Click here to switch to the map view.

The map label for this gene is yrbE [H]

Identifier: 116626190

GI number: 116626190

Start: 8970597

End: 8972762

Strand: Direct

Name: yrbE [H]

Synonym: Acid_7150

Alternate gene names: 116626190

Gene position: 8970597-8972762 (Clockwise)

Preceding gene: 116626189

Following gene: 116626191

Centisome position: 90.02

GC content: 65.7

Gene sequence:

>2166_bases
ATGAAACAGGTTATCCGTAAAGGACTTAAAGACATTATCGTAGACGAGGTTCCGGACCCCGGATTGATCCCTCATCACGT
GCTGGTCAGGCCGCTCTATTCGCTGATTTCAAGCGGCACCGAGACCGCCAGCATCCATCGCGACAGCCTGCTCTCCGAGG
TTGCCGACAATCCGGGCCACCTGCGCAAGATCTGGGACGTCGCGATGAAGACCGGCCCCGCCGCGACCCTTGCCGAAGTC
CGAGCGAAGTTCAGCGAGTACGCTGTCCTCGGGTATTCCGGGGCGGGCGTGGTGGCGGCGCGACATGCCACCGTGACCGA
TCTCGACATCGGCGAGCGGGTGGCCTATGGCGGAGAGGGCACGGGCCACGGCGAAACCATCCTGGTGGGCCGGAACCTCG
CGGCACGGATGCCCGCGGGCGTGGCGTACGAGCACGCCTGCTTCGCGACCCTGGGCAGCATCGCGATGAACGCGGTGCGC
ACCGCTCGCCTCGAACTCGGCGACGTGGTGGCGGTGATCGGTCTCGGCCTGGTGGGGCAACTGGTGGCACAACTGGTGCG
TCAGCAGGGCGGCGTGGTGGTGGGAATCGATCTGAATGCGAAACGCGTGGACCTTGCGCGCTCGCTGGGCGCCGACCACG
GAATTGCGGGGGCCTCGGCGGTCGAAGGTGTGCGCGCGCTGACCAATGGGCGCGGCGTGGATTGCGCGATCGTGGCGGCG
GCATCGAAATCGCCGGCGCCGGCGCAGCACGCGCTCCAACTCTGCCGCGATCGCGGGCGCATCTGCATCGTGGGTGCGGT
CGGCATGGAGTTCCCATGGAACGACATGTACCTCAAGGAAATCCAGCTCTACATGTCGCGCGCCTACGGGCCGGGCAGCT
ACGACGCATCCTACGAAAAGCAGGGTCGCGATTATCCCCTGCCCTACGTGCGCTGGACCGAAAACCGCAATATGGAAGAG
TTCCTGCGGCTGATGGCGGCAGGGCGGATCGACGTACGCCCGCTGATCACCCACCAATTCGAGCTCGACGAAGCGGCCAA
GGGATACGACACAATTTTCACTCCGTCGGCCGATAGCCTGGCGGTGCTGCTCCGCTATCCGGCGGCGTCGGCATCGGACC
CGGTGGCGGCCTTCGCGCCGGTCAGCAAGGTGACCACCGCGTCGGCCGGACGGGCTAAGGAACGGGTTGAGTTCGCCCTG
GTGGGCGCCGGCAACCTGGCGAAGTGGGAGCACCTGCCCAACCTGAAGAAGCTGCCCGGAGTGGGGCTGCGCGCCGTCTA
CTCGGCCGCCGGAGTGCGAGGGAAGAGCTACGCCCTGCGCTTCGGCGCGGAGTACGCGTGTTCCGATTACGACGAGGTGC
TGAAGGATCCGCAAATCGACGCCGTGCTGATCGCGAGCCGCAATCAACATCACGCGGCGCAATCCCTGGCGGCCCTACGC
GCGGGCAAGCACGTTTTTGTGGAAAAGCCGATGGCGTTGACGGCGGAGGAGTGCCAGGCGCTCTGCACTGCGGTCGCCGA
GACCGGCAAGCAGCTCACGGTCGGTTTCAACCGGCGGTTCGCACCCTACTACCGCGAGCTCAAGGACAACCTGAAGCGCC
GCAATTCGCCTGCCGTGGTGCAATGCCGGATCAATTCGCCCGGCATCTCGGGAAGCTACTGGATGGCCGACCCGGCGATC
GGCGGCGCCATCCTGGGCGAGGCCTGCCACTTTATCGACCTGATGTACTGGCTGCTGGATTCCGAGCCGGTGAGCGTCTC
CGCCTATTCGCTGCCGACCGGAAAGGCAGACCCGATCGGAGAGAACAACCTGGTGGCCGCCTTCCACTTTGCCGATGGAT
CCATCGGCAGCCTGACGTACTGCACGGTGGGCAGCAAGACGTCGGGCGGCGAACGAGTGGAGATTTTCGCGCAGGGCGTG
GGCGGTTTCAGCGAGGACTTCAAGCAGGTTGGCGTTCACAAGGGAATGCGCACGTCGCGCTCGAAGATCTGGCCGGATAA
GGGCTACGCGGCGCAGATGGCCGAGTTTGCGGCGAGCATCCGGGAAGGACGCGCGCCCGCGGTGACGGTTTACGATGGCG
CACGCGCCACCCTCGGTTGTCTGGCGATGATGGCGTCGGCGCGCGACCGGACTCCGGTCGCAATGGACTCGGCCGCGTCG
TTATGA

Upstream 100 bases:

>100_bases
GCTGTCGTCGCGGAAACTCTGACCGGAATGGCCTGTATCCCACCGATGGATCTCCAAGCACCGCGCCGCGCTTGTTACCA
TGAAAAGCTGACGCCCCCGC

Downstream 100 bases:

>100_bases
AGATAGTGCCATGAAGGTAGTGCCATGAAGGTCGTGCAGCTGGGGCCGTACCCGCCGCCGCACGGCGGGGTGCAGACCAA
TCTGGTGGCGATCCGCGAAT

Product: oxidoreductase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 721; Mature: 721

Protein sequence:

>721_residues
MKQVIRKGLKDIIVDEVPDPGLIPHHVLVRPLYSLISSGTETASIHRDSLLSEVADNPGHLRKIWDVAMKTGPAATLAEV
RAKFSEYAVLGYSGAGVVAARHATVTDLDIGERVAYGGEGTGHGETILVGRNLAARMPAGVAYEHACFATLGSIAMNAVR
TARLELGDVVAVIGLGLVGQLVAQLVRQQGGVVVGIDLNAKRVDLARSLGADHGIAGASAVEGVRALTNGRGVDCAIVAA
ASKSPAPAQHALQLCRDRGRICIVGAVGMEFPWNDMYLKEIQLYMSRAYGPGSYDASYEKQGRDYPLPYVRWTENRNMEE
FLRLMAAGRIDVRPLITHQFELDEAAKGYDTIFTPSADSLAVLLRYPAASASDPVAAFAPVSKVTTASAGRAKERVEFAL
VGAGNLAKWEHLPNLKKLPGVGLRAVYSAAGVRGKSYALRFGAEYACSDYDEVLKDPQIDAVLIASRNQHHAAQSLAALR
AGKHVFVEKPMALTAEECQALCTAVAETGKQLTVGFNRRFAPYYRELKDNLKRRNSPAVVQCRINSPGISGSYWMADPAI
GGAILGEACHFIDLMYWLLDSEPVSVSAYSLPTGKADPIGENNLVAAFHFADGSIGSLTYCTVGSKTSGGERVEIFAQGV
GGFSEDFKQVGVHKGMRTSRSKIWPDKGYAAQMAEFAASIREGRAPAVTVYDGARATLGCLAMMASARDRTPVAMDSAAS
L

Sequences:

>Translated_721_residues
MKQVIRKGLKDIIVDEVPDPGLIPHHVLVRPLYSLISSGTETASIHRDSLLSEVADNPGHLRKIWDVAMKTGPAATLAEV
RAKFSEYAVLGYSGAGVVAARHATVTDLDIGERVAYGGEGTGHGETILVGRNLAARMPAGVAYEHACFATLGSIAMNAVR
TARLELGDVVAVIGLGLVGQLVAQLVRQQGGVVVGIDLNAKRVDLARSLGADHGIAGASAVEGVRALTNGRGVDCAIVAA
ASKSPAPAQHALQLCRDRGRICIVGAVGMEFPWNDMYLKEIQLYMSRAYGPGSYDASYEKQGRDYPLPYVRWTENRNMEE
FLRLMAAGRIDVRPLITHQFELDEAAKGYDTIFTPSADSLAVLLRYPAASASDPVAAFAPVSKVTTASAGRAKERVEFAL
VGAGNLAKWEHLPNLKKLPGVGLRAVYSAAGVRGKSYALRFGAEYACSDYDEVLKDPQIDAVLIASRNQHHAAQSLAALR
AGKHVFVEKPMALTAEECQALCTAVAETGKQLTVGFNRRFAPYYRELKDNLKRRNSPAVVQCRINSPGISGSYWMADPAI
GGAILGEACHFIDLMYWLLDSEPVSVSAYSLPTGKADPIGENNLVAAFHFADGSIGSLTYCTVGSKTSGGERVEIFAQGV
GGFSEDFKQVGVHKGMRTSRSKIWPDKGYAAQMAEFAASIREGRAPAVTVYDGARATLGCLAMMASARDRTPVAMDSAAS
L
>Mature_721_residues
MKQVIRKGLKDIIVDEVPDPGLIPHHVLVRPLYSLISSGTETASIHRDSLLSEVADNPGHLRKIWDVAMKTGPAATLAEV
RAKFSEYAVLGYSGAGVVAARHATVTDLDIGERVAYGGEGTGHGETILVGRNLAARMPAGVAYEHACFATLGSIAMNAVR
TARLELGDVVAVIGLGLVGQLVAQLVRQQGGVVVGIDLNAKRVDLARSLGADHGIAGASAVEGVRALTNGRGVDCAIVAA
ASKSPAPAQHALQLCRDRGRICIVGAVGMEFPWNDMYLKEIQLYMSRAYGPGSYDASYEKQGRDYPLPYVRWTENRNMEE
FLRLMAAGRIDVRPLITHQFELDEAAKGYDTIFTPSADSLAVLLRYPAASASDPVAAFAPVSKVTTASAGRAKERVEFAL
VGAGNLAKWEHLPNLKKLPGVGLRAVYSAAGVRGKSYALRFGAEYACSDYDEVLKDPQIDAVLIASRNQHHAAQSLAALR
AGKHVFVEKPMALTAEECQALCTAVAETGKQLTVGFNRRFAPYYRELKDNLKRRNSPAVVQCRINSPGISGSYWMADPAI
GGAILGEACHFIDLMYWLLDSEPVSVSAYSLPTGKADPIGENNLVAAFHFADGSIGSLTYCTVGSKTSGGERVEIFAQGV
GGFSEDFKQVGVHKGMRTSRSKIWPDKGYAAQMAEFAASIREGRAPAVTVYDGARATLGCLAMMASARDRTPVAMDSAAS
L

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gfo/idh/mocA family [H]

Homologues:

Organism=Escherichia coli, GI1787307, Length=302, Percent_Identity=26.158940397351, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1787574, Length=239, Percent_Identity=26.3598326359833, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1788075, Length=251, Percent_Identity=27.4900398406374, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87081947, Length=135, Percent_Identity=29.6296296296296, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR000683
- InterPro:   IPR004104 [H]

Pfam domain/function: PF01408 GFO_IDH_MocA; PF02894 GFO_IDH_MocA_C [H]

EC number: NA

Molecular weight: Translated: 76896; Mature: 76896

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQVIRKGLKDIIVDEVPDPGLIPHHVLVRPLYSLISSGTETASIHRDSLLSEVADNPGH
CHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHH
LRKIWDVAMKTGPAATLAEVRAKFSEYAVLGYSGAGVVAARHATVTDLDIGERVAYGGEG
HHHHHHHHHHCCCHHHHHHHHHHHHHEEEEEECCCCEEEECCCEEEECCCCCCEECCCCC
TGHGETILVGRNLAARMPAGVAYEHACFATLGSIAMNAVRTARLELGDVVAVIGLGLVGQ
CCCCCEEEEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVAQLVRQQGGVVVGIDLNAKRVDLARSLGADHGIAGASAVEGVRALTNGRGVDCAIVAA
HHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEE
ASKSPAPAQHALQLCRDRGRICIVGAVGMEFPWNDMYLKEIQLYMSRAYGPGSYDASYEK
CCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHH
QGRDYPLPYVRWTENRNMEEFLRLMAAGRIDVRPLITHQFELDEAAKGYDTIFTPSADSL
CCCCCCCCCEEECCCCCHHHHHHHHHCCCCCCCCHHHEEECCHHHCCCCCEEECCCCCCE
AVLLRYPAASASDPVAAFAPVSKVTTASAGRAKERVEFALVGAGNLAKWEHLPNLKKLPG
EEEEECCCCCCCCCCCHHCCHHHHHCCCCCCHHHCEEEEEEECCCCHHHHHCCCHHHCCC
VGLRAVYSAAGVRGKSYALRFGAEYACSDYDEVLKDPQIDAVLIASRNQHHAAQSLAALR
CCHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHCCCCCCEEEEECCCCHHHHHHHHHHH
AGKHVFVEKPMALTAEECQALCTAVAETGKQLTVGFNRRFAPYYRELKDNLKRRNSPAVV
CCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEE
QCRINSPGISGSYWMADPAIGGAILGEACHFIDLMYWLLDSEPVSVSAYSLPTGKADPIG
EEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCC
ENNLVAAFHFADGSIGSLTYCTVGSKTSGGERVEIFAQGVGGFSEDFKQVGVHKGMRTSR
CCCEEEEEEECCCCCCCEEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCHH
SKIWPDKGYAAQMAEFAASIREGRAPAVTVYDGARATLGCLAMMASARDRTPVAMDSAAS
CCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCEECCCCCC
L
C
>Mature Secondary Structure
MKQVIRKGLKDIIVDEVPDPGLIPHHVLVRPLYSLISSGTETASIHRDSLLSEVADNPGH
CHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHH
LRKIWDVAMKTGPAATLAEVRAKFSEYAVLGYSGAGVVAARHATVTDLDIGERVAYGGEG
HHHHHHHHHHCCCHHHHHHHHHHHHHEEEEEECCCCEEEECCCEEEECCCCCCEECCCCC
TGHGETILVGRNLAARMPAGVAYEHACFATLGSIAMNAVRTARLELGDVVAVIGLGLVGQ
CCCCCEEEEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVAQLVRQQGGVVVGIDLNAKRVDLARSLGADHGIAGASAVEGVRALTNGRGVDCAIVAA
HHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEE
ASKSPAPAQHALQLCRDRGRICIVGAVGMEFPWNDMYLKEIQLYMSRAYGPGSYDASYEK
CCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHH
QGRDYPLPYVRWTENRNMEEFLRLMAAGRIDVRPLITHQFELDEAAKGYDTIFTPSADSL
CCCCCCCCCEEECCCCCHHHHHHHHHCCCCCCCCHHHEEECCHHHCCCCCEEECCCCCCE
AVLLRYPAASASDPVAAFAPVSKVTTASAGRAKERVEFALVGAGNLAKWEHLPNLKKLPG
EEEEECCCCCCCCCCCHHCCHHHHHCCCCCCHHHCEEEEEEECCCCHHHHHCCCHHHCCC
VGLRAVYSAAGVRGKSYALRFGAEYACSDYDEVLKDPQIDAVLIASRNQHHAAQSLAALR
CCHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHCCCCCCEEEEECCCCHHHHHHHHHHH
AGKHVFVEKPMALTAEECQALCTAVAETGKQLTVGFNRRFAPYYRELKDNLKRRNSPAVV
CCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEE
QCRINSPGISGSYWMADPAIGGAILGEACHFIDLMYWLLDSEPVSVSAYSLPTGKADPIG
EEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCC
ENNLVAAFHFADGSIGSLTYCTVGSKTSGGERVEIFAQGVGGFSEDFKQVGVHKGMRTSR
CCCEEEEEEECCCCCCCEEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCHH
SKIWPDKGYAAQMAEFAASIREGRAPAVTVYDGARATLGCLAMMASARDRTPVAMDSAAS
CCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCEECCCCCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9025289 [H]