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The map label for this gene is moeA [H]

Identifier: 116689130

GI number: 116689130

Start: 1218226

End: 1219524

Strand: Reverse

Name: moeA [H]

Synonym: Bcen2424_1107

Alternate gene names: 116689130

Gene position: 1219524-1218226 (Counterclockwise)

Preceding gene: 116689131

Following gene: 116689129

Centisome position: 35.0

GC content: 73.44

Gene sequence:

>1299_bases
ATGATCACGCACTCCTCGCCCGCCTCCCGAACCGCATCCGACCCCGATGCCCCGCTGTCGCTCGCCGACGCGCAGGCGCT
CGCGTGCCGCTTCGCGGTGCCCGTCGACGCGTGTGACACGGTGACGCTGCGCGAGGCGCTCGACCGCGTGCTCGCGGCCG
ACGTGAGCGCGCCGTTCGACATTCCCGCGTACGACAACTCGGCCATGGACGGCTATGCGTTCGACGGCGCCGCCGCGGCA
TTCGCATCGGCGCAGGGCGAGGTCGCGATGCCGGTCGCCGGCACCGCGTTCGCCGGCCATCCGTTCGACGGCGCCGTGGC
GGCCGGTGCATGCGTGCGCATCATGACGGGCGCGCCGATGCCGGCCGGATGCGACACGGTGATTCCGCAGGAACGCGTGC
GCGTCGACGGCGACACGATCCGCTTCGCCGCGCACGACGTCGCGCACGGCGCGAACTGCCGCCGGGCCGGCGAGGATCTC
GCGCGCGGCGCCTGTGCGCTCGCCGCGGGCCGCATCCTGCGGCCGTCCGATCTCGGCCTGCTCGCGTCGTTCGGCATCGC
CGACGTCACGGTGCGCCGCCGCGTGCGCGTCGCCGTGTTCTCGACCGGCGACGAGTTGCGCGAGCCCGGCGAACCGCTCG
GCCGCGGCGCGCTGTACGACAGCAATCGCGGCATGCTGATCGCGATGCTCGAACGGCTGCACGTCGACACGCTCGACCTC
GGCATCGTCCGCGACGACCCGACCGCGCTCGAAGCCGCATTGCGCGCCGCCATCGCCGCGCAAGCCGATGCGGTCATCAC
GTCGGGCGGCGTGTCGGTCGGCGAAGCCGACTTCACGCGCGACGTGATGGCGCGGCTCGGCGACGTGACGTTCGCGAGTC
TCGCGCTGCGGCCCGGCCGGCCGCTCGCGTGCGGCACGCTCGCCCGCGCGGCCGACGGCGCCGGCCACGCGCTGTTCTTC
GGGCTGCCCGGCAATCCTGTCGCGTCCGCCGTGACGTTCGTTGCGATCGTGCGTCCTGCGCTGCTCAAGCTGGCCGGCAC
GCAAACGCCGCCGCCCGCCATGTATACGGCGCTCAGTACGCAGCCGTTGAAGAAGCGTCCCGGCCGCACCGACTACCTGC
GCGGCATCGCGACGCGCGCCGCCGACGGCCAATGGCACGTCGCGCCGGCCGGATCGCAAAGCTCCGCGTCGTTGAGCGGC
CTTGCCGCCGCCAACTGTTTCATCGTCCTGGGCCACGATACCGCGGCAGTCGACGCGGGCGCCCCGGTCGACATCCTGCC
GCTCGACGGCCTGATCTGA

Upstream 100 bases:

>100_bases
CGTTCCCGCCCGGCGCCCGCCACACGCGAAACCCGCGCCCCGGCACCCTCCTCGCGCCACCGGCCACGAACCCGATACGC
CTTGCGGCGCAGTCCGACTG

Downstream 100 bases:

>100_bases
ATTCCAATCGGTATATCTCTACGGGGGCAATCCGCACATGAAGAAACAAATCTCGTCGATCGCCGCGGGGCAGACCGCAA
AGGCGCTGATCCTCGTCTAC

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MITHSSPASRTASDPDAPLSLADAQALACRFAVPVDACDTVTLREALDRVLAADVSAPFDIPAYDNSAMDGYAFDGAAAA
FASAQGEVAMPVAGTAFAGHPFDGAVAAGACVRIMTGAPMPAGCDTVIPQERVRVDGDTIRFAAHDVAHGANCRRAGEDL
ARGACALAAGRILRPSDLGLLASFGIADVTVRRRVRVAVFSTGDELREPGEPLGRGALYDSNRGMLIAMLERLHVDTLDL
GIVRDDPTALEAALRAAIAAQADAVITSGGVSVGEADFTRDVMARLGDVTFASLALRPGRPLACGTLARAADGAGHALFF
GLPGNPVASAVTFVAIVRPALLKLAGTQTPPPAMYTALSTQPLKKRPGRTDYLRGIATRAADGQWHVAPAGSQSSASLSG
LAAANCFIVLGHDTAAVDAGAPVDILPLDGLI

Sequences:

>Translated_432_residues
MITHSSPASRTASDPDAPLSLADAQALACRFAVPVDACDTVTLREALDRVLAADVSAPFDIPAYDNSAMDGYAFDGAAAA
FASAQGEVAMPVAGTAFAGHPFDGAVAAGACVRIMTGAPMPAGCDTVIPQERVRVDGDTIRFAAHDVAHGANCRRAGEDL
ARGACALAAGRILRPSDLGLLASFGIADVTVRRRVRVAVFSTGDELREPGEPLGRGALYDSNRGMLIAMLERLHVDTLDL
GIVRDDPTALEAALRAAIAAQADAVITSGGVSVGEADFTRDVMARLGDVTFASLALRPGRPLACGTLARAADGAGHALFF
GLPGNPVASAVTFVAIVRPALLKLAGTQTPPPAMYTALSTQPLKKRPGRTDYLRGIATRAADGQWHVAPAGSQSSASLSG
LAAANCFIVLGHDTAAVDAGAPVDILPLDGLI
>Mature_432_residues
MITHSSPASRTASDPDAPLSLADAQALACRFAVPVDACDTVTLREALDRVLAADVSAPFDIPAYDNSAMDGYAFDGAAAA
FASAQGEVAMPVAGTAFAGHPFDGAVAAGACVRIMTGAPMPAGCDTVIPQERVRVDGDTIRFAAHDVAHGANCRRAGEDL
ARGACALAAGRILRPSDLGLLASFGIADVTVRRRVRVAVFSTGDELREPGEPLGRGALYDSNRGMLIAMLERLHVDTLDL
GIVRDDPTALEAALRAAIAAQADAVITSGGVSVGEADFTRDVMARLGDVTFASLALRPGRPLACGTLARAADGAGHALFF
GLPGNPVASAVTFVAIVRPALLKLAGTQTPPPAMYTALSTQPLKKRPGRTDYLRGIATRAADGQWHVAPAGSQSSASLSG
LAAANCFIVLGHDTAAVDAGAPVDILPLDGLI

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=431, Percent_Identity=33.6426914153132, Blast_Score=195, Evalue=8e-50,
Organism=Homo sapiens, GI66932975, Length=431, Percent_Identity=33.6426914153132, Blast_Score=194, Evalue=9e-50,
Organism=Escherichia coli, GI1787049, Length=400, Percent_Identity=47, Blast_Score=340, Evalue=7e-95,
Organism=Caenorhabditis elegans, GI25147659, Length=401, Percent_Identity=28.1795511221945, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17562606, Length=385, Percent_Identity=24.9350649350649, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17136978, Length=413, Percent_Identity=27.8450363196126, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24638841, Length=413, Percent_Identity=27.8450363196126, Blast_Score=112, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44135; Mature: 44135

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITHSSPASRTASDPDAPLSLADAQALACRFAVPVDACDTVTLREALDRVLAADVSAPFD
CCCCCCCCCCCCCCCCCCCCHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCC
IPAYDNSAMDGYAFDGAAAAFASAQGEVAMPVAGTAFAGHPFDGAVAAGACVRIMTGAPM
CCCCCCCCCCCCCCCCHHHHHHCCCCCEEECCCCCCCCCCCCCCHHHHHHHEEEEECCCC
PAGCDTVIPQERVRVDGDTIRFAAHDVAHGANCRRAGEDLARGACALAAGRILRPSDLGL
CCCCCCCCCHHHEEECCCEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCH
LASFGIADVTVRRRVRVAVFSTGDELREPGEPLGRGALYDSNRGMLIAMLERLHVDTLDL
HHHCCHHHHEEEEEEEEEEEECCHHHHCCCCCCCCCCEEECCCCHHHHHHHHHCCCEEEE
GIVRDDPTALEAALRAAIAAQADAVITSGGVSVGEADFTRDVMARLGDVTFASLALRPGR
EEECCCHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCC
PLACGTLARAADGAGHALFFGLPGNPVASAVTFVAIVRPALLKLAGTQTPPPAMYTALST
CCHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEECCC
QPLKKRPGRTDYLRGIATRAADGQWHVAPAGSQSSASLSGLAAANCFIVLGHDTAAVDAG
CHHHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEECCEEEEECCCCCEECCC
APVDILPLDGLI
CCEEEECCCCCC
>Mature Secondary Structure
MITHSSPASRTASDPDAPLSLADAQALACRFAVPVDACDTVTLREALDRVLAADVSAPFD
CCCCCCCCCCCCCCCCCCCCHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCC
IPAYDNSAMDGYAFDGAAAAFASAQGEVAMPVAGTAFAGHPFDGAVAAGACVRIMTGAPM
CCCCCCCCCCCCCCCCHHHHHHCCCCCEEECCCCCCCCCCCCCCHHHHHHHEEEEECCCC
PAGCDTVIPQERVRVDGDTIRFAAHDVAHGANCRRAGEDLARGACALAAGRILRPSDLGL
CCCCCCCCCHHHEEECCCEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCH
LASFGIADVTVRRRVRVAVFSTGDELREPGEPLGRGALYDSNRGMLIAMLERLHVDTLDL
HHHCCHHHHEEEEEEEEEEEECCHHHHCCCCCCCCCCEEECCCCHHHHHHHHHCCCEEEE
GIVRDDPTALEAALRAAIAAQADAVITSGGVSVGEADFTRDVMARLGDVTFASLALRPGR
EEECCCHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCC
PLACGTLARAADGAGHALFFGLPGNPVASAVTFVAIVRPALLKLAGTQTPPPAMYTALST
CCHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEECCC
QPLKKRPGRTDYLRGIATRAADGQWHVAPAGSQSSASLSGLAAANCFIVLGHDTAAVDAG
CHHHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEECCEEEEECCCCCEECCC
APVDILPLDGLI
CCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]