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The map label for this gene is aphA [H]

Identifier: 116689276

GI number: 116689276

Start: 1386151

End: 1387173

Strand: Direct

Name: aphA [H]

Synonym: Bcen2424_1254

Alternate gene names: 116689276

Gene position: 1386151-1387173 (Clockwise)

Preceding gene: 116689275

Following gene: 116689279

Centisome position: 39.79

GC content: 69.6

Gene sequence:

>1023_bases
ATGAAAACCTATTTCCATCCCGAACAACTGCTGCACCATCCGCGCAGCTACCTGTCGCGCGGCCAGATGCGCGAACCACA
GGAGGTGCCCGAACGCGCGGCGCGGCTCGTCGCGGCCGTCCGGTCGATCGACTTCGACGTGCGCGAGCCGGCCGATCGCG
GCACCGCGCCGATCGCGGCCGTGCACGACATGAACTACCTGCGCTTTCTCGAGGACGCGCACCGCGACTGGAAGCAGATG
CCTGACGACTGGGGTGACGAAGTGATGTCGAACGTGTTCGTGCGCGACCCGAACCCGCTGCGCGGCGTGCTCGCGAAGGC
CGCGCGCTACCTCGCCGACGGCAGTTGCCCGGTGGGCGCGAACACGTGGCGCGCGGCGTACTGGTCCGCGCAGGGTGCGC
TGGCGGCCGCGGCCGACGTCAACGACGGCGCACGCGAGGCGTACGCGCTGTGCCGGCCGCCCGGCCATCACGCGCGGCGC
GATGCGGCCGGCGGCTTCTGCTACCTGAACAATGCGGCGATCGCCGCGCAGGCGCTGCTCGGTCGCCATCGCCGCGTCGC
GGTGCTCGATACCGACATGCATCACGGACAGGGCGTGCAGGAGATCTTCTACGGCCGCGACGATGTGCTGTACGTGTCGA
TTCACGGCGACCCGACCAACTTCTATCCGGTCGTCGCGGGCTACGAGGAAGAGACGGGGGCGGGCGCCGGCGACGGCTTC
AACCTCAACCTGCCGATGCCGCACGGCGCGCCGGAGTCGGCATTCTTCGAGCGGCTCGACGACGCGTTGCGTGCACTCGC
GCGGTTCCAGCCCGATGCGCTCGTGCTTGCGCTCGGTTTCGACATCTACAAGGACGATCCGCAATCGCAGGTTGCGGTCA
CGACCGACGGGTTCGGGCGGCTCGGCGGCGCGATCGGCGCGCTCGGGTTGCCGACGGTGATCGTGCAGGAGGGCGGTTAT
CACCTCGCGAGTCTCGAGGCGAACGCGCGCGCGTTTTTCGGCGGGTTTGCCGCCGGGCGCTGA

Upstream 100 bases:

>100_bases
GCTGCTCCATGCGGTGCTGGCGCGCGCGGGTATCGCGGCGCGCGTCGATGCGGCTGCTGTCGCGCACGGCGCCTGATCCG
GCGAATCGACGAGGACCATC

Downstream 100 bases:

>100_bases
TCGGGCACTCGGAACCGAAGCGCACGCCGGAAATGACAACGGCCGCATGGCGCGGCCGTAAGAATGCGTGCGGCAGGTTC
CCGGCCGTCCGGGCGTTACC

Product: histone deacetylase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MKTYFHPEQLLHHPRSYLSRGQMREPQEVPERAARLVAAVRSIDFDVREPADRGTAPIAAVHDMNYLRFLEDAHRDWKQM
PDDWGDEVMSNVFVRDPNPLRGVLAKAARYLADGSCPVGANTWRAAYWSAQGALAAAADVNDGAREAYALCRPPGHHARR
DAAGGFCYLNNAAIAAQALLGRHRRVAVLDTDMHHGQGVQEIFYGRDDVLYVSIHGDPTNFYPVVAGYEEETGAGAGDGF
NLNLPMPHGAPESAFFERLDDALRALARFQPDALVLALGFDIYKDDPQSQVAVTTDGFGRLGGAIGALGLPTVIVQEGGY
HLASLEANARAFFGGFAAGR

Sequences:

>Translated_340_residues
MKTYFHPEQLLHHPRSYLSRGQMREPQEVPERAARLVAAVRSIDFDVREPADRGTAPIAAVHDMNYLRFLEDAHRDWKQM
PDDWGDEVMSNVFVRDPNPLRGVLAKAARYLADGSCPVGANTWRAAYWSAQGALAAAADVNDGAREAYALCRPPGHHARR
DAAGGFCYLNNAAIAAQALLGRHRRVAVLDTDMHHGQGVQEIFYGRDDVLYVSIHGDPTNFYPVVAGYEEETGAGAGDGF
NLNLPMPHGAPESAFFERLDDALRALARFQPDALVLALGFDIYKDDPQSQVAVTTDGFGRLGGAIGALGLPTVIVQEGGY
HLASLEANARAFFGGFAAGR
>Mature_340_residues
MKTYFHPEQLLHHPRSYLSRGQMREPQEVPERAARLVAAVRSIDFDVREPADRGTAPIAAVHDMNYLRFLEDAHRDWKQM
PDDWGDEVMSNVFVRDPNPLRGVLAKAARYLADGSCPVGANTWRAAYWSAQGALAAAADVNDGAREAYALCRPPGHHARR
DAAGGFCYLNNAAIAAQALLGRHRRVAVLDTDMHHGQGVQEIFYGRDDVLYVSIHGDPTNFYPVVAGYEEETGAGAGDGF
NLNLPMPHGAPESAFFERLDDALRALARFQPDALVLALGFDIYKDDPQSQVAVTTDGFGRLGGAIGALGLPTVIVQEGGY
HLASLEANARAFFGGFAAGR

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI13128864, Length=240, Percent_Identity=33.75, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI8923769, Length=327, Percent_Identity=25.6880733944954, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI20070354, Length=213, Percent_Identity=37.5586854460094, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI169234807, Length=261, Percent_Identity=33.7164750957854, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI148539870, Length=261, Percent_Identity=33.7164750957854, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI17158039, Length=229, Percent_Identity=32.7510917030568, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI13128860, Length=230, Percent_Identity=28.2608695652174, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI262073088, Length=196, Percent_Identity=33.1632653061224, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI30795204, Length=206, Percent_Identity=33.9805825242718, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI30795202, Length=206, Percent_Identity=33.9805825242718, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI153085395, Length=264, Percent_Identity=32.1969696969697, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI13128862, Length=225, Percent_Identity=28.4444444444444, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI293336691, Length=225, Percent_Identity=28, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI62750347, Length=202, Percent_Identity=36.1386138613861, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI62750349, Length=202, Percent_Identity=36.1386138613861, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI226529806, Length=216, Percent_Identity=35.1851851851852, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI262073092, Length=259, Percent_Identity=23.5521235521236, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17540334, Length=198, Percent_Identity=39.3939393939394, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI193206283, Length=198, Percent_Identity=39.3939393939394, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17540332, Length=198, Percent_Identity=39.3939393939394, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17508561, Length=311, Percent_Identity=29.2604501607717, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17561978, Length=238, Percent_Identity=30.2521008403361, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17537347, Length=228, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17534739, Length=213, Percent_Identity=30.5164319248826, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI193209491, Length=246, Percent_Identity=30.4878048780488, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI25154022, Length=224, Percent_Identity=26.7857142857143, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI25154020, Length=224, Percent_Identity=26.7857142857143, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324307, Length=219, Percent_Identity=35.1598173515982, Blast_Score=132, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6323999, Length=249, Percent_Identity=27.3092369477912, Blast_Score=109, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6321244, Length=208, Percent_Identity=28.8461538461538, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6325325, Length=149, Percent_Identity=26.1744966442953, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24657891, Length=233, Percent_Identity=31.3304721030043, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI281360801, Length=265, Percent_Identity=34.7169811320755, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI281360799, Length=265, Percent_Identity=34.7169811320755, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24644244, Length=246, Percent_Identity=30.0813008130081, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24641720, Length=265, Percent_Identity=34.7169811320755, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI281360899, Length=243, Percent_Identity=35.3909465020576, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24642144, Length=243, Percent_Identity=35.3909465020576, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24642142, Length=243, Percent_Identity=35.3909465020576, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24642146, Length=243, Percent_Identity=35.3909465020576, Blast_Score=109, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 36999; Mature: 36999

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTYFHPEQLLHHPRSYLSRGQMREPQEVPERAARLVAAVRSIDFDVREPADRGTAPIAA
CCCCCCHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEH
VHDMNYLRFLEDAHRDWKQMPDDWGDEVMSNVFVRDPNPLRGVLAKAARYLADGSCPVGA
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
NTWRAAYWSAQGALAAAADVNDGAREAYALCRPPGHHARRDAAGGFCYLNNAAIAAQALL
CCHHHHHCCCCCCEEEECCCCCCHHHHHHHCCCCCCCHHHCCCCCEEEECCHHHHHHHHH
GRHRRVAVLDTDMHHGQGVQEIFYGRDDVLYVSIHGDPTNFYPVVAGYEEETGAGAGDGF
CCCCEEEEEECCCCCCCCHHHHHCCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCCE
NLNLPMPHGAPESAFFERLDDALRALARFQPDALVLALGFDIYKDDPQSQVAVTTDGFGR
EEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHCCCCCCCEEEEEECCCHH
LGGAIGALGLPTVIVQEGGYHLASLEANARAFFGGFAAGR
HHHHHHHCCCCEEEEECCCEEEEEECCCCHHHHCCCCCCC
>Mature Secondary Structure
MKTYFHPEQLLHHPRSYLSRGQMREPQEVPERAARLVAAVRSIDFDVREPADRGTAPIAA
CCCCCCHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEH
VHDMNYLRFLEDAHRDWKQMPDDWGDEVMSNVFVRDPNPLRGVLAKAARYLADGSCPVGA
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
NTWRAAYWSAQGALAAAADVNDGAREAYALCRPPGHHARRDAAGGFCYLNNAAIAAQALL
CCHHHHHCCCCCCEEEECCCCCCHHHHHHHCCCCCCCHHHCCCCCEEEECCHHHHHHHHH
GRHRRVAVLDTDMHHGQGVQEIFYGRDDVLYVSIHGDPTNFYPVVAGYEEETGAGAGDGF
CCCCEEEEEECCCCCCCCHHHHHCCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCCE
NLNLPMPHGAPESAFFERLDDALRALARFQPDALVLALGFDIYKDDPQSQVAVTTDGFGR
EEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHCCCCCCCEEEEEECCCHH
LGGAIGALGLPTVIVQEGGYHLASLEANARAFFGGFAAGR
HHHHHHHCCCCEEEEECCCEEEEEECCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]