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The map label for this gene is mucB [H]

Identifier: 116689151

GI number: 116689151

Start: 1238766

End: 1239818

Strand: Direct

Name: mucB [H]

Synonym: Bcen2424_1129

Alternate gene names: 116689151

Gene position: 1238766-1239818 (Clockwise)

Preceding gene: 116689150

Following gene: 116689152

Centisome position: 35.56

GC content: 67.14

Gene sequence:

>1053_bases
ATGCGGACATTGCAGTTGAATCACGCCATCTCCGGATGGAAGCGGCTGCCGGCCCTCCTGCTTTGCGCAGCCGCCCTGTT
GTCCGTTCAATCCCTTCCCGCCAGCGCCCAGCAACCGGACGATCCCGTCGCGACCCGCAAGGGTGCCGCCGACTGGCTCG
ACCGCGTCCAGCAGGCGGCGCAACAGCAGAGCTACGAAGGTACGTTCGTCTACCAGCGCGGCGGGTATGTGCAGTCGTCA
CGCATCGCGCACGTCTCGTCCCGCGACGGCGAGTTCGAGCGGATCGAGACGCTCGACGGCAAGCCGCGCAAGCTGCTGCG
GCACAACGACGAGCTGTACACGTTCGTGCCCGAGCGCAAGCTGTGCGTGGTCGAGCGCCGCCAGACGCGCGACTCGTTCC
CCGCGCTGCTCGGCGCGAGCGGCGAGCACGTGATGTCCGTCTACGATGCGAAGTCGCTCGGCAAAGACCGTGTGGCCGGG
ATCGACGCGCAGGTCGTCGAGCTCGTGCCGAAGGATGCCTACCGTTTCACGTACAAGCTGTGGGCCGACGCACGCACCGG
GCTGCTGCTGCGTTCGCAGACGCTCGACGCGAACGATCACGTGCTCGAACAGATCGCGTTCTCGCAATTGCAAACCGGCG
GCGCGAGCGGCGACAAGGCCGCGATTGCAGCCGGCATGCGCAACCTGAGCGGCTGGACGGTCGTGCGCCCGCCGGTCGCG
GCGGTCGACATGGAAGCGCAGGGCTGGCAGCTCGCGCCGAGCGTCGCCGGCTTCCAGAAGATTCGTGAAGTGCGCCGGCC
GATGGCCGCGCGCGATGCGGGTGATCCGCCGATCCCGGTCGATCAGGCCGTCTTCACCGACGGCCTCGCGACGATCTCGG
TCTTCATCGAGCCGGCCGAAAAGAATACGCGCAAGGAAGGCGCGGGCAGCACCGGTGCGACGCACGTTCTCGTGAAGCGC
CGCGGCGACTACTGGATCACCGTGCTCGGCGAAGTGCCGCCGGCGACGTTGCAGCAGTTCGCGTCTGCCATAGAATACAA
GGCTTCCAAGTAA

Upstream 100 bases:

>100_bases
ACCTTGAAGCGCACCAGCAATTCGCCCAGCAGCCCGTCGTCACGGGTTCGATGCCGCTGATCCGCGCTGCCGTGACCACC
ACGCCAGGCCAATAAACCCG

Downstream 100 bases:

>100_bases
CGCTACGGCTTCCGACATGACGAAACTCACGCTGCGCAAAGTGCTCGCGGCGGCGGCGCTGTGTGCCTGCCTGCCGCTCG
TCCCGCAAACCGCGGTCGCT

Product: sigma E regulatory protein, MucB/RseB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MRTLQLNHAISGWKRLPALLLCAAALLSVQSLPASAQQPDDPVATRKGAADWLDRVQQAAQQQSYEGTFVYQRGGYVQSS
RIAHVSSRDGEFERIETLDGKPRKLLRHNDELYTFVPERKLCVVERRQTRDSFPALLGASGEHVMSVYDAKSLGKDRVAG
IDAQVVELVPKDAYRFTYKLWADARTGLLLRSQTLDANDHVLEQIAFSQLQTGGASGDKAAIAAGMRNLSGWTVVRPPVA
AVDMEAQGWQLAPSVAGFQKIREVRRPMAARDAGDPPIPVDQAVFTDGLATISVFIEPAEKNTRKEGAGSTGATHVLVKR
RGDYWITVLGEVPPATLQQFASAIEYKASK

Sequences:

>Translated_350_residues
MRTLQLNHAISGWKRLPALLLCAAALLSVQSLPASAQQPDDPVATRKGAADWLDRVQQAAQQQSYEGTFVYQRGGYVQSS
RIAHVSSRDGEFERIETLDGKPRKLLRHNDELYTFVPERKLCVVERRQTRDSFPALLGASGEHVMSVYDAKSLGKDRVAG
IDAQVVELVPKDAYRFTYKLWADARTGLLLRSQTLDANDHVLEQIAFSQLQTGGASGDKAAIAAGMRNLSGWTVVRPPVA
AVDMEAQGWQLAPSVAGFQKIREVRRPMAARDAGDPPIPVDQAVFTDGLATISVFIEPAEKNTRKEGAGSTGATHVLVKR
RGDYWITVLGEVPPATLQQFASAIEYKASK
>Mature_350_residues
MRTLQLNHAISGWKRLPALLLCAAALLSVQSLPASAQQPDDPVATRKGAADWLDRVQQAAQQQSYEGTFVYQRGGYVQSS
RIAHVSSRDGEFERIETLDGKPRKLLRHNDELYTFVPERKLCVVERRQTRDSFPALLGASGEHVMSVYDAKSLGKDRVAG
IDAQVVELVPKDAYRFTYKLWADARTGLLLRSQTLDANDHVLEQIAFSQLQTGGASGDKAAIAAGMRNLSGWTVVRPPVA
AVDMEAQGWQLAPSVAGFQKIREVRRPMAARDAGDPPIPVDQAVFTDGLATISVFIEPAEKNTRKEGAGSTGATHVLVKR
RGDYWITVLGEVPPATLQQFASAIEYKASK

Specific function: Negative regulator of the sigma factor AlgU. Plays a role in the differentiation of P.aeruginosa into the alginate- producing form. Inactivation of mucB causes conversion to mucoidy [H]

COG id: COG3026

COG function: function code T; Negative regulator of sigma E activity

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rseB family [H]

Homologues:

Organism=Escherichia coli, GI1788924, Length=304, Percent_Identity=25.9868421052632, Blast_Score=105, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005588 [H]

Pfam domain/function: PF03888 MucB_RseB [H]

EC number: NA

Molecular weight: Translated: 38293; Mature: 38293

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTLQLNHAISGWKRLPALLLCAAALLSVQSLPASAQQPDDPVATRKGAADWLDRVQQAA
CCEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCHHHHHHHHHHHH
QQQSYEGTFVYQRGGYVQSSRIAHVSSRDGEFERIETLDGKPRKLLRHNDELYTFVPERK
HHCCCCCEEEEECCCEEECCCEEECCCCCCCHHHHHCCCCCHHHHHHCCCCEEEECCCCC
LCVVERRQTRDSFPALLGASGEHVMSVYDAKSLGKDRVAGIDAQVVELVPKDAYRFTYKL
EEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHCCCCHHHHHHCCCCHHHEEEEE
WADARTGLLLRSQTLDANDHVLEQIAFSQLQTGGASGDKAAIAAGMRNLSGWTVVRPPVA
ECCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEECCCCC
AVDMEAQGWQLAPSVAGFQKIREVRRPMAARDAGDPPIPVDQAVFTDGLATISVFIEPAE
EEECCCCCCCCCCHHHHHHHHHHHHCCHHHCCCCCCCCCCCHHHHHCCCEEEEEEEECCH
KNTRKEGAGSTGATHVLVKRRGDYWITVLGEVPPATLQQFASAIEYKASK
HCCHHCCCCCCCCEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRTLQLNHAISGWKRLPALLLCAAALLSVQSLPASAQQPDDPVATRKGAADWLDRVQQAA
CCEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCHHHHHHHHHHHH
QQQSYEGTFVYQRGGYVQSSRIAHVSSRDGEFERIETLDGKPRKLLRHNDELYTFVPERK
HHCCCCCEEEEECCCEEECCCEEECCCCCCCHHHHHCCCCCHHHHHHCCCCEEEECCCCC
LCVVERRQTRDSFPALLGASGEHVMSVYDAKSLGKDRVAGIDAQVVELVPKDAYRFTYKL
EEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHCCCCHHHHHHCCCCHHHEEEEE
WADARTGLLLRSQTLDANDHVLEQIAFSQLQTGGASGDKAAIAAGMRNLSGWTVVRPPVA
ECCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEECCCCC
AVDMEAQGWQLAPSVAGFQKIREVRRPMAARDAGDPPIPVDQAVFTDGLATISVFIEPAE
EEECCCCCCCCCCHHHHHHHHHHHHCCHHHCCCCCCCCCCCHHHHHCCCEEEEEEEECCH
KNTRKEGAGSTGATHVLVKRRGDYWITVLGEVPPATLQQFASAIEYKASK
HCCHHCCCCCCCCEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8412698; 8378309; 8444793; 10984043 [H]