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The map label for this gene is yrkH [H]

Identifier: 116626312

GI number: 116626312

Start: 9126740

End: 9128137

Strand: Direct

Name: yrkH [H]

Synonym: Acid_7272

Alternate gene names: 116626312

Gene position: 9126740-9128137 (Clockwise)

Preceding gene: 116626306

Following gene: 116626317

Centisome position: 91.58

GC content: 65.52

Gene sequence:

>1398_bases
ATGTACTTCCAACAGTTCTATCTCGGATGCCTGTCTCATGCTTCTTACGTGATCGGTTCTGGCGGCATCGCCGCCGTTGT
GGACCCGCAGCGCGACGTCGGCATCTACATCGAAGACGCCGTCAAACACGGCCTCCGCATCGCCCACGTGGTTGAAACCC
ATCTGCATGCCGATTTCATTTCCGGCCACCAGGAACTGGCAACGCTCACCGGCGCGGACATCTACCTGGGCGCCGAGGCC
GGCGCTGCGTTCCCGCACGTTCCGGTGCGCGACGGCGACGAACTCCGCTTCGGCAACTGCGTGCTCCGCTTCCTGGAGAC
TCCGGGCCACACCCTCGAAAGCATCTCGATCCTGGTCACCGACCTCGAACGGTCGCCCGATCCTTATGCGGTGCTCACCG
GCGACACGCTCTTCATCGGCGATGTGGGGCGCCCCGATCTCGCCCCCAATCACACACCGCAGCAGCTCGCAGGCATGCTT
TACGAGAGTTTGCAGAAGAAACTGCTGACTTTGCCCGACGGCGTGGAGGTTTATCCCGCGCACGGCGCCGGGTCCCTCTG
CGGCCGGCAGATGAGCGCCGAGCGCAGCTCCACCATCGGCCAGCAGCGCACCGCCAATTTCGCGCTGCAGGCCAAATCCA
AGGAAGACTTCGTACGCCTGTTGACCGCCGAATTGCCCGAGCGGCCCGGCTACTTCGCGCTCGATGCCGAGCTCAACCGC
TCCGGCCCCGCGCCGCTTGCCGATCTCCCGGTGCCTGCCGCTTTGCTCGCCAAAGAGGTGCTCGCGATGCAGAAGGATGG
GGTGCTGGTGCTCGATACCCGCCCCACCAGCCAGTTCGGCGGCGCGCACATTCCGGGCGCGATTCACGTCGGGCTCGCCG
GGCAGTTCGCCTCGTGGGCCGCGCGCCTGATCGGGCTGCAGGCCAAGATCATTCTGGTCGCCGAAGAGCGCGATGCCATG
CTGGATGCGCGCACCCGGCTGGCGCGCGTCGGCCTCGAAAACGTCGCCGGATATCTGGAGGACGGCATGACGGCGTGGTT
CCGCGAAGGCCTCCCGGTGGACCAGGTGCCGCAGGTCACCGTGCAGGACCTCCATCGCGAAATCGCCCATGTGCAGGTGA
TCGATGTGCGTCAACCGGGAGAATGGGAACAGGGCCACATCGCGCAGGCCACACACCGCCCGCTGCCCAAGATTCCCGGC
AACCTGGACGGACTGGACCGCGACCAGGCGGTGGCCGTGCACTGCAAATCCGGCTATCGCAGTTCCATCGCCACCAGCCT
GTTGAAGCGCGAAGGCTTCAAAAACGTCATGAACGTGATCGGCGGCTACGACGCCTGGGTGGCCTGCGGCCTGCCGGTAG
TGCAGGCGGAACCTTCACCTCAGAGCGCAGGCACGTAG

Upstream 100 bases:

>100_bases
TTGTTTGGCCAATTCGCATGATACATCACCTTGGCAGGCTTGATATCACCTTGACAGGCTTCACGCCGCACCACCACAAT
GGACCCTGCGAGGGGCGCTC

Downstream 100 bases:

>100_bases
GTGCGGAGGAAGCGGGAAGCGTAGTCGGGGACGATGGCGGGCTGGTCGCCGGATTCAGGGAGGAGCCAGACTTCGCCGGG
TTGATAACCTTCGCCGCCGA

Product: beta-lactamase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MYFQQFYLGCLSHASYVIGSGGIAAVVDPQRDVGIYIEDAVKHGLRIAHVVETHLHADFISGHQELATLTGADIYLGAEA
GAAFPHVPVRDGDELRFGNCVLRFLETPGHTLESISILVTDLERSPDPYAVLTGDTLFIGDVGRPDLAPNHTPQQLAGML
YESLQKKLLTLPDGVEVYPAHGAGSLCGRQMSAERSSTIGQQRTANFALQAKSKEDFVRLLTAELPERPGYFALDAELNR
SGPAPLADLPVPAALLAKEVLAMQKDGVLVLDTRPTSQFGGAHIPGAIHVGLAGQFASWAARLIGLQAKIILVAEERDAM
LDARTRLARVGLENVAGYLEDGMTAWFREGLPVDQVPQVTVQDLHREIAHVQVIDVRQPGEWEQGHIAQATHRPLPKIPG
NLDGLDRDQAVAVHCKSGYRSSIATSLLKREGFKNVMNVIGGYDAWVACGLPVVQAEPSPQSAGT

Sequences:

>Translated_465_residues
MYFQQFYLGCLSHASYVIGSGGIAAVVDPQRDVGIYIEDAVKHGLRIAHVVETHLHADFISGHQELATLTGADIYLGAEA
GAAFPHVPVRDGDELRFGNCVLRFLETPGHTLESISILVTDLERSPDPYAVLTGDTLFIGDVGRPDLAPNHTPQQLAGML
YESLQKKLLTLPDGVEVYPAHGAGSLCGRQMSAERSSTIGQQRTANFALQAKSKEDFVRLLTAELPERPGYFALDAELNR
SGPAPLADLPVPAALLAKEVLAMQKDGVLVLDTRPTSQFGGAHIPGAIHVGLAGQFASWAARLIGLQAKIILVAEERDAM
LDARTRLARVGLENVAGYLEDGMTAWFREGLPVDQVPQVTVQDLHREIAHVQVIDVRQPGEWEQGHIAQATHRPLPKIPG
NLDGLDRDQAVAVHCKSGYRSSIATSLLKREGFKNVMNVIGGYDAWVACGLPVVQAEPSPQSAGT
>Mature_465_residues
MYFQQFYLGCLSHASYVIGSGGIAAVVDPQRDVGIYIEDAVKHGLRIAHVVETHLHADFISGHQELATLTGADIYLGAEA
GAAFPHVPVRDGDELRFGNCVLRFLETPGHTLESISILVTDLERSPDPYAVLTGDTLFIGDVGRPDLAPNHTPQQLAGML
YESLQKKLLTLPDGVEVYPAHGAGSLCGRQMSAERSSTIGQQRTANFALQAKSKEDFVRLLTAELPERPGYFALDAELNR
SGPAPLADLPVPAALLAKEVLAMQKDGVLVLDTRPTSQFGGAHIPGAIHVGLAGQFASWAARLIGLQAKIILVAEERDAM
LDARTRLARVGLENVAGYLEDGMTAWFREGLPVDQVPQVTVQDLHREIAHVQVIDVRQPGEWEQGHIAQATHRPLPKIPG
NLDGLDRDQAVAVHCKSGYRSSIATSLLKREGFKNVMNVIGGYDAWVACGLPVVQAEPSPQSAGT

Specific function: Unknown

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI41327741, Length=199, Percent_Identity=30.6532663316583, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17538952, Length=255, Percent_Identity=27.4509803921569, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221330176, Length=258, Percent_Identity=30.2325581395349, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR001763 [H]

Pfam domain/function: PF00753 Lactamase_B; PF00581 Rhodanese [H]

EC number: NA

Molecular weight: Translated: 50076; Mature: 50076

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00380 RHODANESE_1 ; PS50206 RHODANESE_3 ; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYFQQFYLGCLSHASYVIGSGGIAAVVDPQRDVGIYIEDAVKHGLRIAHVVETHLHADFI
CCHHHHHHHHHHHHCEEEECCCEEEEECCCCCCCEEEEHHHHCCCEEHHHHHHHHHHHHH
SGHQELATLTGADIYLGAEAGAAFPHVPVRDGDELRFGNCVLRFLETPGHTLESISILVT
CCHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHCCCCCHHHHEEEEE
DLERSPDPYAVLTGDTLFIGDVGRPDLAPNHTPQQLAGMLYESLQKKLLTLPDGVEVYPA
ECCCCCCCEEEEECCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEC
HGAGSLCGRQMSAERSSTIGQQRTANFALQAKSKEDFVRLLTAELPERPGYFALDAELNR
CCCHHHHHHHHHHHHHHHCCHHHCCCEEEEECCHHHHHHHHHHHCCCCCCEEEEECCCCC
SGPAPLADLPVPAALLAKEVLAMQKDGVLVLDTRPTSQFGGAHIPGAIHVGLAGQFASWA
CCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHCCCCCCCCEEEECCCCHHHHHH
ARLIGLQAKIILVAEERDAMLDARTRLARVGLENVAGYLEDGMTAWFREGLPVDQVPQVT
HHHHCCEEEEEEEECCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
VQDLHREIAHVQVIDVRQPGEWEQGHIAQATHRPLPKIPGNLDGLDRDQAVAVHCKSGYR
HHHHHHHHHEEEEEECCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCH
SSIATSLLKREGFKNVMNVIGGYDAWVACGLPVVQAEPSPQSAGT
HHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEECCCCCCCCCC
>Mature Secondary Structure
MYFQQFYLGCLSHASYVIGSGGIAAVVDPQRDVGIYIEDAVKHGLRIAHVVETHLHADFI
CCHHHHHHHHHHHHCEEEECCCEEEEECCCCCCCEEEEHHHHCCCEEHHHHHHHHHHHHH
SGHQELATLTGADIYLGAEAGAAFPHVPVRDGDELRFGNCVLRFLETPGHTLESISILVT
CCHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHCCCCCHHHHEEEEE
DLERSPDPYAVLTGDTLFIGDVGRPDLAPNHTPQQLAGMLYESLQKKLLTLPDGVEVYPA
ECCCCCCCEEEEECCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEC
HGAGSLCGRQMSAERSSTIGQQRTANFALQAKSKEDFVRLLTAELPERPGYFALDAELNR
CCCHHHHHHHHHHHHHHHCCHHHCCCEEEEECCHHHHHHHHHHHCCCCCCEEEEECCCCC
SGPAPLADLPVPAALLAKEVLAMQKDGVLVLDTRPTSQFGGAHIPGAIHVGLAGQFASWA
CCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHCCCCCCCCEEEECCCCHHHHHH
ARLIGLQAKIILVAEERDAMLDARTRLARVGLENVAGYLEDGMTAWFREGLPVDQVPQVT
HHHHCCEEEEEEEECCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
VQDLHREIAHVQVIDVRQPGEWEQGHIAQATHRPLPKIPGNLDGLDRDQAVAVHCKSGYR
HHHHHHHHHEEEEEECCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCH
SSIATSLLKREGFKNVMNVIGGYDAWVACGLPVVQAEPSPQSAGT
HHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]