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The map label for this gene is nrdB [H]

Identifier: 116688619

GI number: 116688619

Start: 668774

End: 669922

Strand: Direct

Name: nrdB [H]

Synonym: Bcen2424_0596

Alternate gene names: 116688619

Gene position: 668774-669922 (Clockwise)

Preceding gene: 116688618

Following gene: 116688620

Centisome position: 19.2

GC content: 60.4

Gene sequence:

>1149_bases
ATGCGCACCTCCGCCGGGATGGCTGTCGGAATGCAGGCTGCAACGCCTGCCGCCCATCAGGTCCGTGACATTTTCGAAGG
CGATCTCGCGGTGCCGCCGCAAGCATCGGCTGTTCCCGCCGGCGGTACGGAAGCGCGGGTCAATGTCGCCGACAAGCGCA
TCATCAACGGCCAGACTGACGTCAATCAGCTGGTGCCGTTCAAGTACAAGTGGGCGTGGGAAAAGTATCTGGCCGGTTGT
GCGAACCACTGGATGCCGCAGGAAATCAACATGTCCCGCGACATCGCACTGTGGAAGGACCCGAACGGTCTGACCGAGGA
CGAGCGCCGCATCGTGAAGCGCAACCTCGGCTTCTTCGTGACGGCCGATTCGCTCGCGGCGAACAACATCGTGCTCGGCA
CGTACCGCCACATCACGGCGCCCGAGTGCCGGCAGTTCCTGCTGCGCCAGGCGTTCGAGGAAGCGATCCACACGCACGCG
TACCAATACATCGTCGAATCGCTCGGTCTCGACGAAGGCGAGATCTTCAACGCGTACCACGAGGTCACGTCGATCCGCGC
GAAGGACGAATTCCTGATCCCGTTCATTCATACGCTGACGGACCCGGCCTTCAAGACCGGCACGCTCGAAGCGGATCAGA
AGCTGCTGAAGTCGCTGATCGTGTTCGCCTGCATCATGGAAGGCCTGTTCTTCTATGTCGGGTTTACGCAGATCCTCGCG
CTCGGCCGCCAGAACAAGATGACGGGTGCTGCAGAGCAATATCAGTACATCCTGCGCGACGAGTCGATGCACTGCAACTT
CGGCATCGACCTGATCAACCAGATCAAGCTCGAGAACCCGCATCTCTGGACCGCCGAATTCCGCGCCGAGATCCGCGAGC
TGTTCAAGCAGGCTGTCGAACTCGAATACCGCTACGCCGAGGACACGATGCCGCGCGGCGTGCTGGGTTTGAACGCGTCG
ATGTTCAAGAGCTATCTGCGCTTCATCAGCAACCGCCGTTGCCAGCAGATCGGCCTCGACCCGCTGTATCCGAACGAGGA
AAACCCGTTCCCGTGGATGAGCGAGATGATCGACCTGAAGAAGGAGCGCAACTTCTTCGAGACGCGTGTGATCGAGTATC
AGACGGGTGGCGCGCTGTCCTGGGAATAA

Upstream 100 bases:

>100_bases
GATGGTACAAACCGTTCTAAATTGATGGTGAGAATTTATGCTCAACTGGGATGACGAGAAGACTGCCGTAACCCCCGCGA
GCGGAGCGCAGCAAAACGCG

Downstream 100 bases:

>100_bases
CCCGCAGCAGCGAACCCGTTACATGATGGAGCAGCCGGTGGCCTCTCGGCCCCGGCCCAAGGTTTAGGAGCAAGAACGCC
TGATGCAAAGCATGCCCGGT

Product: ribonucleotide-diphosphate reductase subunit beta

Products: NA

Alternate protein names: Ribonucleotide reductase small subunit [H]

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MRTSAGMAVGMQAATPAAHQVRDIFEGDLAVPPQASAVPAGGTEARVNVADKRIINGQTDVNQLVPFKYKWAWEKYLAGC
ANHWMPQEINMSRDIALWKDPNGLTEDERRIVKRNLGFFVTADSLAANNIVLGTYRHITAPECRQFLLRQAFEEAIHTHA
YQYIVESLGLDEGEIFNAYHEVTSIRAKDEFLIPFIHTLTDPAFKTGTLEADQKLLKSLIVFACIMEGLFFYVGFTQILA
LGRQNKMTGAAEQYQYILRDESMHCNFGIDLINQIKLENPHLWTAEFRAEIRELFKQAVELEYRYAEDTMPRGVLGLNAS
MFKSYLRFISNRRCQQIGLDPLYPNEENPFPWMSEMIDLKKERNFFETRVIEYQTGGALSWE

Sequences:

>Translated_382_residues
MRTSAGMAVGMQAATPAAHQVRDIFEGDLAVPPQASAVPAGGTEARVNVADKRIINGQTDVNQLVPFKYKWAWEKYLAGC
ANHWMPQEINMSRDIALWKDPNGLTEDERRIVKRNLGFFVTADSLAANNIVLGTYRHITAPECRQFLLRQAFEEAIHTHA
YQYIVESLGLDEGEIFNAYHEVTSIRAKDEFLIPFIHTLTDPAFKTGTLEADQKLLKSLIVFACIMEGLFFYVGFTQILA
LGRQNKMTGAAEQYQYILRDESMHCNFGIDLINQIKLENPHLWTAEFRAEIRELFKQAVELEYRYAEDTMPRGVLGLNAS
MFKSYLRFISNRRCQQIGLDPLYPNEENPFPWMSEMIDLKKERNFFETRVIEYQTGGALSWE
>Mature_382_residues
MRTSAGMAVGMQAATPAAHQVRDIFEGDLAVPPQASAVPAGGTEARVNVADKRIINGQTDVNQLVPFKYKWAWEKYLAGC
ANHWMPQEINMSRDIALWKDPNGLTEDERRIVKRNLGFFVTADSLAANNIVLGTYRHITAPECRQFLLRQAFEEAIHTHA
YQYIVESLGLDEGEIFNAYHEVTSIRAKDEFLIPFIHTLTDPAFKTGTLEADQKLLKSLIVFACIMEGLFFYVGFTQILA
LGRQNKMTGAAEQYQYILRDESMHCNFGIDLINQIKLENPHLWTAEFRAEIRELFKQAVELEYRYAEDTMPRGVLGLNAS
MFKSYLRFISNRRCQQIGLDPLYPNEENPFPWMSEMIDLKKERNFFETRVIEYQTGGALSWE

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0208

COG function: function code F; Ribonucleotide reductase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonucleoside diphosphate reductase small chain family [H]

Homologues:

Organism=Homo sapiens, GI289177074, Length=358, Percent_Identity=26.536312849162, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI42544136, Length=322, Percent_Identity=27.639751552795, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI260064013, Length=367, Percent_Identity=26.9754768392371, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI4557845, Length=367, Percent_Identity=26.9754768392371, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI289177076, Length=298, Percent_Identity=27.8523489932886, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1788567, Length=293, Percent_Identity=25.938566552901, Blast_Score=101, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17551968, Length=353, Percent_Identity=27.1954674220963, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI193206379, Length=304, Percent_Identity=22.6973684210526, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17567153, Length=227, Percent_Identity=28.1938325991189, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322434, Length=330, Percent_Identity=31.5151515151515, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6321619, Length=320, Percent_Identity=23.4375, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI18079279, Length=320, Percent_Identity=27.5, Blast_Score=143, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009078
- InterPro:   IPR012348
- InterPro:   IPR000358 [H]

Pfam domain/function: PF00268 Ribonuc_red_sm [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 43726; Mature: 43726

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTSAGMAVGMQAATPAAHQVRDIFEGDLAVPPQASAVPAGGTEARVNVADKRIINGQTD
CCCCCCCEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEHHHHHEECCCCC
VNQLVPFKYKWAWEKYLAGCANHWMPQEINMSRDIALWKDPNGLTEDERRIVKRNLGFFV
HHHHCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEE
TADSLAANNIVLGTYRHITAPECRQFLLRQAFEEAIHTHAYQYIVESLGLDEGEIFNAYH
EECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EVTSIRAKDEFLIPFIHTLTDPAFKTGTLEADQKLLKSLIVFACIMEGLFFYVGFTQILA
HHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGRQNKMTGAAEQYQYILRDESMHCNFGIDLINQIKLENPHLWTAEFRAEIRELFKQAVE
HCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHEECCCCCEEHHHHHHHHHHHHHHHHH
LEYRYAEDTMPRGVLGLNASMFKSYLRFISNRRCQQIGLDPLYPNEENPFPWMSEMIDLK
HHHHHHHCCCCCCEECCCHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHH
KERNFFETRVIEYQTGGALSWE
HHCCHHHHEEEEEECCCCCCCC
>Mature Secondary Structure
MRTSAGMAVGMQAATPAAHQVRDIFEGDLAVPPQASAVPAGGTEARVNVADKRIINGQTD
CCCCCCCEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEHHHHHEECCCCC
VNQLVPFKYKWAWEKYLAGCANHWMPQEINMSRDIALWKDPNGLTEDERRIVKRNLGFFV
HHHHCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEE
TADSLAANNIVLGTYRHITAPECRQFLLRQAFEEAIHTHAYQYIVESLGLDEGEIFNAYH
EECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EVTSIRAKDEFLIPFIHTLTDPAFKTGTLEADQKLLKSLIVFACIMEGLFFYVGFTQILA
HHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGRQNKMTGAAEQYQYILRDESMHCNFGIDLINQIKLENPHLWTAEFRAEIRELFKQAVE
HCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHEECCCCCEEHHHHHHHHHHHHHHHHH
LEYRYAEDTMPRGVLGLNASMFKSYLRFISNRRCQQIGLDPLYPNEENPFPWMSEMIDLK
HHHHHHHCCCCCCEECCCHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHH
KERNFFETRVIEYQTGGALSWE
HHCCHHHHEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]