Click here to switch to the map view.

The map label for this gene is pcaK [H]

Identifier: 116688842

GI number: 116688842

Start: 918165

End: 919523

Strand: Direct

Name: pcaK [H]

Synonym: Bcen2424_0819

Alternate gene names: 116688842

Gene position: 918165-919523 (Clockwise)

Preceding gene: 116688841

Following gene: 116688843

Centisome position: 26.35

GC content: 69.98

Gene sequence:

>1359_bases
ATGAGCTCGGCGGCCGATACGCGCGTGCTCGAAGTCGAGCGCGTGATCGACGAGACCCATCGCCCGGGTTTTCACTGGAT
GCTGCTCGCGCTGTGCGGGCTGTGTCTCGTGATCGACGGTTTCGATGCGCAGGCGATGGGCTACGTCGCGCCGAGCGTGA
TCGCCGAATGGGGCGTGCCGAAGCAGGCGCTCGGGCCCGTGTTCAGCGCGAGCCTGTTCGGCATGCTGCTCGGCGCGCTC
GGGCTATCGGTGCTGGCCGACCGGATCGGGCGGCGCCCGGTGCTGATCGGCTCGACGCTGTTCTTCGCGGTGACGATGCT
CGCGACGCCGTTCGCGGGCTCGATCCCCGTGCTGATGGCGCTGCGCTTCGTCACCGGTCTCGGCCTCGGCTGCATCATGC
CGAACGCGATGGCGCTGGTCGGCGAGTTCAGCCCGGCCGCGCATCGCGTGAAGCGGATGATGATCGTGTCATGCGGCTTC
ACGCTCGGCGCGGCGCTCGGCGGCTTCATCAGCGCGGCGCTGATTCCGGCGCTCGGCTGGCGTTCGGTGTTCTTCGTCGG
CGGTGCGGTGCCGCTCGTGCTGACGATCGCGATGGTCGCGCGGCTGCCCGAATCGCTGCAGTTCCTGGTGCTGAAAGGGC
GCGTCGCGCAGGCGCGCGACTGGCTCGCGAGGTTCGCGCCGGAAGCCGGCATCGATGCGAATACGCGGCTCGTCGTGCGC
GAACGCGCGGCGAGCGGCGCGCCGGTGGCCGAACTGTTCCGCCATGGCCGCCTGCCGGTCACGCTGCTGCTGTGGGCGAT
CAGTTTCATGAACCTGATCGATCTGTACTTCCTGTCGAACTGGCTGCCGACCGTGATGCGCGAAGCCGGCTATTCGCCGG
GCACGGCGGTGATCGTCGGCACGGTGCTGCAGACGGGTGGCGTGATCGGCACGCTGTCGCTCGGCTGGTTCATCGAACGT
TACGGCTTCGTGCGCGTGCTGTTCGCCTGCTTCGCGTGCGCGGCCGTGTCGGTGGGGCTGATCGGCTCGGTCGCGCATGC
GCTGCCGTGGCTGCTGGTCGCCGTGTTCGCGGGCGGGTTCTGCGTGGTCGGCGGGCAGCCGGCCGTGAACGCGCTCGCGG
GCCAGTATTACCCGACGTCGCTGCGCTCGACGGGCATCGGCTGGAGCCTCGGCATCGGCCGGATCGGCTCGGTGCTCGGG
CCGCTCGTCGGCGGACAACTGATTGCGCTCAACTGGTCCAACGGCGCGCTGTTCCACGCGGCCGCGGTGCCCGTGCTGTG
CTCGGCGCTGTTCGTGCTCGGCCTTGCGGGCGTCACGCGCCGCAGCGCTGCGCAGGCGCCGAACGCCGCCCTGAATTGA

Upstream 100 bases:

>100_bases
TCGCGAACCAGGTCGGCGACGCCGACGTACTGCGCGAAGCGATGGCGCTCGCGCGCCAGGGCGTGACGCCGCCCGTGCAT
CCGGCCACCGAGGTGGCGCA

Downstream 100 bases:

>100_bases
TGGAGAAAGGAAAACGATGACGCTTGACCTGTCGAAACCGGCGACCGCCGGCTACCTGAGCGGTTTCGCGAACGAATTCG
CGACCGAGGCGCTGCCCGGT

Product: major facilitator transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MSSAADTRVLEVERVIDETHRPGFHWMLLALCGLCLVIDGFDAQAMGYVAPSVIAEWGVPKQALGPVFSASLFGMLLGAL
GLSVLADRIGRRPVLIGSTLFFAVTMLATPFAGSIPVLMALRFVTGLGLGCIMPNAMALVGEFSPAAHRVKRMMIVSCGF
TLGAALGGFISAALIPALGWRSVFFVGGAVPLVLTIAMVARLPESLQFLVLKGRVAQARDWLARFAPEAGIDANTRLVVR
ERAASGAPVAELFRHGRLPVTLLLWAISFMNLIDLYFLSNWLPTVMREAGYSPGTAVIVGTVLQTGGVIGTLSLGWFIER
YGFVRVLFACFACAAVSVGLIGSVAHALPWLLVAVFAGGFCVVGGQPAVNALAGQYYPTSLRSTGIGWSLGIGRIGSVLG
PLVGGQLIALNWSNGALFHAAAVPVLCSALFVLGLAGVTRRSAAQAPNAALN

Sequences:

>Translated_452_residues
MSSAADTRVLEVERVIDETHRPGFHWMLLALCGLCLVIDGFDAQAMGYVAPSVIAEWGVPKQALGPVFSASLFGMLLGAL
GLSVLADRIGRRPVLIGSTLFFAVTMLATPFAGSIPVLMALRFVTGLGLGCIMPNAMALVGEFSPAAHRVKRMMIVSCGF
TLGAALGGFISAALIPALGWRSVFFVGGAVPLVLTIAMVARLPESLQFLVLKGRVAQARDWLARFAPEAGIDANTRLVVR
ERAASGAPVAELFRHGRLPVTLLLWAISFMNLIDLYFLSNWLPTVMREAGYSPGTAVIVGTVLQTGGVIGTLSLGWFIER
YGFVRVLFACFACAAVSVGLIGSVAHALPWLLVAVFAGGFCVVGGQPAVNALAGQYYPTSLRSTGIGWSLGIGRIGSVLG
PLVGGQLIALNWSNGALFHAAAVPVLCSALFVLGLAGVTRRSAAQAPNAALN
>Mature_451_residues
SSAADTRVLEVERVIDETHRPGFHWMLLALCGLCLVIDGFDAQAMGYVAPSVIAEWGVPKQALGPVFSASLFGMLLGALG
LSVLADRIGRRPVLIGSTLFFAVTMLATPFAGSIPVLMALRFVTGLGLGCIMPNAMALVGEFSPAAHRVKRMMIVSCGFT
LGAALGGFISAALIPALGWRSVFFVGGAVPLVLTIAMVARLPESLQFLVLKGRVAQARDWLARFAPEAGIDANTRLVVRE
RAASGAPVAELFRHGRLPVTLLLWAISFMNLIDLYFLSNWLPTVMREAGYSPGTAVIVGTVLQTGGVIGTLSLGWFIERY
GFVRVLFACFACAAVSVGLIGSVAHALPWLLVAVFAGGFCVVGGQPAVNALAGQYYPTSLRSTGIGWSLGIGRIGSVLGP
LVGGQLIALNWSNGALFHAAAVPVLCSALFVLGLAGVTRRSAAQAPNAALN

Specific function: Transporter for 4-hydroxybenzoate. Also required for chemotaxis to aromatic acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=421, Percent_Identity=25.8907363420428, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI166064021, Length=356, Percent_Identity=27.247191011236, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI8923870, Length=370, Percent_Identity=26.2162162162162, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI24497476, Length=406, Percent_Identity=26.6009852216749, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI20070188, Length=406, Percent_Identity=26.6009852216749, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI213021148, Length=462, Percent_Identity=23.8095238095238, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI7662270, Length=220, Percent_Identity=24.5454545454545, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI296080721, Length=210, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI296080719, Length=210, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=1e-10,
Organism=Homo sapiens, GI24497499, Length=210, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI87081723, Length=420, Percent_Identity=34.2857142857143, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI87082231, Length=427, Percent_Identity=23.4192037470726, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786229, Length=394, Percent_Identity=21.5736040609137, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788068, Length=455, Percent_Identity=23.956043956044, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI87082404, Length=385, Percent_Identity=21.2987012987013, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082159, Length=388, Percent_Identity=23.7113402061856, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788074, Length=248, Percent_Identity=26.2096774193548, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=421, Percent_Identity=23.5154394299287, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71980582, Length=429, Percent_Identity=23.0769230769231, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71980584, Length=426, Percent_Identity=23.2394366197183, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17565978, Length=277, Percent_Identity=26.7148014440433, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19922874, Length=402, Percent_Identity=24.3781094527363, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24640198, Length=471, Percent_Identity=23.9915074309979, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24640196, Length=471, Percent_Identity=23.9915074309979, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24640200, Length=471, Percent_Identity=23.9915074309979, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI161077756, Length=463, Percent_Identity=23.110151187905, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28573099, Length=235, Percent_Identity=26.3829787234043, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24649618, Length=378, Percent_Identity=24.3386243386243, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28573101, Length=235, Percent_Identity=26.3829787234043, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI19922616, Length=368, Percent_Identity=23.9130434782609, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47290; Mature: 47158

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAADTRVLEVERVIDETHRPGFHWMLLALCGLCLVIDGFDAQAMGYVAPSVIAEWGVP
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
KQALGPVFSASLFGMLLGALGLSVLADRIGRRPVLIGSTLFFAVTMLATPFAGSIPVLMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCHHHHHH
LRFVTGLGLGCIMPNAMALVGEFSPAAHRVKRMMIVSCGFTLGAALGGFISAALIPALGW
HHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCH
RSVFFVGGAVPLVLTIAMVARLPESLQFLVLKGRVAQARDWLARFAPEAGIDANTRLVVR
HHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCEEEEE
ERAASGAPVAELFRHGRLPVTLLLWAISFMNLIDLYFLSNWLPTVMREAGYSPGTAVIVG
ECCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
TVLQTGGVIGTLSLGWFIERYGFVRVLFACFACAAVSVGLIGSVAHALPWLLVAVFAGGF
HHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
CVVGGQPAVNALAGQYYPTSLRSTGIGWSLGIGRIGSVLGPLVGGQLIALNWSNGALFHA
EEECCCHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHH
AAVPVLCSALFVLGLAGVTRRSAAQAPNAALN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SSAADTRVLEVERVIDETHRPGFHWMLLALCGLCLVIDGFDAQAMGYVAPSVIAEWGVP
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
KQALGPVFSASLFGMLLGALGLSVLADRIGRRPVLIGSTLFFAVTMLATPFAGSIPVLMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCHHHHHH
LRFVTGLGLGCIMPNAMALVGEFSPAAHRVKRMMIVSCGFTLGAALGGFISAALIPALGW
HHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCH
RSVFFVGGAVPLVLTIAMVARLPESLQFLVLKGRVAQARDWLARFAPEAGIDANTRLVVR
HHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCEEEEE
ERAASGAPVAELFRHGRLPVTLLLWAISFMNLIDLYFLSNWLPTVMREAGYSPGTAVIVG
ECCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
TVLQTGGVIGTLSLGWFIERYGFVRVLFACFACAAVSVGLIGSVAHALPWLLVAVFAGGF
HHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
CVVGGQPAVNALAGQYYPTSLRSTGIGWSLGIGRIGSVLGPLVGGQLIALNWSNGALFHA
EEECCCHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHH
AAVPVLCSALFVLGLAGVTRRSAAQAPNAALN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7961399 [H]