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The map label for this gene is ptrB [C]

Identifier: 116690167

GI number: 116690167

Start: 2384778

End: 2386943

Strand: Reverse

Name: ptrB [C]

Synonym: Bcen2424_2146

Alternate gene names: 116690167

Gene position: 2386943-2384778 (Counterclockwise)

Preceding gene: 116690168

Following gene: 116690163

Centisome position: 68.51

GC content: 70.5

Gene sequence:

>2166_bases
ATGCCGCGATCGGACATAATCGCGGTTTGCATGCAGCTTGCCATTCCGCGATCCTCAATGTCCGAATCCTTCCGCTGGCC
CGCCGGGGCCGACCCGTTCCGTTTCCTCGAAGCACTCGACAGCAAGCGCGCCCGCACGTGGGTCGACGAGCAGAATGCGC
GCACCCGCGCCGCGCTGCGCGACGACGATGCCTATCGCGCGCTGACCGCGCGTCTCGCGAAAGCGTATCTGCCGCGCGAA
CGCCCGGTGATTCCGACCCGCTGGCGCGACTGGGCGTACGACCTGTGGCAGGACGATCTTCATCCGAAGGGGCTGTGGCG
CCGCACGCGCTGGGCCGACTGGCGGGCCGGCCAGCCGGCCTGGGAAACGCTGCTCGACATCGACGCGCTCGGCGCCGAAG
AGGGCGAGTCGTGGGTGTTCGAGCAGGAGGCGATCCTGTATCCGGACGGCGATCGCGTGCTGCTGTCGCTGTCGCCGGGC
GGCGCCGATGCGGTCGTCGTGCGCGAATTCGATCTCGTCGAGCGCCGGTTCGTCGACGGCGGTTTCACGATCGACGCGCC
GGGCCATCACACGGTCGGCTGGATCGACCGCGATACCGTGTACGTGAGCTGGGATCGCGGCGAAGCGCATGCGACCGCCG
CCGGCTATCCGTATGAGGCGCGGCGCTGGGTGCGCGGCACGGCGCTTGCCGAGGCGCCCGTCGTGTTCAGCGGCGAACCG
GACGACATCAGCGCAGGCGCGTGGTACGACCCGATCGACCGCCGCCACGTCGCGTGGCGCAGCGTCGATTTCTTCGACGC
ACACGCGTACTGGTTGACCGACGCGGGCGAATGGGCGCGCTACGACGTGCCGACGCATGTCGAGGTCGGGTTCTGGGAGG
GCTGGCTCGTGCTGGAGCCGCGCCTTGACTGGGATTGCGACGGCGTGCGCCACGCGGGCGGCTCGCTGCTCGCGATTCGC
GAAGAGGCGTTCCTCGCCGGCGCGCGCGAATTCACGACGCTGTTCGCGCCGCGGCCGACGACGTCCGCCTGTACGTGGAC
GCACACGCGCACGACGCTGATCGCCAGCTGGCTCGACGACGTGCACAACCGCACGATGCTGTGGCAGCCGCGGCAGGCCG
ACGACGGGGCGTGGACGTGGGACGCGCGGCCGTTCGACTGGCCCGGCGACGCGCAGATCGACGTCGAGCCCGTCGAATCG
ACGCTGAACGACGAGGTGTACGTCGACGTCGACACCTATCTCGATCCGCCCGAATGCTGGCTGGCCGATCTGGCCGACCG
CGCGGACGATGCACCGTCGCGCCGCGTGCTGCTCGACCGGCCGCCGGTGCAGTTCGACGCCGCCGGGCTGGTCGTACGCC
GCGCGAGCGCGCGTTCGCGCGACGGCACGGTCGTGCCGTACACGCTGATCGGGCCGCGCGATGCGCTCGACGCACCTGAA
GGCGTGGCGTGCGTCGCGCGGCCGTGCCTGCTGTCGGGCTATGGCGGCTTCGCGATCCCGAACCTGCCGGGCTACAGCGA
TGCGTTCGGCATCGGCTGGCTCGAACGCGGCGGCGTGATGGCGTTCGCGCACATCCGCGGCGGCGGCGAGTTCGGACCGC
GCTGGCATACCGACGCGCAGCGCGAACACCGCCAGCGTTCGTTCGACGATTTCATCGCAGTGGCCGAGGATCTGGTTGCG
ACCGGCGTGACGAGCGCCGCGCAGTTGGGGATCGAGGGCGGCAGCAACGGCGGGCTGCTGGTCGCCGCGTGCATGATGCA
GCGGCCGGAGTTGTTCGGCGCGGTGCTGTGCCGCGTGCCGCTGCTCGACATGCAGCGCTATCCGAAGCTGCACGCGGGCG
CCGCATGGCTCGACGAATACGGCGATCCGGACGATCCGCGCGAAGGCGCGGCGCTGGCAGCGTATTCGCCCTATCACCGC
GTGCGCGAAGGTGTCGTGTATCCGCCGTTGCTGCTGACGACGTCGACCCGCGACGACCGTGTCCATCCAGCGCATGCACG
CAAGATGGCCGCGCGCATGCAGGCGCTCGGTCACGAACGGGTGTGGTACTGGGAGAACACCGACGGCGGCCACGGCAGCG
CCGACGATCTCGAACGCGCGGAAGCCGATGCGGCCGAATTCGGCTTCCTGTGGGCCCATCTCGGGCCGGCGCCCGCGCGG
CGCTGA

Upstream 100 bases:

>100_bases
CGCGGAGCGGCTCGGGATCGGCCGCAACACGATCACGCGCAAGATCCAGGAACTCCATCTGGAGCCCTGAGCACGATTCG
CGGCATGCGCGGGCCCGCGC

Downstream 100 bases:

>100_bases
TCGCGCGCGGGCCCTGGACGATCAGCCGACGATCGCGACGACGGGCGTGTGGTCGGACGGCTGTTCCCACGTGCGCGGCA
CGCGATCGACTTCGCACGAT

Product: peptidase S9 prolyl oligopeptidase

Products: Hydrolyzed protein [C]

Alternate protein names: NA

Number of amino acids: Translated: 721; Mature: 720

Protein sequence:

>721_residues
MPRSDIIAVCMQLAIPRSSMSESFRWPAGADPFRFLEALDSKRARTWVDEQNARTRAALRDDDAYRALTARLAKAYLPRE
RPVIPTRWRDWAYDLWQDDLHPKGLWRRTRWADWRAGQPAWETLLDIDALGAEEGESWVFEQEAILYPDGDRVLLSLSPG
GADAVVVREFDLVERRFVDGGFTIDAPGHHTVGWIDRDTVYVSWDRGEAHATAAGYPYEARRWVRGTALAEAPVVFSGEP
DDISAGAWYDPIDRRHVAWRSVDFFDAHAYWLTDAGEWARYDVPTHVEVGFWEGWLVLEPRLDWDCDGVRHAGGSLLAIR
EEAFLAGAREFTTLFAPRPTTSACTWTHTRTTLIASWLDDVHNRTMLWQPRQADDGAWTWDARPFDWPGDAQIDVEPVES
TLNDEVYVDVDTYLDPPECWLADLADRADDAPSRRVLLDRPPVQFDAAGLVVRRASARSRDGTVVPYTLIGPRDALDAPE
GVACVARPCLLSGYGGFAIPNLPGYSDAFGIGWLERGGVMAFAHIRGGGEFGPRWHTDAQREHRQRSFDDFIAVAEDLVA
TGVTSAAQLGIEGGSNGGLLVAACMMQRPELFGAVLCRVPLLDMQRYPKLHAGAAWLDEYGDPDDPREGAALAAYSPYHR
VREGVVYPPLLLTTSTRDDRVHPAHARKMAARMQALGHERVWYWENTDGGHGSADDLERAEADAAEFGFLWAHLGPAPAR
R

Sequences:

>Translated_721_residues
MPRSDIIAVCMQLAIPRSSMSESFRWPAGADPFRFLEALDSKRARTWVDEQNARTRAALRDDDAYRALTARLAKAYLPRE
RPVIPTRWRDWAYDLWQDDLHPKGLWRRTRWADWRAGQPAWETLLDIDALGAEEGESWVFEQEAILYPDGDRVLLSLSPG
GADAVVVREFDLVERRFVDGGFTIDAPGHHTVGWIDRDTVYVSWDRGEAHATAAGYPYEARRWVRGTALAEAPVVFSGEP
DDISAGAWYDPIDRRHVAWRSVDFFDAHAYWLTDAGEWARYDVPTHVEVGFWEGWLVLEPRLDWDCDGVRHAGGSLLAIR
EEAFLAGAREFTTLFAPRPTTSACTWTHTRTTLIASWLDDVHNRTMLWQPRQADDGAWTWDARPFDWPGDAQIDVEPVES
TLNDEVYVDVDTYLDPPECWLADLADRADDAPSRRVLLDRPPVQFDAAGLVVRRASARSRDGTVVPYTLIGPRDALDAPE
GVACVARPCLLSGYGGFAIPNLPGYSDAFGIGWLERGGVMAFAHIRGGGEFGPRWHTDAQREHRQRSFDDFIAVAEDLVA
TGVTSAAQLGIEGGSNGGLLVAACMMQRPELFGAVLCRVPLLDMQRYPKLHAGAAWLDEYGDPDDPREGAALAAYSPYHR
VREGVVYPPLLLTTSTRDDRVHPAHARKMAARMQALGHERVWYWENTDGGHGSADDLERAEADAAEFGFLWAHLGPAPAR
R
>Mature_720_residues
PRSDIIAVCMQLAIPRSSMSESFRWPAGADPFRFLEALDSKRARTWVDEQNARTRAALRDDDAYRALTARLAKAYLPRER
PVIPTRWRDWAYDLWQDDLHPKGLWRRTRWADWRAGQPAWETLLDIDALGAEEGESWVFEQEAILYPDGDRVLLSLSPGG
ADAVVVREFDLVERRFVDGGFTIDAPGHHTVGWIDRDTVYVSWDRGEAHATAAGYPYEARRWVRGTALAEAPVVFSGEPD
DISAGAWYDPIDRRHVAWRSVDFFDAHAYWLTDAGEWARYDVPTHVEVGFWEGWLVLEPRLDWDCDGVRHAGGSLLAIRE
EAFLAGAREFTTLFAPRPTTSACTWTHTRTTLIASWLDDVHNRTMLWQPRQADDGAWTWDARPFDWPGDAQIDVEPVEST
LNDEVYVDVDTYLDPPECWLADLADRADDAPSRRVLLDRPPVQFDAAGLVVRRASARSRDGTVVPYTLIGPRDALDAPEG
VACVARPCLLSGYGGFAIPNLPGYSDAFGIGWLERGGVMAFAHIRGGGEFGPRWHTDAQREHRQRSFDDFIAVAEDLVAT
GVTSAAQLGIEGGSNGGLLVAACMMQRPELFGAVLCRVPLLDMQRYPKLHAGAAWLDEYGDPDDPREGAALAAYSPYHRV
REGVVYPPLLLTTSTRDDRVHPAHARKMAARMQALGHERVWYWENTDGGHGSADDLERAEADAAEFGFLWAHLGPAPARR

Specific function: Cleaves Peptide Bonds On The C-Terminal Side Of Lysyl And Argininyl Residues. [C]

COG id: COG1505

COG function: function code E; Serine proteases of the peptidase family S9A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=370, Percent_Identity=33.2432432432432, Blast_Score=180, Evalue=5e-45,
Organism=Homo sapiens, GI284172438, Length=214, Percent_Identity=27.5700934579439, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI284172431, Length=214, Percent_Identity=27.5700934579439, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI284172420, Length=214, Percent_Identity=27.5700934579439, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI284172413, Length=214, Percent_Identity=27.5700934579439, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI70778815, Length=214, Percent_Identity=27.5700934579439, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI108860686, Length=214, Percent_Identity=27.5700934579439, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI108860692, Length=211, Percent_Identity=27.4881516587678, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI1788150, Length=289, Percent_Identity=30.1038062283737, Blast_Score=122, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24583414, Length=277, Percent_Identity=37.5451263537906, Blast_Score=183, Evalue=3e-46,
Organism=Drosophila melanogaster, GI221510989, Length=684, Percent_Identity=25.4385964912281, Blast_Score=177, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: 3.4.21.83 [C]

Molecular weight: Translated: 80722; Mature: 80590

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRSDIIAVCMQLAIPRSSMSESFRWPAGADPFRFLEALDSKRARTWVDEQNARTRAALR
CCCHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHC
DDDAYRALTARLAKAYLPRERPVIPTRWRDWAYDLWQDDLHPKGLWRRTRWADWRAGQPA
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHCCCCCCCCCCCHH
WETLLDIDALGAEEGESWVFEQEAILYPDGDRVLLSLSPGGADAVVVREFDLVERRFVDG
HHHHHHHHHCCCCCCCCEEEECCEEEECCCCEEEEEECCCCCCEEEEEHHHHHHHHHCCC
GFTIDAPGHHTVGWIDRDTVYVSWDRGEAHATAAGYPYEARRWVRGTALAEAPVVFSGEP
CEEECCCCCCEEEEEECCEEEEEECCCCCCEEECCCCHHHHHHHHHHHHCCCCEEECCCC
DDISAGAWYDPIDRRHVAWRSVDFFDAHAYWLTDAGEWARYDVPTHVEVGFWEGWLVLEP
CCCCCCCCCCCCCCCEEEEECCCEEECCEEEEECCCCCEECCCCCEEEEEEECCEEEECC
RLDWDCDGVRHAGGSLLAIREEAFLAGAREFTTLFAPRPTTSACTWTHTRTTLIASWLDD
CCCCCCCCHHHCCCCEEEEEHHHHHCCCHHHHEEECCCCCCCCEEEECHHHHHHHHHHHH
VHNRTMLWQPRQADDGAWTWDARPFDWPGDAQIDVEPVESTLNDEVYVDVDTYLDPPECW
HCCCEEEECCCCCCCCCEEECCCCCCCCCCCEEEEEHHHHCCCCCEEEEECCCCCCHHHH
LADLADRADDAPSRRVLLDRPPVQFDAAGLVVRRASARSRDGTVVPYTLIGPRDALDAPE
HHHHHHHCCCCCCCEEEECCCCCCCCCCCCEEEECCCCCCCCCEEEEEEECCHHCCCCCC
GVACVARPCLLSGYGGFAIPNLPGYSDAFGIGWLERGGVMAFAHIRGGGEFGPRWHTDAQ
CHHHHHCHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEEECCCCCCCCCCCCCHH
REHRQRSFDDFIAVAEDLVATGVTSAAQLGIEGGSNGGLLVAACMMQRPELFGAVLCRVP
HHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHCC
LLDMQRYPKLHAGAAWLDEYGDPDDPREGAALAAYSPYHRVREGVVYPPLLLTTSTRDDR
HHHHHHCCCHHCCHHHHHHCCCCCCCCCCCEEEECCHHHHHHCCCCCCCEEEEECCCCCC
VHPAHARKMAARMQALGHERVWYWENTDGGHGSADDLERAEADAAEFGFLWAHLGPAPAR
CCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHCCHHHHCCCEEECCCCCCC
R
C
>Mature Secondary Structure 
PRSDIIAVCMQLAIPRSSMSESFRWPAGADPFRFLEALDSKRARTWVDEQNARTRAALR
CCHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHC
DDDAYRALTARLAKAYLPRERPVIPTRWRDWAYDLWQDDLHPKGLWRRTRWADWRAGQPA
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHCCCCCCCCCCCHH
WETLLDIDALGAEEGESWVFEQEAILYPDGDRVLLSLSPGGADAVVVREFDLVERRFVDG
HHHHHHHHHCCCCCCCCEEEECCEEEECCCCEEEEEECCCCCCEEEEEHHHHHHHHHCCC
GFTIDAPGHHTVGWIDRDTVYVSWDRGEAHATAAGYPYEARRWVRGTALAEAPVVFSGEP
CEEECCCCCCEEEEEECCEEEEEECCCCCCEEECCCCHHHHHHHHHHHHCCCCEEECCCC
DDISAGAWYDPIDRRHVAWRSVDFFDAHAYWLTDAGEWARYDVPTHVEVGFWEGWLVLEP
CCCCCCCCCCCCCCCEEEEECCCEEECCEEEEECCCCCEECCCCCEEEEEEECCEEEECC
RLDWDCDGVRHAGGSLLAIREEAFLAGAREFTTLFAPRPTTSACTWTHTRTTLIASWLDD
CCCCCCCCHHHCCCCEEEEEHHHHHCCCHHHHEEECCCCCCCCEEEECHHHHHHHHHHHH
VHNRTMLWQPRQADDGAWTWDARPFDWPGDAQIDVEPVESTLNDEVYVDVDTYLDPPECW
HCCCEEEECCCCCCCCCEEECCCCCCCCCCCEEEEEHHHHCCCCCEEEEECCCCCCHHHH
LADLADRADDAPSRRVLLDRPPVQFDAAGLVVRRASARSRDGTVVPYTLIGPRDALDAPE
HHHHHHHCCCCCCCEEEECCCCCCCCCCCCEEEECCCCCCCCCEEEEEEECCHHCCCCCC
GVACVARPCLLSGYGGFAIPNLPGYSDAFGIGWLERGGVMAFAHIRGGGEFGPRWHTDAQ
CHHHHHCHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEEECCCCCCCCCCCCCHH
REHRQRSFDDFIAVAEDLVATGVTSAAQLGIEGGSNGGLLVAACMMQRPELFGAVLCRVP
HHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHCC
LLDMQRYPKLHAGAAWLDEYGDPDDPREGAALAAYSPYHRVREGVVYPPLLLTTSTRDDR
HHHHHHCCCHHCCHHHHHHCCCCCCCCCCCEEEECCHHHHHHCCCCCCCEEEEECCCCCC
VHPAHARKMAARMQALGHERVWYWENTDGGHGSADDLERAEADAAEFGFLWAHLGPAPAR
CCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHCCHHHHCCCEEECCCCCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+ [C]

Kcat value (1/min): 11820 [C]

Specific activity: NA

Km value (mM): 0.23 {tosyl-Arg} 0.33 {N-benzyloxycarbonyl-Lys} 0.31 {N-benzyloxycarbonyl-Lys} 0.92 {benzoyl-Lys} 0.6 {N-benzoyl-Arg} 0.5 {benzoyl-Arg} 0.48 {benzoyl-Arg} 0.25 {benzoyl-Arg} 80 {acetyl-tyrosine} 0.47 {tosyl-Lys-methyl} [C]

Substrates: Protein; H2O [C]

Specific reaction: Protein + H2O = hydrolyzed protein [C]

General reaction: Peptide bond hydrolysis [C]

Inhibitor: Antipain; Aromaticamidines; Benzamidine; Co2+; DFP; Fe2+; Hg2+; L-Arginine; Leupeptin sulfhydryl agents, trypsin inhibitors, 1, 10-phenanthroline; p-Aminobenzamidine; Tosyl -Leuchloromethyl ketone; Zn2+ [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]