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The map label for this gene is xapR [H]

Identifier: 116688105

GI number: 116688105

Start: 81787

End: 82725

Strand: Reverse

Name: xapR [H]

Synonym: Bcen2424_0081

Alternate gene names: 116688105

Gene position: 82725-81787 (Counterclockwise)

Preceding gene: 116688133

Following gene: 116688104

Centisome position: 2.37

GC content: 71.35

Gene sequence:

>939_bases
ATGCTGAACTGCGTTATAAGCCACGCTCATATCACGACGATGGATCTCACCCTGCTCCGCGCGTTCGCGACGGTCGCGCG
CGAAGGCAACCTGACGCGCGCCGCCGCGCAACTGCACGTCACGCAGCCGGCCGTCAGCCTGCAGATCAAGCATCTGCAGG
AAACGCTCGGCGTCGCGCTGTTCACGCGCACGTCGCGCGGGCTCGCGCTCACGCGCGACGGACAGACGCTGCTGCCGCAT
GCGGAACGCGCGCTCGCCGCGGCGGCCGACGTGCAGCGCGCCGCTGCCGCGCTGCGGCACGAAGTGCGCGGCCGGCTGCG
GATCGGCACGATCCTCGATCCGGGCTTCCTGCGGCTCGGCGGCTTCCTGCGCGCGCTGGTCGAGACCCATCCGCAGATCG
AGACCGCGCTGCGGCACGGGATGTCGGGCTGGGTGATCGAACAGGTGCGCGCGCAGGCGCTCGACGTCGGCTACTACATC
GGCCGCCCCGAAGAGGACTCGCCGCGCGACGACGCGCTGTTCCACACCGTCACGCTCACGCGCTTCGAATATCGCGTCCT
GGCGCCGGCCGGCTGGAAGGAGCGCGTGCAGCGCGCGCACGACTGGCGCGCGCTCGCCGCGCTGCCGTGGATCTGGACGC
CGCCGGCGTCCGCGCACCATCGGCTGCTGTCGCGACGTTTCGCGGCGGCCGGCGCGCAGCCGGTGAAGGTCGCCGAGGTC
GACCAGGAGCAGTCGATGCTCGATCTCGTCAAATCGGGGATCGGCTTGACGCTCGCGCGCGATTCGACCGCGCTGGCCGA
AGCGCACGCGCATGCGCTGACGATCGTCGAACCCGTGACGGTGCCGACCGAACTGACGTTCGTGACGCTCGCCGCGCGGC
GCGACGAGCCGGCGATCGCGGCCGCGCTGCGGCTGATCGAAGCGCAGTGGGCGATATGA

Upstream 100 bases:

>100_bases
CATTTTCAGCATAGTGCGTCGCGAGCCGCGCCTGCAGCCCCGCGCGCCATGACGACCCGATGAAGCGTACTCCCGCGCCC
GGCCGCCGATCCAATGAGTT

Downstream 100 bases:

>100_bases
GCGTGGCTGATGTCGAGGTGACCGGTTGCGCAGCGGGTTTCGGTGCCTGATGCCTGCCGCGGATCGCCATCGCGGGCGAA
ATCGCCGCCGAGCCCGCCCC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Xanthosine operon regulatory protein [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MLNCVISHAHITTMDLTLLRAFATVAREGNLTRAAAQLHVTQPAVSLQIKHLQETLGVALFTRTSRGLALTRDGQTLLPH
AERALAAAADVQRAAAALRHEVRGRLRIGTILDPGFLRLGGFLRALVETHPQIETALRHGMSGWVIEQVRAQALDVGYYI
GRPEEDSPRDDALFHTVTLTRFEYRVLAPAGWKERVQRAHDWRALAALPWIWTPPASAHHRLLSRRFAAAGAQPVKVAEV
DQEQSMLDLVKSGIGLTLARDSTALAEAHAHALTIVEPVTVPTELTFVTLAARRDEPAIAAALRLIEAQWAI

Sequences:

>Translated_312_residues
MLNCVISHAHITTMDLTLLRAFATVAREGNLTRAAAQLHVTQPAVSLQIKHLQETLGVALFTRTSRGLALTRDGQTLLPH
AERALAAAADVQRAAAALRHEVRGRLRIGTILDPGFLRLGGFLRALVETHPQIETALRHGMSGWVIEQVRAQALDVGYYI
GRPEEDSPRDDALFHTVTLTRFEYRVLAPAGWKERVQRAHDWRALAALPWIWTPPASAHHRLLSRRFAAAGAQPVKVAEV
DQEQSMLDLVKSGIGLTLARDSTALAEAHAHALTIVEPVTVPTELTFVTLAARRDEPAIAAALRLIEAQWAI
>Mature_312_residues
MLNCVISHAHITTMDLTLLRAFATVAREGNLTRAAAQLHVTQPAVSLQIKHLQETLGVALFTRTSRGLALTRDGQTLLPH
AERALAAAADVQRAAAALRHEVRGRLRIGTILDPGFLRLGGFLRALVETHPQIETALRHGMSGWVIEQVRAQALDVGYYI
GRPEEDSPRDDALFHTVTLTRFEYRVLAPAGWKERVQRAHDWRALAALPWIWTPPASAHHRLLSRRFAAAGAQPVKVAEV
DQEQSMLDLVKSGIGLTLARDSTALAEAHAHALTIVEPVTVPTELTFVTLAARRDEPAIAAALRLIEAQWAI

Specific function: Positive regulator required for the expression of xapA and xapB. Binds to the inducer xanthosine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI2367136, Length=258, Percent_Identity=29.0697674418605, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787806, Length=245, Percent_Identity=25.7142857142857, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI157672245, Length=142, Percent_Identity=38.0281690140845, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI145693105, Length=278, Percent_Identity=23.7410071942446, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788748, Length=255, Percent_Identity=26.2745098039216, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787601, Length=287, Percent_Identity=23.3449477351916, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI48994962, Length=73, Percent_Identity=45.2054794520548, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787879, Length=252, Percent_Identity=25.7936507936508, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788887, Length=156, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1790399, Length=143, Percent_Identity=30.0699300699301, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34220; Mature: 34220

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNCVISHAHITTMDLTLLRAFATVAREGNLTRAAAQLHVTQPAVSLQIKHLQETLGVAL
CCEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHEEEECCHHHHHHHHHHHHHCEEE
FTRTSRGLALTRDGQTLLPHAERALAAAADVQRAAAALRHEVRGRLRIGTILDPGFLRLG
EEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHH
GFLRALVETHPQIETALRHGMSGWVIEQVRAQALDVGYYIGRPEEDSPRDDALFHTVTLT
HHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHCEEECCCCCCCCCCCCEEEEEEEE
RFEYRVLAPAGWKERVQRAHDWRALAALPWIWTPPASAHHRLLSRRFAAAGAQPVKVAEV
EEEEEEECCCCHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHCCCCCEEEECC
DQEQSMLDLVKSGIGLTLARDSTALAEAHAHALTIVEPVTVPTELTFVTLAARRDEPAIA
CHHHHHHHHHHCCCCEEEECCCHHHHHHHHHEEEEEECCCCCCCEEEEEEECCCCCHHHH
AALRLIEAQWAI
HHHHHHHHHCCC
>Mature Secondary Structure
MLNCVISHAHITTMDLTLLRAFATVAREGNLTRAAAQLHVTQPAVSLQIKHLQETLGVAL
CCEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHEEEECCHHHHHHHHHHHHHCEEE
FTRTSRGLALTRDGQTLLPHAERALAAAADVQRAAAALRHEVRGRLRIGTILDPGFLRLG
EEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHH
GFLRALVETHPQIETALRHGMSGWVIEQVRAQALDVGYYIGRPEEDSPRDDALFHTVTLT
HHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHCEEECCCCCCCCCCCCEEEEEEEE
RFEYRVLAPAGWKERVQRAHDWRALAALPWIWTPPASAHHRLLSRRFAAAGAQPVKVAEV
EEEEEEECCCCHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHCCCCCEEEECC
DQEQSMLDLVKSGIGLTLARDSTALAEAHAHALTIVEPVTVPTELTFVTLAARRDEPAIA
CHHHHHHHHHHCCCCEEEECCCHHHHHHHHHEEEEEECCCCCCCEEEEEEECCCCCHHHH
AALRLIEAQWAI
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2201776; 9205837; 9278503; 7559336 [H]