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The map label for this gene is gabP [H]

Identifier: 116688546

GI number: 116688546

Start: 580749

End: 582140

Strand: Direct

Name: gabP [H]

Synonym: Bcen2424_0522

Alternate gene names: 116688546

Gene position: 580749-582140 (Clockwise)

Preceding gene: 116688545

Following gene: 116688547

Centisome position: 16.67

GC content: 66.09

Gene sequence:

>1392_bases
ATGAGTGGAAGCAACACAGGCCTCGGCACTGGCCTGAAGCAGCGTCACGTGACGATGATGTCGATTGCCGGCGTGATCGG
CGCGGGCTTGTTCGTCGGCTCCGGCCACGCGATCGCGGAAGCCGGGCCGGCATCGATACTCGCGTATGCGATCGCGGGCG
TGCTGGTCGTGCTGGTGATGCGCATGCTCGGCGAAATGGCCGTCGCGCATCCGGACAGCGGGTCGTTCTCGACCTATGCC
GATCGCGCGATCGGCCACTGGGCCGGCTTCACGATCGGCTGGCTGTACTGGTGGTTCTGGGTGCTGGTGATCCCGATCGA
GGCGACCGCCGCCGCGACCATCCTCAATGCGTGGTTCCCGGGCATCGCGACGTGGATCTTCGCGCTCGGCATCACGCTGC
TGCTCACCGTCACCAATCTCTTCTCCGTCAAGAACTACGGCGAATTCGAATTCTGGTTCGCGCTGATCAAGGTCGTCGCG
ATCGTCGTGTTCCTGTGCATCGGCGGTGCGGCGATCGTCGGCATCATTCCGGCGCCGGCCGTGTCGGGCGTGTCGAACCT
GTTCGTGCACGACGGCTTCATGCCGCACGGCGCGAGCGCGGTGCTCGCGGCGATGCTCACGACGATGTTCTCGTTCCTCG
GCACCGAGATCGTGACGATCGCGGCCGCCGAATCGGACAACCCGCAACGCCAGATCGTGCGCGCGACGAACTCGGTCATC
TGGCGTATCACGCTGTTCTATCTCGGCTCGATCCTCGTCGTCGCGGCCATCGTGCCGTGGAACGACCCGCTGCTGCCGAA
GCACGGCTCGTATCAGCGCGCGATGGAGCTGATCGGCGTCCCGAACGCGAAGGCGATCATCGACGTGATCGTGCTCGTGT
CGGTCGCGAGCTGCCTGAATTCGGCGCTGTACACCGCGTCGCGGATGCTGTTCTCGCTGTCCCGGCGCAAGGACGCGCCC
GCCTTCCTGCATCGCACCGATTCGACCGGCACGCCGCGTGCGGCCGTGCTTGCGTCGACCGCGTTCGGTTTCCTGACCGT
GATCGCGAACTACCTGATGCCGGAGCAGGTGTTCGGCTTCCTGCTCGCGACGTCGGGCGCGATCGCGCTGCTCGTGTATC
TCGTGATCGCGATCTCGCAACTGCGGATGCGCAAGACGCTCGAATCGGGCGGCGCGGACCTGACGCTGCGGATGTGGCTG
TTCCCGTGGCTCACGTGGGCCGTGATCCTGTTCATCTGCGGCACGCTGACCGTGATGTTCGTCAGCGAGGAGCATCGGAT
GGAAGTCGGCGCGACGGCCGTGCTGGCGTTGATCGTGCTGCTCGCGTCGTGGCTGAACAAGCGCGGCCGCGATGCGCGGG
CGAACGCGGGGCGCCGGGTGTCGGCGACGTGA

Upstream 100 bases:

>100_bases
GACGCACGCGCGGCCGCGACCGGATTCAAGAACGACAACTCCCCGCGCCGCCTTCACGCGACACCCGGTCGTACCGGAAC
CGTTTTTTGGAGAGAGACAG

Downstream 100 bases:

>100_bases
TCTGATCGCGTGATGTAGCGGCGGGGCGGCAGCCCCGCTCATGAACATGGCCTGACCGGCATCTGCCGGCCGGGCCATTT
TTCTTTCGACGACGGACGGA

Product: GABA permease

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MSGSNTGLGTGLKQRHVTMMSIAGVIGAGLFVGSGHAIAEAGPASILAYAIAGVLVVLVMRMLGEMAVAHPDSGSFSTYA
DRAIGHWAGFTIGWLYWWFWVLVIPIEATAAATILNAWFPGIATWIFALGITLLLTVTNLFSVKNYGEFEFWFALIKVVA
IVVFLCIGGAAIVGIIPAPAVSGVSNLFVHDGFMPHGASAVLAAMLTTMFSFLGTEIVTIAAAESDNPQRQIVRATNSVI
WRITLFYLGSILVVAAIVPWNDPLLPKHGSYQRAMELIGVPNAKAIIDVIVLVSVASCLNSALYTASRMLFSLSRRKDAP
AFLHRTDSTGTPRAAVLASTAFGFLTVIANYLMPEQVFGFLLATSGAIALLVYLVIAISQLRMRKTLESGGADLTLRMWL
FPWLTWAVILFICGTLTVMFVSEEHRMEVGATAVLALIVLLASWLNKRGRDARANAGRRVSAT

Sequences:

>Translated_463_residues
MSGSNTGLGTGLKQRHVTMMSIAGVIGAGLFVGSGHAIAEAGPASILAYAIAGVLVVLVMRMLGEMAVAHPDSGSFSTYA
DRAIGHWAGFTIGWLYWWFWVLVIPIEATAAATILNAWFPGIATWIFALGITLLLTVTNLFSVKNYGEFEFWFALIKVVA
IVVFLCIGGAAIVGIIPAPAVSGVSNLFVHDGFMPHGASAVLAAMLTTMFSFLGTEIVTIAAAESDNPQRQIVRATNSVI
WRITLFYLGSILVVAAIVPWNDPLLPKHGSYQRAMELIGVPNAKAIIDVIVLVSVASCLNSALYTASRMLFSLSRRKDAP
AFLHRTDSTGTPRAAVLASTAFGFLTVIANYLMPEQVFGFLLATSGAIALLVYLVIAISQLRMRKTLESGGADLTLRMWL
FPWLTWAVILFICGTLTVMFVSEEHRMEVGATAVLALIVLLASWLNKRGRDARANAGRRVSAT
>Mature_462_residues
SGSNTGLGTGLKQRHVTMMSIAGVIGAGLFVGSGHAIAEAGPASILAYAIAGVLVVLVMRMLGEMAVAHPDSGSFSTYAD
RAIGHWAGFTIGWLYWWFWVLVIPIEATAAATILNAWFPGIATWIFALGITLLLTVTNLFSVKNYGEFEFWFALIKVVAI
VVFLCIGGAAIVGIIPAPAVSGVSNLFVHDGFMPHGASAVLAAMLTTMFSFLGTEIVTIAAAESDNPQRQIVRATNSVIW
RITLFYLGSILVVAAIVPWNDPLLPKHGSYQRAMELIGVPNAKAIIDVIVLVSVASCLNSALYTASRMLFSLSRRKDAPA
FLHRTDSTGTPRAAVLASTAFGFLTVIANYLMPEQVFGFLLATSGAIALLVYLVIAISQLRMRKTLESGGADLTLRMWLF
PWLTWAVILFICGTLTVMFVSEEHRMEVGATAVLALIVLLASWLNKRGRDARANAGRRVSAT

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI258645169, Length=369, Percent_Identity=21.9512195121951, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1789017, Length=436, Percent_Identity=64.2201834862385, Blast_Score=557, Evalue=1e-160,
Organism=Escherichia coli, GI1786302, Length=456, Percent_Identity=37.719298245614, Blast_Score=292, Evalue=3e-80,
Organism=Escherichia coli, GI1786789, Length=429, Percent_Identity=37.2960372960373, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI48994972, Length=460, Percent_Identity=35.6521739130435, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI1788480, Length=410, Percent_Identity=36.5853658536585, Blast_Score=260, Evalue=2e-70,
Organism=Escherichia coli, GI87081708, Length=405, Percent_Identity=36.5432098765432, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI87081915, Length=462, Percent_Identity=33.1168831168831, Blast_Score=245, Evalue=6e-66,
Organism=Escherichia coli, GI1790653, Length=459, Percent_Identity=31.8082788671024, Blast_Score=242, Evalue=3e-65,
Organism=Escherichia coli, GI1786602, Length=464, Percent_Identity=33.4051724137931, Blast_Score=226, Evalue=4e-60,
Organism=Escherichia coli, GI87081869, Length=241, Percent_Identity=28.2157676348548, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17532491, Length=368, Percent_Identity=22.2826086956522, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=434, Percent_Identity=33.4101382488479, Blast_Score=221, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6322892, Length=407, Percent_Identity=34.3980343980344, Blast_Score=201, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6320717, Length=412, Percent_Identity=32.0388349514563, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6324061, Length=434, Percent_Identity=30.8755760368664, Blast_Score=189, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6319824, Length=415, Percent_Identity=30.6024096385542, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6324553, Length=400, Percent_Identity=31, Blast_Score=182, Evalue=9e-47,
Organism=Saccharomyces cerevisiae, GI6321629, Length=402, Percent_Identity=29.6019900497512, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6324059, Length=422, Percent_Identity=31.042654028436, Blast_Score=180, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6319542, Length=412, Percent_Identity=31.0679611650485, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6320251, Length=411, Percent_Identity=29.683698296837, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6324990, Length=477, Percent_Identity=28.0922431865828, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6321053, Length=410, Percent_Identity=28.5365853658537, Blast_Score=166, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6319543, Length=405, Percent_Identity=28.641975308642, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6324924, Length=476, Percent_Identity=27.9411764705882, Blast_Score=162, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6322967, Length=397, Percent_Identity=28.7153652392947, Blast_Score=154, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6324981, Length=394, Percent_Identity=30.2030456852792, Blast_Score=145, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6319608, Length=418, Percent_Identity=25.8373205741627, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6320364, Length=468, Percent_Identity=24.1452991452991, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24668806, Length=398, Percent_Identity=23.1155778894472, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356285, Length=398, Percent_Identity=23.1155778894472, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24668802, Length=398, Percent_Identity=23.1155778894472, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24666159, Length=416, Percent_Identity=20.9134615384615, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221512776, Length=416, Percent_Identity=20.9134615384615, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49624; Mature: 49493

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SGSNTGLGTGLKQRHVTMMSIAGVIGAGLFVGSGHAIAEAGPASILAYAIAGVLVVLVM
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHH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CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8297211; 9205837; 9278503 [H]