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The map label for this gene is glyA [H]

Identifier: 116688829

GI number: 116688829

Start: 907452

End: 908699

Strand: Direct

Name: glyA [H]

Synonym: Bcen2424_0806

Alternate gene names: 116688829

Gene position: 907452-908699 (Clockwise)

Preceding gene: 116688820

Following gene: 116688830

Centisome position: 26.05

GC content: 64.58

Gene sequence:

>1248_bases
ATGTTTGACAGAGCCCAAAGCACCATCGCGAACGTCGATCCCGAAATCTTTGCAGCGATCGAGCAGGAAAACCGCCGCCA
GGAAGATCACATCGAGCTGATCGCGTCGGAAAACTACACGAGCCCGGCCGTGATGGCCGCGCAGGGCTCGCAGCTCACGA
ACAAGTACGCGGAAGGGTATCCGGGCAAGCGCTACTACGGCGGTTGCGAGTACGTCGACGTGGTCGAGCAACTGGCGATC
GACCGTGTGAAGCAGCTGTTCGGTGCGGAAGCGGCGAACGTGCAGCCGAACTCGGGTTCGCAGGCGAACCAGGGCGTGTT
CTTCGCGATGCTCAAGCCGGGCGACACGATCATGGGCATGAGCCTCGCGCACGGCGGCCACCTGACGCACGGCTCGCCGG
TGAACATGTCGGGCAAGTGGTTCAACGTGGTGAGCTACGGCCTGAACGAAAACGAAGACATCGACTACGAAGCGGCCGAG
AAGCTCGCGCAGGAACACAAGCCGAAGCTGATCGTCGCGGGCGCGTCGGCGTTTGCGCTGAAGATCGATTTCGAGCGTCT
GGCGAAGATCGCGAAGTCGGTGGGCGCGTACCTGATGGTCGACATGGCGCACTACGCTGGCCTGATCGCGGCGGGCGTGT
ACCCGAACCCGGTGCCGCACGCGGATTTCGTGACGACGACGACGCACAAGAGCCTGCGCGGCCCGCGCGGCGGCGTGATC
CTGATGAAGGCCGAGTACGAGAAGCCGATCAACTCGGCGATCTTCCCGGGCATCCAGGGCGGCCCGCTGATGCACGTGAT
CGCGGCGAAGGCGGTGGCGTTCAAGGAAGCGCTGTCGCCGGAGTTCAAGGAATATCAGCAGAAGGTGGTCGAGAACGCAC
GCGTGCTGGCCGAAACGCTGGTCAAGCGCGGGCTGCGGATCGTGTCGGGCCGCACCGAAAGCCACGTGATGCTGGTCGAC
CTGCGCGCGAAGAACATCACGGGCAAGGCAGCGGAAGCGGCACTCGGCGCGGCGCACATCACGGTGAACAAGAACGCGAT
CCCGAACGATCCGGAAAAGCCGTTCGTGACGAGCGGCGTGCGCCTGGGTTCGCCGGCGATGACGACGCGTGGCTTCGGGC
CGGCGGAAGCCGAGCAGGTGGGTAACCTGATCGCCGACGTGCTGGAGAACCCGGAGGACGCAGCGACGATCGAGCGCGTG
CGTGCGCAGGTCGCCGAGCTGACCAAGCGTTTCCCGGTCTATCGCTGA

Upstream 100 bases:

>100_bases
TCGCGTCATACGGATTCTTCCGCCACGTCGGGCTGGTCTCGCCAGCAGCGCACCGTACTCGGCCACTCCGGTCAACCTGT
ACACACTTAACGGAAACCGT

Downstream 100 bases:

>100_bases
TCGCCGATGCGCTGCCCGTTCTGCCGGCATGACGACACGCAGGTCGTCGACTCGCGCGTGTCCGAAGATGGCGCCGCGAT
TCGCCGGCGCCGTCGCTGCT

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT 1; Serine methylase 1 [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MFDRAQSTIANVDPEIFAAIEQENRRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAI
DRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLNENEDIDYEAAE
KLAQEHKPKLIVAGASAFALKIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKAEYEKPINSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFKEYQQKVVENARVLAETLVKRGLRIVSGRTESHVMLVD
LRAKNITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGVRLGSPAMTTRGFGPAEAEQVGNLIADVLENPEDAATIERV
RAQVAELTKRFPVYR

Sequences:

>Translated_415_residues
MFDRAQSTIANVDPEIFAAIEQENRRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAI
DRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLNENEDIDYEAAE
KLAQEHKPKLIVAGASAFALKIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKAEYEKPINSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFKEYQQKVVENARVLAETLVKRGLRIVSGRTESHVMLVD
LRAKNITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGVRLGSPAMTTRGFGPAEAEQVGNLIADVLENPEDAATIERV
RAQVAELTKRFPVYR
>Mature_415_residues
MFDRAQSTIANVDPEIFAAIEQENRRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAI
DRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLNENEDIDYEAAE
KLAQEHKPKLIVAGASAFALKIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKAEYEKPINSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFKEYQQKVVENARVLAETLVKRGLRIVSGRTESHVMLVD
LRAKNITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGVRLGSPAMTTRGFGPAEAEQVGNLIADVLENPEDAATIERV
RAQVAELTKRFPVYR

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=454, Percent_Identity=40.9691629955947, Blast_Score=338, Evalue=6e-93,
Organism=Homo sapiens, GI261862352, Length=454, Percent_Identity=40.9691629955947, Blast_Score=338, Evalue=6e-93,
Organism=Homo sapiens, GI261862350, Length=454, Percent_Identity=40.9691629955947, Blast_Score=338, Evalue=6e-93,
Organism=Homo sapiens, GI261862348, Length=454, Percent_Identity=40.9691629955947, Blast_Score=338, Evalue=6e-93,
Organism=Homo sapiens, GI261862346, Length=453, Percent_Identity=40.3973509933775, Blast_Score=330, Evalue=1e-90,
Organism=Homo sapiens, GI22547186, Length=428, Percent_Identity=42.9906542056075, Blast_Score=317, Evalue=9e-87,
Organism=Homo sapiens, GI22547189, Length=413, Percent_Identity=41.4043583535109, Blast_Score=285, Evalue=5e-77,
Organism=Escherichia coli, GI1788902, Length=414, Percent_Identity=63.768115942029, Blast_Score=546, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI25144732, Length=441, Percent_Identity=43.5374149659864, Blast_Score=350, Evalue=1e-96,
Organism=Caenorhabditis elegans, GI25144729, Length=441, Percent_Identity=43.5374149659864, Blast_Score=350, Evalue=1e-96,
Organism=Saccharomyces cerevisiae, GI6319739, Length=411, Percent_Identity=46.7153284671533, Blast_Score=370, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6323087, Length=433, Percent_Identity=44.1108545034642, Blast_Score=343, Evalue=4e-95,
Organism=Drosophila melanogaster, GI24640005, Length=455, Percent_Identity=41.978021978022, Blast_Score=357, Evalue=1e-98,
Organism=Drosophila melanogaster, GI221329721, Length=455, Percent_Identity=41.978021978022, Blast_Score=356, Evalue=2e-98,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 44889; Mature: 44889

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDRAQSTIANVDPEIFAAIEQENRRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGY
CCCHHHHHHHCCCHHHHHHHHHHHCCCHHHEEEEECCCCCCCEEEECCCCHHHHHHHCCC
PGKRYYGGCEYVDVVEQLAIDRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGM
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEE
SLAHGGHLTHGSPVNMSGKWFNVVSYGLNENEDIDYEAAEKLAQEHKPKLIVAGASAFAL
EECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEECCCEEEE
KIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHCCCCCCEE
LMKAEYEKPINSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFKEYQQKVVENARVLAETL
EEEECCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
VKRGLRIVSGRTESHVMLVDLRAKNITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGV
HHCCCEEECCCCCCEEEEEEEECCCCCCHHHHHHHCEEEEEECCCCCCCCCCCCCEECCE
RLGSPAMTTRGFGPAEAEQVGNLIADVLENPEDAATIERVRAQVAELTKRFPVYR
ECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFDRAQSTIANVDPEIFAAIEQENRRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGY
CCCHHHHHHHCCCHHHHHHHHHHHCCCHHHEEEEECCCCCCCEEEECCCCHHHHHHHCCC
PGKRYYGGCEYVDVVEQLAIDRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGM
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEE
SLAHGGHLTHGSPVNMSGKWFNVVSYGLNENEDIDYEAAEKLAQEHKPKLIVAGASAFAL
EECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEECCCEEEE
KIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHCCCCCCEE
LMKAEYEKPINSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFKEYQQKVVENARVLAETL
EEEECCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
VKRGLRIVSGRTESHVMLVDLRAKNITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGV
HHCCCEEECCCCCCEEEEEEEECCCCCCHHHHHHHCEEEEEECCCCCCCCCCCCCEECCE
RLGSPAMTTRGFGPAEAEQVGNLIADVLENPEDAATIERVRAQVAELTKRFPVYR
ECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA