Click here to switch to the map view.

The map label for this gene is maeB [H]

Identifier: 116688654

GI number: 116688654

Start: 702517

End: 704874

Strand: Direct

Name: maeB [H]

Synonym: Bcen2424_0631

Alternate gene names: 116688654

Gene position: 702517-704874 (Clockwise)

Preceding gene: 116688650

Following gene: 116688655

Centisome position: 20.16

GC content: 65.1

Gene sequence:

>2358_bases
ATGATTGGCGCTACAATGCCGTCGAACAGTTATTCTAATCCGCCCGTCTCGAGACACATGTCCACCCAAGCCTCCTCCAA
AGCCAAGCTCCGCGAAGCCGCGCTCGACTATCACGAATTTCCGACTCCCGGCAAAATCGCGATCGCCCCGACCAAGCAGA
TGATCAACCAGCGCGATCTCGCGCTCGCGTATTCGCCGGGTGTGGCGTACGCGTGCGAGGAGATCGTCGAGAACCCGCTG
AACGCCGCGCGCTTCACCGCGCGCAGCAACCTGGTCGGCGTCGTGACGAACGGCACGGCGGTGCTCGGTCTCGGCAACAT
CGGCCCGCTCGCGTCGAAGCCGGTGATGGAAGGCAAGGCCGTGCTGTTCAAGAAGTTCGCGGGCATCGACGTGTTCGACA
TCGAACTGAACGAATCGGACCCGCACAAGCTCGTCGACGTGATCGCCGCGCTGGAGCCGACCTTCGGGGGGATCAACCTC
GAAGACATCAAGGCGCCGGACTGCTTCATCGTCGAGCGCGAAGCGCGCAAGCGGATGAAGATCCCGGTGTTCCACGACGA
CCAGCACGGCACCGCGATCGTCGTGGCCGCGGCCGTCACGAACGGCCTGAAGGTCGTCAACAAGGACATCAAGAAGGTCA
AGCTCGTCGCGTCGGGCGCCGGCGCGGCCGCGCTCGCGTGTCTCGACCTGCTGGTCGACATCGGCCTGCCGCTCGAGAAC
ATCACGGTGACCGACCTGGCCGGCGTGGTCTACAAGGGCCGCACCGAGTTGATGGATCCGGACAAGGAGCGTTTCGCGCG
CGAAACCGACGCCCGCACGCTGGCCGAAGTGATCGACGGCGCGGACATCTTCCTCGGCCTGTCGGCCGCCGGCGTGCTGA
AGCAGGAGATGGTGAAGGGCATGGCCGAGCGCCCGCTGATCCTCGCACTCGCGAATCCGACGCCGGAAATCCTGCCGGAG
CTCGCGCTCGAAGTGCGCCCGGACGCCGTGCTGGCCACCGGCCGCACCGATTACCCGAACCAGGTCAACAACGTCCTGTG
CTTCCCGTTCATCTTCCGCGGTGCGCTCGACGTCGGCGCGACGACGATCACGCGTGAAATGGAGATCGCGGCCGTCAATG
CGATCGCCGAGCTCGCGCAGCACGAGCAGAGCGACATCGTCGCGACCGCATACGGCATCCAGGATCTGTCGTTCGGGCCC
GAATACCTGATTCCGAAGCCGTTCGATCCGCGCCTGATCGTGAAGATCGCGCCGGCCGTCGCGCAGGCCGCGATGGACGG
CGGCGTCGCGACGCGCCCGATCGAGGACATGGAGGCGTACCGCGTCCACCTGCAGCAATTCGTGTATCACAGCGGCACGA
CGATGAAGCCGATCTTCCAGATCGCGCGCGCCGCGCCGGAAGAGAAGAAGCGCGTCGTGTTCGCGGAAGGCGAAGAAGAG
CGCGTGTTGCGTGCCGTTCAGATCATCGTCGACGAAAAACTCGCGAAGCCGATCCTCATCGGCCGCCCGTCGGTGATCGA
GCACCGTATCCAGCGCTACGGCCTGCGCCTCACGCCGGGCACCGATTTCACGGTCGTCAACACTGAGCACGACGAGCGTT
ACCGCGACTTCTGGCAGACGTACCACAAGATGATGGCGCGCAAGGGCATCAGCGAGCAGCTCGCGCGTGTCGAAATGCGC
CGCCGCACGACGCTGATCGGCTCGATGCTGGTGAAGAAGGGCGAAGCGGACGGGATGATCTGCGGCACGATCAGCACCAC
GCACCGCCACCTGCACTTCATCGACCAGGTGATCGGCAAGCGTCCGGGCTGCAGCGTGTACGCGGCGATGAACGGCCTCG
TGCTGCCGGGCCGCCAGATTTTCCTCGTGGATACGCACGTGAACGTCGATCCGACCCCGGAGGAGCTGGCCGAGATCACG
ATCATGGCCGCGGAAGAAGTGCGCCGGTTCGGCATCGAGCCGAAGGTCGCGTTGCTGTCGCACTCGAATTTCGGCACGAG
CAATGCCCCTTCGGCGAAGAAGATGCGCGATACGCTCGCGATCCTGCAGGAAACCGCGCCGGAACTGAAGGTCGACGGCG
AAATGCACGGCGACGTCGCGCTCGACGCGGCGCTGCGCAAGGAAATCCTGCCGGAATCGACGCTGGAAGGCGACGCGAAC
CTGCTGATCCTGCCGAACATCGACGCCGCCAACATCGCGTACAACCTGCTGAAGACGGCCGCCGGCAACAACATCGCGAT
CGGGCCGATCCTGTTGGGCGCCGCGGAGCCGGTGCACGTGCTGACCGAATCGGCGACCGTTCGTCGCATCGTCAACATGG
CGGCGCTGTTGGTGGCCGACGTGAACGCCGCGCGCTGA

Upstream 100 bases:

>100_bases
TTGAAGGAACGGCATTGTACGAGGCGGGCGACGGCGCTCCTGTACCGTCCAGTTCATTTTTGTCGCGACTGTTGCACCCG
AATCGCCGGTCTGGCGGCCG

Downstream 100 bases:

>100_bases
GCCAAAACGAACGCGCCAGCCGGTCGAGCGGCTCGGCGCGCGCGGGAAAATTGTAAACAAAAGCAAAAAGAGGCGCGCCC
GCAATGGGCACGCCGCCGGG

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 785; Mature: 785

Protein sequence:

>785_residues
MIGATMPSNSYSNPPVSRHMSTQASSKAKLREAALDYHEFPTPGKIAIAPTKQMINQRDLALAYSPGVAYACEEIVENPL
NAARFTARSNLVGVVTNGTAVLGLGNIGPLASKPVMEGKAVLFKKFAGIDVFDIELNESDPHKLVDVIAALEPTFGGINL
EDIKAPDCFIVEREARKRMKIPVFHDDQHGTAIVVAAAVTNGLKVVNKDIKKVKLVASGAGAAALACLDLLVDIGLPLEN
ITVTDLAGVVYKGRTELMDPDKERFARETDARTLAEVIDGADIFLGLSAAGVLKQEMVKGMAERPLILALANPTPEILPE
LALEVRPDAVLATGRTDYPNQVNNVLCFPFIFRGALDVGATTITREMEIAAVNAIAELAQHEQSDIVATAYGIQDLSFGP
EYLIPKPFDPRLIVKIAPAVAQAAMDGGVATRPIEDMEAYRVHLQQFVYHSGTTMKPIFQIARAAPEEKKRVVFAEGEEE
RVLRAVQIIVDEKLAKPILIGRPSVIEHRIQRYGLRLTPGTDFTVVNTEHDERYRDFWQTYHKMMARKGISEQLARVEMR
RRTTLIGSMLVKKGEADGMICGTISTTHRHLHFIDQVIGKRPGCSVYAAMNGLVLPGRQIFLVDTHVNVDPTPEELAEIT
IMAAEEVRRFGIEPKVALLSHSNFGTSNAPSAKKMRDTLAILQETAPELKVDGEMHGDVALDAALRKEILPESTLEGDAN
LLILPNIDAANIAYNLLKTAAGNNIAIGPILLGAAEPVHVLTESATVRRIVNMAALLVADVNAAR

Sequences:

>Translated_785_residues
MIGATMPSNSYSNPPVSRHMSTQASSKAKLREAALDYHEFPTPGKIAIAPTKQMINQRDLALAYSPGVAYACEEIVENPL
NAARFTARSNLVGVVTNGTAVLGLGNIGPLASKPVMEGKAVLFKKFAGIDVFDIELNESDPHKLVDVIAALEPTFGGINL
EDIKAPDCFIVEREARKRMKIPVFHDDQHGTAIVVAAAVTNGLKVVNKDIKKVKLVASGAGAAALACLDLLVDIGLPLEN
ITVTDLAGVVYKGRTELMDPDKERFARETDARTLAEVIDGADIFLGLSAAGVLKQEMVKGMAERPLILALANPTPEILPE
LALEVRPDAVLATGRTDYPNQVNNVLCFPFIFRGALDVGATTITREMEIAAVNAIAELAQHEQSDIVATAYGIQDLSFGP
EYLIPKPFDPRLIVKIAPAVAQAAMDGGVATRPIEDMEAYRVHLQQFVYHSGTTMKPIFQIARAAPEEKKRVVFAEGEEE
RVLRAVQIIVDEKLAKPILIGRPSVIEHRIQRYGLRLTPGTDFTVVNTEHDERYRDFWQTYHKMMARKGISEQLARVEMR
RRTTLIGSMLVKKGEADGMICGTISTTHRHLHFIDQVIGKRPGCSVYAAMNGLVLPGRQIFLVDTHVNVDPTPEELAEIT
IMAAEEVRRFGIEPKVALLSHSNFGTSNAPSAKKMRDTLAILQETAPELKVDGEMHGDVALDAALRKEILPESTLEGDAN
LLILPNIDAANIAYNLLKTAAGNNIAIGPILLGAAEPVHVLTESATVRRIVNMAALLVADVNAAR
>Mature_785_residues
MIGATMPSNSYSNPPVSRHMSTQASSKAKLREAALDYHEFPTPGKIAIAPTKQMINQRDLALAYSPGVAYACEEIVENPL
NAARFTARSNLVGVVTNGTAVLGLGNIGPLASKPVMEGKAVLFKKFAGIDVFDIELNESDPHKLVDVIAALEPTFGGINL
EDIKAPDCFIVEREARKRMKIPVFHDDQHGTAIVVAAAVTNGLKVVNKDIKKVKLVASGAGAAALACLDLLVDIGLPLEN
ITVTDLAGVVYKGRTELMDPDKERFARETDARTLAEVIDGADIFLGLSAAGVLKQEMVKGMAERPLILALANPTPEILPE
LALEVRPDAVLATGRTDYPNQVNNVLCFPFIFRGALDVGATTITREMEIAAVNAIAELAQHEQSDIVATAYGIQDLSFGP
EYLIPKPFDPRLIVKIAPAVAQAAMDGGVATRPIEDMEAYRVHLQQFVYHSGTTMKPIFQIARAAPEEKKRVVFAEGEEE
RVLRAVQIIVDEKLAKPILIGRPSVIEHRIQRYGLRLTPGTDFTVVNTEHDERYRDFWQTYHKMMARKGISEQLARVEMR
RRTTLIGSMLVKKGEADGMICGTISTTHRHLHFIDQVIGKRPGCSVYAAMNGLVLPGRQIFLVDTHVNVDPTPEELAEIT
IMAAEEVRRFGIEPKVALLSHSNFGTSNAPSAKKMRDTLAILQETAPELKVDGEMHGDVALDAALRKEILPESTLEGDAN
LLILPNIDAANIAYNLLKTAAGNNIAIGPILLGAAEPVHVLTESATVRRIVNMAALLVADVNAAR

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=343, Percent_Identity=26.530612244898, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI62420882, Length=344, Percent_Identity=28.1976744186047, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI62420880, Length=344, Percent_Identity=28.1976744186047, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI239049447, Length=344, Percent_Identity=28.1976744186047, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI4505145, Length=354, Percent_Identity=27.683615819209, Blast_Score=70, Evalue=1e-11,
Organism=Homo sapiens, GI270265879, Length=317, Percent_Identity=28.391167192429, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1788806, Length=753, Percent_Identity=62.0185922974768, Blast_Score=967, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=322, Percent_Identity=32.9192546583851, Blast_Score=159, Evalue=6e-40,
Organism=Escherichia coli, GI1788800, Length=315, Percent_Identity=31.4285714285714, Blast_Score=148, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17537199, Length=464, Percent_Identity=25.4310344827586, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322823, Length=239, Percent_Identity=30.5439330543933, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI281362674, Length=423, Percent_Identity=27.6595744680851, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281362672, Length=423, Percent_Identity=27.6595744680851, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21356279, Length=423, Percent_Identity=27.6595744680851, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI78707242, Length=408, Percent_Identity=25.9803921568627, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI78707238, Length=408, Percent_Identity=25.9803921568627, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI78707240, Length=349, Percent_Identity=26.3610315186246, Blast_Score=76, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24646388, Length=345, Percent_Identity=28.4057971014493, Blast_Score=73, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24646386, Length=345, Percent_Identity=28.4057971014493, Blast_Score=73, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 85165; Mature: 85165

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGATMPSNSYSNPPVSRHMSTQASSKAKLREAALDYHEFPTPGKIAIAPTKQMINQRDL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHCCCCCE
ALAYSPGVAYACEEIVENPLNAARFTARSNLVGVVTNGTAVLGLGNIGPLASKPVMEGKA
EEEECCCHHHHHHHHHHCCCHHHHHHHCCCEEEEEECCEEEEEECCCCCCCCCCCCCCHH
VLFKKFAGIDVFDIELNESDPHKLVDVIAALEPTFGGINLEDIKAPDCFIVEREARKRMK
HHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEEHHHHCCCC
IPVFHDDQHGTAIVVAAAVTNGLKVVNKDIKKVKLVASGAGAAALACLDLLVDIGLPLEN
CCEEECCCCCCEEEEEEHHHCCHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHCCCCCCC
ITVTDLAGVVYKGRTELMDPDKERFARETDARTLAEVIDGADIFLGLSAAGVLKQEMVKG
EEHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHH
MAERPLILALANPTPEILPELALEVRPDAVLATGRTDYPNQVNNVLCFPFIFRGALDVGA
HHCCCEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHCCEEEHHHHHHHHHHCCC
TTITREMEIAAVNAIAELAQHEQSDIVATAYGIQDLSFGPEYLIPKPFDPRLIVKIAPAV
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEECCCCCCCCCCCCCCCEEEEEECHHH
AQAAMDGGVATRPIEDMEAYRVHLQQFVYHSGTTMKPIFQIARAAPEEKKRVVFAEGEEE
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHCEEEEECCCHH
RVLRAVQIIVDEKLAKPILIGRPSVIEHRIQRYGLRLTPGTDFTVVNTEHDERYRDFWQT
HHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHCCCEECCCCCEEEEECCCHHHHHHHHHH
YHKMMARKGISEQLARVEMRRRTTLIGSMLVKKGEADGMICGTISTTHRHLHFIDQVIGK
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHCC
RPGCSVYAAMNGLVLPGRQIFLVDTHVNVDPTPEELAEITIMAAEEVRRFGIEPKVALLS
CCCCEEEEECCCEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEE
HSNFGTSNAPSAKKMRDTLAILQETAPELKVDGEMHGDVALDAALRKEILPESTLEGDAN
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCC
LLILPNIDAANIAYNLLKTAAGNNIAIGPILLGAAEPVHVLTESATVRRIVNMAALLVAD
EEEECCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHCHHHHHHHHHHHHHHHHC
VNAAR
CCCCC
>Mature Secondary Structure
MIGATMPSNSYSNPPVSRHMSTQASSKAKLREAALDYHEFPTPGKIAIAPTKQMINQRDL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHCCCCCE
ALAYSPGVAYACEEIVENPLNAARFTARSNLVGVVTNGTAVLGLGNIGPLASKPVMEGKA
EEEECCCHHHHHHHHHHCCCHHHHHHHCCCEEEEEECCEEEEEECCCCCCCCCCCCCCHH
VLFKKFAGIDVFDIELNESDPHKLVDVIAALEPTFGGINLEDIKAPDCFIVEREARKRMK
HHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEEHHHHCCCC
IPVFHDDQHGTAIVVAAAVTNGLKVVNKDIKKVKLVASGAGAAALACLDLLVDIGLPLEN
CCEEECCCCCCEEEEEEHHHCCHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHCCCCCCC
ITVTDLAGVVYKGRTELMDPDKERFARETDARTLAEVIDGADIFLGLSAAGVLKQEMVKG
EEHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHH
MAERPLILALANPTPEILPELALEVRPDAVLATGRTDYPNQVNNVLCFPFIFRGALDVGA
HHCCCEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHCCEEEHHHHHHHHHHCCC
TTITREMEIAAVNAIAELAQHEQSDIVATAYGIQDLSFGPEYLIPKPFDPRLIVKIAPAV
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEECCCCCCCCCCCCCCCEEEEEECHHH
AQAAMDGGVATRPIEDMEAYRVHLQQFVYHSGTTMKPIFQIARAAPEEKKRVVFAEGEEE
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHCEEEEECCCHH
RVLRAVQIIVDEKLAKPILIGRPSVIEHRIQRYGLRLTPGTDFTVVNTEHDERYRDFWQT
HHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHCCCEECCCCCEEEEECCCHHHHHHHHHH
YHKMMARKGISEQLARVEMRRRTTLIGSMLVKKGEADGMICGTISTTHRHLHFIDQVIGK
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHCC
RPGCSVYAAMNGLVLPGRQIFLVDTHVNVDPTPEELAEITIMAAEEVRRFGIEPKVALLS
CCCCEEEEECCCEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEE
HSNFGTSNAPSAKKMRDTLAILQETAPELKVDGEMHGDVALDAALRKEILPESTLEGDAN
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCC
LLILPNIDAANIAYNLLKTAAGNNIAIGPILLGAAEPVHVLTESATVRRIVNMAALLVAD
EEEECCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHCHHHHHHHHHHHHHHHHC
VNAAR
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]