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The map label for this gene is purM [H]

Identifier: 116625772

GI number: 116625772

Start: 8423481

End: 8424554

Strand: Direct

Name: purM [H]

Synonym: Acid_6722

Alternate gene names: 116625772

Gene position: 8423481-8424554 (Clockwise)

Preceding gene: 116625768

Following gene: 116625773

Centisome position: 84.53

GC content: 64.34

Gene sequence:

>1074_bases
TTGGGTGCATTCTACGCCGTATACTGGGATTTGTCCACCCGAAAACCAGTTCGCTACCGCGATGCGGGCGTGAATATCGA
CGAGGCCGATCGCGCCGTTTCCGCCATCAAGAAATTTGCCCGGCAGACGTTTACGAAGGGAGTGCTGACAGAGATCGGCA
GCTTCGGCGCCTCCTATCAACTGGCCGGATTCCGCAAGCCGGTGCTGGTCAGTTCGGCCGATGGCGTCGGCACGAAACTC
AAGGTCGCCTTTCTTACCGGGCGCCACGACACCGTGGGCGAAGACCTGGTGAACCACTGCGTAAACGATATCGCGGTGCA
GGGCGCGATGCCGCTTTTCTTCCTGGATTACTTCGCGGTAGGGAAGTTGGATTCCGAGGTTGCCGCCGCGGTGGTGGGCG
GAATCGCGCGCGGTTGCAAGCGGAACGGCTGCGCGCTGATCGGCGGCGAGACCGCCGAGATGCCGGGGATGTATACGGAC
GGCGAATACGACCTGGCGGGCTTCATCGTAGGCGCGGCGGAACGCAGCCACCTGCTCACCGGAAAAACGATTCGCCCGGG
AGACGTGCTGCTCGCGCTGCCCTCCACGGGGCTGCACACCAACGGGTATTCCCTGGCCCGCAAGCTGTTCTTTGAGGTGG
CTGGATACGGACCCAAGACCCTCCTGCCCGATGTCGGCGCGACCGTGGGCGATGCCCTGCTCGCGGTGCATCGCAGCTAC
CTGAAGCCGATCCGTACCCTGATGGCAGCCGGACTTCTGCGGGGCGCGGCGCACATCACGGGCGGCGGCATCACGGACAA
CACACCGCGCATGCTGCCCAAGAACTTCGGCGTGGTGATCGATACCTCGTCCTGGAAGATCCCGCCGTTGTTTGAGGCGC
TGCGGCGCATCGGTGACATCCCGGAGGACGATTACCGTCGCACGTTGAACCTGGGCGTCGGCATGATTCTCGCGGTACCG
GCCCGTGGCGCGCTTAAGGCCCAGGCCGCACTGCGCAAGATCGGCGAGACGCCCTTCCGGATCGGCAGCGTGGTGGAACT
CAAGCGCGGCCGTCCGCGCGTGGAGTACCAGTGA

Upstream 100 bases:

>100_bases
CAGCAGTAGCGCTGTGACTAGTTTTTTCATAATGGCAATAGTTCCGTTTAGGCGATAGATCAGGTCAAATGGTTACGGGT
GTGCGACAAGGCCACCGCTA

Downstream 100 bases:

>100_bases
AGCGACTCGGCATTCTGATCTCCGGCCGGGGATCGAATTTCGAGGCGATTGCCGCGAACGTGCAGAGCGGCGCGCTGAAC
GCCGATATCGCGGTGGTGAT

Product: phosphoribosylformylglycinamidine cyclo-ligase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MGAFYAVYWDLSTRKPVRYRDAGVNIDEADRAVSAIKKFARQTFTKGVLTEIGSFGASYQLAGFRKPVLVSSADGVGTKL
KVAFLTGRHDTVGEDLVNHCVNDIAVQGAMPLFFLDYFAVGKLDSEVAAAVVGGIARGCKRNGCALIGGETAEMPGMYTD
GEYDLAGFIVGAAERSHLLTGKTIRPGDVLLALPSTGLHTNGYSLARKLFFEVAGYGPKTLLPDVGATVGDALLAVHRSY
LKPIRTLMAAGLLRGAAHITGGGITDNTPRMLPKNFGVVIDTSSWKIPPLFEALRRIGDIPEDDYRRTLNLGVGMILAVP
ARGALKAQAALRKIGETPFRIGSVVELKRGRPRVEYQ

Sequences:

>Translated_357_residues
MGAFYAVYWDLSTRKPVRYRDAGVNIDEADRAVSAIKKFARQTFTKGVLTEIGSFGASYQLAGFRKPVLVSSADGVGTKL
KVAFLTGRHDTVGEDLVNHCVNDIAVQGAMPLFFLDYFAVGKLDSEVAAAVVGGIARGCKRNGCALIGGETAEMPGMYTD
GEYDLAGFIVGAAERSHLLTGKTIRPGDVLLALPSTGLHTNGYSLARKLFFEVAGYGPKTLLPDVGATVGDALLAVHRSY
LKPIRTLMAAGLLRGAAHITGGGITDNTPRMLPKNFGVVIDTSSWKIPPLFEALRRIGDIPEDDYRRTLNLGVGMILAVP
ARGALKAQAALRKIGETPFRIGSVVELKRGRPRVEYQ
>Mature_356_residues
GAFYAVYWDLSTRKPVRYRDAGVNIDEADRAVSAIKKFARQTFTKGVLTEIGSFGASYQLAGFRKPVLVSSADGVGTKLK
VAFLTGRHDTVGEDLVNHCVNDIAVQGAMPLFFLDYFAVGKLDSEVAAAVVGGIARGCKRNGCALIGGETAEMPGMYTDG
EYDLAGFIVGAAERSHLLTGKTIRPGDVLLALPSTGLHTNGYSLARKLFFEVAGYGPKTLLPDVGATVGDALLAVHRSYL
KPIRTLMAAGLLRGAAHITGGGITDNTPRMLPKNFGVVIDTSSWKIPPLFEALRRIGDIPEDDYRRTLNLGVGMILAVPA
RGALKAQAALRKIGETPFRIGSVVELKRGRPRVEYQ

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=359, Percent_Identity=44.0111420612813, Blast_Score=291, Evalue=5e-79,
Organism=Homo sapiens, GI209869995, Length=359, Percent_Identity=44.0111420612813, Blast_Score=291, Evalue=5e-79,
Organism=Homo sapiens, GI209869993, Length=359, Percent_Identity=44.0111420612813, Blast_Score=291, Evalue=5e-79,
Organism=Escherichia coli, GI1788845, Length=345, Percent_Identity=47.8260869565217, Blast_Score=310, Evalue=8e-86,
Organism=Caenorhabditis elegans, GI17567511, Length=343, Percent_Identity=42.5655976676385, Blast_Score=243, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6321203, Length=356, Percent_Identity=42.9775280898876, Blast_Score=276, Evalue=4e-75,
Organism=Drosophila melanogaster, GI24582400, Length=259, Percent_Identity=40.1544401544402, Blast_Score=196, Evalue=2e-50,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 38227; Mature: 38096

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAFYAVYWDLSTRKPVRYRDAGVNIDEADRAVSAIKKFARQTFTKGVLTEIGSFGASYQ
CCCEEEEEEECCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
LAGFRKPVLVSSADGVGTKLKVAFLTGRHDTVGEDLVNHCVNDIAVQGAMPLFFLDYFAV
ECCCCCCEEEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
GKLDSEVAAAVVGGIARGCKRNGCALIGGETAEMPGMYTDGEYDLAGFIVGAAERSHLLT
CCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEC
GKTIRPGDVLLALPSTGLHTNGYSLARKLFFEVAGYGPKTLLPDVGATVGDALLAVHRSY
CCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHH
LKPIRTLMAAGLLRGAAHITGGGITDNTPRMLPKNFGVVIDTSSWKIPPLFEALRRIGDI
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHCCC
PEDDYRRTLNLGVGMILAVPARGALKAQAALRKIGETPFRIGSVVELKRGRPRVEYQ
CCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHCCCHHHHCCCCCCCCC
>Mature Secondary Structure 
GAFYAVYWDLSTRKPVRYRDAGVNIDEADRAVSAIKKFARQTFTKGVLTEIGSFGASYQ
CCEEEEEEECCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
LAGFRKPVLVSSADGVGTKLKVAFLTGRHDTVGEDLVNHCVNDIAVQGAMPLFFLDYFAV
ECCCCCCEEEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
GKLDSEVAAAVVGGIARGCKRNGCALIGGETAEMPGMYTDGEYDLAGFIVGAAERSHLLT
CCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEC
GKTIRPGDVLLALPSTGLHTNGYSLARKLFFEVAGYGPKTLLPDVGATVGDALLAVHRSY
CCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHH
LKPIRTLMAAGLLRGAAHITGGGITDNTPRMLPKNFGVVIDTSSWKIPPLFEALRRIGDI
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHCCC
PEDDYRRTLNLGVGMILAVPARGALKAQAALRKIGETPFRIGSVVELKRGRPRVEYQ
CCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHCCCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA