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The map label for this gene is phoR [H]

Identifier: 116689328

GI number: 116689328

Start: 1436690

End: 1438009

Strand: Direct

Name: phoR [H]

Synonym: Bcen2424_1306

Alternate gene names: 116689328

Gene position: 1436690-1438009 (Clockwise)

Preceding gene: 116689327

Following gene: 116689330

Centisome position: 41.24

GC content: 65.3

Gene sequence:

>1320_bases
ATGAACATCATCTGGGCGCGCTTTCTGGTGTCGCTCGTGCTGCTCGTGCTGATCGGCGTATTGGTCGGCGTCTTCGCCGG
CCCGACCGCGGGCCTCGTGTTCGTGGTCGTGATGCTGGTCGCGCAGGGCTTTTTCAGCACCTTCCATACGCAGCGTCTGT
GGCGCCTGCTCGATGCGCCCGTCTACGGCGAGGTGCCGAGCGCGCCGGGCATCTGGGGCGAGATCTACTATCGGCTGCAC
AAGCTCGCGAAGCAGTGGCATGCGCAGGTGCGGCAGGTCGAACAGCAGCACTCGCGTTTCATCCAGGCGATCCAGGCCTC
GCCGAACGGTGTCGCGATGCTCGATGATCACGACCAGATCGAGTGGTGCAATGCGATCGCCGAAGTCCATTTCGGCCTCG
ATGCGAAGCGCGACCTGCGCCAGCACATCACGAACCTGGTGCGCCATCCCGATTTCGTCCGCTACCTCAATGCGCAGCAT
TACGACGAGACGCTGTTGATGCGCGGCATGGGCGACTCGCGGCAGAACGTGCTGGCCGTGCAGGTGTTTCCGTACGGCGA
GAACCGCAAGCTGCTGCTCACGCAGGACATCACCGAGCTCGAACGCACCGACGCGATGCGGCGTGACTTCGTCGCGAACG
TGTCGCACGAGCTGAAGACGCCGCTCACCGTGCTGTCGGGTTTCCTGGAGACGATGCGCGAGCTGCCGCTGAACGAGGAG
GACCGCGCGCGCTATCTCGACATGATGGAGCAGCAGGCGTCACGGATGCGGCACATCGTGACCGACCTGCTGGTGCTCGC
GAAGCTGGAAGGCGAGAGCAAGCCGCCGGTCGATCATGCGATCGACATGCGGGCGGTGTTCGATCATCTGAAGGAGGATG
CGCAGACGCTGTCGAACGGGCATCACGACATCGCGTTCTCGATCGACGAGACGCTCGGCGTCACGGGGGCGCAGACGGAG
CTGTTCAGCGCGTTCGCGAATCTCGTCACGAACGCGATCCGCTATACGCCGGACGGCGGCAAGATCGTCGTGTCGTGGCG
GCGCGAGGGCGCGCAGGGCGTGTTTTCGGTCACGGACAGCGGCTTCGGGATTCCGGCCGCCGATTTGCCGCGGCTCACCG
AGCGCTTCTACCGTGTCGATCGCAGCCGCTCGCGCGATACGGGCGGCACGGGCCTCGGGCTCGCGATCGTCAAGCACGTG
CTGCAGCGGCACGATGCGCATCTGTACGTGCAGAGCGAGGAAGGGCGCGGCAGTACGTTCACCGCGCGGTTCCCGGGCTC
GCGCGTCATCGCGATCCGGCCGGCTGCTTACGAAGCATGA

Upstream 100 bases:

>100_bases
AACCGTGCGCGGCAGCGGCTACCGCCTCGCCAAGCACGCGTAACGTATTCGGGCATGCCGCGTGCCGCGGCGTGCCGCTC
CTTCTTTCGGACGCTGAATC

Downstream 100 bases:

>100_bases
TCGTGTAGCGGCTCGTCGGCGTTCAAAAAAGCAGCCCGCGGGCTGCTTTTTTTCATGGCGATGCGTCGGCGCGATCTGCA
TCGCGCCGACGGTTCACGAG

Product: PAS/PAC sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MNIIWARFLVSLVLLVLIGVLVGVFAGPTAGLVFVVVMLVAQGFFSTFHTQRLWRLLDAPVYGEVPSAPGIWGEIYYRLH
KLAKQWHAQVRQVEQQHSRFIQAIQASPNGVAMLDDHDQIEWCNAIAEVHFGLDAKRDLRQHITNLVRHPDFVRYLNAQH
YDETLLMRGMGDSRQNVLAVQVFPYGENRKLLLTQDITELERTDAMRRDFVANVSHELKTPLTVLSGFLETMRELPLNEE
DRARYLDMMEQQASRMRHIVTDLLVLAKLEGESKPPVDHAIDMRAVFDHLKEDAQTLSNGHHDIAFSIDETLGVTGAQTE
LFSAFANLVTNAIRYTPDGGKIVVSWRREGAQGVFSVTDSGFGIPAADLPRLTERFYRVDRSRSRDTGGTGLGLAIVKHV
LQRHDAHLYVQSEEGRGSTFTARFPGSRVIAIRPAAYEA

Sequences:

>Translated_439_residues
MNIIWARFLVSLVLLVLIGVLVGVFAGPTAGLVFVVVMLVAQGFFSTFHTQRLWRLLDAPVYGEVPSAPGIWGEIYYRLH
KLAKQWHAQVRQVEQQHSRFIQAIQASPNGVAMLDDHDQIEWCNAIAEVHFGLDAKRDLRQHITNLVRHPDFVRYLNAQH
YDETLLMRGMGDSRQNVLAVQVFPYGENRKLLLTQDITELERTDAMRRDFVANVSHELKTPLTVLSGFLETMRELPLNEE
DRARYLDMMEQQASRMRHIVTDLLVLAKLEGESKPPVDHAIDMRAVFDHLKEDAQTLSNGHHDIAFSIDETLGVTGAQTE
LFSAFANLVTNAIRYTPDGGKIVVSWRREGAQGVFSVTDSGFGIPAADLPRLTERFYRVDRSRSRDTGGTGLGLAIVKHV
LQRHDAHLYVQSEEGRGSTFTARFPGSRVIAIRPAAYEA
>Mature_439_residues
MNIIWARFLVSLVLLVLIGVLVGVFAGPTAGLVFVVVMLVAQGFFSTFHTQRLWRLLDAPVYGEVPSAPGIWGEIYYRLH
KLAKQWHAQVRQVEQQHSRFIQAIQASPNGVAMLDDHDQIEWCNAIAEVHFGLDAKRDLRQHITNLVRHPDFVRYLNAQH
YDETLLMRGMGDSRQNVLAVQVFPYGENRKLLLTQDITELERTDAMRRDFVANVSHELKTPLTVLSGFLETMRELPLNEE
DRARYLDMMEQQASRMRHIVTDLLVLAKLEGESKPPVDHAIDMRAVFDHLKEDAQTLSNGHHDIAFSIDETLGVTGAQTE
LFSAFANLVTNAIRYTPDGGKIVVSWRREGAQGVFSVTDSGFGIPAADLPRLTERFYRVDRSRSRDTGGTGLGLAIVKHV
LQRHDAHLYVQSEEGRGSTFTARFPGSRVIAIRPAAYEA

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=367, Percent_Identity=38.9645776566758, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI145693157, Length=344, Percent_Identity=28.7790697674419, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1788393, Length=261, Percent_Identity=29.8850574712644, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI48994928, Length=357, Percent_Identity=26.0504201680672, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786783, Length=234, Percent_Identity=31.1965811965812, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1789149, Length=337, Percent_Identity=28.7833827893175, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1790861, Length=216, Percent_Identity=32.4074074074074, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1790436, Length=248, Percent_Identity=29.8387096774194, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1790346, Length=225, Percent_Identity=28.8888888888889, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI87082128, Length=250, Percent_Identity=25.6, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87081816, Length=234, Percent_Identity=28.6324786324786, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788549, Length=400, Percent_Identity=22.75, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788713, Length=253, Percent_Identity=25.296442687747, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1787894, Length=232, Percent_Identity=27.1551724137931, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790551, Length=254, Percent_Identity=28.3464566929134, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789403, Length=225, Percent_Identity=27.1111111111111, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1786912, Length=229, Percent_Identity=25.3275109170306, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49474; Mature: 49474

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIIWARFLVSLVLLVLIGVLVGVFAGPTAGLVFVVVMLVAQGFFSTFHTQRLWRLLDAP
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VYGEVPSAPGIWGEIYYRLHKLAKQWHAQVRQVEQQHSRFIQAIQASPNGVAMLDDHDQI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
EWCNAIAEVHFGLDAKRDLRQHITNLVRHPDFVRYLNAQHYDETLLMRGMGDSRQNVLAV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHCCCCCCCCEEEE
QVFPYGENRKLLLTQDITELERTDAMRRDFVANVSHELKTPLTVLSGFLETMRELPLNEE
EEEECCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCH
DRARYLDMMEQQASRMRHIVTDLLVLAKLEGESKPPVDHAIDMRAVFDHLKEDAQTLSNG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
HHDIAFSIDETLGVTGAQTELFSAFANLVTNAIRYTPDGGKIVVSWRREGAQGVFSVTDS
CCEEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCCCEEEECCC
GFGIPAADLPRLTERFYRVDRSRSRDTGGTGLGLAIVKHVLQRHDAHLYVQSEEGRGSTF
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEE
TARFPGSRVIAIRPAAYEA
EEECCCCEEEEECCCCCCC
>Mature Secondary Structure
MNIIWARFLVSLVLLVLIGVLVGVFAGPTAGLVFVVVMLVAQGFFSTFHTQRLWRLLDAP
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VYGEVPSAPGIWGEIYYRLHKLAKQWHAQVRQVEQQHSRFIQAIQASPNGVAMLDDHDQI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
EWCNAIAEVHFGLDAKRDLRQHITNLVRHPDFVRYLNAQHYDETLLMRGMGDSRQNVLAV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHCCCCCCCCEEEE
QVFPYGENRKLLLTQDITELERTDAMRRDFVANVSHELKTPLTVLSGFLETMRELPLNEE
EEEECCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCH
DRARYLDMMEQQASRMRHIVTDLLVLAKLEGESKPPVDHAIDMRAVFDHLKEDAQTLSNG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
HHDIAFSIDETLGVTGAQTELFSAFANLVTNAIRYTPDGGKIVVSWRREGAQGVFSVTDS
CCEEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCCCEEEECCC
GFGIPAADLPRLTERFYRVDRSRSRDTGGTGLGLAIVKHVLQRHDAHLYVQSEEGRGSTF
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEE
TARFPGSRVIAIRPAAYEA
EEECCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2556368 [H]