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The map label for this gene is dsbD [H]

Identifier: 116688401

GI number: 116688401

Start: 420449

End: 422296

Strand: Direct

Name: dsbD [H]

Synonym: Bcen2424_0377

Alternate gene names: 116688401

Gene position: 420449-422296 (Clockwise)

Preceding gene: 116688400

Following gene: 116688404

Centisome position: 12.07

GC content: 68.56

Gene sequence:

>1848_bases
ATGTTTAACGGTATGGCGCTTTCGGTGCGCGTGCGCGCGCTGCGGTTTCTTGCGGTCCTGTTGTCGTTCGTGTTCGTGCT
GAGCGGATTGTCCGCCGCGCGCGCGGCCGACGATTTCCTCGATCCGTCGGTTGCGTTCAAGTTCAGCGCGAGCGAATCGC
CGGGACAGGTGGACGTCCGCTTCAAGATCGCCAACGGCTATTACATGTATCGCGAGCGGTTCGCGTTCGCAGTGAAGAGC
GGTCAGGCCACGCTCGGGGAGCCGCAATTCCCGGCCGGCCACGTGAAGTTCGACCAGACGTTCCAGAAGAACGTCGAGAC
CTATCGCGATGAAGTCGTCGTTCACGTGCCGGTAAAGCAGGCGGCCGGGCCGTTCGAGCTCGCGGTGACGTCGCAAGGGT
GTGCGGACGAAGGGATCTGCTATCCGCCGGCCGAGCACGTGATGAAGGTCGATGGCGCAGCGCTCGGCGCCGCCTCCTCG
TCCGGTGACACGGCTGCCGCGGGTAGCTGGTTCGACAAGGTCACGAGCGCCGATTTCGCGCAGTCGCTGCTCGAAGGCCA
CGGCTTCTTCACGATCGTCGCGCTCTATTTCGTCGCGGGTGTCGTGCTGAGCCTGCTGCCGTGTTCGTACCCGATGATTC
CGATCGTGTCCGCGATCATCATCGGCCAGGGCACGCGTGCGACGCATGCACGCGGCTTCGCGCTGTCGCTGACCTACGTG
GTCGGCATGGCGCTGGTCTACACGGTACTCGGGATCGCCGCCGCGCTGGTCGGCCAGAGCCTCGGCGCATGGTTGCAGAA
CCCATGGGTGCTTGGCGCGTTCGCCGTGCTGCTGACCGCGTTCGCGGTGTCGCTGATCTCGGGCAAGGACATCGCATTGC
CGGAGCGCTGGCAGAACGGCGCGGCCGAGGCATCGAGCGCGCGCCAGGGCGGCCACTTCGTCGCGGTCGCGGCGATGGGC
GCGTTGTCGGCGCTGGTCGTCGGCGCGTGCATGACGGCGCCGCTGTTCGCCGTGCTCGCTTTCATCGCGCACACCGGCAA
TGCGTTGCTCGGCGGCGCGGCGCTGTTCGCGATGGGGCTCGGGCTCGGCGTGCCGCTGCTGGTCGTCGGCGTCGGGGCCG
GGACGGTGCTGCCGCGCGCCGGCGCGTGGATGGACGGCGTCAAGGTGTTCTTTGGCATCGTGCTGCTCGCGGCCGCGTTG
TGGATCGTCTGGCCGGTGCTGGCGGGCGCGCTGAAGATGGTGCTCGCGGCGTTGTGGCTGCTGATCGCGGCCGCGGCGCT
CGGGCTGTTCACGCCGAATGCCGGTGCCGCGTCGATCTGGCGCCGCCTGGGCCGCGGCGTGGGCGCCGCGCTCGCGATCT
GGGCCGCGACGCTGCTCGTCGGCCTGGCTGCGGGCTCGACCGATCCCGTCAAGCCGCTGGCCGTGCTGGCGGCGCGTACG
GTAGCGTCCGGCGGCGCGGCGACGGCCGGCGCAGCTGCCGCGCAGGACGGTCCTGCGTTCGCATCGGTGCGCTCGAGCGG
CGAACTCGACGCGCTGCTGAAGACGTCGGGCCAGCCCGTGATGCTCGACTTCTACGCCGATTGGTGCGTGAGCTGCAAGG
AGATGGAGCATCTGACGTTCACCGACGCGCGCGTGCAGGCGCGGCTCGCGAAGCTCCACCTGGTGCGCGCGGACGTCACC
GCAAACAACCCGGACGATCAGGCGCTGCTCAAACGCTTCAACCTGTTCGGGCCGCCGGGCATCATCTTCTTCGATCGCAA
CGGCAACGAGATCAGCCGCGTGGTTGGCTATCAGGCGGCCGATACGTTCCTGCGCAGCCTCGATCGGGCGGCCGTGCCGA
CGGTATGA

Upstream 100 bases:

>100_bases
CTCGCGCATCATCCTTACGAGACGCCCGAAATCGTCTCGTGGCAGACGGCATCGGCCGCGTATGGCCAGTGGGTGACCAG
CGAAACTCAACGTCTATTTC

Downstream 100 bases:

>100_bases
CGGTGTCAGTCGGGCCGAACCGGCGACGGACGATTCGGGCTGGCTGACAGTCTCGATCGACGGTAAACAAAAAAACGGCG
GAACACCGAGGTGTCCCGCC

Product: protein-disulfide reductase

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 615; Mature: 615

Protein sequence:

>615_residues
MFNGMALSVRVRALRFLAVLLSFVFVLSGLSAARAADDFLDPSVAFKFSASESPGQVDVRFKIANGYYMYRERFAFAVKS
GQATLGEPQFPAGHVKFDQTFQKNVETYRDEVVVHVPVKQAAGPFELAVTSQGCADEGICYPPAEHVMKVDGAALGAASS
SGDTAAAGSWFDKVTSADFAQSLLEGHGFFTIVALYFVAGVVLSLLPCSYPMIPIVSAIIIGQGTRATHARGFALSLTYV
VGMALVYTVLGIAAALVGQSLGAWLQNPWVLGAFAVLLTAFAVSLISGKDIALPERWQNGAAEASSARQGGHFVAVAAMG
ALSALVVGACMTAPLFAVLAFIAHTGNALLGGAALFAMGLGLGVPLLVVGVGAGTVLPRAGAWMDGVKVFFGIVLLAAAL
WIVWPVLAGALKMVLAALWLLIAAAALGLFTPNAGAASIWRRLGRGVGAALAIWAATLLVGLAAGSTDPVKPLAVLAART
VASGGAATAGAAAAQDGPAFASVRSSGELDALLKTSGQPVMLDFYADWCVSCKEMEHLTFTDARVQARLAKLHLVRADVT
ANNPDDQALLKRFNLFGPPGIIFFDRNGNEISRVVGYQAADTFLRSLDRAAVPTV

Sequences:

>Translated_615_residues
MFNGMALSVRVRALRFLAVLLSFVFVLSGLSAARAADDFLDPSVAFKFSASESPGQVDVRFKIANGYYMYRERFAFAVKS
GQATLGEPQFPAGHVKFDQTFQKNVETYRDEVVVHVPVKQAAGPFELAVTSQGCADEGICYPPAEHVMKVDGAALGAASS
SGDTAAAGSWFDKVTSADFAQSLLEGHGFFTIVALYFVAGVVLSLLPCSYPMIPIVSAIIIGQGTRATHARGFALSLTYV
VGMALVYTVLGIAAALVGQSLGAWLQNPWVLGAFAVLLTAFAVSLISGKDIALPERWQNGAAEASSARQGGHFVAVAAMG
ALSALVVGACMTAPLFAVLAFIAHTGNALLGGAALFAMGLGLGVPLLVVGVGAGTVLPRAGAWMDGVKVFFGIVLLAAAL
WIVWPVLAGALKMVLAALWLLIAAAALGLFTPNAGAASIWRRLGRGVGAALAIWAATLLVGLAAGSTDPVKPLAVLAART
VASGGAATAGAAAAQDGPAFASVRSSGELDALLKTSGQPVMLDFYADWCVSCKEMEHLTFTDARVQARLAKLHLVRADVT
ANNPDDQALLKRFNLFGPPGIIFFDRNGNEISRVVGYQAADTFLRSLDRAAVPTV
>Mature_615_residues
MFNGMALSVRVRALRFLAVLLSFVFVLSGLSAARAADDFLDPSVAFKFSASESPGQVDVRFKIANGYYMYRERFAFAVKS
GQATLGEPQFPAGHVKFDQTFQKNVETYRDEVVVHVPVKQAAGPFELAVTSQGCADEGICYPPAEHVMKVDGAALGAASS
SGDTAAAGSWFDKVTSADFAQSLLEGHGFFTIVALYFVAGVVLSLLPCSYPMIPIVSAIIIGQGTRATHARGFALSLTYV
VGMALVYTVLGIAAALVGQSLGAWLQNPWVLGAFAVLLTAFAVSLISGKDIALPERWQNGAAEASSARQGGHFVAVAAMG
ALSALVVGACMTAPLFAVLAFIAHTGNALLGGAALFAMGLGLGVPLLVVGVGAGTVLPRAGAWMDGVKVFFGIVLLAAAL
WIVWPVLAGALKMVLAALWLLIAAAALGLFTPNAGAASIWRRLGRGVGAALAIWAATLLVGLAAGSTDPVKPLAVLAART
VASGGAATAGAAAAQDGPAFASVRSSGELDALLKTSGQPVMLDFYADWCVSCKEMEHLTFTDARVQARLAKLHLVRADVT
ANNPDDQALLKRFNLFGPPGIIFFDRNGNEISRVVGYQAADTFLRSLDRAAVPTV

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=596, Percent_Identity=33.7248322147651, Blast_Score=309, Evalue=3e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 63881; Mature: 63881

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNGMALSVRVRALRFLAVLLSFVFVLSGLSAARAADDFLDPSVAFKFSASESPGQVDVR
CCCCEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEECCCCCCEEEEE
FKIANGYYMYRERFAFAVKSGQATLGEPQFPAGHVKFDQTFQKNVETYRDEVVVHVPVKQ
EEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEHHH
AAGPFELAVTSQGCADEGICYPPAEHVMKVDGAALGAASSSGDTAAAGSWFDKVTSADFA
CCCCEEEEEECCCCCCCCCCCCCHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHHHHHHHH
QSLLEGHGFFTIVALYFVAGVVLSLLPCSYPMIPIVSAIIIGQGTRATHARGFALSLTYV
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
VGMALVYTVLGIAAALVGQSLGAWLQNPWVLGAFAVLLTAFAVSLISGKDIALPERWQNG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCC
AAEASSARQGGHFVAVAAMGALSALVVGACMTAPLFAVLAFIAHTGNALLGGAALFAMGL
CHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
GLGVPLLVVGVGAGTVLPRAGAWMDGVKVFFGIVLLAAALWIVWPVLAGALKMVLAALWL
HCCCHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIAAAALGLFTPNAGAASIWRRLGRGVGAALAIWAATLLVGLAAGSTDPVKPLAVLAART
HHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
VASGGAATAGAAAAQDGPAFASVRSSGELDALLKTSGQPVMLDFYADWCVSCKEMEHLTF
HCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHCCCCCEEEEEHHHHHHHHHHHCCCEE
TDARVQARLAKLHLVRADVTANNPDDQALLKRFNLFGPPGIIFFDRNGNEISRVVGYQAA
HHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHH
DTFLRSLDRAAVPTV
HHHHHHHHHHCCCCC
>Mature Secondary Structure
MFNGMALSVRVRALRFLAVLLSFVFVLSGLSAARAADDFLDPSVAFKFSASESPGQVDVR
CCCCEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEECCCCCCEEEEE
FKIANGYYMYRERFAFAVKSGQATLGEPQFPAGHVKFDQTFQKNVETYRDEVVVHVPVKQ
EEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEHHH
AAGPFELAVTSQGCADEGICYPPAEHVMKVDGAALGAASSSGDTAAAGSWFDKVTSADFA
CCCCEEEEEECCCCCCCCCCCCCHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHHHHHHHH
QSLLEGHGFFTIVALYFVAGVVLSLLPCSYPMIPIVSAIIIGQGTRATHARGFALSLTYV
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
VGMALVYTVLGIAAALVGQSLGAWLQNPWVLGAFAVLLTAFAVSLISGKDIALPERWQNG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCC
AAEASSARQGGHFVAVAAMGALSALVVGACMTAPLFAVLAFIAHTGNALLGGAALFAMGL
CHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
GLGVPLLVVGVGAGTVLPRAGAWMDGVKVFFGIVLLAAALWIVWPVLAGALKMVLAALWL
HCCCHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIAAAALGLFTPNAGAASIWRRLGRGVGAALAIWAATLLVGLAAGSTDPVKPLAVLAART
HHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
VASGGAATAGAAAAQDGPAFASVRSSGELDALLKTSGQPVMLDFYADWCVSCKEMEHLTF
HCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHCCCCCEEEEEHHHHHHHHHHHCCCEE
TDARVQARLAKLHLVRADVTANNPDDQALLKRFNLFGPPGIIFFDRNGNEISRVVGYQAA
HHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHH
DTFLRSLDRAAVPTV
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]