Click here to switch to the map view.

The map label for this gene is ymxG [H]

Identifier: 116626241

GI number: 116626241

Start: 9045508

End: 9046794

Strand: Direct

Name: ymxG [H]

Synonym: Acid_7201

Alternate gene names: 116626241

Gene position: 9045508-9046794 (Clockwise)

Preceding gene: 116626238

Following gene: 116626242

Centisome position: 90.77

GC content: 61.54

Gene sequence:

>1287_bases
ATGACCTCATCTAACAATCCTTTACGCGATATCGAAATGACCACGCTCGCTAATGGCGTCCGCGTGATTACCGAGGCCAT
GCAGCACGTTCGTTCCGTGTCCGTGGGCATTTGGATCGGCGCGGGCTCGCGCCGGGAAACTACGGAGCAGAACGGTATCT
CCCACTTCATCGAGCACATGCTCTTCAAGGGGACCACCACCCGCTCCGCCGAAGACATCGCGCGCGCCGTGGACGCCCTC
GGCGGGAATCTCGATGCCTTCACCGCCAAAGAGCTGGTCTGCTTCAACACCAAGGTTCTCGACCAGCACCTCTCCCAGGC
CTTCGAGGTTTTGGCCGACCTGGTGCTCAATCCCATGTTCCGGGAGGAGGACATCGAGAAGGAGAAGGGCGTCATCCTCG
AGGAAATCAAGATGGAGGCGGACAGCCCGGACTACCTGGTCCACGAAATCTTCTCCTCAAACTTCTGGAAAGATCACCCT
CTCGGTAAACCGATCCTGGGTACTCCGCAGAGCGTCCGCCGCTTCGACAGCACCATGATCCGGGACTTCTACCGGTCCGT
GTACTCGCCGGCGAACATGGTGGTCACCGCCGCCGGGCACATGACCCATGAGGGCTTGACCGCGCTCGTCCAGCAATACT
TTGCTTCGCTGCCTCCCGGACCCGCGGCGCCGCCCGACCTCCAGCCCAGCACGCACGCGCGAATCGCTCTGCGCAACAAG
AAATCCCTGGAGCAGGTCCACCTTTGCCTCGGCGTCCCCTCGTATCCGCTGCCGCACGAAGAGCGCTTCGCCTGCTACGT
ACTCAATACCCTGCTGGGCGGAGGGATGAGTTCACGCCTTTTCCAAAACATCCGCGAGCGGCAGGGCTTGGCTTACGCCG
TCTTCAGCGAGCTGAATCCGTATCGCGACACCGGCTGCCTCTCGATTTACGCCGGAACCAGCGCCGAATCCGCCCGCCAG
GTGGTGGAATCGATCACGACGGAGTTCCGCCAGCTCAAGGGCGACCGGGTCGGCGACGAGGAGCTCCGCCGCGCCAAGGA
TCATCTCAAGGGCTCGCTGATGCTCGGCCTGGAATCTACCGCCAGCCGCATGTCCAACCTCGCCCGGCAGGAGATGTACT
TCGGCCGGTTCTTTACGCTGGACGAACTCGTGGAGAGCATCGAAGCAGTCACGGCCGAGGACGTCCGGCGAATCGCTCAG
ACCTTCTTCGACTCCCGCCAGATCGCCCTGACCATCCTCGGAAATCTCGAAAATTTCCGGATTACCCGCGAAGAACTTGG
CTGCTAG

Upstream 100 bases:

>100_bases
CAGTGTAACCGACCCGGTCGAGGGACTGGTTCACCGCTCCCAACCCCGCCAGAGCCCCGAAGGTGCTACAAAGGGAACAG
GGCTATTCTCTCTCTTCGCA

Downstream 100 bases:

>100_bases
GGCCATAACTTTAGGTAATCCGGTACTGCACTTATGCCGACCGACGAGGGACTAAATTGGTCCACTTCCACTAAATCCCC
AAACATCGTTGATAACAAAG

Product: peptidase M16 domain-containing protein

Products: NA

Alternate protein names: ORFP [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MTSSNNPLRDIEMTTLANGVRVITEAMQHVRSVSVGIWIGAGSRRETTEQNGISHFIEHMLFKGTTTRSAEDIARAVDAL
GGNLDAFTAKELVCFNTKVLDQHLSQAFEVLADLVLNPMFREEDIEKEKGVILEEIKMEADSPDYLVHEIFSSNFWKDHP
LGKPILGTPQSVRRFDSTMIRDFYRSVYSPANMVVTAAGHMTHEGLTALVQQYFASLPPGPAAPPDLQPSTHARIALRNK
KSLEQVHLCLGVPSYPLPHEERFACYVLNTLLGGGMSSRLFQNIRERQGLAYAVFSELNPYRDTGCLSIYAGTSAESARQ
VVESITTEFRQLKGDRVGDEELRRAKDHLKGSLMLGLESTASRMSNLARQEMYFGRFFTLDELVESIEAVTAEDVRRIAQ
TFFDSRQIALTILGNLENFRITREELGC

Sequences:

>Translated_428_residues
MTSSNNPLRDIEMTTLANGVRVITEAMQHVRSVSVGIWIGAGSRRETTEQNGISHFIEHMLFKGTTTRSAEDIARAVDAL
GGNLDAFTAKELVCFNTKVLDQHLSQAFEVLADLVLNPMFREEDIEKEKGVILEEIKMEADSPDYLVHEIFSSNFWKDHP
LGKPILGTPQSVRRFDSTMIRDFYRSVYSPANMVVTAAGHMTHEGLTALVQQYFASLPPGPAAPPDLQPSTHARIALRNK
KSLEQVHLCLGVPSYPLPHEERFACYVLNTLLGGGMSSRLFQNIRERQGLAYAVFSELNPYRDTGCLSIYAGTSAESARQ
VVESITTEFRQLKGDRVGDEELRRAKDHLKGSLMLGLESTASRMSNLARQEMYFGRFFTLDELVESIEAVTAEDVRRIAQ
TFFDSRQIALTILGNLENFRITREELGC
>Mature_427_residues
TSSNNPLRDIEMTTLANGVRVITEAMQHVRSVSVGIWIGAGSRRETTEQNGISHFIEHMLFKGTTTRSAEDIARAVDALG
GNLDAFTAKELVCFNTKVLDQHLSQAFEVLADLVLNPMFREEDIEKEKGVILEEIKMEADSPDYLVHEIFSSNFWKDHPL
GKPILGTPQSVRRFDSTMIRDFYRSVYSPANMVVTAAGHMTHEGLTALVQQYFASLPPGPAAPPDLQPSTHARIALRNKK
SLEQVHLCLGVPSYPLPHEERFACYVLNTLLGGGMSSRLFQNIRERQGLAYAVFSELNPYRDTGCLSIYAGTSAESARQV
VESITTEFRQLKGDRVGDEELRRAKDHLKGSLMLGLESTASRMSNLARQEMYFGRFFTLDELVESIEAVTAEDVRRIAQT
FFDSRQIALTILGNLENFRITREELGC

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=432, Percent_Identity=29.1666666666667, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI46593007, Length=425, Percent_Identity=26.5882352941176, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI24308013, Length=440, Percent_Identity=27.7272727272727, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI50592988, Length=418, Percent_Identity=22.2488038277512, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1787770, Length=296, Percent_Identity=22.6351351351351, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71999683, Length=423, Percent_Identity=27.6595744680851, Blast_Score=191, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17553678, Length=431, Percent_Identity=25.9860788863109, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17510601, Length=450, Percent_Identity=22, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6323192, Length=418, Percent_Identity=26.0765550239234, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6321813, Length=424, Percent_Identity=24.2924528301887, Blast_Score=139, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6319426, Length=428, Percent_Identity=24.0654205607477, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21357875, Length=418, Percent_Identity=29.1866028708134, Blast_Score=191, Evalue=8e-49,
Organism=Drosophila melanogaster, GI24646943, Length=418, Percent_Identity=29.1866028708134, Blast_Score=191, Evalue=8e-49,
Organism=Drosophila melanogaster, GI19921772, Length=427, Percent_Identity=23.8875878220141, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24641429, Length=277, Percent_Identity=22.0216606498195, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 47898; Mature: 47767

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSNNPLRDIEMTTLANGVRVITEAMQHVRSVSVGIWIGAGSRRETTEQNGISHFIEHM
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHH
LFKGTTTRSAEDIARAVDALGGNLDAFTAKELVCFNTKVLDQHLSQAFEVLADLVLNPMF
HHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
REEDIEKEKGVILEEIKMEADSPDYLVHEIFSSNFWKDHPLGKPILGTPQSVRRFDSTMI
HHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
RDFYRSVYSPANMVVTAAGHMTHEGLTALVQQYFASLPPGPAAPPDLQPSTHARIALRNK
HHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCH
KSLEQVHLCLGVPSYPLPHEERFACYVLNTLLGGGMSSRLFQNIRERQGLAYAVFSELNP
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHCCC
YRDTGCLSIYAGTSAESARQVVESITTEFRQLKGDRVGDEELRRAKDHLKGSLMLGLEST
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEECHHHH
ASRMSNLARQEMYFGRFFTLDELVESIEAVTAEDVRRIAQTFFDSRQIALTILGNLENFR
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHE
ITREELGC
ECHHHHCC
>Mature Secondary Structure 
TSSNNPLRDIEMTTLANGVRVITEAMQHVRSVSVGIWIGAGSRRETTEQNGISHFIEHM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHH
LFKGTTTRSAEDIARAVDALGGNLDAFTAKELVCFNTKVLDQHLSQAFEVLADLVLNPMF
HHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
REEDIEKEKGVILEEIKMEADSPDYLVHEIFSSNFWKDHPLGKPILGTPQSVRRFDSTMI
HHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
RDFYRSVYSPANMVVTAAGHMTHEGLTALVQQYFASLPPGPAAPPDLQPSTHARIALRNK
HHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCH
KSLEQVHLCLGVPSYPLPHEERFACYVLNTLLGGGMSSRLFQNIRERQGLAYAVFSELNP
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHCCC
YRDTGCLSIYAGTSAESARQVVESITTEFRQLKGDRVGDEELRRAKDHLKGSLMLGLEST
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEECHHHH
ASRMSNLARQEMYFGRFFTLDELVESIEAVTAEDVRRIAQTFFDSRQIALTILGNLENFR
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHE
ITREELGC
ECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 8098035 [H]