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The map label for this gene is lldD [H]

Identifier: 116626283

GI number: 116626283

Start: 9093621

End: 9094718

Strand: Direct

Name: lldD [H]

Synonym: Acid_7243

Alternate gene names: 116626283

Gene position: 9093621-9094718 (Clockwise)

Preceding gene: 116626282

Following gene: 116626288

Centisome position: 91.25

GC content: 67.12

Gene sequence:

>1098_bases
ATGATCGACCCGCCAATGATCACGCGCCGCGGTGCCATGCTCTCCGCCGTCGCCGCCGCCCTCGCGCGCGGCCAGAGCGG
CATGGAAAAGCTCCTCTCCCTCTACGATTTTGAGACCGAGGCACACACTAAAATCTCCCACGGCGCCTGGGAGCGGATCT
CCGGCGGCGCCGCTGACGAGATCACCCTCCGCTGGAATCGCGAGGCCTACGACCACATCCGCCTCAAGCCGCGCGTGCTC
GTCGATGTCTCGAAAATCGATACGCGCGTCAATTTGCTCGGCGCCGAACTGCCCTTCCCCATCCTGCTCGCGCCTACCGG
CGGACAGGGCTTCATTCATCCCGATGGCGATGCCGCCGCAGCCCGCGGCGCCGCGGCCGCGCACGCGACCTACGTGATCT
CCAGCAGCGCCTCCATGCGCGTGGAAGACGTGGCCCGCGCCTCCACCGGCACCGTCTGGTTCCAGCTCTACGTGCAGAAG
GACCGCGGCTTCACCCGCGAAATGGTGCGCCGCGCCGAAGACGCCGGATGCCGCGCCCTGTGTGTCACGGTGGATTCGCC
CACCTTCGGCCTGCGCAATCGCGAAGAGCGCGCTAAGGGCGAGCTTCCCGAACGCCAGCTACCCAATCTTCAAGGGAAGG
ACTATCTGGACCCCAGCCTCACCTGGAAAGATATCGAGTGGCTGCAAGGCATCGCGCGTCGCCCCGTGCTCCTCAAAGGC
ATCCTCAATCCCGACGATGCCGCCATCGCTGCCAAAGCCGGCGCCTCCGGCATCGTCGTCTCCAACCACGGCGCCCGCAA
TCTAGACACCGTCCCCGCTACGATCGATGCCCTACCCCTGGTCGTGGAAAAAGTGGCCGGCCGCGCCCCCGTGATCGTCG
ATGGTGGCATCCGCCGCGGCACCGACGTCATCAAGGCCCTCGCGCTCGGCGCCGCTGCCGTCCAGATCGGCCGTCCCTAC
CTCTGGGGCCTCGGTGTCTCCGGTGCTGAAGGCGTCACGCGCGTCGTCGAGATCCTGCGCAAGGAACTCGAACTCGCCAT
GGCCCTGATGGGCCGCCCCACGATCGCTTCCATCACGCGTTCCGCCCTGTGGCCCTGA

Upstream 100 bases:

>100_bases
GTGACGACCAGATCGCCGTCATCGATCTCAAGACTCTCCAGGTCACCGGCCACCTCACCACCGGCAAAGGCCCCGACGGC
ATGGCTTGGGCAGTCCGCCA

Downstream 100 bases:

>100_bases
CGCTACTCGAACGAGTCACATCACCGCAATCCCAACCCGCCGCGAACCGCGACCGTCAGGGAGCGATCTACAGTTCTCAC
TGCGCCCGCAAGCTCCGTCG

Product: FMN-dependent alpha-hydroxy acid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MIDPPMITRRGAMLSAVAAALARGQSGMEKLLSLYDFETEAHTKISHGAWERISGGAADEITLRWNREAYDHIRLKPRVL
VDVSKIDTRVNLLGAELPFPILLAPTGGQGFIHPDGDAAAARGAAAAHATYVISSSASMRVEDVARASTGTVWFQLYVQK
DRGFTREMVRRAEDAGCRALCVTVDSPTFGLRNREERAKGELPERQLPNLQGKDYLDPSLTWKDIEWLQGIARRPVLLKG
ILNPDDAAIAAKAGASGIVVSNHGARNLDTVPATIDALPLVVEKVAGRAPVIVDGGIRRGTDVIKALALGAAAVQIGRPY
LWGLGVSGAEGVTRVVEILRKELELAMALMGRPTIASITRSALWP

Sequences:

>Translated_365_residues
MIDPPMITRRGAMLSAVAAALARGQSGMEKLLSLYDFETEAHTKISHGAWERISGGAADEITLRWNREAYDHIRLKPRVL
VDVSKIDTRVNLLGAELPFPILLAPTGGQGFIHPDGDAAAARGAAAAHATYVISSSASMRVEDVARASTGTVWFQLYVQK
DRGFTREMVRRAEDAGCRALCVTVDSPTFGLRNREERAKGELPERQLPNLQGKDYLDPSLTWKDIEWLQGIARRPVLLKG
ILNPDDAAIAAKAGASGIVVSNHGARNLDTVPATIDALPLVVEKVAGRAPVIVDGGIRRGTDVIKALALGAAAVQIGRPY
LWGLGVSGAEGVTRVVEILRKELELAMALMGRPTIASITRSALWP
>Mature_365_residues
MIDPPMITRRGAMLSAVAAALARGQSGMEKLLSLYDFETEAHTKISHGAWERISGGAADEITLRWNREAYDHIRLKPRVL
VDVSKIDTRVNLLGAELPFPILLAPTGGQGFIHPDGDAAAARGAAAAHATYVISSSASMRVEDVARASTGTVWFQLYVQK
DRGFTREMVRRAEDAGCRALCVTVDSPTFGLRNREERAKGELPERQLPNLQGKDYLDPSLTWKDIEWLQGIARRPVLLKG
ILNPDDAAIAAKAGASGIVVSNHGARNLDTVPATIDALPLVVEKVAGRAPVIVDGGIRRGTDVIKALALGAAAVQIGRPY
LWGLGVSGAEGVTRVVEILRKELELAMALMGRPTIASITRSALWP

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI54234014, Length=344, Percent_Identity=42.7325581395349, Blast_Score=271, Evalue=5e-73,
Organism=Homo sapiens, GI7705393, Length=344, Percent_Identity=42.7325581395349, Blast_Score=271, Evalue=5e-73,
Organism=Homo sapiens, GI11068137, Length=361, Percent_Identity=39.8891966759003, Blast_Score=260, Evalue=1e-69,
Organism=Escherichia coli, GI1790033, Length=368, Percent_Identity=34.7826086956522, Blast_Score=218, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI193208036, Length=353, Percent_Identity=37.6770538243626, Blast_Score=242, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI32566217, Length=270, Percent_Identity=34.8148148148148, Blast_Score=169, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6323587, Length=355, Percent_Identity=37.4647887323944, Blast_Score=238, Evalue=1e-63,
Organism=Drosophila melanogaster, GI281363140, Length=353, Percent_Identity=41.0764872521246, Blast_Score=276, Evalue=1e-74,
Organism=Drosophila melanogaster, GI78707190, Length=353, Percent_Identity=41.0764872521246, Blast_Score=276, Evalue=1e-74,
Organism=Drosophila melanogaster, GI78707188, Length=353, Percent_Identity=41.0764872521246, Blast_Score=276, Evalue=1e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 39214; Mature: 39214

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDPPMITRRGAMLSAVAAALARGQSGMEKLLSLYDFETEAHTKISHGAWERISGGAADE
CCCCCCCHHCHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHCCCCCCHHHHHCCCCCCE
ITLRWNREAYDHIRLKPRVLVDVSKIDTRVNLLGAELPFPILLAPTGGQGFIHPDGDAAA
EEEEECCCCHHHEECCCEEEEEHHHHHHHHEEEECCCCCCEEEECCCCCCCCCCCCCHHH
ARGAAAAHATYVISSSASMRVEDVARASTGTVWFQLYVQKDRGFTREMVRRAEDAGCRAL
HCCCHHHHEEEEEECCCCCHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHCCCCEEE
CVTVDSPTFGLRNREERAKGELPERQLPNLQGKDYLDPSLTWKDIEWLQGIARRPVLLKG
EEEECCCCCCCCCCHHHHHCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEE
ILNPDDAAIAAKAGASGIVVSNHGARNLDTVPATIDALPLVVEKVAGRAPVIVDGGIRRG
CCCCCCCCEEECCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCH
TDVIKALALGAAAVQIGRPYLWGLGVSGAEGVTRVVEILRKELELAMALMGRPTIASITR
HHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
SALWP
HHCCC
>Mature Secondary Structure
MIDPPMITRRGAMLSAVAAALARGQSGMEKLLSLYDFETEAHTKISHGAWERISGGAADE
CCCCCCCHHCHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHCCCCCCHHHHHCCCCCCE
ITLRWNREAYDHIRLKPRVLVDVSKIDTRVNLLGAELPFPILLAPTGGQGFIHPDGDAAA
EEEEECCCCHHHEECCCEEEEEHHHHHHHHEEEECCCCCCEEEECCCCCCCCCCCCCHHH
ARGAAAAHATYVISSSASMRVEDVARASTGTVWFQLYVQKDRGFTREMVRRAEDAGCRAL
HCCCHHHHEEEEEECCCCCHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHCCCCEEE
CVTVDSPTFGLRNREERAKGELPERQLPNLQGKDYLDPSLTWKDIEWLQGIARRPVLLKG
EEEECCCCCCCCCCHHHHHCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEE
ILNPDDAAIAAKAGASGIVVSNHGARNLDTVPATIDALPLVVEKVAGRAPVIVDGGIRRG
CCCCCCCCEEECCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCH
TDVIKALALGAAAVQIGRPYLWGLGVSGAEGVTRVVEILRKELELAMALMGRPTIASITR
HHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
SALWP
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA