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The map label for this gene is uvrC

Identifier: 116625695

GI number: 116625695

Start: 8330883

End: 8332754

Strand: Direct

Name: uvrC

Synonym: Acid_6644

Alternate gene names: 116625695

Gene position: 8330883-8332754 (Clockwise)

Preceding gene: 116625691

Following gene: 116625696

Centisome position: 83.6

GC content: 61.59

Gene sequence:

>1872_bases
ATGGAACTCCGTGACAAGGTAGGTCAACTCCCCTTCTCGCCCGGAGTGTATCTCTACAAGGATTCCGGGGGCAAGGTGAT
CTACGTCGGCAAGGCCAAGAGCCTTCGGAACCGGGTCCGGAGCTATTTTTCGGAGGACAAGCTTGGCGATATCAAGACCG
GAACGCTGATCACGGAAGCCTGCGATATCGACTACATCCTGGTCGATAACGAAAAGGAAGCTCTCGCTCTCGAAAACAAC
CTGATCAAGCAGTACAAGCCGCGCTTCAACATCCTGCTGCGCGATGACAAGACGTACCCCTACGTCAAAGTCACCAACGA
AAAGTATCCGCGCGTGTACGTTACGCGACGGCTGCGCAAGGATGGAGCTCAGTACTTCGGACCGTTCTTCCCGGCCAACC
TGGCGCACCGCCTGGTGCACTTCATCCATCGCCATTTCCAGGTGCCTTCCTGTAAGGTGGATCTCACGCGATTCCATCCG
AAGCCCTGCCTGCAATTCCACATTCACCGCTGCCTGGGACCGTGCGTGCAAGGCTTGACTACGGACGAAGCGTACGCGGC
CGCCGTGCGTGATGTGCGCCTCTTCCTGGACGGCCGCCACAGCGACCTGGCGCGCGGGTTGCGGGCGCGCATGGAAGCGG
CCAGCCTGGAAATGCGCTTCGAGGAAGCCGCGGGCTTGCGCGACCTGATCACCACGGTGGAGGAGATTGAAGAACGCCAG
AAAATGGCGGCCGCCAAGGGCGACGATGTCGATATCTTCGCGGTATATGCCGAACCGCCGCTGGTCGCGCTCAACATCTT
CCACCTGCGCAACGGCCAGATCGTGGACCGCCGCGAGCTCTTCTGGGAAGATCAGTTCGAATACGACGAATCGCTCTTCC
TCTCCTCGCTGCTCAAGCAGATTTACCTGGACCAGCAGTTCGTGCCCGCCGAAATCCACGTTCCGGTGGAGTTCGAAGAT
CTGGAAGCGCTGGAGGAGCTGCTCACCGAAAAGCGCCAGCGGCGCGTGGAAATCCGCACGCCCCAGCGCGGCCAGAAGAA
GGCGCTGCTCGGCCTGGTGGAGACCAACGCCAAGCATAGCTTCGACGCGCGCTTCCGCGTGCTGAAGCCGAGCTCGCGGG
CCATCCAGGAAGCGCTGCAGGACGCGCTCAACCTGCCCGACGCTCCCTCGCGCATCGAGTGTTTCGACATCTCGCACATT
CAGGGCACGGATAAAGTGGCCAGCATGGTGGTGTGGGAAGACGGCAAGATGAAGAAGTCCGACTACCGGAAATTCATCAT
CCGAACGGTGGTGGGCAATGACGATTTCGCCAGCATGCGCGAAGTGGTCACGCGGCGGTATTCGCGGCTGCAGGAAGAAA
AGCAGCCGATGCCGGGACTGGTGCTTATCGATGGCGGGCTGGGGCAGTTGCACGCCGCCGCCGAAGCCCTGGAGGCGATC
GGGATCGCCGATCAGCCGCTGGCCTCGATCGCCAAACGCGAGGAGATCATCTACGTGTTCGGCCAGGAGGACGAGCCGGT
GGTGCTGGACCGCTTCTCGCCGATCCTGCACCTGGTTCAATCCATCCGCGACGAGGCCCACCGGTTCGCGGTCACGTTCC
ACCGTTCGCTGCGCAATACGCGGCAATTGACCAGCGAACTCGACGCGATTCGCGGAGTGGGGGCCAAGACTGTACAGAAG
CTGCTCAAGGAATTCGGCAGCCTGGAACGGGTGCGCGCCGCCACGGAGACTCAGCTCGCGACCGTAGTCGGACGCGCCGC
CGCGAAGCGTGTGATCGCGCATTACACGACAGTGGAAGCAGCACCGGAGCCTGTGGCTTCAGTTGCACAGAGTGAGGATG
CCGCGCCAGATGTACCCGACCCGCAAGCGTGA

Upstream 100 bases:

>100_bases
GCGTTTCTTGAGTTGGGGATCCTGTGCGAAGAGCGACGACAGCGCCAACAATAGCAGCGCCGCAATACAGCGTGACATAA
TTAAATTATAACTTCCCTCC

Downstream 100 bases:

>100_bases
GAAAATGAGGTATATGCGTTTCCGACTTCTGGGAGCCGCGCTACTTTTTTGCCTCCTGGCGACCGCCCAGACTACGCTCA
CCGTCGATCAGCTGATGAAG

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 623; Mature: 623

Protein sequence:

>623_residues
MELRDKVGQLPFSPGVYLYKDSGGKVIYVGKAKSLRNRVRSYFSEDKLGDIKTGTLITEACDIDYILVDNEKEALALENN
LIKQYKPRFNILLRDDKTYPYVKVTNEKYPRVYVTRRLRKDGAQYFGPFFPANLAHRLVHFIHRHFQVPSCKVDLTRFHP
KPCLQFHIHRCLGPCVQGLTTDEAYAAAVRDVRLFLDGRHSDLARGLRARMEAASLEMRFEEAAGLRDLITTVEEIEERQ
KMAAAKGDDVDIFAVYAEPPLVALNIFHLRNGQIVDRRELFWEDQFEYDESLFLSSLLKQIYLDQQFVPAEIHVPVEFED
LEALEELLTEKRQRRVEIRTPQRGQKKALLGLVETNAKHSFDARFRVLKPSSRAIQEALQDALNLPDAPSRIECFDISHI
QGTDKVASMVVWEDGKMKKSDYRKFIIRTVVGNDDFASMREVVTRRYSRLQEEKQPMPGLVLIDGGLGQLHAAAEALEAI
GIADQPLASIAKREEIIYVFGQEDEPVVLDRFSPILHLVQSIRDEAHRFAVTFHRSLRNTRQLTSELDAIRGVGAKTVQK
LLKEFGSLERVRAATETQLATVVGRAAAKRVIAHYTTVEAAPEPVASVAQSEDAAPDVPDPQA

Sequences:

>Translated_623_residues
MELRDKVGQLPFSPGVYLYKDSGGKVIYVGKAKSLRNRVRSYFSEDKLGDIKTGTLITEACDIDYILVDNEKEALALENN
LIKQYKPRFNILLRDDKTYPYVKVTNEKYPRVYVTRRLRKDGAQYFGPFFPANLAHRLVHFIHRHFQVPSCKVDLTRFHP
KPCLQFHIHRCLGPCVQGLTTDEAYAAAVRDVRLFLDGRHSDLARGLRARMEAASLEMRFEEAAGLRDLITTVEEIEERQ
KMAAAKGDDVDIFAVYAEPPLVALNIFHLRNGQIVDRRELFWEDQFEYDESLFLSSLLKQIYLDQQFVPAEIHVPVEFED
LEALEELLTEKRQRRVEIRTPQRGQKKALLGLVETNAKHSFDARFRVLKPSSRAIQEALQDALNLPDAPSRIECFDISHI
QGTDKVASMVVWEDGKMKKSDYRKFIIRTVVGNDDFASMREVVTRRYSRLQEEKQPMPGLVLIDGGLGQLHAAAEALEAI
GIADQPLASIAKREEIIYVFGQEDEPVVLDRFSPILHLVQSIRDEAHRFAVTFHRSLRNTRQLTSELDAIRGVGAKTVQK
LLKEFGSLERVRAATETQLATVVGRAAAKRVIAHYTTVEAAPEPVASVAQSEDAAPDVPDPQA
>Mature_623_residues
MELRDKVGQLPFSPGVYLYKDSGGKVIYVGKAKSLRNRVRSYFSEDKLGDIKTGTLITEACDIDYILVDNEKEALALENN
LIKQYKPRFNILLRDDKTYPYVKVTNEKYPRVYVTRRLRKDGAQYFGPFFPANLAHRLVHFIHRHFQVPSCKVDLTRFHP
KPCLQFHIHRCLGPCVQGLTTDEAYAAAVRDVRLFLDGRHSDLARGLRARMEAASLEMRFEEAAGLRDLITTVEEIEERQ
KMAAAKGDDVDIFAVYAEPPLVALNIFHLRNGQIVDRRELFWEDQFEYDESLFLSSLLKQIYLDQQFVPAEIHVPVEFED
LEALEELLTEKRQRRVEIRTPQRGQKKALLGLVETNAKHSFDARFRVLKPSSRAIQEALQDALNLPDAPSRIECFDISHI
QGTDKVASMVVWEDGKMKKSDYRKFIIRTVVGNDDFASMREVVTRRYSRLQEEKQPMPGLVLIDGGLGQLHAAAEALEAI
GIADQPLASIAKREEIIYVFGQEDEPVVLDRFSPILHLVQSIRDEAHRFAVTFHRSLRNTRQLTSELDAIRGVGAKTVQK
LLKEFGSLERVRAATETQLATVVGRAAAKRVIAHYTTVEAAPEPVASVAQSEDAAPDVPDPQA

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=586, Percent_Identity=36.518771331058, Blast_Score=357, Evalue=2e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_SOLUE (Q01S04)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_827851.1
- ProteinModelPortal:   Q01S04
- STRING:   Q01S04
- GeneID:   4425237
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_6644
- NMPDR:   fig|234267.9.peg.6315
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q01S04
- ProtClustDB:   PRK14669
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 70749; Mature: 70749

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRDKVGQLPFSPGVYLYKDSGGKVIYVGKAKSLRNRVRSYFSEDKLGDIKTGTLITEA
CCCHHHHCCCCCCCCEEEEECCCCEEEEEECHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
CDIDYILVDNEKEALALENNLIKQYKPRFNILLRDDKTYPYVKVTNEKYPRVYVTRRLRK
CCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCCCHHHHHHHHH
DGAQYFGPFFPANLAHRLVHFIHRHFQVPSCKVDLTRFHPKPCLQFHIHRCLGPCVQGLT
CCHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEHHHCCCCHHHHHHHHHHHHHHHCCCC
TDEAYAAAVRDVRLFLDGRHSDLARGLRARMEAASLEMRFEEAAGLRDLITTVEEIEERQ
CCHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
KMAAAKGDDVDIFAVYAEPPLVALNIFHLRNGQIVDRRELFWEDQFEYDESLFLSSLLKQ
HHHHCCCCCEEEEEEECCCCEEEEEEEEECCCCEECHHHHHHCCCCCHHHHHHHHHHHHH
IYLDQQFVPAEIHVPVEFEDLEALEELLTEKRQRRVEIRTPQRGQKKALLGLVETNAKHS
HHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCEEECCCCCCCCHHHHHHHHHCCCCCC
FDARFRVLKPSSRAIQEALQDALNLPDAPSRIECFDISHIQGTDKVASMVVWEDGKMKKS
CCCEEEEECCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHEEEEECCCCCCHH
DYRKFIIRTVVGNDDFASMREVVTRRYSRLQEEKQPMPGLVLIDGGLGQLHAAAEALEAI
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHH
GIADQPLASIAKREEIIYVFGQEDEPVVLDRFSPILHLVQSIRDEAHRFAVTFHRSLRNT
CCCCCHHHHHHCCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQLTSELDAIRGVGAKTVQKLLKEFGSLERVRAATETQLATVVGRAAAKRVIAHYTTVEA
HHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
APEPVASVAQSEDAAPDVPDPQA
CCCHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MELRDKVGQLPFSPGVYLYKDSGGKVIYVGKAKSLRNRVRSYFSEDKLGDIKTGTLITEA
CCCHHHHCCCCCCCCEEEEECCCCEEEEEECHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
CDIDYILVDNEKEALALENNLIKQYKPRFNILLRDDKTYPYVKVTNEKYPRVYVTRRLRK
CCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCCCHHHHHHHHH
DGAQYFGPFFPANLAHRLVHFIHRHFQVPSCKVDLTRFHPKPCLQFHIHRCLGPCVQGLT
CCHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEHHHCCCCHHHHHHHHHHHHHHHCCCC
TDEAYAAAVRDVRLFLDGRHSDLARGLRARMEAASLEMRFEEAAGLRDLITTVEEIEERQ
CCHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
KMAAAKGDDVDIFAVYAEPPLVALNIFHLRNGQIVDRRELFWEDQFEYDESLFLSSLLKQ
HHHHCCCCCEEEEEEECCCCEEEEEEEEECCCCEECHHHHHHCCCCCHHHHHHHHHHHHH
IYLDQQFVPAEIHVPVEFEDLEALEELLTEKRQRRVEIRTPQRGQKKALLGLVETNAKHS
HHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCEEECCCCCCCCHHHHHHHHHCCCCCC
FDARFRVLKPSSRAIQEALQDALNLPDAPSRIECFDISHIQGTDKVASMVVWEDGKMKKS
CCCEEEEECCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHEEEEECCCCCCHH
DYRKFIIRTVVGNDDFASMREVVTRRYSRLQEEKQPMPGLVLIDGGLGQLHAAAEALEAI
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHH
GIADQPLASIAKREEIIYVFGQEDEPVVLDRFSPILHLVQSIRDEAHRFAVTFHRSLRNT
CCCCCHHHHHHCCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQLTSELDAIRGVGAKTVQKLLKEFGSLERVRAATETQLATVVGRAAAKRVIAHYTTVEA
HHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
APEPVASVAQSEDAAPDVPDPQA
CCCHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA