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The map label for this gene is lpxD [H]

Identifier: 116690030

GI number: 116690030

Start: 2224770

End: 2225864

Strand: Reverse

Name: lpxD [H]

Synonym: Bcen2424_2009

Alternate gene names: 116690030

Gene position: 2225864-2224770 (Counterclockwise)

Preceding gene: 116690031

Following gene: 116690029

Centisome position: 63.89

GC content: 68.58

Gene sequence:

>1095_bases
ATGGCATTGACGCTTGAGGAACTCGTAAAACGGTTCGGCGGCGAGATCGCCGGCGACGCACAGTGCAAGGTGGGCGGGCT
CGCACCGCTCGACCAGGCGGGCCCTCAGCAGCTCGCGTTCCTCGCGAACCCGAAGTACCTGTCGCAGGTCGAGTCGACCC
GCGCCGGTGCGGTCCTGATCGCACCGAAGGATCTGGAAAAGCTGGGTGCGGCCGCTCAAGGCCGGACGGCCGGCCCCCGC
AACTTCATCGTGACGCCGAATCCGTACGCGTACTTCGCGCGCGTCGCGCAGATGTTCATCGATCTCGCCACGCCGCCGCG
CGCGGCCGGCGTGCATCCGAGCGCGACGATCGATCCGGCCGCGAAGGTCGCCGCGACCGCGGTGATCGGCCCGCACGTGA
CGATCGAGGCCGGCGCGGTGATCGAAGACGGCGTGCAGCTCGACGCGAACGTGTTCGTCGGCCGCGGCACGACGATCGGC
GCCGGCTCGCATTTTTATCCGAACGCATCGGTGTACCACGGCTGCAAGGTCGGCCCGCGCGCGATCGTCCATGCGGGCGC
CGTGATCGGTTCCGACGGCTTCGGCTTCGCACCGGATTTCGTCGGTGACGGCGACGCGCGCACCGGCAGCTGGGTCAAGA
TCCCGCAGGTCGGCGGCGTGACGATCGGCCCGGACGTCGAAATCGGCGCGAACACGACGATCGATCGCGGTGCGATGGCG
GATACCGTCATCGAGGAATGCGTGAAGATCGACAACCAGGTCCAGATCGGCCACAACTGCCGGATCGGCGCGTACACGGT
GATCGCCGGCAGCGCCGGCATCGCGGGCAGCACGACGATCGGCCGCCACTGCATGATCGGTGGCGCGGCCGGGATCGCCG
GCCACGTGACGCTCGGCGACTATGTGATCATCACCGCGAAGTCGGGCGTATCGAAGTCGCTGCCGAAGGCCGGCATCTAT
ACCAGCGCGTTTCCGGCCGTCGACCACGGCGAATGGAACAAGAGCGCCGCGCTCGTGCGCAACCTCGACAAGCTGCGCGA
GCGCATCAAGGCGCTCGAAGCCGCGCTCGCCGCCCAGGGCGGCACCGACGCCTGA

Upstream 100 bases:

>100_bases
GTGCAGGAAGCCGTGTACGTCAGCCCGCGCATCGACATCACCGACAAGGTGCTCAAGGCGCTCGCGTCCGGCTCGACGAA
CTGAACGGAGCAGACGACGA

Downstream 100 bases:

>100_bases
GCGCATCATGCGAGACCACGAACCGGGCACGGCCAGCGCAACCGGCCCGGTTTGCCAGACGGGGCCGCGCGGCGGCCCGC
TTCAGCCTTTGCATCACCAC

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: UDP-2,3-Bis(3-Hydroxytetradecanoyl)Glucosamine; [Acyl-Carrier Protein]. [C]

Alternate protein names: NA

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MALTLEELVKRFGGEIAGDAQCKVGGLAPLDQAGPQQLAFLANPKYLSQVESTRAGAVLIAPKDLEKLGAAAQGRTAGPR
NFIVTPNPYAYFARVAQMFIDLATPPRAAGVHPSATIDPAAKVAATAVIGPHVTIEAGAVIEDGVQLDANVFVGRGTTIG
AGSHFYPNASVYHGCKVGPRAIVHAGAVIGSDGFGFAPDFVGDGDARTGSWVKIPQVGGVTIGPDVEIGANTTIDRGAMA
DTVIEECVKIDNQVQIGHNCRIGAYTVIAGSAGIAGSTTIGRHCMIGGAAGIAGHVTLGDYVIITAKSGVSKSLPKAGIY
TSAFPAVDHGEWNKSAALVRNLDKLRERIKALEAALAAQGGTDA

Sequences:

>Translated_364_residues
MALTLEELVKRFGGEIAGDAQCKVGGLAPLDQAGPQQLAFLANPKYLSQVESTRAGAVLIAPKDLEKLGAAAQGRTAGPR
NFIVTPNPYAYFARVAQMFIDLATPPRAAGVHPSATIDPAAKVAATAVIGPHVTIEAGAVIEDGVQLDANVFVGRGTTIG
AGSHFYPNASVYHGCKVGPRAIVHAGAVIGSDGFGFAPDFVGDGDARTGSWVKIPQVGGVTIGPDVEIGANTTIDRGAMA
DTVIEECVKIDNQVQIGHNCRIGAYTVIAGSAGIAGSTTIGRHCMIGGAAGIAGHVTLGDYVIITAKSGVSKSLPKAGIY
TSAFPAVDHGEWNKSAALVRNLDKLRERIKALEAALAAQGGTDA
>Mature_363_residues
ALTLEELVKRFGGEIAGDAQCKVGGLAPLDQAGPQQLAFLANPKYLSQVESTRAGAVLIAPKDLEKLGAAAQGRTAGPRN
FIVTPNPYAYFARVAQMFIDLATPPRAAGVHPSATIDPAAKVAATAVIGPHVTIEAGAVIEDGVQLDANVFVGRGTTIGA
GSHFYPNASVYHGCKVGPRAIVHAGAVIGSDGFGFAPDFVGDGDARTGSWVKIPQVGGVTIGPDVEIGANTTIDRGAMAD
TVIEECVKIDNQVQIGHNCRIGAYTVIAGSAGIAGSTTIGRHCMIGGAAGIAGHVTLGDYVIITAKSGVSKSLPKAGIYT
SAFPAVDHGEWNKSAALVRNLDKLRERIKALEAALAAQGGTDA

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=358, Percent_Identity=39.9441340782123, Blast_Score=261, Evalue=4e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.- [C]

Molecular weight: Translated: 37153; Mature: 37021

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALTLEELVKRFGGEIAGDAQCKVGGLAPLDQAGPQQLAFLANPKYLSQVESTRAGAVLI
CCCCHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCHHEEEECCCHHHHHHHHCCCCEEEE
APKDLEKLGAAAQGRTAGPRNFIVTPNPYAYFARVAQMFIDLATPPRAAGVHPSATIDPA
CCCCHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHH
AKVAATAVIGPHVTIEAGAVIEDGVQLDANVFVGRGTTIGAGSHFYPNASVYHGCKVGPR
HHHHHHEEECCCEEEECCCEEECCEEECCEEEEECCCEECCCCCCCCCCCEECCCCCCCH
AIVHAGAVIGSDGFGFAPDFVGDGDARTGSWVKIPQVGGVTIGPDVEIGANTTIDRGAMA
HHHEECEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCEEECCCCEECCCCCCCCCHHH
DTVIEECVKIDNQVQIGHNCRIGAYTVIAGSAGIAGSTTIGRHCMIGGAAGIAGHVTLGD
HHHHHHHHHCCCEEEECCCCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCCEEEEEECC
YVIITAKSGVSKSLPKAGIYTSAFPAVDHGEWNKSAALVRNLDKLRERIKALEAALAAQG
EEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
GTDA
CCCC
>Mature Secondary Structure 
ALTLEELVKRFGGEIAGDAQCKVGGLAPLDQAGPQQLAFLANPKYLSQVESTRAGAVLI
CCCHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCHHEEEECCCHHHHHHHHCCCCEEEE
APKDLEKLGAAAQGRTAGPRNFIVTPNPYAYFARVAQMFIDLATPPRAAGVHPSATIDPA
CCCCHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHH
AKVAATAVIGPHVTIEAGAVIEDGVQLDANVFVGRGTTIGAGSHFYPNASVYHGCKVGPR
HHHHHHEEECCCEEEECCCEEECCEEECCEEEEECCCEECCCCCCCCCCCEECCCCCCCH
AIVHAGAVIGSDGFGFAPDFVGDGDARTGSWVKIPQVGGVTIGPDVEIGANTTIDRGAMA
HHHEECEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCEEECCCCEECCCCCCCCCHHH
DTVIEECVKIDNQVQIGHNCRIGAYTVIAGSAGIAGSTTIGRHCMIGGAAGIAGHVTLGD
HHHHHHHHHCCCEEEECCCCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCCEEEEEECC
YVIITAKSGVSKSLPKAGIYTSAFPAVDHGEWNKSAALVRNLDKLRERIKALEAALAAQG
EEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
GTDA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-3-O-(3-Hydroxytetradecanoyl)Glucosamine; (R)-3-Hydroxytetradecanoyl-[Acyl-Carrier Protein] [C]

Specific reaction: UDP-3-O-(3-Hydroxytetradecanoyl)Glucosamine + (R)-3-Hydroxytetradecanoyl-[Acyl-Carrier Protein] = UDP-2,3-Bis(3-Hydroxytetradecanoyl)Glucosamine + [Acyl-Carrier Protein]. [C]

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA