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The map label for this gene is atoC [H]

Identifier: 116626864

GI number: 116626864

Start: 9830244

End: 9831689

Strand: Direct

Name: atoC [H]

Synonym: Acid_7839

Alternate gene names: 116626864

Gene position: 9830244-9831689 (Clockwise)

Preceding gene: 116626863

Following gene: 116626865

Centisome position: 98.64

GC content: 63.76

Gene sequence:

>1446_bases
ATGATGTCGCAGCAACCACCACATATTCTGATCGCAGACGATGAACGCTCGATCCGGCTGATGCTGGAGACAGGTCTTAC
TCTGAATGGATTTCGAGTGACGAGCGCGCGCAATGGGCGCGAAGCGCTGGAACTGGCAACTGCGGGCAAGTTCGACGCCG
TGCTCAGCGATATTTACATGCCCGATTTGGGCGGCTTGGAACTGGTGGATGCATTACGGGCGGCCGATGCCAACTTGCCG
ATCGTGCTGATGACCGCGCAGGGGTCGCTGCAAGTGGCGGTGGAAGCCGTGACGCGCGGGGCCAGCGATTTTATCGGCAA
GCCGTTCGACGTTTCGGCGGTGGTGGAGCTGCTGAAGAGACTGCTGGAAGGGCGGCGGGAAGCCGAAGCCGTAACTACCG
CAGGTCCCGAGGACAAGCTCACCGAGATCGGACTGGTGGGGCGCAGCGTGCCGATGATCCAGGTATACAAGTTGATCGCG
CAAGCGGCGCGTACGGATGCCACGGTGCTGATTCTGGGCGAATCGGGCACCGGTAAGGAACTGGTGGCGCGGGCGATTCA
TGACTTCAGCGCGCGGAGCGGTCGTCCGTTCCTGAGCGTGAATTGTTCCGGCCTGACAGATACGCTGCTGGAAGCGGAGC
TGTTCGGCCACACGCGGGGGGCGTTCACTGGGGCTAACAGCGACCGTGCCGGGTTGTTCGAGGCAGCGGACGGCGGAACG
CTCTTCCTGGACGAGCTGGCCTCTACGAGCCAGGCGTTTCAGCAGAGCCTGCTGCGGGTATTGCAGAGCGGTGAAGTGCG
CCGGGTGGGCGCCACGCAATCGCGGCGCTTCAACGTGCGCGTGATCGGCGCCAGCAATGCTCCGCTACGCGACCTGGTGG
CGGCAGGGAGCTTCCGCGCCGACCTTTTCTACCGGTTGAGCGTGTTAAGCGTGGAGTTGCCGCCGCTGCGCGAGCGCGCC
GGGGATATCGAACTTCTCACCGGCCATTTTCTGCAGCGCTTCCGCGAGCCGGGCGATGCTCCGCTGCATTTGACGCGGGA
GGCCGCCGAGGCGCTGGCCGCGCATAGTTTTCCCGGCAATGTGCGGGAACTGGAAAATGCGCTGCGGCGCGCCGTGGCCC
TGTCCACCGGCGGCGTGGTGACAATCGACTGCCTGCCGGGAGAGATCGCCGCAAAACGTGTTAAACCCGCGGCCGCGGAA
CGGCCCGAGCAGCGGCTGATCGCGGACCGCCCCAATATGGAGGAACTGCAACGTCGCTACTTGCAGCTTATCCTGGAAGA
GACGGGTTGGAACCGCCGCCGGGCGGCTGCCGTCCTTGATCTTGACCGCCGAACCATCCAGCGGCTGATTGCCCGATATC
AGTTGCACGGGGCGGTCGATCCGGAAGGCGAGAGTGAGTTGGAGACTGAGGCGGAAGTTGTGGAAAGGCCGATGGATATC
GTGTGA

Upstream 100 bases:

>100_bases
AAATCGCGGAACTTCATCACGGCTCGGTTGCGGTAAGGAGCGAAGTCGGGAAGGGTTCCACATTTACCCTGCGGATTCCC
CGCTCGGAGGCTTAATTCTT

Downstream 100 bases:

>100_bases
TGCAGTTCCCGTGGGGCCGGATCGGGATCGGCCTGGCTACGACATCAGGCGCAGTGCTCGCGTTACTGTTCACATCCGTA
GCCGCTGCCCAATCCACGCC

Product: two-component response regulator CbrB

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MMSQQPPHILIADDERSIRLMLETGLTLNGFRVTSARNGREALELATAGKFDAVLSDIYMPDLGGLELVDALRAADANLP
IVLMTAQGSLQVAVEAVTRGASDFIGKPFDVSAVVELLKRLLEGRREAEAVTTAGPEDKLTEIGLVGRSVPMIQVYKLIA
QAARTDATVLILGESGTGKELVARAIHDFSARSGRPFLSVNCSGLTDTLLEAELFGHTRGAFTGANSDRAGLFEAADGGT
LFLDELASTSQAFQQSLLRVLQSGEVRRVGATQSRRFNVRVIGASNAPLRDLVAAGSFRADLFYRLSVLSVELPPLRERA
GDIELLTGHFLQRFREPGDAPLHLTREAAEALAAHSFPGNVRELENALRRAVALSTGGVVTIDCLPGEIAAKRVKPAAAE
RPEQRLIADRPNMEELQRRYLQLILEETGWNRRRAAAVLDLDRRTIQRLIARYQLHGAVDPEGESELETEAEVVERPMDI
V

Sequences:

>Translated_481_residues
MMSQQPPHILIADDERSIRLMLETGLTLNGFRVTSARNGREALELATAGKFDAVLSDIYMPDLGGLELVDALRAADANLP
IVLMTAQGSLQVAVEAVTRGASDFIGKPFDVSAVVELLKRLLEGRREAEAVTTAGPEDKLTEIGLVGRSVPMIQVYKLIA
QAARTDATVLILGESGTGKELVARAIHDFSARSGRPFLSVNCSGLTDTLLEAELFGHTRGAFTGANSDRAGLFEAADGGT
LFLDELASTSQAFQQSLLRVLQSGEVRRVGATQSRRFNVRVIGASNAPLRDLVAAGSFRADLFYRLSVLSVELPPLRERA
GDIELLTGHFLQRFREPGDAPLHLTREAAEALAAHSFPGNVRELENALRRAVALSTGGVVTIDCLPGEIAAKRVKPAAAE
RPEQRLIADRPNMEELQRRYLQLILEETGWNRRRAAAVLDLDRRTIQRLIARYQLHGAVDPEGESELETEAEVVERPMDI
V
>Mature_481_residues
MMSQQPPHILIADDERSIRLMLETGLTLNGFRVTSARNGREALELATAGKFDAVLSDIYMPDLGGLELVDALRAADANLP
IVLMTAQGSLQVAVEAVTRGASDFIGKPFDVSAVVELLKRLLEGRREAEAVTTAGPEDKLTEIGLVGRSVPMIQVYKLIA
QAARTDATVLILGESGTGKELVARAIHDFSARSGRPFLSVNCSGLTDTLLEAELFGHTRGAFTGANSDRAGLFEAADGGT
LFLDELASTSQAFQQSLLRVLQSGEVRRVGATQSRRFNVRVIGASNAPLRDLVAAGSFRADLFYRLSVLSVELPPLRERA
GDIELLTGHFLQRFREPGDAPLHLTREAAEALAAHSFPGNVRELENALRRAVALSTGGVVTIDCLPGEIAAKRVKPAAAE
RPEQRLIADRPNMEELQRRYLQLILEETGWNRRRAAAVLDLDRRTIQRLIARYQLHGAVDPEGESELETEAEVVERPMDI
V

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=465, Percent_Identity=40.8602150537634, Blast_Score=321, Evalue=7e-89,
Organism=Escherichia coli, GI1790437, Length=452, Percent_Identity=41.5929203539823, Blast_Score=316, Evalue=2e-87,
Organism=Escherichia coli, GI1790299, Length=458, Percent_Identity=39.3013100436681, Blast_Score=295, Evalue=6e-81,
Organism=Escherichia coli, GI1788905, Length=459, Percent_Identity=36.8191721132898, Blast_Score=275, Evalue=4e-75,
Organism=Escherichia coli, GI87082152, Length=331, Percent_Identity=43.5045317220544, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI87082117, Length=331, Percent_Identity=41.6918429003021, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI1789087, Length=261, Percent_Identity=45.9770114942529, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI87081872, Length=324, Percent_Identity=40.1234567901235, Blast_Score=218, Evalue=7e-58,
Organism=Escherichia coli, GI1789233, Length=324, Percent_Identity=37.962962962963, Blast_Score=211, Evalue=7e-56,
Organism=Escherichia coli, GI1786524, Length=320, Percent_Identity=41.5625, Blast_Score=191, Evalue=7e-50,
Organism=Escherichia coli, GI1787583, Length=234, Percent_Identity=40.5982905982906, Blast_Score=169, Evalue=5e-43,
Organism=Escherichia coli, GI1789828, Length=241, Percent_Identity=33.195020746888, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI87081858, Length=226, Percent_Identity=33.1858407079646, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1786784, Length=123, Percent_Identity=39.0243902439024, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1789809, Length=136, Percent_Identity=30.1470588235294, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788191, Length=125, Percent_Identity=32.8, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1786911, Length=136, Percent_Identity=31.6176470588235, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1787375, Length=114, Percent_Identity=30.7017543859649, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1789402, Length=124, Percent_Identity=31.4516129032258, Blast_Score=62, Evalue=8e-11,
Organism=Escherichia coli, GI87082012, Length=126, Percent_Identity=28.5714285714286, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 52294; Mature: 52294

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSQQPPHILIADDERSIRLMLETGLTLNGFRVTSARNGREALELATAGKFDAVLSDIYM
CCCCCCCEEEEECCCCCEEEEEECCCEECCEEEECCCCCHHHHHHHHCCCHHHHHHHHCC
PDLGGLELVDALRAADANLPIVLMTAQGSLQVAVEAVTRGASDFIGKPFDVSAVVELLKR
CCCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHH
LLEGRREAEAVTTAGPEDKLTEIGLVGRSVPMIQVYKLIAQAARTDATVLILGESGTGKE
HHHCHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHH
LVARAIHDFSARSGRPFLSVNCSGLTDTLLEAELFGHTRGAFTGANSDRAGLFEAADGGT
HHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCE
LFLDELASTSQAFQQSLLRVLQSGEVRRVGATQSRRFNVRVIGASNAPLRDLVAAGSFRA
EEHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEEEEEECCCCCHHHHHHCCCHHH
DLFYRLSVLSVELPPLRERAGDIELLTGHFLQRFREPGDAPLHLTREAAEALAAHSFPGN
HHHHEEEEEEEECCCHHHHCCCEEHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHCCCCCC
VRELENALRRAVALSTGGVVTIDCLPGEIAAKRVKPAAAERPEQRLIADRPNMEELQRRY
HHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHCCCHHHCCCHHHHHCCCCCHHHHHHHH
LQLILEETGWNRRRAAAVLDLDRRTIQRLIARYQLHGAVDPEGESELETEAEVVERPMDI
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCC
V
C
>Mature Secondary Structure
MMSQQPPHILIADDERSIRLMLETGLTLNGFRVTSARNGREALELATAGKFDAVLSDIYM
CCCCCCCEEEEECCCCCEEEEEECCCEECCEEEECCCCCHHHHHHHHCCCHHHHHHHHCC
PDLGGLELVDALRAADANLPIVLMTAQGSLQVAVEAVTRGASDFIGKPFDVSAVVELLKR
CCCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHH
LLEGRREAEAVTTAGPEDKLTEIGLVGRSVPMIQVYKLIAQAARTDATVLILGESGTGKE
HHHCHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHH
LVARAIHDFSARSGRPFLSVNCSGLTDTLLEAELFGHTRGAFTGANSDRAGLFEAADGGT
HHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCE
LFLDELASTSQAFQQSLLRVLQSGEVRRVGATQSRRFNVRVIGASNAPLRDLVAAGSFRA
EEHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEEEEEECCCCCHHHHHHCCCHHH
DLFYRLSVLSVELPPLRERAGDIELLTGHFLQRFREPGDAPLHLTREAAEALAAHSFPGN
HHHHEEEEEEEECCCHHHHCCCEEHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHCCCCCC
VRELENALRRAVALSTGGVVTIDCLPGEIAAKRVKPAAAERPEQRLIADRPNMEELQRRY
HHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHCCCHHHCCCHHHHHCCCCCHHHHHHHH
LQLILEETGWNRRRAAAVLDLDRRTIQRLIARYQLHGAVDPEGESELETEAEVVERPMDI
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCC
V
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]