Click here to switch to the map view.

The map label for this gene is hemB [H]

Identifier: 116688402

GI number: 116688402

Start: 422425

End: 423423

Strand: Reverse

Name: hemB [H]

Synonym: Bcen2424_0378

Alternate gene names: 116688402

Gene position: 423423-422425 (Counterclockwise)

Preceding gene: 116688403

Following gene: 116688356

Centisome position: 12.15

GC content: 64.96

Gene sequence:

>999_bases
ATGAGCTTCCATCCGCTTCATCGTCCGCGCCGGATGCGCCGCGACGACTTCTCCCGCCGCCTGATGCGCGAAAACCGCCT
GACCACCGACGACCTGATCTACCCGGTGTTCGTCGTCGAAGGCACCCAGCAACGCCAGCCCATCCCGTCGATGCCCGGCG
TCGAGCGCGTGTCGGTCGACCTGCTGATGCACGTCGCCGAGCAGTGCGTCGAACTCGGCGTGCCCGTGCTGTCGCTGTTC
CCGGCCATCGATCCGTCGGTGAAAACACCCGACGGTCGCGAGGCGGCCAATCCGGAAGGCCTGATTCCGCGCGCCGTGCG
TGAGCTGAAAAAGCGCTTCCCCGAACTCGGCGTGCTGACCGACGTCGCGCTCGATCCGTACACGAGCCACGGCCAGGACG
GCGTGCTCGACGAGAACGGCTACGTGATCAACGATGACACGATCGAAATCCTGATCGAACAGGCACGTGCGCAGGCCGAA
GCCGGCGTCGACATCGTCGCGCCGTCGGACATGATGGACGGGCGCATCGGCGCGATCCGCGAGATGCTGGAAAGCGACGG
TCATATCCATACGCGGATCATGGCCTATTCGGCGAAGTTCGCGTCGGCGTTCTACGGCCCGTTCCGCGATGCGGTCGGTT
CGGCATCCAACCTGGGCAAGGGCAACAAGATGACCTACCAGATGGATCCGGCGAACAGCGACGAAGCGCTGCGTGAAGTG
CGCCTCGACATCGACGAAGGCGCCGACATGGTGATGGTCAAGCCCGGCATGCCGTATCTCGACATCGTGCGCCGCGTGAA
GGACGAGTTCCGCTTCCCGACCTACGTGTACCAGGTGAGCGGCGAATACGCGATGCTGAAGGCGGCCGCGATGAACGGCT
GGCTCGACCACGACAAGGTCGTGCTCGAATCGCTGCTCGCGTTCAAGCGGGCAGGCGCCGACGGCGTGCTCACGTACTTC
GCGCTCGATGCCGCGCGTCTGCTGAAAGCGCAGCGCTGA

Upstream 100 bases:

>100_bases
ACGCAACGCGTGCCGCTCGATCGCTATCATATACCAACGATCTCGAAAATGACCTAAGGGTTCCGTAAGGTCTTCTTGCC
CTGATTTCTGCCAAATCGCC

Downstream 100 bases:

>100_bases
TCGCGCGTCGGCACGCACCTGCAAAAACGGCGGGACACCTCGGTGTTCCGCCGTTTTTTTGTTTACCGTCGATCGAGACT
GTCAGCCAGCCCGAATCGTC

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MSFHPLHRPRRMRRDDFSRRLMRENRLTTDDLIYPVFVVEGTQQRQPIPSMPGVERVSVDLLMHVAEQCVELGVPVLSLF
PAIDPSVKTPDGREAANPEGLIPRAVRELKKRFPELGVLTDVALDPYTSHGQDGVLDENGYVINDDTIEILIEQARAQAE
AGVDIVAPSDMMDGRIGAIREMLESDGHIHTRIMAYSAKFASAFYGPFRDAVGSASNLGKGNKMTYQMDPANSDEALREV
RLDIDEGADMVMVKPGMPYLDIVRRVKDEFRFPTYVYQVSGEYAMLKAAAMNGWLDHDKVVLESLLAFKRAGADGVLTYF
ALDAARLLKAQR

Sequences:

>Translated_332_residues
MSFHPLHRPRRMRRDDFSRRLMRENRLTTDDLIYPVFVVEGTQQRQPIPSMPGVERVSVDLLMHVAEQCVELGVPVLSLF
PAIDPSVKTPDGREAANPEGLIPRAVRELKKRFPELGVLTDVALDPYTSHGQDGVLDENGYVINDDTIEILIEQARAQAE
AGVDIVAPSDMMDGRIGAIREMLESDGHIHTRIMAYSAKFASAFYGPFRDAVGSASNLGKGNKMTYQMDPANSDEALREV
RLDIDEGADMVMVKPGMPYLDIVRRVKDEFRFPTYVYQVSGEYAMLKAAAMNGWLDHDKVVLESLLAFKRAGADGVLTYF
ALDAARLLKAQR
>Mature_331_residues
SFHPLHRPRRMRRDDFSRRLMRENRLTTDDLIYPVFVVEGTQQRQPIPSMPGVERVSVDLLMHVAEQCVELGVPVLSLFP
AIDPSVKTPDGREAANPEGLIPRAVRELKKRFPELGVLTDVALDPYTSHGQDGVLDENGYVINDDTIEILIEQARAQAEA
GVDIVAPSDMMDGRIGAIREMLESDGHIHTRIMAYSAKFASAFYGPFRDAVGSASNLGKGNKMTYQMDPANSDEALREVR
LDIDEGADMVMVKPGMPYLDIVRRVKDEFRFPTYVYQVSGEYAMLKAAAMNGWLDHDKVVLESLLAFKRAGADGVLTYFA
LDAARLLKAQR

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=331, Percent_Identity=44.4108761329305, Blast_Score=244, Evalue=1e-64,
Organism=Escherichia coli, GI87081728, Length=320, Percent_Identity=45.9375, Blast_Score=257, Evalue=6e-70,
Organism=Saccharomyces cerevisiae, GI6321398, Length=307, Percent_Identity=39.0879478827362, Blast_Score=199, Evalue=7e-52,
Organism=Drosophila melanogaster, GI21358291, Length=291, Percent_Identity=44.3298969072165, Blast_Score=238, Evalue=5e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 37084; Mature: 36953

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFHPLHRPRRMRRDDFSRRLMRENRLTTDDLIYPVFVVEGTQQRQPIPSMPGVERVSVD
CCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHEEEEEEEECCCCCCCCCCCCCHHHHHHH
LLMHVAEQCVELGVPVLSLFPAIDPSVKTPDGREAANPEGLIPRAVRELKKRFPELGVLT
HHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHH
DVALDPYTSHGQDGVLDENGYVINDDTIEILIEQARAQAEAGVDIVAPSDMMDGRIGAIR
HHCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCEEEECCCHHHCCHHHHHH
EMLESDGHIHTRIMAYSAKFASAFYGPFRDAVGSASNLGKGNKMTYQMDPANSDEALREV
HHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCEEEEECCCCHHHHHHHH
RLDIDEGADMVMVKPGMPYLDIVRRVKDEFRFPTYVYQVSGEYAMLKAAAMNGWLDHDKV
HHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCHHHH
VLESLLAFKRAGADGVLTYFALDAARLLKAQR
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SFHPLHRPRRMRRDDFSRRLMRENRLTTDDLIYPVFVVEGTQQRQPIPSMPGVERVSVD
CCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHEEEEEEEECCCCCCCCCCCCCHHHHHHH
LLMHVAEQCVELGVPVLSLFPAIDPSVKTPDGREAANPEGLIPRAVRELKKRFPELGVLT
HHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHH
DVALDPYTSHGQDGVLDENGYVINDDTIEILIEQARAQAEAGVDIVAPSDMMDGRIGAIR
HHCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCEEEECCCHHHCCHHHHHH
EMLESDGHIHTRIMAYSAKFASAFYGPFRDAVGSASNLGKGNKMTYQMDPANSDEALREV
HHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCEEEEECCCCHHHHHHHH
RLDIDEGADMVMVKPGMPYLDIVRRVKDEFRFPTYVYQVSGEYAMLKAAAMNGWLDHDKV
HHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCHHHH
VLESLLAFKRAGADGVLTYFALDAARLLKAQR
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9529530; 10984043; 10356331; 12079382 [H]