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The map label for this gene is thrS [H]

Identifier: 116626335

GI number: 116626335

Start: 9156264

End: 9158198

Strand: Direct

Name: thrS [H]

Synonym: Acid_7295

Alternate gene names: 116626335

Gene position: 9156264-9158198 (Clockwise)

Preceding gene: 116626334

Following gene: 116626336

Centisome position: 91.88

GC content: 60.41

Gene sequence:

>1935_bases
ATGAGTAACATCCAGATCACTCTGCCCGATGGAAGTACACAGTCGGTCGCGGCAGAGACACGTCCGATCGATATCGCGAA
GTCGATCAGCCCTCGCCTGGCAGACGCGGCGCTTGTCGCCAAGGTCAACGGTGAGCTGTTCGACCTCACCCGTCCGATCG
AGAAGGACGCGACGCTGGAGATCCTGACGGCGAAGAACCCCGAGTCGCTGGACGTGTACCGCCATTCGACCGCGCACTTG
CTGGCGGCCGCTGTGCTGGAGTTGTACCCGGAGACGCAGTTGGGGATCGGCCCGCCGATCGAGAACGGCTTCTATTACGA
TTTCGACCGGCCGGCGCCATTCACGCCGGAGGACCTGGAAAAGATCGAGAAAAAGATGTGGGAGATCCAGGCCCGCGCGC
TGCCTTACGAGCGGGTGCTGACGCCGAAGGACGAGGGCCTCAAGAAGTACTCCGAGGCTTGGATGAAGTGTCAGCTGATC
GACGAGCGAGCCGGCGAAATTTTTACGGAATACACGCTGGGGCCGAAATTCATCGATTTCTGCCGCGGTCCGCACCTGCC
CGATACTTCGAAGATCAAGGCGTTCAAACTGCTCTCGATCGCGGGCGCGTACTGGAAGGGCGACGAGAAGAACAAGCAGC
TGCAGCGGATCTACGGCACGGCCTTTTTCTCGCCAAAAGACCTGGACGCGTACCTGAAGCAGGTGGAGGAGGCGAAGAAG
CGCGACCACCGCAAGCTCGGCAAGGAACTCGACCTGTTCAGCATTCAGGAGCTGGCGGGGCCGGGACTGATTTTCTTCCA
TCCCAAAGGCGGGATCATTCGCAAGCTGTTGGAAGACTGGATGCGCGATCAGTACCTGAAGCGCGGATACAGCCTGGTGT
ACACGCCGCACGTGGCCAAGCTGGACCTTTGGAAGACTTCCGGTCACGCGAATTTCTACGCGCAGAATATGTTCACGCCG
ATCGAGCTGGACGATGCCGAATACCAGCTGAAGCCGATGAACTGCCCGTTCCACATTTTGATTTACGCCGACCGGCAGCG
CAGCTATCGCGACCTTCCGGTGCGGTTGGGCGAACTCGGCACGGTATACCGGTACGAACGCTCGGGCACGTTGAACGGAT
TGTTCCGCGTTCGCGGGTTTACGCAGGACGACGCACACATCTTCTGTATGCAAAGCCAGGCGGAAGAGGAAGTGGTGAAC
TGCCTGCAATTCGCAATCGATACGCTGGCGGCCTATGGGTTTGAGAAATACGACGCCGAAATTTCGACCTGGGATGGCGG
CGCGAGCGGCAAGTACGATGGCACTCCGGATCAGTGGGAGATGGCGGAAGGCGCGCTGCGGCGGGCCGTGGACAAGCTGA
AGATCAACGCCAAGGTGGTCGCCGATGAAGCGGCTTTCTACGGACCGAAGATCGACGTAAAGCTGGTGGATGCGATCGGG
CGCAAGTGGCAGCTCTCCACGGTGCAGTTCGATTTCACGCTGCCGCGGCGGTTCGGGCTGGAGTACATCGGCGAGGATGG
CAAGGCGCACCAGCCGATCATGGTGCATCGCGCGTTGTACGGGTCGATCGAGCGCTTCTTCGGGATTCTGGTGGAGCATT
ACGCCGGGGCTTTCCCGGTGTGGCTGGCGCCGGTGCAGGCGACGATACTGCCAATTACCGACCGGCAGACGGAGTATGCG
CGCGGCATCAAGAAGCAACTGGAGGAGGCGGGCATTCGCGCGACGGTGGACGAGCGCAACGAGAAAGTGAACCTGAAGAT
CCGCGATGCACAGATGCAGAAGATCCCGTACATGCTGGTGGTGGGGGATCGCGAGCAGGAGAGCGGGAAGGTTGCGGTGC
GCAATCGCAAGCATGCCGACCAGGGCGTCAAGACGCTGGCGGATTTCATCGCGGAGATCCGCGCGCTGATCGAATCCAAA
GCCGTTTCGGAGTAG

Upstream 100 bases:

>100_bases
CAATTGGGCCTCAAGCTCAGTTTCTAACCGCTCCGGCACGGGGGAATAGGGCTCCCGTGCCGCCCCTTCCCCGCCCCACG
TGTTACGCTGAAAATTCCCT

Downstream 100 bases:

>100_bases
CCCGATGTACGCCACGTCAGAAGGCACGACGCGGTACGCAGCACGCTTCGCGGAGTTCGCCAGCGCGGCATTCTATCGGA
CCGTGATGGGGCTGGAGGTA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 644; Mature: 643

Protein sequence:

>644_residues
MSNIQITLPDGSTQSVAAETRPIDIAKSISPRLADAALVAKVNGELFDLTRPIEKDATLEILTAKNPESLDVYRHSTAHL
LAAAVLELYPETQLGIGPPIENGFYYDFDRPAPFTPEDLEKIEKKMWEIQARALPYERVLTPKDEGLKKYSEAWMKCQLI
DERAGEIFTEYTLGPKFIDFCRGPHLPDTSKIKAFKLLSIAGAYWKGDEKNKQLQRIYGTAFFSPKDLDAYLKQVEEAKK
RDHRKLGKELDLFSIQELAGPGLIFFHPKGGIIRKLLEDWMRDQYLKRGYSLVYTPHVAKLDLWKTSGHANFYAQNMFTP
IELDDAEYQLKPMNCPFHILIYADRQRSYRDLPVRLGELGTVYRYERSGTLNGLFRVRGFTQDDAHIFCMQSQAEEEVVN
CLQFAIDTLAAYGFEKYDAEISTWDGGASGKYDGTPDQWEMAEGALRRAVDKLKINAKVVADEAAFYGPKIDVKLVDAIG
RKWQLSTVQFDFTLPRRFGLEYIGEDGKAHQPIMVHRALYGSIERFFGILVEHYAGAFPVWLAPVQATILPITDRQTEYA
RGIKKQLEEAGIRATVDERNEKVNLKIRDAQMQKIPYMLVVGDREQESGKVAVRNRKHADQGVKTLADFIAEIRALIESK
AVSE

Sequences:

>Translated_644_residues
MSNIQITLPDGSTQSVAAETRPIDIAKSISPRLADAALVAKVNGELFDLTRPIEKDATLEILTAKNPESLDVYRHSTAHL
LAAAVLELYPETQLGIGPPIENGFYYDFDRPAPFTPEDLEKIEKKMWEIQARALPYERVLTPKDEGLKKYSEAWMKCQLI
DERAGEIFTEYTLGPKFIDFCRGPHLPDTSKIKAFKLLSIAGAYWKGDEKNKQLQRIYGTAFFSPKDLDAYLKQVEEAKK
RDHRKLGKELDLFSIQELAGPGLIFFHPKGGIIRKLLEDWMRDQYLKRGYSLVYTPHVAKLDLWKTSGHANFYAQNMFTP
IELDDAEYQLKPMNCPFHILIYADRQRSYRDLPVRLGELGTVYRYERSGTLNGLFRVRGFTQDDAHIFCMQSQAEEEVVN
CLQFAIDTLAAYGFEKYDAEISTWDGGASGKYDGTPDQWEMAEGALRRAVDKLKINAKVVADEAAFYGPKIDVKLVDAIG
RKWQLSTVQFDFTLPRRFGLEYIGEDGKAHQPIMVHRALYGSIERFFGILVEHYAGAFPVWLAPVQATILPITDRQTEYA
RGIKKQLEEAGIRATVDERNEKVNLKIRDAQMQKIPYMLVVGDREQESGKVAVRNRKHADQGVKTLADFIAEIRALIESK
AVSE
>Mature_643_residues
SNIQITLPDGSTQSVAAETRPIDIAKSISPRLADAALVAKVNGELFDLTRPIEKDATLEILTAKNPESLDVYRHSTAHLL
AAAVLELYPETQLGIGPPIENGFYYDFDRPAPFTPEDLEKIEKKMWEIQARALPYERVLTPKDEGLKKYSEAWMKCQLID
ERAGEIFTEYTLGPKFIDFCRGPHLPDTSKIKAFKLLSIAGAYWKGDEKNKQLQRIYGTAFFSPKDLDAYLKQVEEAKKR
DHRKLGKELDLFSIQELAGPGLIFFHPKGGIIRKLLEDWMRDQYLKRGYSLVYTPHVAKLDLWKTSGHANFYAQNMFTPI
ELDDAEYQLKPMNCPFHILIYADRQRSYRDLPVRLGELGTVYRYERSGTLNGLFRVRGFTQDDAHIFCMQSQAEEEVVNC
LQFAIDTLAAYGFEKYDAEISTWDGGASGKYDGTPDQWEMAEGALRRAVDKLKINAKVVADEAAFYGPKIDVKLVDAIGR
KWQLSTVQFDFTLPRRFGLEYIGEDGKAHQPIMVHRALYGSIERFFGILVEHYAGAFPVWLAPVQATILPITDRQTEYAR
GIKKQLEEAGIRATVDERNEKVNLKIRDAQMQKIPYMLVVGDREQESGKVAVRNRKHADQGVKTLADFIAEIRALIESKA
VSE

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38570111, Length=647, Percent_Identity=40.4945904173107, Blast_Score=483, Evalue=1e-136,
Organism=Homo sapiens, GI38202255, Length=643, Percent_Identity=40.2799377916019, Blast_Score=481, Evalue=1e-136,
Organism=Homo sapiens, GI20070344, Length=659, Percent_Identity=37.4810318664643, Blast_Score=414, Evalue=1e-115,
Organism=Escherichia coli, GI1788013, Length=648, Percent_Identity=44.5987654320988, Blast_Score=565, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI71984184, Length=640, Percent_Identity=40.46875, Blast_Score=467, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI71984192, Length=640, Percent_Identity=40.46875, Blast_Score=467, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6322112, Length=651, Percent_Identity=39.7849462365591, Blast_Score=465, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6322654, Length=396, Percent_Identity=36.1111111111111, Blast_Score=247, Evalue=5e-66,
Organism=Drosophila melanogaster, GI24583842, Length=636, Percent_Identity=39.3081761006289, Blast_Score=484, Evalue=1e-136,
Organism=Drosophila melanogaster, GI28574141, Length=636, Percent_Identity=39.3081761006289, Blast_Score=484, Evalue=1e-136,
Organism=Drosophila melanogaster, GI24583839, Length=636, Percent_Identity=39.3081761006289, Blast_Score=483, Evalue=1e-136,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 73182; Mature: 73051

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNIQITLPDGSTQSVAAETRPIDIAKSISPRLADAALVAKVNGELFDLTRPIEKDATLE
CCCEEEECCCCCCCCCCCCCCCCHHHHHCCCHHHHHHEEEECCCCEEECCCCCCCCCEEE
ILTAKNPESLDVYRHSTAHLLAAAVLELYPETQLGIGPPIENGFYYDFDRPAPFTPEDLE
EEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHH
KIEKKMWEIQARALPYERVLTPKDEGLKKYSEAWMKCQLIDERAGEIFTEYTLGPKFIDF
HHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHEEHHHHHHHCCEEHHHCCCHHHHHH
CRGPHLPDTSKIKAFKLLSIAGAYWKGDEKNKQLQRIYGTAFFSPKDLDAYLKQVEEAKK
HCCCCCCCCCCHHHHHHHHHHCHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
RDHRKLGKELDLFSIQELAGPGLIFFHPKGGIIRKLLEDWMRDQYLKRGYSLVYTPHVAK
HHHHHHCCCCCHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEECCCEEE
LDLWKTSGHANFYAQNMFTPIELDDAEYQLKPMNCPFHILIYADRQRSYRDLPVRLGELG
EEEEECCCCCCEEHHCCCCCEEECCCCEEEEECCCCEEEEEEECCCCCCCCCCEECCCCC
TVYRYERSGTLNGLFRVRGFTQDDAHIFCMQSQAEEEVVNCLQFAIDTLAAYGFEKYDAE
CEEEEECCCCCCEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCHHHCCE
ISTWDGGASGKYDGTPDQWEMAEGALRRAVDKLKINAKVVADEAAFYGPKIDVKLVDAIG
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHCCCCCCEEEHHHCC
RKWQLSTVQFDFTLPRRFGLEYIGEDGKAHQPIMVHRALYGSIERFFGILVEHYAGAFPV
CEEEEEEEEEEEECCHHHCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCE
WLAPVQATILPITDRQTEYARGIKKQLEEAGIRATVDERNEKVNLKIRDAQMQKIPYMLV
EEECCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEECCHHHHCCEEEE
VGDREQESGKVAVRNRKHADQGVKTLADFIAEIRALIESKAVSE
ECCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SNIQITLPDGSTQSVAAETRPIDIAKSISPRLADAALVAKVNGELFDLTRPIEKDATLE
CCEEEECCCCCCCCCCCCCCCCHHHHHCCCHHHHHHEEEECCCCEEECCCCCCCCCEEE
ILTAKNPESLDVYRHSTAHLLAAAVLELYPETQLGIGPPIENGFYYDFDRPAPFTPEDLE
EEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHH
KIEKKMWEIQARALPYERVLTPKDEGLKKYSEAWMKCQLIDERAGEIFTEYTLGPKFIDF
HHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHEEHHHHHHHCCEEHHHCCCHHHHHH
CRGPHLPDTSKIKAFKLLSIAGAYWKGDEKNKQLQRIYGTAFFSPKDLDAYLKQVEEAKK
HCCCCCCCCCCHHHHHHHHHHCHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
RDHRKLGKELDLFSIQELAGPGLIFFHPKGGIIRKLLEDWMRDQYLKRGYSLVYTPHVAK
HHHHHHCCCCCHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEECCCEEE
LDLWKTSGHANFYAQNMFTPIELDDAEYQLKPMNCPFHILIYADRQRSYRDLPVRLGELG
EEEEECCCCCCEEHHCCCCCEEECCCCEEEEECCCCEEEEEEECCCCCCCCCCEECCCCC
TVYRYERSGTLNGLFRVRGFTQDDAHIFCMQSQAEEEVVNCLQFAIDTLAAYGFEKYDAE
CEEEEECCCCCCEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCHHHCCE
ISTWDGGASGKYDGTPDQWEMAEGALRRAVDKLKINAKVVADEAAFYGPKIDVKLVDAIG
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHCCCCCCEEEHHHCC
RKWQLSTVQFDFTLPRRFGLEYIGEDGKAHQPIMVHRALYGSIERFFGILVEHYAGAFPV
CEEEEEEEEEEEECCHHHCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCE
WLAPVQATILPITDRQTEYARGIKKQLEEAGIRATVDERNEKVNLKIRDAQMQKIPYMLV
EEECCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEECCHHHHCCEEEE
VGDREQESGKVAVRNRKHADQGVKTLADFIAEIRALIESKAVSE
ECCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA