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The map label for this gene is phhA [H]

Identifier: 116688102

GI number: 116688102

Start: 79461

End: 80423

Strand: Reverse

Name: phhA [H]

Synonym: Bcen2424_0078

Alternate gene names: 116688102

Gene position: 80423-79461 (Counterclockwise)

Preceding gene: 116688104

Following gene: 116688101

Centisome position: 2.31

GC content: 67.71

Gene sequence:

>963_bases
ATGCGCCCAATCCGCGCGCAGCCCGCTCTACACTTGCATGGTTCCAACCCCAGCGTGCAGAGCCTGATCATGTCCACCGT
CGTCACCGCGAAACTGCAGGAGCAGTTCGATGCGGGCCTCGAAACCCGCGCCGATTTCACCATCGACCAGCCGCTGCAGC
GCTACGGCCAGGTCGATCACGCGGTGTGGCAGCAGCTCTATGCGCGCCAGTCCGCCCTGCTGCGCGGCCGCGCGTGCGAT
GCGTTCGTCGCCGGACTCGGCAAGATTGCGCTGCCGGCCGATCGTGTACCGTCGTTCGCGGACGTGAACCGCCAGTTGAA
GCCCGCGACCGGTTGGGAAATCGTCGCGGTGCCGGGCCTCGTGCCTGACCGCGTGTTCTTCGAGCACCTCGCGAACCGGC
GTTTCCCCGTCACCTGGTGGATGCGCCGTCCCGACCAGCTCGACTACCTGCAGGAACCCGACTGCTTCCACGACCTGTTC
GGCCACGTGCCGCTGCTGATCGACCCGGTGTTCGCCGACTACATGCAGGCGTATGGCCGCACCGCGCTCGCGGTCGCCGA
CGACGAAGCGGCACTGGCGCGGCTCGCGCGCCTCTATTGGTATACGGTGGAATTCGGGCTGATCCGCGACCCGCGCGGGA
CCAACGGGCTGTCGATCTACGGCGCCGGGATCGTGTCGAGCAAGGGCGAAAGCCTGTACAGCCTCGAAAGCGCGGCGCCG
AACCGGCTCGGGTTCGACCTCGAGCGCGTGATGCGCACGAAGTACCGGATCGACACGTTCCAGAAGACTTACTTCGTGAT
CGACGATTTCGCGCAGTTGTTCGCGCTCGCCGACGTCGACGGCCGCGCACTGGCCGATCGGCTCGCGGCGCTGCCCGAAT
TCGCGGCCGGCGCGGTGCTCGACACCGACCGCGTGCTGCATCGCGGCACGGGCGAAGGCTGGCCCGACGACGCCGACGCG
TAA

Upstream 100 bases:

>100_bases
GCGCGAGATCGAAGTGATCGAGTTCCAGCATGAGCATTCTCCGCATTGATTCGTGATTTGATGCGCGATTATCGCATCAG
TCAGCAAATCGACGCCAACT

Downstream 100 bases:

>100_bases
CGTACCGCGGCGCCGACCGCCGTCGGCCGACCGCCCGTCACCCTTTGCGCAACTATGAAACAATGAACGATGCCGGCCTC
GCCGCGCGGTGCAGCCGCGC

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MRPIRAQPALHLHGSNPSVQSLIMSTVVTAKLQEQFDAGLETRADFTIDQPLQRYGQVDHAVWQQLYARQSALLRGRACD
AFVAGLGKIALPADRVPSFADVNRQLKPATGWEIVAVPGLVPDRVFFEHLANRRFPVTWWMRRPDQLDYLQEPDCFHDLF
GHVPLLIDPVFADYMQAYGRTALAVADDEAALARLARLYWYTVEFGLIRDPRGTNGLSIYGAGIVSSKGESLYSLESAAP
NRLGFDLERVMRTKYRIDTFQKTYFVIDDFAQLFALADVDGRALADRLAALPEFAAGAVLDTDRVLHRGTGEGWPDDADA

Sequences:

>Translated_320_residues
MRPIRAQPALHLHGSNPSVQSLIMSTVVTAKLQEQFDAGLETRADFTIDQPLQRYGQVDHAVWQQLYARQSALLRGRACD
AFVAGLGKIALPADRVPSFADVNRQLKPATGWEIVAVPGLVPDRVFFEHLANRRFPVTWWMRRPDQLDYLQEPDCFHDLF
GHVPLLIDPVFADYMQAYGRTALAVADDEAALARLARLYWYTVEFGLIRDPRGTNGLSIYGAGIVSSKGESLYSLESAAP
NRLGFDLERVMRTKYRIDTFQKTYFVIDDFAQLFALADVDGRALADRLAALPEFAAGAVLDTDRVLHRGTGEGWPDDADA
>Mature_320_residues
MRPIRAQPALHLHGSNPSVQSLIMSTVVTAKLQEQFDAGLETRADFTIDQPLQRYGQVDHAVWQQLYARQSALLRGRACD
AFVAGLGKIALPADRVPSFADVNRQLKPATGWEIVAVPGLVPDRVFFEHLANRRFPVTWWMRRPDQLDYLQEPDCFHDLF
GHVPLLIDPVFADYMQAYGRTALAVADDEAALARLARLYWYTVEFGLIRDPRGTNGLSIYGAGIVSSKGESLYSLESAAP
NRLGFDLERVMRTKYRIDTFQKTYFVIDDFAQLFALADVDGRALADRLAALPEFAAGAVLDTDRVLHRGTGEGWPDDADA

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI88900503, Length=226, Percent_Identity=35.8407079646018, Blast_Score=134, Evalue=9e-32,
Organism=Homo sapiens, GI88900505, Length=226, Percent_Identity=35.8407079646018, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI88900501, Length=226, Percent_Identity=35.8407079646018, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI4557819, Length=227, Percent_Identity=33.920704845815, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI31795563, Length=229, Percent_Identity=33.1877729257642, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4759248, Length=224, Percent_Identity=32.5892857142857, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71980736, Length=218, Percent_Identity=33.9449541284404, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17531391, Length=230, Percent_Identity=35.6521739130435, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI115532103, Length=236, Percent_Identity=31.3559322033898, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI115533973, Length=236, Percent_Identity=31.3559322033898, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71980731, Length=150, Percent_Identity=32.6666666666667, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI62472054, Length=224, Percent_Identity=34.375, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24660393, Length=224, Percent_Identity=34.375, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI17136776, Length=224, Percent_Identity=30.3571428571429, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI17136774, Length=224, Percent_Identity=30.3571428571429, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24654994, Length=180, Percent_Identity=36.6666666666667, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 35725; Mature: 35725

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPIRAQPALHLHGSNPSVQSLIMSTVVTAKLQEQFDAGLETRADFTIDQPLQRYGQVDH
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCHHH
AVWQQLYARQSALLRGRACDAFVAGLGKIALPADRVPSFADVNRQLKPATGWEIVAVPGL
HHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHCCCHHHCCCCCCCCCCEEEEEECCC
VPDRVFFEHLANRRFPVTWWMRRPDQLDYLQEPDCFHDLFGHVPLLIDPVFADYMQAYGR
CCHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCCEEHHHHHHHHHHHCC
TALAVADDEAALARLARLYWYTVEFGLIRDPRGTNGLSIYGAGIVSSKGESLYSLESAAP
EEEEEECCHHHHHHHHHHHHHHEEEEEEECCCCCCCEEEEECCEECCCCCCCEEHHHCCC
NRLGFDLERVMRTKYRIDTFQKTYFVIDDFAQLFALADVDGRALADRLAALPEFAAGAVL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCC
DTDRVLHRGTGEGWPDDADA
CHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MRPIRAQPALHLHGSNPSVQSLIMSTVVTAKLQEQFDAGLETRADFTIDQPLQRYGQVDH
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCHHH
AVWQQLYARQSALLRGRACDAFVAGLGKIALPADRVPSFADVNRQLKPATGWEIVAVPGL
HHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHCCCHHHCCCCCCCCCCEEEEEECCC
VPDRVFFEHLANRRFPVTWWMRRPDQLDYLQEPDCFHDLFGHVPLLIDPVFADYMQAYGR
CCHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCCEEHHHHHHHHHHHCC
TALAVADDEAALARLARLYWYTVEFGLIRDPRGTNGLSIYGAGIVSSKGESLYSLESAAP
EEEEEECCHHHHHHHHHHHHHHEEEEEEECCCCCCCEEEEECCEECCCCCCCEEHHHCCC
NRLGFDLERVMRTKYRIDTFQKTYFVIDDFAQLFALADVDGRALADRLAALPEFAAGAVL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCC
DTDRVLHRGTGEGWPDDADA
CHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]