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The map label for this gene is sbm [H]

Identifier: 116626450

GI number: 116626450

Start: 9297301

End: 9298800

Strand: Direct

Name: sbm [H]

Synonym: Acid_7412

Alternate gene names: 116626450

Gene position: 9297301-9298800 (Clockwise)

Preceding gene: 116626449

Following gene: 116626451

Centisome position: 93.29

GC content: 64.47

Gene sequence:

>1500_bases
ATGAATCAGGAAATCGGCGAACCCGGCCAATTCCCTTACACGCGCGGAGTGTATCGCGAGATGTATCGGAGCCGGCTGTG
GACAATGCGCCAATACGCCGGCTTTGGCACGGCGGAGGAGAGCAATCGCCGGTACCGCTATCTTCTTTCGCAAGGCACCA
CCGGGCTTTCCGTGGCGTTCGATCTGCCGACCCAAATGGGTTACGACAGCGACCACCCGATGGCATCGGGAGAGGTGGGC
CGCGTAGGCGTCGCAATCTCCTCGCTGGCCGATATGGAGCGGCTCTTCCATGAGATCCCGCTGGACAAAGTCTCCACCTC
GATGACGATCAACTCCACGGCCGGGATCCTGCTGGCGCTTTATGCGCTGGTGGCGGAACGGCAGGGGGCGGAACGGAGCA
AACTCTCGGGGACGATCCAGAACGACATCCTGAAGGAATACATCGCGCGCGGCACGTATATTTACCCACCGCGTCCGGCG
ATGCGGATCGTTACAGACATCTTCGCGTGGGCGGGCCGTGAGATGCCGGAATGGAATACGATTTCGATCAGCGGATATCA
CATCCGCGAGGCCGGATCGACCGCCACGCAGGAGCTCGCGTTCACGTTCGCGAATGCGATCGCGTACATCGAGGCTGCCA
TCGCGGCGGGGCTGGCGGTGGATTCCTTCGCGCCGCGGCTCTCCTTCTTCTTCAACTCGCACAGTGATTTTCTGGAGGAG
GTCGCCAAATTCCGCGCGGCGCGGCGGATTTACGCGCACCTGATGCGCGACCGTTTCGGCGCGCGCGACCCGCGCTCCCT
GATGCTGCGTTTCCACGTGCAGACGGCGGGATCCACGCTGACGGCGCAGCAACCGGACGTCAATATCGTGCGTACGGCGC
TGCAGGCCATGGCGGCGGTGCTAGGCGGCGCACAATCGCTGCACACGAATTCGCGGGACGAGGCGCTGGCGCTGCCGACC
GAGGAATCGGCGCGAATCGCGCTGCGGACGCAGCAGATCATCGCGTACGAATCGGGCGTCACGAACACGGTGGACCCGGT
GGGCGGGAGCGAGCACATCGAAGGGCTGACAGATTCCATAGAGTGCGGCGTACACGAGTACCTGAAGGCGATCGAGGAGG
CGGGCGGCACGCTGCGCGCGATCGAGACGGGCTACATCCAGAACCAGATCCAGAACGCCGCGTACGAGTATCAGCGCTCG
GTGGAGACCGGAGAACGGATCGTCGTCGGAGTGAACCGGTTCCAAAAGGATGAGGAGCGCGGCGCCCCCGTGTTCCGGCT
GGACCCCGCGCTCGAAAAGGCGCAGGTCGAGGGCGTGCGCGAGGTACGGGCAGGACGGAGCCAGAGCGCGGTCACCGAGA
AACTCGCGGCGCTGGAGCAGGCTGCGCGGGGCACGGCGAACGTGATGCCGCGGATTCTGGAAGCGGCCGCCGCGTATGCG
ACGGTGGGCGAGATCTCCGATACCCTGCGCGCTGTTTTCGGCGAACACCGCGAGGGATAA

Upstream 100 bases:

>100_bases
CGGCTAACCTGGTTCGGCTCGGAATGGCGGGGTTCTGCACGATTCTGATGTTGTGGTTTGGCATCAGTTCCTTCCTGCGC
GCCCGCAAGATCTCGCGCTC

Downstream 100 bases:

>100_bases
GGACGCCGGGTGCAGCGAGCTTCGCTCGACTGCGCGCAAGCTGAAGCGTGCGCCACCAAAGCGATGCTGTTCAGTGGTGG
GACATGCTTTAGCCTGCCCG

Product: methylmalonyl-CoA mutase

Products: succinyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MNQEIGEPGQFPYTRGVYREMYRSRLWTMRQYAGFGTAEESNRRYRYLLSQGTTGLSVAFDLPTQMGYDSDHPMASGEVG
RVGVAISSLADMERLFHEIPLDKVSTSMTINSTAGILLALYALVAERQGAERSKLSGTIQNDILKEYIARGTYIYPPRPA
MRIVTDIFAWAGREMPEWNTISISGYHIREAGSTATQELAFTFANAIAYIEAAIAAGLAVDSFAPRLSFFFNSHSDFLEE
VAKFRAARRIYAHLMRDRFGARDPRSLMLRFHVQTAGSTLTAQQPDVNIVRTALQAMAAVLGGAQSLHTNSRDEALALPT
EESARIALRTQQIIAYESGVTNTVDPVGGSEHIEGLTDSIECGVHEYLKAIEEAGGTLRAIETGYIQNQIQNAAYEYQRS
VETGERIVVGVNRFQKDEERGAPVFRLDPALEKAQVEGVREVRAGRSQSAVTEKLAALEQAARGTANVMPRILEAAAAYA
TVGEISDTLRAVFGEHREG

Sequences:

>Translated_499_residues
MNQEIGEPGQFPYTRGVYREMYRSRLWTMRQYAGFGTAEESNRRYRYLLSQGTTGLSVAFDLPTQMGYDSDHPMASGEVG
RVGVAISSLADMERLFHEIPLDKVSTSMTINSTAGILLALYALVAERQGAERSKLSGTIQNDILKEYIARGTYIYPPRPA
MRIVTDIFAWAGREMPEWNTISISGYHIREAGSTATQELAFTFANAIAYIEAAIAAGLAVDSFAPRLSFFFNSHSDFLEE
VAKFRAARRIYAHLMRDRFGARDPRSLMLRFHVQTAGSTLTAQQPDVNIVRTALQAMAAVLGGAQSLHTNSRDEALALPT
EESARIALRTQQIIAYESGVTNTVDPVGGSEHIEGLTDSIECGVHEYLKAIEEAGGTLRAIETGYIQNQIQNAAYEYQRS
VETGERIVVGVNRFQKDEERGAPVFRLDPALEKAQVEGVREVRAGRSQSAVTEKLAALEQAARGTANVMPRILEAAAAYA
TVGEISDTLRAVFGEHREG
>Mature_499_residues
MNQEIGEPGQFPYTRGVYREMYRSRLWTMRQYAGFGTAEESNRRYRYLLSQGTTGLSVAFDLPTQMGYDSDHPMASGEVG
RVGVAISSLADMERLFHEIPLDKVSTSMTINSTAGILLALYALVAERQGAERSKLSGTIQNDILKEYIARGTYIYPPRPA
MRIVTDIFAWAGREMPEWNTISISGYHIREAGSTATQELAFTFANAIAYIEAAIAAGLAVDSFAPRLSFFFNSHSDFLEE
VAKFRAARRIYAHLMRDRFGARDPRSLMLRFHVQTAGSTLTAQQPDVNIVRTALQAMAAVLGGAQSLHTNSRDEALALPT
EESARIALRTQQIIAYESGVTNTVDPVGGSEHIEGLTDSIECGVHEYLKAIEEAGGTLRAIETGYIQNQIQNAAYEYQRS
VETGERIVVGVNRFQKDEERGAPVFRLDPALEKAQVEGVREVRAGRSQSAVTEKLAALEQAARGTANVMPRILEAAAAYA
TVGEISDTLRAVFGEHREG

Specific function: Unknown

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=492, Percent_Identity=48.1707317073171, Blast_Score=476, Evalue=1e-134,
Organism=Escherichia coli, GI1789284, Length=490, Percent_Identity=50.8163265306122, Blast_Score=479, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI25144500, Length=490, Percent_Identity=50.6122448979592, Blast_Score=502, Evalue=1e-142,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: 5.4.99.2

Molecular weight: Translated: 54925; Mature: 54925

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQEIGEPGQFPYTRGVYREMYRSRLWTMRQYAGFGTAEESNRRYRYLLSQGTTGLSVAF
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHCCCCCEEEEE
DLPTQMGYDSDHPMASGEVGRVGVAISSLADMERLFHEIPLDKVSTSMTINSTAGILLAL
ECCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCEEECCHHHHHHHH
YALVAERQGAERSKLSGTIQNDILKEYIARGTYIYPPRPAMRIVTDIFAWAGREMPEWNT
HHHHHHHCCCCHHHHCCHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHCCCCCCCCCE
ISISGYHIREAGSTATQELAFTFANAIAYIEAAIAAGLAVDSFAPRLSFFFNSHSDFLEE
EEEECEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
VAKFRAARRIYAHLMRDRFGARDPRSLMLRFHVQTAGSTLTAQQPDVNIVRTALQAMAAV
HHHHHHHHHHHHHHHHHHCCCCCCHHEEEEEEEECCCCEEECCCCCHHHHHHHHHHHHHH
LGGAQSLHTNSRDEALALPTEESARIALRTQQIIAYESGVTNTVDPVGGSEHIEGLTDSI
HCCHHHHCCCCCCCEEECCCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCHHHHHCCHHHH
ECGVHEYLKAIEEAGGTLRAIETGYIQNQIQNAAYEYQRSVETGERIVVGVNRFQKDEER
HCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHCHHHH
GAPVFRLDPALEKAQVEGVREVRAGRSQSAVTEKLAALEQAARGTANVMPRILEAAAAYA
CCCEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
TVGEISDTLRAVFGEHREG
HHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNQEIGEPGQFPYTRGVYREMYRSRLWTMRQYAGFGTAEESNRRYRYLLSQGTTGLSVAF
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHCCCCCEEEEE
DLPTQMGYDSDHPMASGEVGRVGVAISSLADMERLFHEIPLDKVSTSMTINSTAGILLAL
ECCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCEEECCHHHHHHHH
YALVAERQGAERSKLSGTIQNDILKEYIARGTYIYPPRPAMRIVTDIFAWAGREMPEWNT
HHHHHHHCCCCHHHHCCHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHCCCCCCCCCE
ISISGYHIREAGSTATQELAFTFANAIAYIEAAIAAGLAVDSFAPRLSFFFNSHSDFLEE
EEEECEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
VAKFRAARRIYAHLMRDRFGARDPRSLMLRFHVQTAGSTLTAQQPDVNIVRTALQAMAAV
HHHHHHHHHHHHHHHHHHCCCCCCHHEEEEEEEECCCCEEECCCCCHHHHHHHHHHHHHH
LGGAQSLHTNSRDEALALPTEESARIALRTQQIIAYESGVTNTVDPVGGSEHIEGLTDSI
HCCHHHHCCCCCCCEEECCCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCHHHHHCCHHHH
ECGVHEYLKAIEEAGGTLRAIETGYIQNQIQNAAYEYQRSVETGERIVVGVNRFQKDEER
HCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHCHHHH
GAPVFRLDPALEKAQVEGVREVRAGRSQSAVTEKLAALEQAARGTANVMPRILEAAAAYA
CCCEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
TVGEISDTLRAVFGEHREG
HHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-methylmalonyl-CoA

Specific reaction: (R)-methylmalonyl-CoA = succinyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1355087; 9278503 [H]