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The map label for this gene is folP-A [H]

Identifier: 116689320

GI number: 116689320

Start: 1428579

End: 1429478

Strand: Direct

Name: folP-A [H]

Synonym: Bcen2424_1298

Alternate gene names: 116689320

Gene position: 1428579-1429478 (Clockwise)

Preceding gene: 116689319

Following gene: 116689321

Centisome position: 41.01

GC content: 71.33

Gene sequence:

>900_bases
TTGCTCGTGTCCGATTCCGCTGTGTCCCCGTTCATTCCCGCGCCGCTCCAGTGCGGCCGCTTCGAACTGACGTTCGAACG
CCCGCTCGTGATGGGCATCCTCAACGCCACGCCCGATTCGTTCTCCGACGGCGGCCGCTTCCTCGCGCGCGACGATGCGC
TGCGCCAGGCCGAGCGGATGATCGCCGACGGCGCGGACCTGCTCGACATCGGCGGCGAATCGACGCGCCCCGGTGCGCCG
CCGGTGCCGCTCGACGAGGAGCTCGCGCGCGTGGTTCCGCTCGTCGAGGCGCTGCGGCCGTTCAACGTGCCGCTGTCGAT
CGATACCTACAAGCCGGCCGTGATGCGCGCGGCGCTGGCCGCCGGCGCGGATCTGATCAACGACATATGGGGGTTCCGCC
AGCCGGGCGCGATCGATGCGGTGCGCGACGGCAACAGCGGCCTGTGCGCGATGCACATGCTCGGCGAGCCGCAGACGATG
CAGGTCGGCGAGCCCGACTACGGCGACGTCGTGACCGACGTCCGCGATTTTCTCGCTGCGCGCGCCGAGGCGCTGCGCGA
CGCGGGGGTGGCGGCGGAGCGCATCTGCGTCGACCCCGGCTTCGGGTTCGGCAAGGCGGTCGTCGACGACAACTATGCGC
TGCTCGCCGCGTTGCCGGACACGGCGCCCGCGCGCCCCGACGGGAGCGCTTATCCGATTCTCGCGGGCATGTCGCGCAAG
TCGATGCTCGGTGCGGTGATCGGCGGCAAGCCGCCGATGGAGCGCGTCGCGGCGAGCGTGGCGGCCGCGGTGTGCGCGGT
CGAGCGGGGCGCCGCGATCGTGCGCGTGCACGACGTCGCGGCGACGGTCGATGCGCTAAAAGTATGGAATACCGTGCGCG
CAGCCGCACGGCAACGATAA

Upstream 100 bases:

>100_bases
GCGCCGGCGCCGGCTACGCCGGCGGCATAATCTCCGCTTTAACGCCGTTCACGGGCTGGTGTGGCTTCACACCGGCCCGT
TTTGCATTCATCCACGCCCG

Downstream 100 bases:

>100_bases
GCAAGTCAGAAAGACGAAGGAGGAAGGACTCATGGGACGTCGATATTTCGGCACGGACGGCATTCGCGGCACGGTGGGCG
AAGCGCCCATCACGCCGGAC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MLVSDSAVSPFIPAPLQCGRFELTFERPLVMGILNATPDSFSDGGRFLARDDALRQAERMIADGADLLDIGGESTRPGAP
PVPLDEELARVVPLVEALRPFNVPLSIDTYKPAVMRAALAAGADLINDIWGFRQPGAIDAVRDGNSGLCAMHMLGEPQTM
QVGEPDYGDVVTDVRDFLAARAEALRDAGVAAERICVDPGFGFGKAVVDDNYALLAALPDTAPARPDGSAYPILAGMSRK
SMLGAVIGGKPPMERVAASVAAAVCAVERGAAIVRVHDVAATVDALKVWNTVRAAARQR

Sequences:

>Translated_299_residues
MLVSDSAVSPFIPAPLQCGRFELTFERPLVMGILNATPDSFSDGGRFLARDDALRQAERMIADGADLLDIGGESTRPGAP
PVPLDEELARVVPLVEALRPFNVPLSIDTYKPAVMRAALAAGADLINDIWGFRQPGAIDAVRDGNSGLCAMHMLGEPQTM
QVGEPDYGDVVTDVRDFLAARAEALRDAGVAAERICVDPGFGFGKAVVDDNYALLAALPDTAPARPDGSAYPILAGMSRK
SMLGAVIGGKPPMERVAASVAAAVCAVERGAAIVRVHDVAATVDALKVWNTVRAAARQR
>Mature_299_residues
MLVSDSAVSPFIPAPLQCGRFELTFERPLVMGILNATPDSFSDGGRFLARDDALRQAERMIADGADLLDIGGESTRPGAP
PVPLDEELARVVPLVEALRPFNVPLSIDTYKPAVMRAALAAGADLINDIWGFRQPGAIDAVRDGNSGLCAMHMLGEPQTM
QVGEPDYGDVVTDVRDFLAARAEALRDAGVAAERICVDPGFGFGKAVVDDNYALLAALPDTAPARPDGSAYPILAGMSRK
SMLGAVIGGKPPMERVAASVAAAVCAVERGAAIVRVHDVAATVDALKVWNTVRAAARQR

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=278, Percent_Identity=45.6834532374101, Blast_Score=234, Evalue=6e-63,
Organism=Saccharomyces cerevisiae, GI6324073, Length=311, Percent_Identity=29.5819935691318, Blast_Score=110, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 31428; Mature: 31428

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVSDSAVSPFIPAPLQCGRFELTFERPLVMGILNATPDSFSDGGRFLARDDALRQAERM
CCCCCCCCCCCCCCCCCCCCEEEEECCCCEEHHHHCCCCCCCCCCCEEEHHHHHHHHHHH
IADGADLLDIGGESTRPGAPPVPLDEELARVVPLVEALRPFNVPLSIDTYKPAVMRAALA
HHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHH
AGADLINDIWGFRQPGAIDAVRDGNSGLCAMHMLGEPQTMQVGEPDYGDVVTDVRDFLAA
HHHHHHHHHHCCCCCCCCEEEECCCCCEEEEEECCCCCEEECCCCCCHHHHHHHHHHHHH
RAEALRDAGVAAERICVDPGFGFGKAVVDDNYALLAALPDTAPARPDGSAYPILAGMSRK
HHHHHHHCCCHHHHEEECCCCCCCCEEECCCEEEEEECCCCCCCCCCCCCCCEEECCCHH
SMLGAVIGGKPPMERVAASVAAAVCAVERGAAIVRVHDVAATVDALKVWNTVRAAARQR
HHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLVSDSAVSPFIPAPLQCGRFELTFERPLVMGILNATPDSFSDGGRFLARDDALRQAERM
CCCCCCCCCCCCCCCCCCCCEEEEECCCCEEHHHHCCCCCCCCCCCEEEHHHHHHHHHHH
IADGADLLDIGGESTRPGAPPVPLDEELARVVPLVEALRPFNVPLSIDTYKPAVMRAALA
HHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHH
AGADLINDIWGFRQPGAIDAVRDGNSGLCAMHMLGEPQTMQVGEPDYGDVVTDVRDFLAA
HHHHHHHHHHCCCCCCCCEEEECCCCCEEEEEECCCCCEEECCCCCCHHHHHHHHHHHHH
RAEALRDAGVAAERICVDPGFGFGKAVVDDNYALLAALPDTAPARPDGSAYPILAGMSRK
HHHHHHHCCCHHHHEEECCCCCCCCEEECCCEEEEEECCCCCCCCCCCCCCCEEECCCHH
SMLGAVIGGKPPMERVAASVAAAVCAVERGAAIVRVHDVAATVDALKVWNTVRAAARQR
HHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]