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The map label for this gene is accC [H]

Identifier: 116626839

GI number: 116626839

Start: 9788478

End: 9789839

Strand: Direct

Name: accC [H]

Synonym: Acid_7812

Alternate gene names: 116626839

Gene position: 9788478-9789839 (Clockwise)

Preceding gene: 116626838

Following gene: 116626840

Centisome position: 98.22

GC content: 60.94

Gene sequence:

>1362_bases
TTGCCGTCCGTACGGTTTAAGAAGATCCTGATCGCCAATCGGGGCGAAATTGCCGTTCGCGTCATCAGCGCCTGCAAGGA
ACTTGGAATCCAGACCGTAGCGGTTTACTCGGAGGCGGACCGGTATAGTTCGCACGTGCGGTTTGCCGACCAGGCGATCT
GTATCGGACCGGCCAAGAGCGCGCGAAGCTACCTGGATATCCCCTCGATCATCAGCGCGGCGGAGATTACCAACGTCGAT
GCGATCCATCCCGGGTACGGCTTCCTGAGCGAAAATGCCAGCTTCGCGGAAGTCTGCGAAACCTCGGGACTCAAATTCAT
CGGGCCACGGCCGGACGTGATCCGGCTGATGGGGGTGAAGGAACGGGCGCGCGCGTTCATGCGCGAGATGGGCGTCCCGG
TGCTCCCGGGTTCGCCAGGAGTTCTCTCGTCGGCGGAGGAGGGACTGGAGCTAGCCGAGAAGGTCGGATACCCTGTCATC
CTGAAGGCCTCAGCCGGCGGCGGCGGGCGCGGCATGCGGGTGGTGAACGGGCCGGAGGAGCTGCCTTCCAATTTCATCCA
GGCGCAGAACGAGGCGGGAAGCGCGTTCAGCTCGGCAGATGTTTACCTGGAGAAATACATTGGCGCGCCGCGGCATATCG
AATTCCAGATTCTGGCCGATGAACACGGGAACGTGGAGATTCTGGGCGAGCGCGAATGCAGCGTGCAGCGCCGGCACCAG
AAGCTGCTCGAGGAATCGCCTTCGCCGGCGGTGACGGACAAGCAGCGCGCCGGTATTTCGGTAGCGCTACGCAAAGCGAT
CGCGCATGCGGGTTACACCAACGCCGGCACGGTGGAGTTTCTGATGGACGAGCACGGCAACCTCAATTTCATCGAGGTGA
ACGCGCGCGTGCAGGTGGAACATCCGGTCACCGAATTTGTGACCGGGATCGATATCGTGAAGAGCCAGATCCGGATCGCT
CAAGGCGAGACGTTGAAGGAGATTCTGCCCGGGCCGGTGGAACTGCGCGGCCACTCGATCGAGTGCCGCATCAACGCGGA
GAATCCGGAGACGTTTGTGCCTTCGCCCGGACGTATTACAGGCTTCCACCTTCCCGGCGGCATCGGTGTGCGCGTGGATA
CGTGGGCCTATACGGATTGCGTGATCCCGCCATTTTATGATTCGCTGGTCGCCAAACTGGTGACGTACGGGAGCGATCGC
GGCGAGGCGATCCGGCGCATGCAGCGCGCGCTCGGGATGTTTATCGTGGAGGGCATTCATACGTCGATTCCTCTGCAGCA
GAAGATTCTCGCCGATCCCGATTTTCAAGCGGGCAACTTCGATACGAATTTCATCAAGCGCTTCATGCCCGGTCACAAAT
GA

Upstream 100 bases:

>100_bases
AGCATGAAACTGATGAACGAAATCGAATCCGAGACCAGCGGCGTTATTGAAAGCAAGCTGGTGATGAACGGGCAGCCGGT
GGAGTACGGGGAGGCTCTAT

Downstream 100 bases:

>100_bases
AGCCGAGTCCGCTTGCCGCGGCCCTGTTGTGCTGCGCGCTGGGCGCGAGTTTTCAGTGGCTCACGGTGCGGGCGAATTAC
GGGGGCGACCGGACTGCGCT

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MPSVRFKKILIANRGEIAVRVISACKELGIQTVAVYSEADRYSSHVRFADQAICIGPAKSARSYLDIPSIISAAEITNVD
AIHPGYGFLSENASFAEVCETSGLKFIGPRPDVIRLMGVKERARAFMREMGVPVLPGSPGVLSSAEEGLELAEKVGYPVI
LKASAGGGGRGMRVVNGPEELPSNFIQAQNEAGSAFSSADVYLEKYIGAPRHIEFQILADEHGNVEILGERECSVQRRHQ
KLLEESPSPAVTDKQRAGISVALRKAIAHAGYTNAGTVEFLMDEHGNLNFIEVNARVQVEHPVTEFVTGIDIVKSQIRIA
QGETLKEILPGPVELRGHSIECRINAENPETFVPSPGRITGFHLPGGIGVRVDTWAYTDCVIPPFYDSLVAKLVTYGSDR
GEAIRRMQRALGMFIVEGIHTSIPLQQKILADPDFQAGNFDTNFIKRFMPGHK

Sequences:

>Translated_453_residues
MPSVRFKKILIANRGEIAVRVISACKELGIQTVAVYSEADRYSSHVRFADQAICIGPAKSARSYLDIPSIISAAEITNVD
AIHPGYGFLSENASFAEVCETSGLKFIGPRPDVIRLMGVKERARAFMREMGVPVLPGSPGVLSSAEEGLELAEKVGYPVI
LKASAGGGGRGMRVVNGPEELPSNFIQAQNEAGSAFSSADVYLEKYIGAPRHIEFQILADEHGNVEILGERECSVQRRHQ
KLLEESPSPAVTDKQRAGISVALRKAIAHAGYTNAGTVEFLMDEHGNLNFIEVNARVQVEHPVTEFVTGIDIVKSQIRIA
QGETLKEILPGPVELRGHSIECRINAENPETFVPSPGRITGFHLPGGIGVRVDTWAYTDCVIPPFYDSLVAKLVTYGSDR
GEAIRRMQRALGMFIVEGIHTSIPLQQKILADPDFQAGNFDTNFIKRFMPGHK
>Mature_452_residues
PSVRFKKILIANRGEIAVRVISACKELGIQTVAVYSEADRYSSHVRFADQAICIGPAKSARSYLDIPSIISAAEITNVDA
IHPGYGFLSENASFAEVCETSGLKFIGPRPDVIRLMGVKERARAFMREMGVPVLPGSPGVLSSAEEGLELAEKVGYPVIL
KASAGGGGRGMRVVNGPEELPSNFIQAQNEAGSAFSSADVYLEKYIGAPRHIEFQILADEHGNVEILGERECSVQRRHQK
LLEESPSPAVTDKQRAGISVALRKAIAHAGYTNAGTVEFLMDEHGNLNFIEVNARVQVEHPVTEFVTGIDIVKSQIRIAQ
GETLKEILPGPVELRGHSIECRINAENPETFVPSPGRITGFHLPGGIGVRVDTWAYTDCVIPPFYDSLVAKLVTYGSDRG
EAIRRMQRALGMFIVEGIHTSIPLQQKILADPDFQAGNFDTNFIKRFMPGHK

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=455, Percent_Identity=46.8131868131868, Blast_Score=394, Evalue=1e-110,
Organism=Homo sapiens, GI106049295, Length=455, Percent_Identity=46.8131868131868, Blast_Score=394, Evalue=1e-110,
Organism=Homo sapiens, GI106049292, Length=455, Percent_Identity=46.8131868131868, Blast_Score=394, Evalue=1e-110,
Organism=Homo sapiens, GI116805327, Length=440, Percent_Identity=44.7727272727273, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI65506442, Length=454, Percent_Identity=44.273127753304, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI189095269, Length=454, Percent_Identity=44.273127753304, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI295821183, Length=454, Percent_Identity=44.273127753304, Blast_Score=384, Evalue=1e-107,
Organism=Homo sapiens, GI38679974, Length=511, Percent_Identity=30.7240704500978, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI38679971, Length=511, Percent_Identity=30.7240704500978, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI38679977, Length=511, Percent_Identity=30.7240704500978, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI38679967, Length=511, Percent_Identity=30.7240704500978, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI38679960, Length=511, Percent_Identity=30.7240704500978, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI134142062, Length=507, Percent_Identity=29.7830374753452, Blast_Score=216, Evalue=4e-56,
Organism=Escherichia coli, GI1789654, Length=443, Percent_Identity=54.4018058690745, Blast_Score=459, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI17562816, Length=445, Percent_Identity=46.0674157303371, Blast_Score=376, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI71987519, Length=455, Percent_Identity=43.2967032967033, Blast_Score=365, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17567343, Length=452, Percent_Identity=43.8053097345133, Blast_Score=359, Evalue=1e-99,
Organism=Caenorhabditis elegans, GI133931226, Length=497, Percent_Identity=28.169014084507, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71997168, Length=511, Percent_Identity=27.7886497064579, Blast_Score=184, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI71997163, Length=511, Percent_Identity=27.7886497064579, Blast_Score=184, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6319685, Length=449, Percent_Identity=43.2071269487751, Blast_Score=360, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6319695, Length=445, Percent_Identity=44.2696629213483, Blast_Score=337, Evalue=2e-93,
Organism=Saccharomyces cerevisiae, GI6321376, Length=445, Percent_Identity=44.9438202247191, Blast_Score=333, Evalue=5e-92,
Organism=Saccharomyces cerevisiae, GI6324343, Length=525, Percent_Identity=30.2857142857143, Blast_Score=209, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6323863, Length=475, Percent_Identity=31.1578947368421, Blast_Score=208, Evalue=1e-54,
Organism=Drosophila melanogaster, GI281363050, Length=444, Percent_Identity=47.5225225225225, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652224, Length=444, Percent_Identity=47.5225225225225, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652222, Length=444, Percent_Identity=47.5225225225225, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652220, Length=444, Percent_Identity=47.5225225225225, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652218, Length=444, Percent_Identity=47.5225225225225, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652212, Length=444, Percent_Identity=47.5225225225225, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652210, Length=444, Percent_Identity=47.5225225225225, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652214, Length=444, Percent_Identity=47.5225225225225, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI19921944, Length=444, Percent_Identity=47.5225225225225, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652216, Length=444, Percent_Identity=47.5225225225225, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24651757, Length=448, Percent_Identity=42.1875, Blast_Score=358, Evalue=3e-99,
Organism=Drosophila melanogaster, GI24651759, Length=404, Percent_Identity=40.5940594059406, Blast_Score=314, Evalue=7e-86,
Organism=Drosophila melanogaster, GI161076407, Length=502, Percent_Identity=29.6812749003984, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24586460, Length=502, Percent_Identity=29.6812749003984, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI161076409, Length=503, Percent_Identity=29.6222664015905, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24586458, Length=502, Percent_Identity=29.6812749003984, Blast_Score=203, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49345; Mature: 49214

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSVRFKKILIANRGEIAVRVISACKELGIQTVAVYSEADRYSSHVRFADQAICIGPAKS
CCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHEECCCEEEECCCHH
ARSYLDIPSIISAAEITNVDAIHPGYGFLSENASFAEVCETSGLKFIGPRPDVIRLMGVK
HHHHCCCHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHCCCEEECCCCCEEEECCCH
ERARAFMREMGVPVLPGSPGVLSSAEEGLELAEKVGYPVILKASAGGGGRGMRVVNGPEE
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCEEECCHHH
LPSNFIQAQNEAGSAFSSADVYLEKYIGAPRHIEFQILADEHGNVEILGERECSVQRRHQ
HHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEECCHHHHHHHHH
KLLEESPSPAVTDKQRAGISVALRKAIAHAGYTNAGTVEFLMDEHGNLNFIEVNARVQVE
HHHHCCCCCCCCCHHHCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEEEEEEEEC
HPVTEFVTGIDIVKSQIRIAQGETLKEILPGPVELRGHSIECRINAENPETFVPSPGRIT
CCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEECCCEEEEEEECCCCCCCCCCCCCEE
GFHLPGGIGVRVDTWAYTDCVIPPFYDSLVAKLVTYGSDRGEAIRRMQRALGMFIVEGIH
EEECCCCCEEEEECEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
TSIPLQQKILADPDFQAGNFDTNFIKRFMPGHK
CCCCCHHHHCCCCCCCCCCCCHHHHHHHCCCCC
>Mature Secondary Structure 
PSVRFKKILIANRGEIAVRVISACKELGIQTVAVYSEADRYSSHVRFADQAICIGPAKS
CCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHEECCCEEEECCCHH
ARSYLDIPSIISAAEITNVDAIHPGYGFLSENASFAEVCETSGLKFIGPRPDVIRLMGVK
HHHHCCCHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHCCCEEECCCCCEEEECCCH
ERARAFMREMGVPVLPGSPGVLSSAEEGLELAEKVGYPVILKASAGGGGRGMRVVNGPEE
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCEEECCHHH
LPSNFIQAQNEAGSAFSSADVYLEKYIGAPRHIEFQILADEHGNVEILGERECSVQRRHQ
HHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEECCHHHHHHHHH
KLLEESPSPAVTDKQRAGISVALRKAIAHAGYTNAGTVEFLMDEHGNLNFIEVNARVQVE
HHHHCCCCCCCCCHHHCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEEEEEEEEC
HPVTEFVTGIDIVKSQIRIAQGETLKEILPGPVELRGHSIECRINAENPETFVPSPGRIT
CCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEECCCEEEEEEECCCCCCCCCCCCCEE
GFHLPGGIGVRVDTWAYTDCVIPPFYDSLVAKLVTYGSDRGEAIRRMQRALGMFIVEGIH
EEECCCCCEEEEECEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
TSIPLQQKILADPDFQAGNFDTNFIKRFMPGHK
CCCCCHHHHCCCCCCCCCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]