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The map label for this gene is wecB [H]

Identifier: 116689357

GI number: 116689357

Start: 1471556

End: 1472773

Strand: Direct

Name: wecB [H]

Synonym: Bcen2424_1335

Alternate gene names: 116689357

Gene position: 1471556-1472773 (Clockwise)

Preceding gene: 116689356

Following gene: 116689358

Centisome position: 42.24

GC content: 65.52

Gene sequence:

>1218_bases
ATGAAGAAGATCTTGCTTGTGTTCGGGACTCGGCCGGAGGCCATCAAGATGGCGCCGCTGGTGCGCGCGCTGAAGGCGCA
GGCGGATGTCGACGCCCGGGTGTGCGTGACCGCACAGCATCGCGAAATGCTCGACCAGGTGCTGACGCTGTTCGACATCA
AGCCCGACTACGATCTCAACCTGATGCGGCAAGGCCAGACGCTGACCGACGTGACGACCGGCATCCTCCAGGCGATCGGC
ATGGTCTTCGACGAATTGCGACCGGACATCGTGCTGGTGCACGGCGATACGACGACCACGCTCGCGGTGAGCCTGGCGGC
GTTCTATCGCTATCTGCCGGTCGGTCACGTGGAAGCCGGCTTGCGCAGCGGCGACATCTGGTCGCCGTGGCCGGAGGAAC
TGAATCGCCGCGTGACCGATGCGGTGTCGTCATGGCATTTCGCCCCAACCGGGCAGGCGCGCGACAACCTGCTGAGCGAA
GGCGTGCCGGGCGGGGCGGTCTCGCTGACCGGCAATACCGTGATCGATGCGTTGCACGAGGTCAAGCGCATGCTGGATCG
CACCGCCGCGCTGTCGGACAGGATCGCCGCCTACTTCCCGTTCCTCGAACCGTCGCGGCGCGTCGTGCTGATCACCGGCC
ATCGCCGTGAAAGTTTCGGCGAACCGTTCCGGCATTTCTGCGACGCGCTGTGCACACTGGCGAGCCGCTATCGCGATGCG
CAGTTCGTCTATCCGCTGCATCTGAACCCGAACGTGCGGGAGCCAGCACGCGCACGGCTCGGCGGCGTTCCCAACATCTA
CCTGATCGAGCCGCAGGAATATCTGTCGTTCGTATTCCTGATGTCGCGCGCGTATTTCATCATCACGGATTCGGGCGGCA
TTCAGGAAGAAGGGCCGGCGCTCGGCAAGCCGGTGCTCGTCACGCGCGAGACGACCGAGCGGCCCGAAGCGATTCAGGCC
GGCACCGCGCGGCTCGTCGGCACCGACCAGGAGCGGATCGTGTGGGAGGCGTCGCGGCTGTTCGACAGCGAGAGCGCTTA
CGAGGAAATGTCGCGCGCGAGCAATCCGTACGGCGACGGCCATGCGAGCGAGCGGATCGTTCACGCGCTGATGCGCACGC
CCGGCGTGCCGACGAAGACGACGAGTTTTGCGATGGGCGCCGCGGAAATGCCGTTCAACGCGCTCACGCTCGGATTGCAG
GCGTTGCGCTCGCCGTGA

Upstream 100 bases:

>100_bases
CGCGTGTTGATCGCGTGCGAGTACGGGATGCGCCGCCCGAATACATGCTTCGCGCCACGTGCCGGATCGCCAGGCGCGAA
GTGGCTAAACGAGGATAACG

Downstream 100 bases:

>100_bases
AGAAGGACGCGCGGTAGCGCCTGCCGGCGCGTTCGACGCAGGCGTCAAACATCCGGTCCGGCCGCGAGGTCGGCCGGATG
TTTGCCTGTATGCGACCCGG

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MKKILLVFGTRPEAIKMAPLVRALKAQADVDARVCVTAQHREMLDQVLTLFDIKPDYDLNLMRQGQTLTDVTTGILQAIG
MVFDELRPDIVLVHGDTTTTLAVSLAAFYRYLPVGHVEAGLRSGDIWSPWPEELNRRVTDAVSSWHFAPTGQARDNLLSE
GVPGGAVSLTGNTVIDALHEVKRMLDRTAALSDRIAAYFPFLEPSRRVVLITGHRRESFGEPFRHFCDALCTLASRYRDA
QFVYPLHLNPNVREPARARLGGVPNIYLIEPQEYLSFVFLMSRAYFIITDSGGIQEEGPALGKPVLVTRETTERPEAIQA
GTARLVGTDQERIVWEASRLFDSESAYEEMSRASNPYGDGHASERIVHALMRTPGVPTKTTSFAMGAAEMPFNALTLGLQ
ALRSP

Sequences:

>Translated_405_residues
MKKILLVFGTRPEAIKMAPLVRALKAQADVDARVCVTAQHREMLDQVLTLFDIKPDYDLNLMRQGQTLTDVTTGILQAIG
MVFDELRPDIVLVHGDTTTTLAVSLAAFYRYLPVGHVEAGLRSGDIWSPWPEELNRRVTDAVSSWHFAPTGQARDNLLSE
GVPGGAVSLTGNTVIDALHEVKRMLDRTAALSDRIAAYFPFLEPSRRVVLITGHRRESFGEPFRHFCDALCTLASRYRDA
QFVYPLHLNPNVREPARARLGGVPNIYLIEPQEYLSFVFLMSRAYFIITDSGGIQEEGPALGKPVLVTRETTERPEAIQA
GTARLVGTDQERIVWEASRLFDSESAYEEMSRASNPYGDGHASERIVHALMRTPGVPTKTTSFAMGAAEMPFNALTLGLQ
ALRSP
>Mature_405_residues
MKKILLVFGTRPEAIKMAPLVRALKAQADVDARVCVTAQHREMLDQVLTLFDIKPDYDLNLMRQGQTLTDVTTGILQAIG
MVFDELRPDIVLVHGDTTTTLAVSLAAFYRYLPVGHVEAGLRSGDIWSPWPEELNRRVTDAVSSWHFAPTGQARDNLLSE
GVPGGAVSLTGNTVIDALHEVKRMLDRTAALSDRIAAYFPFLEPSRRVVLITGHRRESFGEPFRHFCDALCTLASRYRDA
QFVYPLHLNPNVREPARARLGGVPNIYLIEPQEYLSFVFLMSRAYFIITDSGGIQEEGPALGKPVLVTRETTERPEAIQA
GTARLVGTDQERIVWEASRLFDSESAYEEMSRASNPYGDGHASERIVHALMRTPGVPTKTTSFAMGAAEMPFNALTLGLQ
ALRSP

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=368, Percent_Identity=60.5978260869565, Blast_Score=450, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 44865; Mature: 44865

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKILLVFGTRPEAIKMAPLVRALKAQADVDARVCVTAQHREMLDQVLTLFDIKPDYDLN
CCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCH
LMRQGQTLTDVTTGILQAIGMVFDELRPDIVLVHGDTTTTLAVSLAAFYRYLPVGHVEAG
HHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHHC
LRSGDIWSPWPEELNRRVTDAVSSWHFAPTGQARDNLLSEGVPGGAVSLTGNTVIDALHE
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCEEEECCHHHHHHHHH
VKRMLDRTAALSDRIAAYFPFLEPSRRVVLITGHRRESFGEPFRHFCDALCTLASRYRDA
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHCCHHHHHHHHHHHHHHHHCCCC
QFVYPLHLNPNVREPARARLGGVPNIYLIEPQEYLSFVFLMSRAYFIITDSGGIQEEGPA
EEEEEEECCCCCCCCHHHHHCCCCEEEEECHHHHHHHHHHHHCCEEEEECCCCCCCCCCC
LGKPVLVTRETTERPEAIQAGTARLVGTDQERIVWEASRLFDSESAYEEMSRASNPYGDG
CCCCEEEECCCCCCCHHHHCCCEEEECCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCC
HASERIVHALMRTPGVPTKTTSFAMGAAEMPFNALTLGLQALRSP
HHHHHHHHHHHHCCCCCCCCCHHCCCCHHCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKILLVFGTRPEAIKMAPLVRALKAQADVDARVCVTAQHREMLDQVLTLFDIKPDYDLN
CCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCH
LMRQGQTLTDVTTGILQAIGMVFDELRPDIVLVHGDTTTTLAVSLAAFYRYLPVGHVEAG
HHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHHC
LRSGDIWSPWPEELNRRVTDAVSSWHFAPTGQARDNLLSEGVPGGAVSLTGNTVIDALHE
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCEEEECCHHHHHHHHH
VKRMLDRTAALSDRIAAYFPFLEPSRRVVLITGHRRESFGEPFRHFCDALCTLASRYRDA
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHCCHHHHHHHHHHHHHHHHCCCC
QFVYPLHLNPNVREPARARLGGVPNIYLIEPQEYLSFVFLMSRAYFIITDSGGIQEEGPA
EEEEEEECCCCCCCCHHHHHCCCCEEEEECHHHHHHHHHHHHCCEEEEECCCCCCCCCCC
LGKPVLVTRETTERPEAIQAGTARLVGTDQERIVWEASRLFDSESAYEEMSRASNPYGDG
CCCCEEEECCCCCCCHHHHCCCEEEECCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCC
HASERIVHALMRTPGVPTKTTSFAMGAAEMPFNALTLGLQALRSP
HHHHHHHHHHHHCCCCCCCCCHHCCCCHHCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]