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The map label for this gene is lon [H]

Identifier: 116689942

GI number: 116689942

Start: 2134336

End: 2136759

Strand: Reverse

Name: lon [H]

Synonym: Bcen2424_1921

Alternate gene names: 116689942

Gene position: 2136759-2134336 (Counterclockwise)

Preceding gene: 116689943

Following gene: 116689941

Centisome position: 61.33

GC content: 63.08

Gene sequence:

>2424_bases
ATGTCAGGCACCCAACTTCTCCCGCCGGAACGCATCACGCTCCCGCTGCTGCCGCTGCGGGACGTCGTCGTTTTCCCGCA
CATGGTCATTCCGCTCTTCGTGGGCCGGCCGAAATCGATCAAGGCCCTCGAAGCAGCGATGGAAGGCGGCAAGCACATCA
TGCTCGTCGCCCAGAAAACCGCGGCCAAGGACGAACCGACCGAAAAGGACATGTACGAGGTCGGTTGTATCGCCAACATT
CTGCAGATGCTGAAGCTGCCGGACGGCACCGTGAAGGTGCTCGTCGAGGGCCTGCAGCGCGCGAAGGCATTGTCCATCGA
AGAACAGGAGACGCAGTTCTCCTGCGAAGTGATGCCGCTCGAGCCCGATCATGCGGATAGCGCCGAAACGGAAGCGCTGC
GCCGTGCGATCGTGTCGCAGTTCGACCAGTACGTGAAGCTGAACAAGAAGATCCCGCCGGAAATTCTTACGTCGCTGTCG
GGCATCGATGAAGCAGGCCGTCTCGCCGACATGATCGCCGAGCGCCTGCCGCTGAAGCTCGACCAGAAGCAGCACATCCT
CGAGATGTTCCCGGTCATCGAGCGCCTCGAGCACCTGCTCGCGCAGCTCGAAGCCGAGATCGACATCCTGCAGGTCGAAA
AGCGCATCCGCGGGCGCGTGAAGCGCCAGATGGAAAAGAGCCAGCGCGAGTACTACCTGAACGAACAGGTCAAGGCGATC
CAGAAGGAACTGGGCGAAGGCGAGGAGGGTGCGGATCTCGAGGAACTCGAGAAGCGCATCAACGCCGCGCGCATGCCGAA
GGAAGCCAAGAAGAAGGCCGACGCCGAGCTGAAGAAGCTGAAGCTGATGTCGCCGATGTCGGCGGAAGCGACCGTCGTGC
GCAACTACATCGACACGCTGATCGGCCTGCCGTGGCGCAAGAAGAGCAAGGTCAACAACGACCTGTCGAACGCCGAGCAG
GTGCTCGACGAGGATCACTTCGGCCTCGAGAAGGTCAAGGAACGGATCCTCGAGTATCTCGCGGTGCAACAGCGCGTGGA
CAAGGTCAAGGCGCCGATCCTGTGCCTCGTCGGGCCTCCGGGTGTCGGCAAGACCTCGCTCGGCCAGTCGATCGCCCGTG
CGACGAACCGCAAGTTCGTCCGCATGGCGCTCGGCGGCGTGCGTGACGAAGCCGAGATCCGCGGTCACCGCCGTACGTAC
ATCGGTTCGATGCCGGGCAAGATCCTGCAAAGCCTCGCGAAGGTCGGCGTGCGCAATCCGCTCTTCCTGCTCGACGAAGT
CGACAAGATGGGCATGGATTTCCGCGGCGATCCGTCGTCGGCGCTGCTCGAAGTGCTCGATCCGGAACAGAACCACACGT
TCGCCGACCACTACATCGAAGTCGACTTCGACCTGTCGGACGTGATGTTCGTCGCGACGTCGAACTCGCTGAACATCCCG
CCGCCGCTGCTCGACCGGATGGAAGTGATCCGTCTGTCGGGCTACACGGAAGACGAGAAGGTCAGCATTGCCCAGCGTTA
CCTGCTGCCGAAGCAGAAGAAGAACAACGGGCTGAAGGACGGCGAGATCGAGGTCACCGAGCAGGCGATCCGCGACATCA
TCCGCTACTACACGCGCGAAGCCGGTGTGCGTTCGCTCGAGCGGGAAGTGTCGAAGATCTGCCGCAAGGTCGTGAAGATG
CTGCTGTTGAAGAAGGCATCGGGCGCGATCAAGGTCGATGGCGAGAACCTCGACACGTTCCTCGGCGTGCGCAAGTACGA
CTTCGGCCTCGCGGCGAAGGAAAACCAGGTCGGTCAGGTGACGGGCCTCGCGTGGACGGAAGTCGGCGGCGACCTGCTGA
CGATCGAAGCCGCGGTGATGCCAGGCAAGGGCAACGTGATCCGTACGGGTTCGCTCGGCGACGTGATGAAGGAGTCGGTC
GAGGCTGCGCGTTCGGTCGTGCGCTCGCGTTCGCGTCGTCTCGGCATCAAGGACGAAGCGTTCGAGAAGCAGGACATCCA
CATCCACGTGCCGGAAGGCGCGACGCCGAAGGACGGTCCGTCCGCCGGCGGTGCGATGACGACCGCGCTGGTGTCGGTGC
TGACGGGTATTCCCGTGCGGGCCGACGTCGCGATGACGGGCGAAATCACGTTGCGTGGCGAAGTGCTGCCGATCGGCGGG
CTGAAGGAAAAGCTGCTGGCTGCGCATCGCGGCGGCATCAAGCTCGTGCTGATTCCGGAAGAGAACGTGAAGGATCTCGC
GGACATTCCGGACAACGTGAAGAACGCGATCGAGATCGTGCCGGTCCGCTGGATCGACAAGGTGCTGGAGCTCGCGCTCG
AGCGTTCGCCGACGCCGCTGCCGCCGGAAGAAGAAGCGAAGGCTGCGGCGCCGGTCGGTGAGGCGGCGAAGGATGCCGGC
TCGACGGAAGTCGTCAAGCACTGA

Upstream 100 bases:

>100_bases
TGGTTACTTTCTTACCGAATATTTCCCGCACTTGAAGGCTTGCAATTCGTTGTGGCGGCCTCAATTACCGAACAATTGAT
TCCACTCATGGGGAAATGAA

Downstream 100 bases:

>100_bases
CCCTGAGCACCGTCGTTGCTGACGGTCGTTCACGAAACCCGCGGCGATGTCCGCGGGTTTTTTTTATGCGCAGCACAATC
GTGCGAGCGCGTGGGTTAAA

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 807; Mature: 806

Protein sequence:

>807_residues
MSGTQLLPPERITLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKTAAKDEPTEKDMYEVGCIANI
LQMLKLPDGTVKVLVEGLQRAKALSIEEQETQFSCEVMPLEPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLS
GIDEAGRLADMIAERLPLKLDQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
QKELGEGEEGADLEELEKRINAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTLIGLPWRKKSKVNNDLSNAEQ
VLDEDHFGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTY
IGSMPGKILQSLAKVGVRNPLFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYIEVDFDLSDVMFVATSNSLNIP
PPLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKDGEIEVTEQAIRDIIRYYTREAGVRSLEREVSKICRKVVKM
LLLKKASGAIKVDGENLDTFLGVRKYDFGLAAKENQVGQVTGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESV
EAARSVVRSRSRRLGIKDEAFEKQDIHIHVPEGATPKDGPSAGGAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
LKEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNAIEIVPVRWIDKVLELALERSPTPLPPEEEAKAAAPVGEAAKDAG
STEVVKH

Sequences:

>Translated_807_residues
MSGTQLLPPERITLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKTAAKDEPTEKDMYEVGCIANI
LQMLKLPDGTVKVLVEGLQRAKALSIEEQETQFSCEVMPLEPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLS
GIDEAGRLADMIAERLPLKLDQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
QKELGEGEEGADLEELEKRINAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTLIGLPWRKKSKVNNDLSNAEQ
VLDEDHFGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTY
IGSMPGKILQSLAKVGVRNPLFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYIEVDFDLSDVMFVATSNSLNIP
PPLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKDGEIEVTEQAIRDIIRYYTREAGVRSLEREVSKICRKVVKM
LLLKKASGAIKVDGENLDTFLGVRKYDFGLAAKENQVGQVTGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESV
EAARSVVRSRSRRLGIKDEAFEKQDIHIHVPEGATPKDGPSAGGAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
LKEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNAIEIVPVRWIDKVLELALERSPTPLPPEEEAKAAAPVGEAAKDAG
STEVVKH
>Mature_806_residues
SGTQLLPPERITLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKTAAKDEPTEKDMYEVGCIANIL
QMLKLPDGTVKVLVEGLQRAKALSIEEQETQFSCEVMPLEPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSG
IDEAGRLADMIAERLPLKLDQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAIQ
KELGEGEEGADLEELEKRINAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTLIGLPWRKKSKVNNDLSNAEQV
LDEDHFGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTYI
GSMPGKILQSLAKVGVRNPLFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYIEVDFDLSDVMFVATSNSLNIPP
PLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKDGEIEVTEQAIRDIIRYYTREAGVRSLEREVSKICRKVVKML
LLKKASGAIKVDGENLDTFLGVRKYDFGLAAKENQVGQVTGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESVE
AARSVVRSRSRRLGIKDEAFEKQDIHIHVPEGATPKDGPSAGGAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGGL
KEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNAIEIVPVRWIDKVLELALERSPTPLPPEEEAKAAAPVGEAAKDAGS
TEVVKH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=568, Percent_Identity=46.4788732394366, Blast_Score=516, Evalue=1e-146,
Organism=Homo sapiens, GI21396489, Length=684, Percent_Identity=40.4970760233918, Blast_Score=505, Evalue=1e-143,
Organism=Escherichia coli, GI1786643, Length=770, Percent_Identity=69.8701298701299, Blast_Score=1079, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=692, Percent_Identity=39.5953757225434, Blast_Score=476, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17556486, Length=540, Percent_Identity=41.4814814814815, Blast_Score=437, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6319449, Length=720, Percent_Identity=40.2777777777778, Blast_Score=512, Evalue=1e-146,
Organism=Drosophila melanogaster, GI221513036, Length=671, Percent_Identity=41.7287630402384, Blast_Score=511, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24666867, Length=671, Percent_Identity=41.7287630402384, Blast_Score=510, Evalue=1e-144,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89266; Mature: 89135

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGTQLLPPERITLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKT
CCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECC
AAKDEPTEKDMYEVGCIANILQMLKLPDGTVKVLVEGLQRAKALSIEEQETQFSCEVMPL
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHCCCEEEEEEEC
EPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSGIDEAGRLADMIAERLPLKL
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCC
DQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKELGEGEEGADLEELEKRINAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTL
HHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
IGLPWRKKSKVNNDLSNAEQVLDEDHFGLEKVKERILEYLAVQQRVDKVKAPILCLVGPP
HCCCCCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGKILQSLAKVGVRNP
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCHHHHHHHHHHHCCCCC
LFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYIEVDFDLSDVMFVATSNSLNIP
CHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEEECCEEEEEECCCCEEEEEECCCCCCC
PPLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKDGEIEVTEQAIRDIIRYYTRE
CHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
AGVRSLEREVSKICRKVVKMLLLKKASGAIKVDGENLDTFLGVRKYDFGLAAKENQVGQV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHCCHHHCCCCCCCCCCCCCE
TGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESVEAARSVVRSRSRRLGIKDEA
ECEEHHHCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHC
FEKQDIHIHVPEGATPKDGPSAGGAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
CCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECEEEECEEEEECEEEECCC
LKEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNAIEIVPVRWIDKVLELALERSPTPL
HHHHHHHHHCCCEEEEEECCCCHHHHHCCCHHHHHHHEEECHHHHHHHHHHHHHCCCCCC
PPEEEAKAAAPVGEAAKDAGSTEVVKH
CCCHHHHHCCCCCHHHHCCCCCHHCCC
>Mature Secondary Structure 
SGTQLLPPERITLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKT
CCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECC
AAKDEPTEKDMYEVGCIANILQMLKLPDGTVKVLVEGLQRAKALSIEEQETQFSCEVMPL
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHCCCEEEEEEEC
EPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSGIDEAGRLADMIAERLPLKL
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCC
DQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKELGEGEEGADLEELEKRINAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTL
HHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
IGLPWRKKSKVNNDLSNAEQVLDEDHFGLEKVKERILEYLAVQQRVDKVKAPILCLVGPP
HCCCCCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGKILQSLAKVGVRNP
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCHHHHHHHHHHHCCCCC
LFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYIEVDFDLSDVMFVATSNSLNIP
CHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEEECCEEEEEECCCCEEEEEECCCCCCC
PPLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKDGEIEVTEQAIRDIIRYYTRE
CHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
AGVRSLEREVSKICRKVVKMLLLKKASGAIKVDGENLDTFLGVRKYDFGLAAKENQVGQV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHCCHHHCCCCCCCCCCCCCE
TGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESVEAARSVVRSRSRRLGIKDEA
ECEEHHHCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHC
FEKQDIHIHVPEGATPKDGPSAGGAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
CCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECEEEECEEEEECEEEECCC
LKEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNAIEIVPVRWIDKVLELALERSPTPL
HHHHHHHHHCCCEEEEEECCCCHHHHHCCCHHHHHHHEEECHHHHHHHHHHHHHCCCCCC
PPEEEAKAAAPVGEAAKDAGSTEVVKH
CCCHHHHHCCCCCHHHHCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]