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The map label for this gene is proY [H]

Identifier: 116689234

GI number: 116689234

Start: 1334761

End: 1336128

Strand: Reverse

Name: proY [H]

Synonym: Bcen2424_1212

Alternate gene names: 116689234

Gene position: 1336128-1334761 (Counterclockwise)

Preceding gene: 116689235

Following gene: 116689232

Centisome position: 38.35

GC content: 66.3

Gene sequence:

>1368_bases
ATGAAAAACTTGCAGCGCCACCTGAGCGCGCGGCACATCCGCTTTCTCGCGCTGGGCTCGGCGATCGGTACGGGCCTGTT
CTACGGCTCCGCGTCCGCGATCCAGCTTGCCGGCCCGGCCGTGATCCTCGCGTACATCCTGGGCGGCGCGGCCGTCTACA
TGGTGATGCGCGCGCTCGGCGAGATGGCCGTGCGCGAACCCGTCGCCGGCTCGTTCGGCCACTACGCGACCGAGAACCTC
GGCCCCTTCGCGGGCTTCGTCACCGGCTGGACCTACACGCTCGAAATGGTGATCGTCGCGATCGCGGACATCACCGCGTT
CGGCATCTACATGGGCTTCTGGTTTCCGGACGTCCCGCAATGGATCTGGGTGCTCGGCGTCGTCGCGATCATCTGCGGGC
TGAACCTGTGCCACGTGAAAGTGTTCGGCGAGCTCGAATTCTGGCTGTCGATCATCAAGGTCGGCGCGATCGTCGCAATG
ATCGGCGGCGGCGTCGCGATCCTGCTGACCGGCATGCACTTCGGTCATTCGGCCGACTTGCCGACGTTCGCGAACCTGTG
GAACCACGGCGGCTTCTTGCCGAACGGCATCGGCGGGCTGATCGCGTCGCTGTCGGTGGTGATCTTCGCGTACGGCGGGA
TCGAGGTGATCGGGATGAGCGCCGGTGAGGCGAAGGACCCGGAACGCGTGATTCCGCGCGCGATCAACGCGGTGCCCGCA
CGCATCCTGCTGTTCTACGTGCTGACGATGGTGGTGCTGATGTCGATCAGCCCGTGGACGGGTGTCGGCAGCGACGGCAG
CCCGTTCGTGCAGATCTTCTCGGCGCTCGGCGTGAAATCGGCCGCGACGATCCTGAACCTCGTCGTGATCAGCGCGGCGA
TCTCGGCGATCAACAGCGACATCTTCGGCGCGGGCCGGATGATGTTCGGGATGGCGCGGCAGGGTCAGGCGCCGCGCGTG
CTGATGACGACATCGCGCCACGGCGTGCCGTGGGTCACGGTGCTCGTGATGGCCGGCGCGCTGCTGGTGGGCGTGCTGCT
CAACTACCTGATGCCGAAGGACGTGTTCCTGGTGGTCGCCGCGATCGCGACGTTCGCGACCGTGTGGGTGTGGCTGATGA
TCCTGCTGTCGCAGGTGGCGATGCGTCGCCGCCTGTCGAGTGCCGAAGTCGCCGCGCTGAAGTTCAAGGTGCCGCTGTGG
CCCGTCGCGCCCGCGCTGACGATCGCCTTCATGGGCTTCGTGATCGTGATGCTCGGCTGGTTCGAGGATACGCGCGTGGC
GCTGTATGTCGGCGCGGCATGGCTCGCGCTGCTCGCGGCCGTGTTCTACGCACGGATTCGCCCGAAATTCGCACCTGCGT
CACGTTGA

Upstream 100 bases:

>100_bases
GCTTGTTATCATTCGTTCACATTCAAGTTGTATAGACAACTTGGCGCACTCGAACCGGCCCCGCTCGCCAGGTTCGTCGC
ATAACGATATCGGAGACTCG

Downstream 100 bases:

>100_bases
CGCACGGCGGACTGGCCGGTGCGGCGCGCCGGTTCCGACGCGCCTTCCGATGTCCCGGTTCCGCGCGGCGCCCGTCGCGC
CGGACGCCGCGGATCGACTC

Product: amino acid permease-associated region

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MKNLQRHLSARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYILGGAAVYMVMRALGEMAVREPVAGSFGHYATENL
GPFAGFVTGWTYTLEMVIVAIADITAFGIYMGFWFPDVPQWIWVLGVVAIICGLNLCHVKVFGELEFWLSIIKVGAIVAM
IGGGVAILLTGMHFGHSADLPTFANLWNHGGFLPNGIGGLIASLSVVIFAYGGIEVIGMSAGEAKDPERVIPRAINAVPA
RILLFYVLTMVVLMSISPWTGVGSDGSPFVQIFSALGVKSAATILNLVVISAAISAINSDIFGAGRMMFGMARQGQAPRV
LMTTSRHGVPWVTVLVMAGALLVGVLLNYLMPKDVFLVVAAIATFATVWVWLMILLSQVAMRRRLSSAEVAALKFKVPLW
PVAPALTIAFMGFVIVMLGWFEDTRVALYVGAAWLALLAAVFYARIRPKFAPASR

Sequences:

>Translated_455_residues
MKNLQRHLSARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYILGGAAVYMVMRALGEMAVREPVAGSFGHYATENL
GPFAGFVTGWTYTLEMVIVAIADITAFGIYMGFWFPDVPQWIWVLGVVAIICGLNLCHVKVFGELEFWLSIIKVGAIVAM
IGGGVAILLTGMHFGHSADLPTFANLWNHGGFLPNGIGGLIASLSVVIFAYGGIEVIGMSAGEAKDPERVIPRAINAVPA
RILLFYVLTMVVLMSISPWTGVGSDGSPFVQIFSALGVKSAATILNLVVISAAISAINSDIFGAGRMMFGMARQGQAPRV
LMTTSRHGVPWVTVLVMAGALLVGVLLNYLMPKDVFLVVAAIATFATVWVWLMILLSQVAMRRRLSSAEVAALKFKVPLW
PVAPALTIAFMGFVIVMLGWFEDTRVALYVGAAWLALLAAVFYARIRPKFAPASR
>Mature_455_residues
MKNLQRHLSARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYILGGAAVYMVMRALGEMAVREPVAGSFGHYATENL
GPFAGFVTGWTYTLEMVIVAIADITAFGIYMGFWFPDVPQWIWVLGVVAIICGLNLCHVKVFGELEFWLSIIKVGAIVAM
IGGGVAILLTGMHFGHSADLPTFANLWNHGGFLPNGIGGLIASLSVVIFAYGGIEVIGMSAGEAKDPERVIPRAINAVPA
RILLFYVLTMVVLMSISPWTGVGSDGSPFVQIFSALGVKSAATILNLVVISAAISAINSDIFGAGRMMFGMARQGQAPRV
LMTTSRHGVPWVTVLVMAGALLVGVLLNYLMPKDVFLVVAAIATFATVWVWLMILLSQVAMRRRLSSAEVAALKFKVPLW
PVAPALTIAFMGFVIVMLGWFEDTRVALYVGAAWLALLAAVFYARIRPKFAPASR

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of proline [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=358, Percent_Identity=25.6983240223464, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI110347453, Length=338, Percent_Identity=26.6272189349112, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1786602, Length=438, Percent_Identity=61.6438356164384, Blast_Score=519, Evalue=1e-148,
Organism=Escherichia coli, GI1786789, Length=451, Percent_Identity=43.9024390243902, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1786302, Length=437, Percent_Identity=44.1647597254005, Blast_Score=364, Evalue=1e-102,
Organism=Escherichia coli, GI1790653, Length=437, Percent_Identity=39.8169336384439, Blast_Score=346, Evalue=2e-96,
Organism=Escherichia coli, GI48994972, Length=442, Percent_Identity=42.0814479638009, Blast_Score=336, Evalue=2e-93,
Organism=Escherichia coli, GI87081915, Length=402, Percent_Identity=38.3084577114428, Blast_Score=289, Evalue=2e-79,
Organism=Escherichia coli, GI87081708, Length=445, Percent_Identity=35.5056179775281, Blast_Score=264, Evalue=8e-72,
Organism=Escherichia coli, GI1789017, Length=413, Percent_Identity=35.8353510895884, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1788480, Length=432, Percent_Identity=34.4907407407407, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI87081869, Length=194, Percent_Identity=26.2886597938144, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082023, Length=281, Percent_Identity=24.9110320284698, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17532491, Length=423, Percent_Identity=24.113475177305, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17531343, Length=328, Percent_Identity=25.9146341463415, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17540018, Length=420, Percent_Identity=24.7619047619048, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324061, Length=441, Percent_Identity=32.1995464852608, Blast_Score=192, Evalue=9e-50,
Organism=Saccharomyces cerevisiae, GI6320772, Length=438, Percent_Identity=31.2785388127854, Blast_Score=184, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6324553, Length=388, Percent_Identity=34.2783505154639, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6324924, Length=411, Percent_Identity=31.6301703163017, Blast_Score=166, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6324990, Length=366, Percent_Identity=31.9672131147541, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6322892, Length=411, Percent_Identity=29.1970802919708, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324059, Length=440, Percent_Identity=29.7727272727273, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6321629, Length=406, Percent_Identity=27.8325123152709, Blast_Score=150, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6320717, Length=398, Percent_Identity=25.6281407035176, Blast_Score=145, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6319824, Length=416, Percent_Identity=25.7211538461538, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6320251, Length=397, Percent_Identity=26.448362720403, Blast_Score=143, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6319542, Length=396, Percent_Identity=27.020202020202, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6319543, Length=393, Percent_Identity=27.2264631043257, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6321053, Length=427, Percent_Identity=25.5269320843091, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6322967, Length=402, Percent_Identity=26.6169154228856, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6319608, Length=354, Percent_Identity=28.5310734463277, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6324981, Length=415, Percent_Identity=27.2289156626506, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320364, Length=505, Percent_Identity=23.7623762376238, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24667468, Length=336, Percent_Identity=25.5952380952381, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI161077963, Length=344, Percent_Identity=22.9651162790698, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 48608; Mature: 48608

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLQRHLSARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYILGGAAVYMVMRALG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
EMAVREPVAGSFGHYATENLGPFAGFVTGWTYTLEMVIVAIADITAFGIYMGFWFPDVPQ
HHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
WIWVLGVVAIICGLNLCHVKVFGELEFWLSIIKVGAIVAMIGGGVAILLTGMHFGHSADL
HHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
PTFANLWNHGGFLPNGIGGLIASLSVVIFAYGGIEVIGMSAGEAKDPERVIPRAINAVPA
CHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
RILLFYVLTMVVLMSISPWTGVGSDGSPFVQIFSALGVKSAATILNLVVISAAISAINSD
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
IFGAGRMMFGMARQGQAPRVLMTTSRHGVPWVTVLVMAGALLVGVLLNYLMPKDVFLVVA
HHHCHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AIATFATVWVWLMILLSQVAMRRRLSSAEVAALKFKVPLWPVAPALTIAFMGFVIVMLGW
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHC
FEDTRVALYVGAAWLALLAAVFYARIRPKFAPASR
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKNLQRHLSARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYILGGAAVYMVMRALG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
EMAVREPVAGSFGHYATENLGPFAGFVTGWTYTLEMVIVAIADITAFGIYMGFWFPDVPQ
HHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
WIWVLGVVAIICGLNLCHVKVFGELEFWLSIIKVGAIVAMIGGGVAILLTGMHFGHSADL
HHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
PTFANLWNHGGFLPNGIGGLIASLSVVIFAYGGIEVIGMSAGEAKDPERVIPRAINAVPA
CHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
RILLFYVLTMVVLMSISPWTGVGSDGSPFVQIFSALGVKSAATILNLVVISAAISAINSD
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
IFGAGRMMFGMARQGQAPRVLMTTSRHGVPWVTVLVMAGALLVGVLLNYLMPKDVFLVVA
HHHCHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AIATFATVWVWLMILLSQVAMRRRLSSAEVAALKFKVPLWPVAPALTIAFMGFVIVMLGW
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHC
FEDTRVALYVGAAWLALLAAVFYARIRPKFAPASR
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]