTTCACCGCGTACTGGCGCGC
GGCGCGCCGCGATCGCACGGTCGCCGCGCCGTTGCCGGCACCCGAGCGGATCGCGTTTCATCCGTGGCCGCAAGCCGTGC
GCGACCGCGCGCTGGCGCTCGATGCACTCGCGTTGCGTCCGCATGCGCCGGACTGGGCCGGCGGCCTGCGCGATGCGTGG
CCGGCGCCCGACGAAGCCGGCGCGCTCGCGCGACTCGACACGTTTCTGACGACCTCGCTCGCCGGCTATGCGGATGCGCG
CGACCGTCCCGACCGCCCCGCGACGAGCCGGCTGTCGCCGTTCCTGCGTTTCGGCAACGTGTCGCCGCGACAGGTGTGGC
ATGCGGTGCAGGGCGCCGCGAACGCAGGCGGCGCGGTATACGCGGCGCACGCCGACAAGTTCCTCAGCGAACTCGGCTGG
CGCGAATTCAGCTACACGCTGCTGTATCACTTCCCGGCGCTCGCGACCGACAATTTCCGTGCGCAATTCGATGCAATGCC
GTGGCGCGACGATCCCGCCGCGTTACGTGCGTGGCAGCGCGGCCGCACCGGCTATCCGCTCGTCGATGCGGGCCTGCGCG
AGCTGTGGACGACCGGCTGGATGCACAACCGCGTGCGGATGGTCGTCGCGTCGTTCCTGATCAAGCATCTGCTGATCGAC
TGGCGCGCGGGCGAAGCATGGTTCCGCGACACGCTGGTCGACGCCGATCCCGCGAACAACGCGGCGAGCTGGCAATGGGT
GGCTGGCTGCGGCGCCGACGCCGCGCCGTATTTCCGCATCTTCAATCCGGTCGCGCAGGGGCAGAAGTGCGACCCGGACG
GCGCGTACGTGCGGCGCTGGGTGCCCGAGCTTGCCGGCCTCGACGACGCGTCGATCCATGCGCCGTGGGAAGCGTCGCCG
CTGGCGCTCGAGGCGGCCGGCGTCCGGCTCGGCATCGACTATCCGGCGCCGCTCGTCGAGCATGCGGCCGCGCGCGCCCG
TGCGCTCGATGCGCTGGCCGCGTTGCCGAAGCGCCGCTGA

Upstream 100 bases:

>100_bases
TGAGAAACCTTCCGGGCGTGCTGCCGGTCGGTGGCGCGACTTCCATCGGATTGAAGCGGATCGTGTGGTCGAGCGCGATG
TCGCTCGTGGCGTGCCGGCC

Downstream 100 bases:

>100_bases
CCGCACGCGCCGGTTCGCCGCATCAATTGCAGAACGCGACGTGCTCGAGCAGCGCGTACGCGACGCCCGAATCGAAGTAG
GCCGCGCCGCACCACGCGAC

Product: deoxyribodipyrimidine photo-lyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 519; Mature: 518

Protein sequence:

>519_residues
MTAGVDTAQRSRDNTRLLLLSPSRCLPVSAKPSVAPAIVWFRDDLRVTDQPALTRAVESGRPLVCVFVDDTGAGAGPALG
GAARWWLHGSLAGLDAALARHDGRLLLLRGDAQREIERVVGDTGAAAVYWNRRYAQPQRDADAALKASLKARGVTVESSN
GSLLNEPWEVLTGSGGPYQVFTAYWRAARRDRTVAAPLPAPERIAFHPWPQAVRDRALALDALALRPHAPDWAGGLRDAW
PAPDEAGALARLDTFLTTSLAGYADARDRPDRPATSRLSPFLRFGNVSPRQVWHAVQGAANAGGAVYAAHADKFLSELGW
REFSYTLLYHFPALATDNFRAQFDAMPWRDDPAALRAWQRGRTGYPLVDAGLRELWTTGWMHNRVRMVVASFLIKHLLID
WRAGEAWFRDTLVDADPANNAASWQWVAGCGADAAPYFRIFNPVAQGQKCDPDGAYVRRWVPELAGLDDASIHAPWEASP
LALEAAGVRLGIDYPAPLVEHAAARARALDALAALPKRR

Sequences:

>Translated_519_residues
MTAGVDTAQRSRDNTRLLLLSPSRCLPVSAKPSVAPAIVWFRDDLRVTDQPALTRAVESGRPLVCVFVDDTGAGAGPALG
GAARWWLHGSLAGLDAALARHDGRLLLLRGDAQREIERVVGDTGAAAVYWNRRYAQPQRDADAALKASLKARGVTVESSN
GSLLNEPWEVLTGSGGPYQVFTAYWRAARRDRTVAAPLPAPERIAFHPWPQAVRDRALALDALALRPHAPDWAGGLRDAW
PAPDEAGALARLDTFLTTSLAGYADARDRPDRPATSRLSPFLRFGNVSPRQVWHAVQGAANAGGAVYAAHADKFLSELGW
REFSYTLLYHFPALATDNFRAQFDAMPWRDDPAALRAWQRGRTGYPLVDAGLRELWTTGWMHNRVRMVVASFLIKHLLID
WRAGEAWFRDTLVDADPANNAASWQWVAGCGADAAPYFRIFNPVAQGQKCDPDGAYVRRWVPELAGLDDASIHAPWEASP
LALEAAGVRLGIDYPAPLVEHAAARARALDALAALPKRR
>Mature_518_residues
TAGVDTAQRSRDNTRLLLLSPSRCLPVSAKPSVAPAIVWFRDDLRVTDQPALTRAVESGRPLVCVFVDDTGAGAGPALGG
AARWWLHGSLAGLDAALARHDGRLLLLRGDAQREIERVVGDTGAAAVYWNRRYAQPQRDADAALKASLKARGVTVESSNG
SLLNEPWEVLTGSGGPYQVFTAYWRAARRDRTVAAPLPAPERIAFHPWPQAVRDRALALDALALRPHAPDWAGGLRDAWP
APDEAGALARLDTFLTTSLAGYADARDRPDRPATSRLSPFLRFGNVSPRQVWHAVQGAANAGGAVYAAHADKFLSELGWR
EFSYTLLYHFPALATDNFRAQFDAMPWRDDPAALRAWQRGRTGYPLVDAGLRELWTTGWMHNRVRMVVASFLIKHLLIDW
RAGEAWFRDTLVDADPANNAASWQWVAGCGADAAPYFRIFNPVAQGQKCDPDGAYVRRWVPELAGLDDASIHAPWEASPL
ALEAAGVRLGIDYPAPLVEHAAARARALDALAALPKRR

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI188536100, Length=501, Percent_Identity=28.9421157684631, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI4758072, Length=496, Percent_Identity=28.0241935483871, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI188536103, Length=457, Percent_Identity=28.6652078774617, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI1786926, Length=503, Percent_Identity=37.375745526839, Blast_Score=271, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6324962, Length=523, Percent_Identity=27.3422562141491, Blast_Score=187, Evalue=4e-48,
Organism=Drosophila melanogaster, GI17137248, Length=499, Percent_Identity=29.8597194388778, Blast_Score=198, Evalue=9e-51,
Organism=Drosophila melanogaster, GI24585455, Length=499, Percent_Identity=29.8597194388778, Blast_Score=198, Evalue=9e-51,
Organism=Drosophila melanogaster, GI24648152, Length=539, Percent_Identity=25.6029684601113, Blast_Score=141, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 56633; Mature: 56502

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: PS00691 DNA_PHOTOLYASES_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAGVDTAQRSRDNTRLLLLSPSRCLPVSAKPSVAPAIVWFRDDLRVTDQPALTRAVESG
CCCCCCHHHHCCCCCEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHCC
RPLVCVFVDDTGAGAGPALGGAARWWLHGSLAGLDAALARHDGRLLLLRGDAQREIERVV
CCEEEEEEECCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHH
GDTGAAAVYWNRRYAQPQRDADAALKASLKARGVTVESSNGSLLNEPWEVLTGSGGPYQV
CCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCCCHHHEECCCCCHHH
FTAYWRAARRDRTVAAPLPAPERIAFHPWPQAVRDRALALDALALRPHAPDWAGGLRDAW
HHHHHHHHHCCCEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PAPDEAGALARLDTFLTTSLAGYADARDRPDRPATSRLSPFLRFGNVSPRQVWHAVQGAA
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCC
NAGGAVYAAHADKFLSELGWREFSYTLLYHFPALATDNFRAQFDAMPWRDDPAALRAWQR
CCCCEEEEHHHHHHHHHHCCCHHEEEEEEECCCCCCCCCHHHCCCCCCCCCHHHHHHHHC
GRTGYPLVDAGLRELWTTGWMHNRVRMVVASFLIKHLLIDWRAGEAWFRDTLVDADPANN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCC
AASWQWVAGCGADAAPYFRIFNPVAQGQKCDPDGAYVRRWVPELAGLDDASIHAPWEASP
CCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEECCCCCCC
LALEAAGVRLGIDYPAPLVEHAAARARALDALAALPKRR
EEEEECCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TAGVDTAQRSRDNTRLLLLSPSRCLPVSAKPSVAPAIVWFRDDLRVTDQPALTRAVESG
CCCCCHHHHCCCCCEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHCC
RPLVCVFVDDTGAGAGPALGGAARWWLHGSLAGLDAALARHDGRLLLLRGDAQREIERVV
CCEEEEEEECCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHH
GDTGAAAVYWNRRYAQPQRDADAALKASLKARGVTVESSNGSLLNEPWEVLTGSGGPYQV
CCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCCCHHHEECCCCCHHH
FTAYWRAARRDRTVAAPLPAPERIAFHPWPQAVRDRALALDALALRPHAPDWAGGLRDAW
HHHHHHHHHCCCEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PAPDEAGALARLDTFLTTSLAGYADARDRPDRPATSRLSPFLRFGNVSPRQVWHAVQGAA
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCC
NAGGAVYAAHADKFLSELGWREFSYTLLYHFPALATDNFRAQFDAMPWRDDPAALRAWQR
CCCCEEEEHHHHHHHHHHCCCHHEEEEEEECCCCCCCCCHHHCCCCCCCCCHHHHHHHHC
GRTGYPLVDAGLRELWTTGWMHNRVRMVVASFLIKHLLIDWRAGEAWFRDTLVDADPANN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCC
AASWQWVAGCGADAAPYFRIFNPVAQGQKCDPDGAYVRRWVPELAGLDDASIHAPWEASP
CCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEECCCCCCC
LALEAAGVRLGIDYPAPLVEHAAARARALDALAALPKRR
EEEEECCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7678007 [H]