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The map label for this gene is gmk

Identifier: 116689022

GI number: 116689022

Start: 1105742

End: 1106425

Strand: Direct

Name: gmk

Synonym: Bcen2424_0999

Alternate gene names: 116689022

Gene position: 1105742-1106425 (Clockwise)

Preceding gene: 116689021

Following gene: 116689023

Centisome position: 31.74

GC content: 64.62

Gene sequence:

>684_bases
ATGACCGATTCCACCCGCGACGGCCACGCGTCGCATTCGCTGCATGGCGGCGTCTATCCCGGTAACCTGTTCATGGTCGT
CGCGCCGTCGGGCGCCGGCAAGTCGACGCTCGTGAATGCGCTGCTGTCGAAGGACAGCGACATCTGCCTGTCGATCTCGT
ACACGACGCGCAAGCCGCGCCCGGGCGAGCAGGACGGCCAGCACTACCACTTCACGACCGTCGAGGATTTCCGCGCACGT
CACGCGGCGCACGAATTCCTCGAGAGCGCGGAAGTGCACGGCAACTACTACGGCACGTCGCGCGTCTGGATCGAAGAGCA
GATGAGGAACGGCCACGACGTGCTGCTCGAAATCGACTGGCAGGGTGCGTTGCAGGTGAAGAAGCAGTTCCGCAACGCGG
TCGGCATCTTCATCCTGCCGCCGTCGCTCGATGCGCTCGAAGAGCGCCTGAAGAAGCGCGGCCAGGACGAACCGAACGTG
ATCACGCGGCGCCTGCTGGCCGCCGGCAGCGAGATCGCGCACGCGTCGGAAGCGGAATACGTGGTGATCAACGAGAATTT
CGAGCGTGCGCTCGCGGAACTCGAATGCATCGTCGCGGCGACGCGCCTGCGTTTTGCTTCGCAGTACGCGCGACACACGG
AGCTGTTCATCGACCTCGGCGTCCATCTGCCCCACGCGGAATGA

Upstream 100 bases:

>100_bases
TCGAAGGCGGCGGCGAAGGAACTCGCCGACGCGTCGATGGCGCTGAAGCTGCTGATCGAGCAGATGCGCGAGCAAGTGCA
AAACCTGGAGTAAAAGCAAC

Downstream 100 bases:

>100_bases
CGCGGGGCACGAGGGACATAAGGTAGAATAAGGACTATATTCAGAAGGAATTACCAACATGGCTCGCATTACCGTCGAAG
ACTGCCTGAAGCAAATCCCG

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MTDSTRDGHASHSLHGGVYPGNLFMVVAPSGAGKSTLVNALLSKDSDICLSISYTTRKPRPGEQDGQHYHFTTVEDFRAR
HAAHEFLESAEVHGNYYGTSRVWIEEQMRNGHDVLLEIDWQGALQVKKQFRNAVGIFILPPSLDALEERLKKRGQDEPNV
ITRRLLAAGSEIAHASEAEYVVINENFERALAELECIVAATRLRFASQYARHTELFIDLGVHLPHAE

Sequences:

>Translated_227_residues
MTDSTRDGHASHSLHGGVYPGNLFMVVAPSGAGKSTLVNALLSKDSDICLSISYTTRKPRPGEQDGQHYHFTTVEDFRAR
HAAHEFLESAEVHGNYYGTSRVWIEEQMRNGHDVLLEIDWQGALQVKKQFRNAVGIFILPPSLDALEERLKKRGQDEPNV
ITRRLLAAGSEIAHASEAEYVVINENFERALAELECIVAATRLRFASQYARHTELFIDLGVHLPHAE
>Mature_226_residues
TDSTRDGHASHSLHGGVYPGNLFMVVAPSGAGKSTLVNALLSKDSDICLSISYTTRKPRPGEQDGQHYHFTTVEDFRARH
AAHEFLESAEVHGNYYGTSRVWIEEQMRNGHDVLLEIDWQGALQVKKQFRNAVGIFILPPSLDALEERLKKRGQDEPNVI
TRRLLAAGSEIAHASEAEYVVINENFERALAELECIVAATRLRFASQYARHTELFIDLGVHLPHAE

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=175, Percent_Identity=38.8571428571429, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI4504221, Length=175, Percent_Identity=38.8571428571429, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI226874831, Length=175, Percent_Identity=38.8571428571429, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI262118259, Length=134, Percent_Identity=30.5970149253731, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI262118255, Length=134, Percent_Identity=30.5970149253731, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI4505237, Length=134, Percent_Identity=30.5970149253731, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI262118263, Length=134, Percent_Identity=30.5970149253731, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI38570142, Length=174, Percent_Identity=27.0114942528736, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI21361598, Length=200, Percent_Identity=27, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1790080, Length=201, Percent_Identity=47.7611940298507, Blast_Score=194, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI193203132, Length=180, Percent_Identity=35.5555555555556, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17508835, Length=180, Percent_Identity=35.5555555555556, Blast_Score=111, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6320662, Length=182, Percent_Identity=36.8131868131868, Blast_Score=127, Evalue=1e-30,
Organism=Drosophila melanogaster, GI21356141, Length=182, Percent_Identity=37.9120879120879, Blast_Score=120, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24640542, Length=177, Percent_Identity=25.4237288135593, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI45554489, Length=177, Percent_Identity=25.4237288135593, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_BURCA (Q1BY73)

Other databases:

- EMBL:   CP000378
- RefSeq:   YP_620405.1
- ProteinModelPortal:   Q1BY73
- STRING:   Q1BY73
- GeneID:   4093555
- GenomeReviews:   CP000378_GR
- KEGG:   bcn:Bcen_0520
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- ProtClustDB:   PRK00300
- BioCyc:   BCEN331271:BCEN_0520-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 25387; Mature: 25256

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSTRDGHASHSLHGGVYPGNLFMVVAPSGAGKSTLVNALLSKDSDICLSISYTTRKPR
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCCC
PGEQDGQHYHFTTVEDFRARHAAHEFLESAEVHGNYYGTSRVWIEEQMRNGHDVLLEIDW
CCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCEECCEEEEHHHHHCCCCEEEEEECC
QGALQVKKQFRNAVGIFILPPSLDALEERLKKRGQDEPNVITRRLLAAGSEIAHASEAEY
CHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHCCCCCCCE
VVINENFERALAELECIVAATRLRFASQYARHTELFIDLGVHLPHAE
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCC
>Mature Secondary Structure 
TDSTRDGHASHSLHGGVYPGNLFMVVAPSGAGKSTLVNALLSKDSDICLSISYTTRKPR
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCCC
PGEQDGQHYHFTTVEDFRARHAAHEFLESAEVHGNYYGTSRVWIEEQMRNGHDVLLEIDW
CCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCEECCEEEEHHHHHCCCCEEEEEECC
QGALQVKKQFRNAVGIFILPPSLDALEERLKKRGQDEPNVITRRLLAAGSEIAHASEAEY
CHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHCCCCCCCE
VVINENFERALAELECIVAATRLRFASQYARHTELFIDLGVHLPHAE
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA