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The map label for this gene is fabF [H]

Identifier: 116689147

GI number: 116689147

Start: 1235657

End: 1236889

Strand: Direct

Name: fabF [H]

Synonym: Bcen2424_1125

Alternate gene names: 116689147

Gene position: 1235657-1236889 (Clockwise)

Preceding gene: 116689146

Following gene: 116689148

Centisome position: 35.47

GC content: 66.26

Gene sequence:

>1233_bases
GTGAGCCGCCGTCGTGTTGTCGTTACAGGCCTGGGGCTGATTTCGCCTGTTGGCAATAGTGTTGCCGACGGCTGGGCCAA
TCTCGTCGCCGGCAAGTCCGGTATCGCCACCGTCACGAAGTTCGATGCGTCGAACCTCGCGTGCCATTTCGCGGGCGAAG
TGAAGGGTTTCAGCGCCGAGGAGTACATCCCGGCGAAGGAAGCCCGGAACATGGATACGTTCATCCATTACGGCATCGCC
GCCGGCGTCCAGGCCATGCGGGACAGCGGGCTGGAAGTGACCGAAGCCAATGCGGAACGCATCGGCGTGCTGGTCGGTTC
CGGCATCGGCGGCCTGCCGATGATCGAGGATACGCACCAGACCTACGTCGATCGCGGTGCGCGCCGGATCTCGCCGTTCT
TCGTGCCGGGTTCGATCATCAACATGATCTCGGGTCACCTGAGCATCATGTTCGGCCTGAAGGGCCCCAACCTCGCGGCC
GTCACGGCCTGCACGACCGGCCTGCACAGCATCGGCCTCGCCGCGCGGCTGATCCAGGCCGGCGACGCCGACGTGATGGT
CGCGGGCGGTGCCGAATCGACGGTGTCGCCGCTCGGCATCGGCGGGTTCGCCGCCGCGCGCGCGCTGTCGACCCGCAACG
ACGATCCGGCTACCGCGTCGCGTCCGTGGGACAAGGACCGCGACGGCTTCGTGCTGGGCGAGGGTTCCGGCGTGATGGTG
CTCGAGGAGTACGAGGCGGCGAAGGCGCGCGGCGCGAAGATCTACGCAGAAGTCGTGGGCTTCGGCATGACGGGCGACGC
GTACCACATGACCGCGCCGAACATGGACGGCCCGCGCCGCTGCATGGTCGCGGCGCTGCGCGACGCCGGCCTGAATGCCG
ACGAGGTGCAGTACCTGAACGCGCATGGCACGTCGACGCCGCTGGGCGACAAGAACGAGTCCGACGCGGTGAAGGCGGCC
TTCGGCGAGCACGCGTACAAGATGGTGGTCAACTCGACGAAGTCGATGACGGGCCACCTGCTGGGTGGCGCGGGCGGCCT
CGAATCGGTGTTCACGGTACTGGCGCTGCACAACAACGTGTCGCCGCCGACCATCAACATCTTCAACCAGGACCCCGAGT
GCGATCTCGATTACTGCGCGAACACCGCGCGTGACATGAAGATCGACGTAGCCGTGAAGAACAACTTCGGCTTCGGCGGC
ACCAACGGCACGCTGGTGTTCAAGCGCGTCTGA

Upstream 100 bases:

>100_bases
TTCGCGCCGGACGGACTAACAGCCACAGGGCTCGCAGGGCTGGTTCCTGTGGCCACTGTGGCTTTTGTTTTTGTCATCCA
ATAATGGAAAAGAGGTTACC

Downstream 100 bases:

>100_bases
CGTCGAATCGCTTGACGAGTCCATTCGATGCTCCGGCCGGGCGTCCGCAGCGCTTTGCGTTGCGGGCCTCGGCCGTGTCG
TATCTCGTGCTGGCCGCGTT

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MSRRRVVVTGLGLISPVGNSVADGWANLVAGKSGIATVTKFDASNLACHFAGEVKGFSAEEYIPAKEARNMDTFIHYGIA
AGVQAMRDSGLEVTEANAERIGVLVGSGIGGLPMIEDTHQTYVDRGARRISPFFVPGSIINMISGHLSIMFGLKGPNLAA
VTACTTGLHSIGLAARLIQAGDADVMVAGGAESTVSPLGIGGFAAARALSTRNDDPATASRPWDKDRDGFVLGEGSGVMV
LEEYEAAKARGAKIYAEVVGFGMTGDAYHMTAPNMDGPRRCMVAALRDAGLNADEVQYLNAHGTSTPLGDKNESDAVKAA
FGEHAYKMVVNSTKSMTGHLLGGAGGLESVFTVLALHNNVSPPTINIFNQDPECDLDYCANTARDMKIDVAVKNNFGFGG
TNGTLVFKRV

Sequences:

>Translated_410_residues
MSRRRVVVTGLGLISPVGNSVADGWANLVAGKSGIATVTKFDASNLACHFAGEVKGFSAEEYIPAKEARNMDTFIHYGIA
AGVQAMRDSGLEVTEANAERIGVLVGSGIGGLPMIEDTHQTYVDRGARRISPFFVPGSIINMISGHLSIMFGLKGPNLAA
VTACTTGLHSIGLAARLIQAGDADVMVAGGAESTVSPLGIGGFAAARALSTRNDDPATASRPWDKDRDGFVLGEGSGVMV
LEEYEAAKARGAKIYAEVVGFGMTGDAYHMTAPNMDGPRRCMVAALRDAGLNADEVQYLNAHGTSTPLGDKNESDAVKAA
FGEHAYKMVVNSTKSMTGHLLGGAGGLESVFTVLALHNNVSPPTINIFNQDPECDLDYCANTARDMKIDVAVKNNFGFGG
TNGTLVFKRV
>Mature_409_residues
SRRRVVVTGLGLISPVGNSVADGWANLVAGKSGIATVTKFDASNLACHFAGEVKGFSAEEYIPAKEARNMDTFIHYGIAA
GVQAMRDSGLEVTEANAERIGVLVGSGIGGLPMIEDTHQTYVDRGARRISPFFVPGSIINMISGHLSIMFGLKGPNLAAV
TACTTGLHSIGLAARLIQAGDADVMVAGGAESTVSPLGIGGFAAARALSTRNDDPATASRPWDKDRDGFVLGEGSGVMVL
EEYEAAKARGAKIYAEVVGFGMTGDAYHMTAPNMDGPRRCMVAALRDAGLNADEVQYLNAHGTSTPLGDKNESDAVKAAF
GEHAYKMVVNSTKSMTGHLLGGAGGLESVFTVLALHNNVSPPTINIFNQDPECDLDYCANTARDMKIDVAVKNNFGFGGT
NGTLVFKRV

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=417, Percent_Identity=45.8033573141487, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI223972627, Length=162, Percent_Identity=47.5308641975309, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI41872631, Length=438, Percent_Identity=22.6027397260274, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1787337, Length=413, Percent_Identity=61.501210653753, Blast_Score=496, Evalue=1e-141,
Organism=Escherichia coli, GI1788663, Length=412, Percent_Identity=38.1067961165049, Blast_Score=242, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI71983541, Length=412, Percent_Identity=35.6796116504854, Blast_Score=237, Evalue=9e-63,
Organism=Caenorhabditis elegans, GI71983535, Length=255, Percent_Identity=40.7843137254902, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI212642053, Length=424, Percent_Identity=24.0566037735849, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17550940, Length=413, Percent_Identity=23.728813559322, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320904, Length=449, Percent_Identity=36.0801781737194, Blast_Score=261, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24644341, Length=414, Percent_Identity=43.9613526570048, Blast_Score=339, Evalue=2e-93,
Organism=Drosophila melanogaster, GI221330659, Length=355, Percent_Identity=25.0704225352113, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI19920632, Length=355, Percent_Identity=25.0704225352113, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24581345, Length=368, Percent_Identity=22.8260869565217, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 42848; Mature: 42717

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRRVVVTGLGLISPVGNSVADGWANLVAGKSGIATVTKFDASNLACHFAGEVKGFSAE
CCCCEEEEEECCHHCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCCCHH
EYIPAKEARNMDTFIHYGIAAGVQAMRDSGLEVTEANAERIGVLVGSGIGGLPMIEDTHQ
HCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEEECCCCCCCCCCCHHH
TYVDRGARRISPFFVPGSIINMISGHLSIMFGLKGPNLAAVTACTTGLHSIGLAARLIQA
HHHHCCHHHCCCEECCHHHHHHHCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHC
GDADVMVAGGAESTVSPLGIGGFAAARALSTRNDDPATASRPWDKDRDGFVLGEGSGVMV
CCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEE
LEEYEAAKARGAKIYAEVVGFGMTGDAYHMTAPNMDGPRRCMVAALRDAGLNADEVQYLN
EECCHHHHHCCCEEEEEHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCHHHEEEEE
AHGTSTPLGDKNESDAVKAAFGEHAYKMVVNSTKSMTGHLLGGAGGLESVFTVLALHNNV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCEEEECCCCCHHHHHHHHHHHCCC
SPPTINIFNQDPECDLDYCANTARDMKIDVAVKNNFGFGGTNGTLVFKRV
CCCEEEEECCCCCCCHHHHCCCCCCEEEEEEEECCCCCCCCCCEEEEEEC
>Mature Secondary Structure 
SRRRVVVTGLGLISPVGNSVADGWANLVAGKSGIATVTKFDASNLACHFAGEVKGFSAE
CCCEEEEEECCHHCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCCCHH
EYIPAKEARNMDTFIHYGIAAGVQAMRDSGLEVTEANAERIGVLVGSGIGGLPMIEDTHQ
HCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEEECCCCCCCCCCCHHH
TYVDRGARRISPFFVPGSIINMISGHLSIMFGLKGPNLAAVTACTTGLHSIGLAARLIQA
HHHHCCHHHCCCEECCHHHHHHHCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHC
GDADVMVAGGAESTVSPLGIGGFAAARALSTRNDDPATASRPWDKDRDGFVLGEGSGVMV
CCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEE
LEEYEAAKARGAKIYAEVVGFGMTGDAYHMTAPNMDGPRRCMVAALRDAGLNADEVQYLN
EECCHHHHHCCCEEEEEHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCHHHEEEEE
AHGTSTPLGDKNESDAVKAAFGEHAYKMVVNSTKSMTGHLLGGAGGLESVFTVLALHNNV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCEEEECCCCCHHHHHHHHHHHCCC
SPPTINIFNQDPECDLDYCANTARDMKIDVAVKNNFGFGGTNGTLVFKRV
CCCEEEEECCCCCCCHHHHCCCCCCEEEEEEEECCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]