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The map label for this gene is typA [H]

Identifier: 116626294

GI number: 116626294

Start: 9105490

End: 9107286

Strand: Direct

Name: typA [H]

Synonym: Acid_7254

Alternate gene names: 116626294

Gene position: 9105490-9107286 (Clockwise)

Preceding gene: 116626293

Following gene: 116626295

Centisome position: 91.37

GC content: 61.27

Gene sequence:

>1797_bases
ATGAAAAGCAGCAATCCAAAGATTCGCAACATCGCCATCATCGCCCACGTCGATCACGGCAAGACCACTCTCGTCGATGC
CATGCTCAATCAGAGCGGTATCTTCGGCTCCCACGAGGAGCACGTTGACCGCGTCATGGATTCCAACGACCTGGAACGCG
AACGCGGCATCACCATCCTGGCCAAGATCACCGGCGTGCGTTATCACGGCGTGAAGATCAACATCGTCGATACCCCCGGC
CACGCGGATTTCGGCGGCGAAGTCGAGCGCGCCCTCAAAATCGTCGATGGCGTCATGCTCCTCGTCGATGCCAGCGAAGG
CCCTCTCCCCCAGACCCGCTACGTCCTCAGCAAGGCGCTCGAAGCCAAGCTCACCCCCATCGTCGTCATCAACAAGATCG
ATCGCCCCGACGCCCGCGTCGCGGAAGTTCTCAACGAAATCTACGATCTCTTCATCGATCTCGACGCCCACGAAGACCAG
CTCGATTTCCCCGTCCTCTATGCCATCGCCAAAAATGGCATCGCCAAGGCCACGATGGAAGATGAGTCCACCGACCTGCG
CCCGCTCTTCGATGCCATCGTCAAAACCATCCCGCCGCCCGTCGGCGACCCCGAGGGCACCCTCCAGATGCTCATCGCCA
ATCTGGATTACAGCGATTACCTCGGCCGCCTCGGTATCGGCCGCGTCGTCAACGGCACCCTCCGGTACGGCGACATGGTC
AGCATCGCCAAACTCGATGGCTCGATGCACACCACCAAAATCACCAAGATGTATTCCTTCGAAGGCCTGAAGCGCATCGA
TGAAACGGTCGGCGCCCAGGGCGACATCCTCGCCATCGCCGGCGTCGAAGGCATCACCATCGGCGAGACCGTCACCAGCG
CCGAGAACCCCGACCCGCTCCCGCCCATCCAGATCGATGAGCCTACCATCGCGATGGCCTTCTCGATCAACACCTCGCCC
TTCGCCGGCCGCGAAGGTCAGTGGGTCACCTCGCGCAACCTGCGCGACCGCCTCGATAAGGAACTGCTCACCAACGTCTC
CATCAAAGTCGAAGAGATCGGCCACGACACCTTCAAAGTCATGGGCCGCGGCGAATTGCAGCTCGCTATCCTCATCGAGA
TGATGCGCCGCGAAGGCTTCGAGCTCGCCGTCGGCAAACCCGAAATTCTCACCCGCACCATCGATCATCAGCTCCAGGAG
CCCGTCGAGCACCTGATTGTCGATTGCCCCGAGAACTTCCTCGGCGTCGTCATCGAAAAGCTTGGCGTCCGCAAGGGCAA
GATGACCAAGATGATCAACCACGGCTCCGGCCGCGTGCGACTCGAGTTCCACGTTCCCTCGCGCGGCCTGATCGGGCTGC
GCAGCGAAATCCTCACCGATACCCGCGGCACCGCCATCATGAACTCGCTCTTCCACGGCTACATCCCGTGGCAGGGCGAC
ATCCCCTCCCGTCCCACCGGTTCGCTGGTCGCCGACCGCGCCGGCAAAACCACCGGCTACGCCATCTTCAACCTCCAGGA
ACGCGGCGAGATCTTCGTCAGTCCCGGCACCGAAGTCTACGAGGGCATGATCGTCGGCGAAAACGCCCGCGATGCCGATC
TCGACGTCAACATCGTCAAGGAAAAGAAGCTCACTAACATGCGCGCCTCCACCTCCGACGAAGGCATCCGCCTCGTCCCC
CCGCGCATTCTGAACCTCGAACAGGCCATCGAATTCATCCGCGACGACGAATTCGTCGAGGTCACCCCGGTCAGCATCCG
CCTCCGCAAAAAGGTCCTGAAGTCCAACCAGCGCTAA

Upstream 100 bases:

>100_bases
CGCATCGGCCTGCGGGTTCCCGCGCATGATAAACTAATGGTTCAGCCCCATCGCCTCGCGCCTGGCGCTCGCCCCTCAAC
TTCCGATCAAAAGTGAATTC

Downstream 100 bases:

>100_bases
GAACTTCCTTTTCTTATGGAGTGAACCCCAAAAGTGAGACAGGAGGAATAGACGCACTTTGCATCGAATGGAGGCAAAAT
GGCCAAGATGAAAAAGTGGC

Product: GTP-binding protein TypA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 598; Mature: 598

Protein sequence:

>598_residues
MKSSNPKIRNIAIIAHVDHGKTTLVDAMLNQSGIFGSHEEHVDRVMDSNDLERERGITILAKITGVRYHGVKINIVDTPG
HADFGGEVERALKIVDGVMLLVDASEGPLPQTRYVLSKALEAKLTPIVVINKIDRPDARVAEVLNEIYDLFIDLDAHEDQ
LDFPVLYAIAKNGIAKATMEDESTDLRPLFDAIVKTIPPPVGDPEGTLQMLIANLDYSDYLGRLGIGRVVNGTLRYGDMV
SIAKLDGSMHTTKITKMYSFEGLKRIDETVGAQGDILAIAGVEGITIGETVTSAENPDPLPPIQIDEPTIAMAFSINTSP
FAGREGQWVTSRNLRDRLDKELLTNVSIKVEEIGHDTFKVMGRGELQLAILIEMMRREGFELAVGKPEILTRTIDHQLQE
PVEHLIVDCPENFLGVVIEKLGVRKGKMTKMINHGSGRVRLEFHVPSRGLIGLRSEILTDTRGTAIMNSLFHGYIPWQGD
IPSRPTGSLVADRAGKTTGYAIFNLQERGEIFVSPGTEVYEGMIVGENARDADLDVNIVKEKKLTNMRASTSDEGIRLVP
PRILNLEQAIEFIRDDEFVEVTPVSIRLRKKVLKSNQR

Sequences:

>Translated_598_residues
MKSSNPKIRNIAIIAHVDHGKTTLVDAMLNQSGIFGSHEEHVDRVMDSNDLERERGITILAKITGVRYHGVKINIVDTPG
HADFGGEVERALKIVDGVMLLVDASEGPLPQTRYVLSKALEAKLTPIVVINKIDRPDARVAEVLNEIYDLFIDLDAHEDQ
LDFPVLYAIAKNGIAKATMEDESTDLRPLFDAIVKTIPPPVGDPEGTLQMLIANLDYSDYLGRLGIGRVVNGTLRYGDMV
SIAKLDGSMHTTKITKMYSFEGLKRIDETVGAQGDILAIAGVEGITIGETVTSAENPDPLPPIQIDEPTIAMAFSINTSP
FAGREGQWVTSRNLRDRLDKELLTNVSIKVEEIGHDTFKVMGRGELQLAILIEMMRREGFELAVGKPEILTRTIDHQLQE
PVEHLIVDCPENFLGVVIEKLGVRKGKMTKMINHGSGRVRLEFHVPSRGLIGLRSEILTDTRGTAIMNSLFHGYIPWQGD
IPSRPTGSLVADRAGKTTGYAIFNLQERGEIFVSPGTEVYEGMIVGENARDADLDVNIVKEKKLTNMRASTSDEGIRLVP
PRILNLEQAIEFIRDDEFVEVTPVSIRLRKKVLKSNQR
>Mature_598_residues
MKSSNPKIRNIAIIAHVDHGKTTLVDAMLNQSGIFGSHEEHVDRVMDSNDLERERGITILAKITGVRYHGVKINIVDTPG
HADFGGEVERALKIVDGVMLLVDASEGPLPQTRYVLSKALEAKLTPIVVINKIDRPDARVAEVLNEIYDLFIDLDAHEDQ
LDFPVLYAIAKNGIAKATMEDESTDLRPLFDAIVKTIPPPVGDPEGTLQMLIANLDYSDYLGRLGIGRVVNGTLRYGDMV
SIAKLDGSMHTTKITKMYSFEGLKRIDETVGAQGDILAIAGVEGITIGETVTSAENPDPLPPIQIDEPTIAMAFSINTSP
FAGREGQWVTSRNLRDRLDKELLTNVSIKVEEIGHDTFKVMGRGELQLAILIEMMRREGFELAVGKPEILTRTIDHQLQE
PVEHLIVDCPENFLGVVIEKLGVRKGKMTKMINHGSGRVRLEFHVPSRGLIGLRSEILTDTRGTAIMNSLFHGYIPWQGD
IPSRPTGSLVADRAGKTTGYAIFNLQERGEIFVSPGTEVYEGMIVGENARDADLDVNIVKEKKLTNMRASTSDEGIRLVP
PRILNLEQAIEFIRDDEFVEVTPVSIRLRKKVLKSNQR

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=366, Percent_Identity=30.327868852459, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI94966754, Length=139, Percent_Identity=43.8848920863309, Blast_Score=123, Evalue=6e-28,
Organism=Homo sapiens, GI18390331, Length=148, Percent_Identity=44.5945945945946, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI4503483, Length=160, Percent_Identity=35.625, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI25306283, Length=178, Percent_Identity=35.3932584269663, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI310132016, Length=117, Percent_Identity=41.8803418803419, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI310110807, Length=117, Percent_Identity=41.8803418803419, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI310123363, Length=117, Percent_Identity=41.8803418803419, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI19923640, Length=178, Percent_Identity=35.3932584269663, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI25306287, Length=178, Percent_Identity=35.3932584269663, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI217272894, Length=139, Percent_Identity=37.410071942446, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI217272892, Length=139, Percent_Identity=37.410071942446, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI94966752, Length=135, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=8e-15,
Organism=Homo sapiens, GI34147630, Length=236, Percent_Identity=33.0508474576271, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI48994988, Length=594, Percent_Identity=52.6936026936027, Blast_Score=625, Evalue=1e-180,
Organism=Escherichia coli, GI1788922, Length=502, Percent_Identity=30.0796812749004, Blast_Score=165, Evalue=7e-42,
Organism=Escherichia coli, GI1789738, Length=150, Percent_Identity=38.6666666666667, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1790835, Length=148, Percent_Identity=32.4324324324324, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789737, Length=131, Percent_Identity=35.1145038167939, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1790412, Length=131, Percent_Identity=35.1145038167939, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17557151, Length=321, Percent_Identity=29.9065420560748, Blast_Score=135, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17556745, Length=131, Percent_Identity=41.9847328244275, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17533571, Length=137, Percent_Identity=45.2554744525547, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17506493, Length=172, Percent_Identity=31.9767441860465, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71988811, Length=141, Percent_Identity=37.5886524822695, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71988819, Length=128, Percent_Identity=39.84375, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17552882, Length=134, Percent_Identity=34.3283582089552, Blast_Score=89, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI71994658, Length=131, Percent_Identity=37.4045801526718, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17556456, Length=289, Percent_Identity=28.719723183391, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323320, Length=511, Percent_Identity=26.614481409002, Blast_Score=133, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6324707, Length=162, Percent_Identity=38.2716049382716, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6320593, Length=162, Percent_Identity=38.2716049382716, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6322359, Length=154, Percent_Identity=40.2597402597403, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323098, Length=141, Percent_Identity=43.2624113475177, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324166, Length=183, Percent_Identity=36.0655737704918, Blast_Score=94, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6324761, Length=269, Percent_Identity=29.7397769516729, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322937, Length=208, Percent_Identity=25.9615384615385, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI78706572, Length=532, Percent_Identity=27.0676691729323, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI28574573, Length=138, Percent_Identity=40.5797101449275, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24585711, Length=164, Percent_Identity=34.1463414634146, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24585713, Length=164, Percent_Identity=34.1463414634146, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24585709, Length=164, Percent_Identity=34.1463414634146, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24582462, Length=146, Percent_Identity=42.4657534246575, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21357743, Length=136, Percent_Identity=39.7058823529412, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI221458488, Length=166, Percent_Identity=39.7590361445783, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28572034, Length=263, Percent_Identity=26.2357414448669, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI281363316, Length=239, Percent_Identity=29.7071129707113, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17864358, Length=239, Percent_Identity=29.7071129707113, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI19921738, Length=252, Percent_Identity=30.1587301587302, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 66112; Mature: 66112

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSSNPKIRNIAIIAHVDHGKTTLVDAMLNQSGIFGSHEEHVDRVMDSNDLERERGITIL
CCCCCCCEEEEEEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHCCCEEE
AKITGVRYHGVKINIVDTPGHADFGGEVERALKIVDGVMLLVDASEGPLPQTRYVLSKAL
EEECCEEEECEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHH
EAKLTPIVVINKIDRPDARVAEVLNEIYDLFIDLDAHEDQLDFPVLYAIAKNGIAKATME
HHCCCCEEEEECCCCCHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHCCCEEEECC
DESTDLRPLFDAIVKTIPPPVGDPEGTLQMLIANLDYSDYLGRLGIGRVVNGTLRYGDMV
CCCCCHHHHHHHHHHHCCCCCCCCCHHHHHEEECCCHHHHHHHCCCCHHCCCEECCCCEE
SIAKLDGSMHTTKITKMYSFEGLKRIDETVGAQGDILAIAGVEGITIGETVTSAENPDPL
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEECCEECCCCCCCCC
PPIQIDEPTIAMAFSINTSPFAGREGQWVTSRNLRDRLDKELLTNVSIKVEEIGHDTFKV
CCEEECCCCEEEEEEECCCCCCCCCCCEEECCCHHHHHHHHHHHCCCEEEEECCCCEEEE
MGRGELQLAILIEMMRREGFELAVGKPEILTRTIDHQLQEPVEHLIVDCPENFLGVVIEK
ECCCCCHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LGVRKGKMTKMINHGSGRVRLEFHVPSRGLIGLRSEILTDTRGTAIMNSLFHGYIPWQGD
HCCCCCHHHHHEECCCCEEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCC
IPSRPTGSLVADRAGKTTGYAIFNLQERGEIFVSPGTEVYEGMIVGENARDADLDVNIVK
CCCCCCCCHHHHCCCCCCCEEEEEEECCCCEEECCCHHHHCCEEECCCCCCCCCEEEEEC
EKKLTNMRASTSDEGIRLVPPRILNLEQAIEFIRDDEFVEVTPVSIRLRKKVLKSNQR
HHHHHCCCCCCCCCCEEECCHHHCCHHHHHHHHCCCCEEEEECHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKSSNPKIRNIAIIAHVDHGKTTLVDAMLNQSGIFGSHEEHVDRVMDSNDLERERGITIL
CCCCCCCEEEEEEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHCCCEEE
AKITGVRYHGVKINIVDTPGHADFGGEVERALKIVDGVMLLVDASEGPLPQTRYVLSKAL
EEECCEEEECEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHH
EAKLTPIVVINKIDRPDARVAEVLNEIYDLFIDLDAHEDQLDFPVLYAIAKNGIAKATME
HHCCCCEEEEECCCCCHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHCCCEEEECC
DESTDLRPLFDAIVKTIPPPVGDPEGTLQMLIANLDYSDYLGRLGIGRVVNGTLRYGDMV
CCCCCHHHHHHHHHHHCCCCCCCCCHHHHHEEECCCHHHHHHHCCCCHHCCCEECCCCEE
SIAKLDGSMHTTKITKMYSFEGLKRIDETVGAQGDILAIAGVEGITIGETVTSAENPDPL
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEECCEECCCCCCCCC
PPIQIDEPTIAMAFSINTSPFAGREGQWVTSRNLRDRLDKELLTNVSIKVEEIGHDTFKV
CCEEECCCCEEEEEEECCCCCCCCCCCEEECCCHHHHHHHHHHHCCCEEEEECCCCEEEE
MGRGELQLAILIEMMRREGFELAVGKPEILTRTIDHQLQEPVEHLIVDCPENFLGVVIEK
ECCCCCHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LGVRKGKMTKMINHGSGRVRLEFHVPSRGLIGLRSEILTDTRGTAIMNSLFHGYIPWQGD
HCCCCCHHHHHEECCCCEEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCC
IPSRPTGSLVADRAGKTTGYAIFNLQERGEIFVSPGTEVYEGMIVGENARDADLDVNIVK
CCCCCCCCHHHHCCCCCCCEEEEEEECCCCEEECCCHHHHCCEEECCCCCCCCCEEEEEC
EKKLTNMRASTSDEGIRLVPPRILNLEQAIEFIRDDEFVEVTPVSIRLRKKVLKSNQR
HHHHHCCCCCCCCCCEEECCHHHCCHHHHHHHHCCCCEEEEECHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]