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The map label for this gene is mtnP [H]

Identifier: 116626100

GI number: 116626100

Start: 8875474

End: 8876334

Strand: Reverse

Name: mtnP [H]

Synonym: Acid_7058

Alternate gene names: 116626100

Gene position: 8876334-8875474 (Counterclockwise)

Preceding gene: 116626101

Following gene: 116626099

Centisome position: 89.07

GC content: 62.6

Gene sequence:

>861_bases
TTGAAAGCGGAAATCGGAATCATCGGGGGCAGCGGACTGTACCACATGCCCGGATTTGAAGCGCAGGAGGAGGCCAACAT
CACCACGCCATTCGGCAGCCCCTCCGACAATTACGTGCTCGGCACACTTGGCGGCCGCCATGTCGCGTTCCTCGCGCGCC
ACGGCCGCGGGCATCGCATTTCACCTTCGGAGTTGAACTTCCGCGCGAACATTTACGGCATGAAATCGCTGGGCGTGGAG
CGCATCATTTCGCTCAGCGCCGTGGGTTCCCTGAAGGAAGAGCACCGCCCCCAGGATTTCGTAATCCCCGACCAGTTCTT
CGATCGCACCCGCGGACGCATCTCCACCTTCTTCGGCGAGGGTCTGGTGGCCCACATCAGCTTCGCCGACCCTGTCTGCC
CGGAGATGAGCGACGTCGTGGAGGCTGCCTGCGCCCGGGCCGGCGTAAACGCCAAGCGCGGCGGCACATACCTCTGCATG
GAAGGCCCGGCATTTTCCACCAAGGCCGAATCCAACGTCTACCGCAGTTGGGGCATGGACGTGATCGGCATGACCAACCT
GCAGGAGGCCAAACTCGCGCGCGAAGCCGAGATCTGCTACGTCAGCGTCGCGATGGTCACAGATTACGATTGCTGGCATC
CGGAACACGACGCGGTCACGGTCAACGACATAATCGCCAATCTTGTGAAGAACGCCGAGAACGCCTGCAGGGTGGTGGCG
GAGGCAGTCGCCGCGGCGCCGCACGCGCGGAGTTGCAAATGCGGGTCGGCGCTCGCCCACGCGATCCTCACCGATCGCGG
AGCAGTACCCGAGGCCACCAAGCAGAAGCTGGGGATCTTGATTGCCAAGTACTTTGTGTGA

Upstream 100 bases:

>100_bases
TGAACGAGCCGCGCGCCGGCGCCGGCGGCCACATCTACGTCTTTGTCCATCCCGCCTCCACCGGAGGCGTGTTGTTGGAA
CTCATTCAGGAGAGCACCAA

Downstream 100 bases:

>100_bases
GGACATGGCGCGCCAGGTCCTGGAGCAGTGCATCGCGGGCGCGGCGCCCGAGCGGCTGCCGCAAGCGCTGCTCGAGGAGC
CGTGCGCCAAAGCGCTCTTC

Product: methylthioadenosine phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MKAEIGIIGGSGLYHMPGFEAQEEANITTPFGSPSDNYVLGTLGGRHVAFLARHGRGHRISPSELNFRANIYGMKSLGVE
RIISLSAVGSLKEEHRPQDFVIPDQFFDRTRGRISTFFGEGLVAHISFADPVCPEMSDVVEAACARAGVNAKRGGTYLCM
EGPAFSTKAESNVYRSWGMDVIGMTNLQEAKLAREAEICYVSVAMVTDYDCWHPEHDAVTVNDIIANLVKNAENACRVVA
EAVAAAPHARSCKCGSALAHAILTDRGAVPEATKQKLGILIAKYFV

Sequences:

>Translated_286_residues
MKAEIGIIGGSGLYHMPGFEAQEEANITTPFGSPSDNYVLGTLGGRHVAFLARHGRGHRISPSELNFRANIYGMKSLGVE
RIISLSAVGSLKEEHRPQDFVIPDQFFDRTRGRISTFFGEGLVAHISFADPVCPEMSDVVEAACARAGVNAKRGGTYLCM
EGPAFSTKAESNVYRSWGMDVIGMTNLQEAKLAREAEICYVSVAMVTDYDCWHPEHDAVTVNDIIANLVKNAENACRVVA
EAVAAAPHARSCKCGSALAHAILTDRGAVPEATKQKLGILIAKYFV
>Mature_286_residues
MKAEIGIIGGSGLYHMPGFEAQEEANITTPFGSPSDNYVLGTLGGRHVAFLARHGRGHRISPSELNFRANIYGMKSLGVE
RIISLSAVGSLKEEHRPQDFVIPDQFFDRTRGRISTFFGEGLVAHISFADPVCPEMSDVVEAACARAGVNAKRGGTYLCM
EGPAFSTKAESNVYRSWGMDVIGMTNLQEAKLAREAEICYVSVAMVTDYDCWHPEHDAVTVNDIIANLVKNAENACRVVA
EAVAAAPHARSCKCGSALAHAILTDRGAVPEATKQKLGILIAKYFV

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA) [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=237, Percent_Identity=44.3037974683544, Blast_Score=214, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI71980569, Length=245, Percent_Identity=42.0408163265306, Blast_Score=186, Evalue=9e-48,
Organism=Saccharomyces cerevisiae, GI6323045, Length=307, Percent_Identity=36.4820846905537, Blast_Score=187, Evalue=1e-48,
Organism=Drosophila melanogaster, GI20130079, Length=276, Percent_Identity=35.1449275362319, Blast_Score=184, Evalue=4e-47,
Organism=Drosophila melanogaster, GI221459247, Length=245, Percent_Identity=34.6938775510204, Blast_Score=161, Evalue=5e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 30861; Mature: 30861

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAEIGIIGGSGLYHMPGFEAQEEANITTPFGSPSDNYVLGTLGGRHVAFLARHGRGHRI
CCCEEEEEECCCEECCCCCCCCCCCCEECCCCCCCCCEEEECCCCCEEEEEEECCCCCCC
SPSELNFRANIYGMKSLGVERIISLSAVGSLKEEHRPQDFVIPDQFFDRTRGRISTFFGE
CHHHCCEEEEEEEHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCC
GLVAHISFADPVCPEMSDVVEAACARAGVNAKRGGTYLCMEGPAFSTKAESNVYRSWGMD
CEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCHHHHHHHCCCC
VIGMTNLQEAKLAREAEICYVSVAMVTDYDCWHPEHDAVTVNDIIANLVKNAENACRVVA
EEECCCCHHHHHHHHCCEEEEEEEEEECCCCCCCCCCCEEHHHHHHHHHHCHHHHHHHHH
EAVAAAPHARSCKCGSALAHAILTDRGAVPEATKQKLGILIAKYFV
HHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKAEIGIIGGSGLYHMPGFEAQEEANITTPFGSPSDNYVLGTLGGRHVAFLARHGRGHRI
CCCEEEEEECCCEECCCCCCCCCCCCEECCCCCCCCCEEEECCCCCEEEEEEECCCCCCC
SPSELNFRANIYGMKSLGVERIISLSAVGSLKEEHRPQDFVIPDQFFDRTRGRISTFFGE
CHHHCCEEEEEEEHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCC
GLVAHISFADPVCPEMSDVVEAACARAGVNAKRGGTYLCMEGPAFSTKAESNVYRSWGMD
CEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCHHHHHHHCCCC
VIGMTNLQEAKLAREAEICYVSVAMVTDYDCWHPEHDAVTVNDIIANLVKNAENACRVVA
EEECCCCHHHHHHHHCCEEEEEEEEEECCCCCCCCCCCEEHHHHHHHHHHCHHHHHHHHH
EAVAAAPHARSCKCGSALAHAILTDRGAVPEATKQKLGILIAKYFV
HHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA