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The map label for this gene is kbl [C]

Identifier: 116688807

GI number: 116688807

Start: 889812

End: 891140

Strand: Direct

Name: kbl [C]

Synonym: Bcen2424_0784

Alternate gene names: 116688807

Gene position: 889812-891140 (Clockwise)

Preceding gene: 116688806

Following gene: 116688808

Centisome position: 25.54

GC content: 68.85

Gene sequence:

>1329_bases
ATGGCACTGGGAGAGCATCTTCGCCAGCAACTGGCGGCGAAAGCGCTGAAACGGCAACTGGAGCGCGCGACCGACGCCGC
GGCGGCGCCGGGTGTGCCCGGTACGCTGGTTGCGCAGACCGCGTCGGCACGCAGCCGCTTCGAGTCGATGCCGCAGTATC
AGCAGGTCCGCATCATGCGCGAGATGGGCGAGAAACTGCGGGTCGAGTCGCCGTTTTTCCGCGTGCACGACGGCGTCGCC
GGGGCGACCACGCAGATCGGCGGCCGCGAATACCTGAACTTCGCCAACTACAACTATCTGGGTCTGGCCGGTGATCCGGC
GGTGTCCGCGCGCGCGAAAGCCGCGATCGACCGCTATGGCACCTCGGCTTCGGCGAGCCGGATGGTCGCGGGCGAGCGTC
CGGTGCAGCGCGCGCTCGAGCGTGCGCTGGCCGCGTTCTACGAGACCGACGACTGCGTCGCGTTCGTGAGCGGCCATGCG
ACCAACGTGACCGTGATCGGCGCGCTGTTCGGCCCCGGCGATCTGGTGGTCCACGACGCGCTCGCGCACAACAGCATCGT
GCAGGGCGCGCAGTTGAGCGGCGCGAAGCGGCTGAGCTTCCCGCACAACGACTGGCAGGCGCTCGACGAGCTGCTGTCGC
GCGTGCGCCGCGAATACCGGCACGTGCTGATCGCGATCGAAGGGCTGTACAGCATGGACGGCGATTTCCCCGACCTGCAG
CGCTTCGTCGACGTGAAGACGCGTCACGGGGCATTCCTGCTGGTCGACGAGGCCCATTCGCTCGGCGTGCTCGGCGCGAC
CGGCAAGGGCATCCGCGAGCATGCCGGCGTCGCGCCCGACCAGGTCGACATGTGGATGGGCACGATGAGCAAGACGCTGG
CCGGATGCGGTGGTTTCATCGCCGGCTGCCAGCCGCTCGTCGACATGCTGCGCCATCTGGCGCCGGGTTTCCTGTACAGC
GTCGGGCTCGCACCGACGCTCGCCGAAGCGTCGCTGGCCGCGCTCGAACGTCTGCAGGCCGAGCCGGAGCGCGTCGCGCA
ACTGCAGGCGCGCGGGCGACAGTTCCTGACCGAGGCGCGTGCGGCCGGGCTGAATACCGGCACGAGCGCCGGCTATGCGG
TCGTGCCGGTGATCACGGGCAGTTCGCTGAAGGCCGCGCAGTGGGCGAATGCGATGTTCGACGAAGGGATCAACGTGCAG
CCGATCTTCTATCCGGCCGTCGAGGAAAAGGCGGCGCGCCTGCGCTTTTTCATCTGTTCGACGCATGAGCCGGAGCAGAT
CAGCCGGACGGTGGGCGTGTTGTCGCGCCTCGCGGGGCGCAGCGCGTGA

Upstream 100 bases:

>100_bases
GATGCGTGGCAGTGGGCCGAGTTTTTCGAGACCTGAAACCACACTTTTTCAAGATACGCGGCGTAACATAGCGTCTTTTC
GAGATAGAGCGAAGGACGCA

Downstream 100 bases:

>100_bases
CGCAGGTCGCCGCGGTCGCGCAAGCGGTGGCGCGCGCCGGCGAGCCGGTGCGGTTTCGCGCGGCCAGTGCGAATGATGCG
GCAGCATGCGCGCCGCTCGT

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MALGEHLRQQLAAKALKRQLERATDAAAAPGVPGTLVAQTASARSRFESMPQYQQVRIMREMGEKLRVESPFFRVHDGVA
GATTQIGGREYLNFANYNYLGLAGDPAVSARAKAAIDRYGTSASASRMVAGERPVQRALERALAAFYETDDCVAFVSGHA
TNVTVIGALFGPGDLVVHDALAHNSIVQGAQLSGAKRLSFPHNDWQALDELLSRVRREYRHVLIAIEGLYSMDGDFPDLQ
RFVDVKTRHGAFLLVDEAHSLGVLGATGKGIREHAGVAPDQVDMWMGTMSKTLAGCGGFIAGCQPLVDMLRHLAPGFLYS
VGLAPTLAEASLAALERLQAEPERVAQLQARGRQFLTEARAAGLNTGTSAGYAVVPVITGSSLKAAQWANAMFDEGINVQ
PIFYPAVEEKAARLRFFICSTHEPEQISRTVGVLSRLAGRSA

Sequences:

>Translated_442_residues
MALGEHLRQQLAAKALKRQLERATDAAAAPGVPGTLVAQTASARSRFESMPQYQQVRIMREMGEKLRVESPFFRVHDGVA
GATTQIGGREYLNFANYNYLGLAGDPAVSARAKAAIDRYGTSASASRMVAGERPVQRALERALAAFYETDDCVAFVSGHA
TNVTVIGALFGPGDLVVHDALAHNSIVQGAQLSGAKRLSFPHNDWQALDELLSRVRREYRHVLIAIEGLYSMDGDFPDLQ
RFVDVKTRHGAFLLVDEAHSLGVLGATGKGIREHAGVAPDQVDMWMGTMSKTLAGCGGFIAGCQPLVDMLRHLAPGFLYS
VGLAPTLAEASLAALERLQAEPERVAQLQARGRQFLTEARAAGLNTGTSAGYAVVPVITGSSLKAAQWANAMFDEGINVQ
PIFYPAVEEKAARLRFFICSTHEPEQISRTVGVLSRLAGRSA
>Mature_441_residues
ALGEHLRQQLAAKALKRQLERATDAAAAPGVPGTLVAQTASARSRFESMPQYQQVRIMREMGEKLRVESPFFRVHDGVAG
ATTQIGGREYLNFANYNYLGLAGDPAVSARAKAAIDRYGTSASASRMVAGERPVQRALERALAAFYETDDCVAFVSGHAT
NVTVIGALFGPGDLVVHDALAHNSIVQGAQLSGAKRLSFPHNDWQALDELLSRVRREYRHVLIAIEGLYSMDGDFPDLQR
FVDVKTRHGAFLLVDEAHSLGVLGATGKGIREHAGVAPDQVDMWMGTMSKTLAGCGGFIAGCQPLVDMLRHLAPGFLYSV
GLAPTLAEASLAALERLQAEPERVAQLQARGRQFLTEARAAGLNTGTSAGYAVVPVITGSSLKAAQWANAMFDEGINVQP
IFYPAVEEKAARLRFFICSTHEPEQISRTVGVLSRLAGRSA

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI119220554, Length=364, Percent_Identity=33.5164835164835, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI7657118, Length=364, Percent_Identity=34.0659340659341, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI284448556, Length=341, Percent_Identity=34.3108504398827, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI4758668, Length=349, Percent_Identity=32.6647564469914, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI83977442, Length=354, Percent_Identity=28.8135593220339, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI83977440, Length=346, Percent_Identity=29.4797687861272, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI83977444, Length=346, Percent_Identity=29.4797687861272, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI5454084, Length=296, Percent_Identity=32.4324324324324, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI4502025, Length=351, Percent_Identity=29.3447293447293, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI40316939, Length=351, Percent_Identity=29.3447293447293, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI1790046, Length=352, Percent_Identity=36.6477272727273, Blast_Score=224, Evalue=8e-60,
Organism=Escherichia coli, GI1786993, Length=355, Percent_Identity=30.4225352112676, Blast_Score=138, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI32566772, Length=353, Percent_Identity=33.1444759206799, Blast_Score=204, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI71994529, Length=396, Percent_Identity=29.5454545454545, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17560912, Length=423, Percent_Identity=28.8416075650118, Blast_Score=189, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17560914, Length=423, Percent_Identity=28.8416075650118, Blast_Score=188, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI71982617, Length=350, Percent_Identity=30.2857142857143, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71982625, Length=350, Percent_Identity=30.2857142857143, Blast_Score=145, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6320267, Length=395, Percent_Identity=29.3670886075949, Blast_Score=173, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6320438, Length=349, Percent_Identity=29.512893982808, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6323954, Length=271, Percent_Identity=26.9372693726937, Blast_Score=102, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24662918, Length=360, Percent_Identity=31.6666666666667, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI17136286, Length=369, Percent_Identity=28.4552845528455, Blast_Score=164, Evalue=8e-41,
Organism=Drosophila melanogaster, GI17137420, Length=349, Percent_Identity=29.512893982808, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24653280, Length=290, Percent_Identity=29.6551724137931, Blast_Score=138, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24653276, Length=290, Percent_Identity=29.6551724137931, Blast_Score=138, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24653278, Length=290, Percent_Identity=29.6551724137931, Blast_Score=138, Evalue=7e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 47514; Mature: 47382

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALGEHLRQQLAAKALKRQLERATDAAAAPGVPGTLVAQTASARSRFESMPQYQQVRIMR
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHH
EMGEKLRVESPFFRVHDGVAGATTQIGGREYLNFANYNYLGLAGDPAVSARAKAAIDRYG
HHHHHHCCCCCHHHCCCCCCCCHHCCCCHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCC
TSASASRMVAGERPVQRALERALAAFYETDDCVAFVSGHATNVTVIGALFGPGDLVVHDA
CCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEEEECCCHHHHHHH
LAHNSIVQGAQLSGAKRLSFPHNDWQALDELLSRVRREYRHVLIAIEGLYSMDGDFPDLQ
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
RFVDVKTRHGAFLLVDEAHSLGVLGATGKGIREHAGVAPDQVDMWMGTMSKTLAGCGGFI
HHHHHHCCCCEEEEEECCCCCEEECCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCHHH
AGCQPLVDMLRHLAPGFLYSVGLAPTLAEASLAALERLQAEPERVAQLQARGRQFLTEAR
HHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AAGLNTGTSAGYAVVPVITGSSLKAAQWANAMFDEGINVQPIFYPAVEEKAARLRFFICS
HCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCEEECCHHHHHHHHEEEEEEC
THEPEQISRTVGVLSRLAGRSA
CCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ALGEHLRQQLAAKALKRQLERATDAAAAPGVPGTLVAQTASARSRFESMPQYQQVRIMR
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHH
EMGEKLRVESPFFRVHDGVAGATTQIGGREYLNFANYNYLGLAGDPAVSARAKAAIDRYG
HHHHHHCCCCCHHHCCCCCCCCHHCCCCHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCC
TSASASRMVAGERPVQRALERALAAFYETDDCVAFVSGHATNVTVIGALFGPGDLVVHDA
CCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEEEECCCHHHHHHH
LAHNSIVQGAQLSGAKRLSFPHNDWQALDELLSRVRREYRHVLIAIEGLYSMDGDFPDLQ
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
RFVDVKTRHGAFLLVDEAHSLGVLGATGKGIREHAGVAPDQVDMWMGTMSKTLAGCGGFI
HHHHHHCCCCEEEEEECCCCCEEECCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCHHH
AGCQPLVDMLRHLAPGFLYSVGLAPTLAEASLAALERLQAEPERVAQLQARGRQFLTEAR
HHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AAGLNTGTSAGYAVVPVITGSSLKAAQWANAMFDEGINVQPIFYPAVEEKAARLRFFICS
HCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCEEECCHHHHHHHHEEEEEEC
THEPEQISRTVGVLSRLAGRSA
CCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA