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The map label for this gene is tuaD [H]

Identifier: 116625747

GI number: 116625747

Start: 8400554

End: 8401963

Strand: Direct

Name: tuaD [H]

Synonym: Acid_6697

Alternate gene names: 116625747

Gene position: 8400554-8401963 (Clockwise)

Preceding gene: 116625740

Following gene: 116625749

Centisome position: 84.3

GC content: 64.33

Gene sequence:

>1410_bases
ATGAGAGTCACTGTAATCGGAACGGGTTATGTAGGGACGGTCACAGGCGCCTGCCTGGCCTACCTTGGCCATCAGGTGAC
ATGCGTGGACACCGACGCCGCCAAGATTGCACGCCTGCAGCGCGGCGAATCACCAATCTACGAACCTCACCTGGAGCCGT
TGTTGGCCTTGGCCGCGGAGCGCGGCGGACTGGAATTCAGCACGGAAGTATCGGGGGCGGTCTGCGCCAGCGACGTGATC
TTTATCGCGGTGGGCACACCGCCTCTGCCTTCGGGAGAGGCCAACCTAACATACCTGGAATCCGCGGCGCGCAGCATCGG
CGCTGCCATGGACGGTTCGCGCTTCCGCGTGATCGTGAACAAATCCACGGTGCCGGTGGGATCGGGCAACCTGGTGGAGG
CCTTGGTACGCGAGGGCGTGGGTGAGACGCGCGCCGGGGAACGGATCCGGTTCGGCGTGGCGAGCAATCCTGAGTTTCTG
CGTGAAGGTTCGGCGGTGGCCGATTCGCTCTATCCCGACCGCATCGTGGTGGGCGGAGACGCGGCCACGGTGGCGGTGAT
GCGCGAGTTGTACGAACCGCTGGTGGCGCAGGTCTTCACGCCGCCGCCGGGAGTGCCGCGGCCGTCCTCGATGATTTCGG
TGCCGCTGCTCTCCACGTCGCTGACCAGCGCGGAGATGATCAAATACGCGGCCAATGCATTTCTGGCGATGAAGATCGGC
TTCGCCAACGAGATCGCGAACATCTGCGAGCGCGTCGGCGCGGAAGGCCCGGAGGTGATGGCGGGGATCGGCCTGGATTC
GCGCATCGGTGCCAAGTTTCTCAATCCGGGAGTGGGCTGGGGCGGAAGCTGCTTCGGCAAAGACATTCAATCGCTGCTGC
ACACCGCGAAGGAATACGGGTACACGAGCAAGCTGCTGGAAGCAACGCTTGAAGTTAACGCGGCGCAGCGGCAAATGGTG
ATTCAAAAGCTCCAGGAGAAGCTGTACATTCTCAAAGGCCGCACGATCGGGCTGCTGGGCCTCGCATTCAAGCCGGACAC
CGACGATCTGCGCGACGCGCCGGCGCTGCACATCGCCGAACGGCTGATGCAGATGGGGGTGCGGGTCAAGGCTTACGACC
CGATCGCCAACGCTGCATGCCGCGAACAGCGTCCGGAGTTGAAGATGCGCTACTGCGACTCGGTGCAGGAACTGGCATCG
GGCGCCGATGCGCTGGTGCTGGTGACGGAGTGGCACGAGTTCCACAATCTGGACCTGGGCGAGCTGGCCGGGCTGATGGC
CAACCCGATCCTGGTGGACGGGCGCAACTTCTTCGTGCCCGAGCGGGCGATGCAGGCGGGCTTCGATTATTGCGGGATCG
GCCGCTGCGCGCGCACGCGCTCCACGGCGCGGATGGAAGCCACTACCTGA

Upstream 100 bases:

>100_bases
GGGGCAACTTAAATTGTAGCCGATCCGACACTCCGGACCGCGTCCGGCTGACAGCCCTTGTTATACTTTGCAAACGGGGA
ATCAGGGGGCCTCGCACGCC

Downstream 100 bases:

>100_bases
CGCTGTGGCTGTCTTCGCGGATCGCGACGCCGAGCGCGGTGCCGAGAACTTCAGCGCCGGGCGCGACGCGGCCGGTGACG
GTCACCTTCGAACCGCGCGA

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH; Teichuronic acid biosynthesis protein tuaD [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MRVTVIGTGYVGTVTGACLAYLGHQVTCVDTDAAKIARLQRGESPIYEPHLEPLLALAAERGGLEFSTEVSGAVCASDVI
FIAVGTPPLPSGEANLTYLESAARSIGAAMDGSRFRVIVNKSTVPVGSGNLVEALVREGVGETRAGERIRFGVASNPEFL
REGSAVADSLYPDRIVVGGDAATVAVMRELYEPLVAQVFTPPPGVPRPSSMISVPLLSTSLTSAEMIKYAANAFLAMKIG
FANEIANICERVGAEGPEVMAGIGLDSRIGAKFLNPGVGWGGSCFGKDIQSLLHTAKEYGYTSKLLEATLEVNAAQRQMV
IQKLQEKLYILKGRTIGLLGLAFKPDTDDLRDAPALHIAERLMQMGVRVKAYDPIANAACREQRPELKMRYCDSVQELAS
GADALVLVTEWHEFHNLDLGELAGLMANPILVDGRNFFVPERAMQAGFDYCGIGRCARTRSTARMEATT

Sequences:

>Translated_469_residues
MRVTVIGTGYVGTVTGACLAYLGHQVTCVDTDAAKIARLQRGESPIYEPHLEPLLALAAERGGLEFSTEVSGAVCASDVI
FIAVGTPPLPSGEANLTYLESAARSIGAAMDGSRFRVIVNKSTVPVGSGNLVEALVREGVGETRAGERIRFGVASNPEFL
REGSAVADSLYPDRIVVGGDAATVAVMRELYEPLVAQVFTPPPGVPRPSSMISVPLLSTSLTSAEMIKYAANAFLAMKIG
FANEIANICERVGAEGPEVMAGIGLDSRIGAKFLNPGVGWGGSCFGKDIQSLLHTAKEYGYTSKLLEATLEVNAAQRQMV
IQKLQEKLYILKGRTIGLLGLAFKPDTDDLRDAPALHIAERLMQMGVRVKAYDPIANAACREQRPELKMRYCDSVQELAS
GADALVLVTEWHEFHNLDLGELAGLMANPILVDGRNFFVPERAMQAGFDYCGIGRCARTRSTARMEATT
>Mature_469_residues
MRVTVIGTGYVGTVTGACLAYLGHQVTCVDTDAAKIARLQRGESPIYEPHLEPLLALAAERGGLEFSTEVSGAVCASDVI
FIAVGTPPLPSGEANLTYLESAARSIGAAMDGSRFRVIVNKSTVPVGSGNLVEALVREGVGETRAGERIRFGVASNPEFL
REGSAVADSLYPDRIVVGGDAATVAVMRELYEPLVAQVFTPPPGVPRPSSMISVPLLSTSLTSAEMIKYAANAFLAMKIG
FANEIANICERVGAEGPEVMAGIGLDSRIGAKFLNPGVGWGGSCFGKDIQSLLHTAKEYGYTSKLLEATLEVNAAQRQMV
IQKLQEKLYILKGRTIGLLGLAFKPDTDDLRDAPALHIAERLMQMGVRVKAYDPIANAACREQRPELKMRYCDSVQELAS
GADALVLVTEWHEFHNLDLGELAGLMANPILVDGRNFFVPERAMQAGFDYCGIGRCARTRSTARMEATT

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=466, Percent_Identity=32.8326180257511, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI296040438, Length=367, Percent_Identity=33.2425068119891, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI296040443, Length=317, Percent_Identity=33.4384858044164, Blast_Score=161, Evalue=1e-39,
Organism=Escherichia coli, GI1788340, Length=375, Percent_Identity=28.5333333333333, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI48994968, Length=426, Percent_Identity=28.8732394366197, Blast_Score=132, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17560350, Length=484, Percent_Identity=33.0578512396694, Blast_Score=244, Evalue=6e-65,
Organism=Drosophila melanogaster, GI17136908, Length=483, Percent_Identity=33.3333333333333, Blast_Score=238, Evalue=6e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 50127; Mature: 50127

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVTVIGTGYVGTVTGACLAYLGHQVTCVDTDAAKIARLQRGESPIYEPHLEPLLALAAE
CEEEEEECCCHHHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHH
RGGLEFSTEVSGAVCASDVIFIAVGTPPLPSGEANLTYLESAARSIGAAMDGSRFRVIVN
CCCCEEECCCCCCEEECCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEE
KSTVPVGSGNLVEALVREGVGETRAGERIRFGVASNPEFLREGSAVADSLYPDRIVVGGD
CCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHCCCHHHHHCCCCEEEECCC
AATVAVMRELYEPLVAQVFTPPPGVPRPSSMISVPLLSTSLTSAEMIKYAANAFLAMKIG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHEEEEEEC
FANEIANICERVGAEGPEVMAGIGLDSRIGAKFLNPGVGWGGSCFGKDIQSLLHTAKEYG
HHHHHHHHHHHHCCCCCCEEEECCCCHHHCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCC
YTSKLLEATLEVNAAQRQMVIQKLQEKLYILKGRTIGLLGLAFKPDTDDLRDAPALHIAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEEEEECCCCCHHHCCHHHHHHH
RLMQMGVRVKAYDPIANAACREQRPELKMRYCDSVQELASGADALVLVTEWHEFHNLDLG
HHHHCCCEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEECHHHHCCCHH
ELAGLMANPILVDGRNFFVPERAMQAGFDYCGIGRCARTRSTARMEATT
HHHHHHCCCEEECCCCCCCCHHHHHCCCCCCCCCHHHHCCCCCEEECCC
>Mature Secondary Structure
MRVTVIGTGYVGTVTGACLAYLGHQVTCVDTDAAKIARLQRGESPIYEPHLEPLLALAAE
CEEEEEECCCHHHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHH
RGGLEFSTEVSGAVCASDVIFIAVGTPPLPSGEANLTYLESAARSIGAAMDGSRFRVIVN
CCCCEEECCCCCCEEECCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEE
KSTVPVGSGNLVEALVREGVGETRAGERIRFGVASNPEFLREGSAVADSLYPDRIVVGGD
CCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHCCCHHHHHCCCCEEEECCC
AATVAVMRELYEPLVAQVFTPPPGVPRPSSMISVPLLSTSLTSAEMIKYAANAFLAMKIG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHEEEEEEC
FANEIANICERVGAEGPEVMAGIGLDSRIGAKFLNPGVGWGGSCFGKDIQSLLHTAKEYG
HHHHHHHHHHHHCCCCCCEEEECCCCHHHCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCC
YTSKLLEATLEVNAAQRQMVIQKLQEKLYILKGRTIGLLGLAFKPDTDDLRDAPALHIAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEEEEECCCCCHHHCCHHHHHHH
RLMQMGVRVKAYDPIANAACREQRPELKMRYCDSVQELASGADALVLVTEWHEFHNLDLG
HHHHCCCEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEECHHHHCCCHH
ELAGLMANPILVDGRNFFVPERAMQAGFDYCGIGRCARTRSTARMEATT
HHHHHHCCCEEECCCCCCCCHHHHHCCCCCCCCCHHHHCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10048024; 9384377; 10376820 [H]