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The map label for this gene is ytcI [H]

Identifier: 116625640

GI number: 116625640

Start: 8264291

End: 8265850

Strand: Reverse

Name: ytcI [H]

Synonym: Acid_6589

Alternate gene names: 116625640

Gene position: 8265850-8264291 (Counterclockwise)

Preceding gene: 116625641

Following gene: 116625639

Centisome position: 82.94

GC content: 63.33

Gene sequence:

>1560_bases
ATGTCAGCGTTTGTTGAAGCTCGTGATTTCCTGATCTCGAACCGCTGCGATTACGCAACGGCATATCGCGACTTCGTCTT
TCCGCGCCTGACGCATTTCAACTGGGCGCTCGATTATTTCGATTCGCTTCCCGGCGAGCAACTCGCCTTGTGGATCGTCG
AGGAGGATGGCTCCGAGCTCCGGCTCACGTTCGCCGAACTGTCCGCGCGCTCCAACCGCACCGCCAACCTGCTGCGCCGT
CGCGGCGTGCGGCGCGGCGATCGCGTGCTGGTTATGCTCGGCAACGAGGTCGCACTCTGGGAGACAATGCTCGCCGCATT
CAAGCTCGGAGCCGTGGTCATTCCCACGACCCCGCTCCTCGGCACCGCGGATCTCCAGGACCGCCTGGCTCGCGGCCAGG
TCCGCCACGTCGTGGCCGGCCGGCATATCGATAGCTTCGCGGACATCGCCGGGGATTTTTCGCGCATCAGTCTCGATGGC
GCTTCCCGCGAATCGGCGCTCTTCGAGCCTGATGGTCCCACGCTGGCCTCCGACCCACTGCTGCTCTACTTCACTTCGGG
CACCACCGCCCAGCCCAAGCTTGTGCAGCACTCCCACGAGAGTTATCCCGTGGGCCACCTCTCCACCATGTACTGGCTTG
GCCTCCAGCCCGGCGACGTGCACTGGAATATCAGCTCGCCGGGATGGGCCAAGCATGCCTGGAGCTGTTTCTTCGCGCCC
TGGAATGCCGGCGCCACGGTCTTCATTTATAACTACGCACGCTTCCACGCTGCCGATGCGCTGCGCGTTCTCGCCTCCAA
GCCGGTGACCTCGCTGTGCGCGCCTCCCACTGTGTGGCGCATGCTCGTGCTGGAAGATCTTGCGGCGCACCGCGTGCAGT
TACGCGAGGTCATGAGCGCCGGCGAACCGCTCAACCCGGAGGTGATTCAACGCATTCGCGCGGAGTGGAAGCTCACCGTC
CGGGATGGCTATGGCCAGACCGAGACCACCGCCATGGTCGGCAATCCTCCCGGCCAGCCGCTCAAGCCCGGCTCCATGGG
CCGCCCACTACCCGGCTACCGGATTGAACTGACCGACGAAGGTGAAATCTGCCTGGAACTCGCCGCGCGCCCTGCCGGTC
TCATGCTCGGCTACACCGGCGTGCCGGGTCCCGCCGACGACAAATTCTACCGTACCGGCGACGTCGCCACCTGCGACGAA
GAGGGTTATCTCACGTATGTCGGCCGTGCCGACGATGTCTTCAAGTCGTCGGACTATCGCATTAGTCCTTTCGAACTGGA
GAGCCTTCTGCTCCGCCATCCCGCCGTGGCCGAAGCCGCCATAGTTCCCTGCGAGGACAAGGCGCGCGGCTGCGTGCCCA
AGGCCTACATCACCCTGATCGCAGGCTACAAGCCCAGCGAAAAAATGGCCCGCTATCTCTTCTCTTTCATCCGCCAGACC
TTCTCCCCCTTCAAGCGAATTCGCCGCATCGAATTCTGCGAGCTTCCCAAAACGATCTCCGGCAAAATCCGCCGCGCCGA
ACTCCGTACCCGCAAACCCTTGAAGGAATACCGCGACTGA

Upstream 100 bases:

>100_bases
CGGCCCCCTTAGTGAAGCCAGCGTCGCCAATGGCAGCGCGCCGCAAAAATTCCCCGATTTCACCCGGGGCAAATGGCAAA
CCCGCCAGCCTGTTTAAGGC

Downstream 100 bases:

>100_bases
GAAGGGGTTTCAATCGCACAATACCGCTCTTACCATCAACAAATCTGCTTTACATCGGGTCCGGTCCATGACAGAATCCC
GGGCAGTAACAAGAGTTAGC

Product: AMP-dependent synthetase and ligase

Products: AMP; diphosphate; acetyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 519; Mature: 518

Protein sequence:

>519_residues
MSAFVEARDFLISNRCDYATAYRDFVFPRLTHFNWALDYFDSLPGEQLALWIVEEDGSELRLTFAELSARSNRTANLLRR
RGVRRGDRVLVMLGNEVALWETMLAAFKLGAVVIPTTPLLGTADLQDRLARGQVRHVVAGRHIDSFADIAGDFSRISLDG
ASRESALFEPDGPTLASDPLLLYFTSGTTAQPKLVQHSHESYPVGHLSTMYWLGLQPGDVHWNISSPGWAKHAWSCFFAP
WNAGATVFIYNYARFHAADALRVLASKPVTSLCAPPTVWRMLVLEDLAAHRVQLREVMSAGEPLNPEVIQRIRAEWKLTV
RDGYGQTETTAMVGNPPGQPLKPGSMGRPLPGYRIELTDEGEICLELAARPAGLMLGYTGVPGPADDKFYRTGDVATCDE
EGYLTYVGRADDVFKSSDYRISPFELESLLLRHPAVAEAAIVPCEDKARGCVPKAYITLIAGYKPSEKMARYLFSFIRQT
FSPFKRIRRIEFCELPKTISGKIRRAELRTRKPLKEYRD

Sequences:

>Translated_519_residues
MSAFVEARDFLISNRCDYATAYRDFVFPRLTHFNWALDYFDSLPGEQLALWIVEEDGSELRLTFAELSARSNRTANLLRR
RGVRRGDRVLVMLGNEVALWETMLAAFKLGAVVIPTTPLLGTADLQDRLARGQVRHVVAGRHIDSFADIAGDFSRISLDG
ASRESALFEPDGPTLASDPLLLYFTSGTTAQPKLVQHSHESYPVGHLSTMYWLGLQPGDVHWNISSPGWAKHAWSCFFAP
WNAGATVFIYNYARFHAADALRVLASKPVTSLCAPPTVWRMLVLEDLAAHRVQLREVMSAGEPLNPEVIQRIRAEWKLTV
RDGYGQTETTAMVGNPPGQPLKPGSMGRPLPGYRIELTDEGEICLELAARPAGLMLGYTGVPGPADDKFYRTGDVATCDE
EGYLTYVGRADDVFKSSDYRISPFELESLLLRHPAVAEAAIVPCEDKARGCVPKAYITLIAGYKPSEKMARYLFSFIRQT
FSPFKRIRRIEFCELPKTISGKIRRAELRTRKPLKEYRD
>Mature_518_residues
SAFVEARDFLISNRCDYATAYRDFVFPRLTHFNWALDYFDSLPGEQLALWIVEEDGSELRLTFAELSARSNRTANLLRRR
GVRRGDRVLVMLGNEVALWETMLAAFKLGAVVIPTTPLLGTADLQDRLARGQVRHVVAGRHIDSFADIAGDFSRISLDGA
SRESALFEPDGPTLASDPLLLYFTSGTTAQPKLVQHSHESYPVGHLSTMYWLGLQPGDVHWNISSPGWAKHAWSCFFAPW
NAGATVFIYNYARFHAADALRVLASKPVTSLCAPPTVWRMLVLEDLAAHRVQLREVMSAGEPLNPEVIQRIRAEWKLTVR
DGYGQTETTAMVGNPPGQPLKPGSMGRPLPGYRIELTDEGEICLELAARPAGLMLGYTGVPGPADDKFYRTGDVATCDEE
GYLTYVGRADDVFKSSDYRISPFELESLLLRHPAVAEAAIVPCEDKARGCVPKAYITLIAGYKPSEKMARYLFSFIRQTF
SPFKRIRRIEFCELPKTISGKIRRAELRTRKPLKEYRD

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42544132, Length=544, Percent_Identity=35.8455882352941, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI122937307, Length=553, Percent_Identity=37.0705244122966, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI38505220, Length=501, Percent_Identity=35.1297405189621, Blast_Score=292, Evalue=5e-79,
Organism=Homo sapiens, GI58082049, Length=526, Percent_Identity=33.2699619771863, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI157311624, Length=526, Percent_Identity=33.4600760456274, Blast_Score=269, Evalue=6e-72,
Organism=Homo sapiens, GI157311622, Length=526, Percent_Identity=33.4600760456274, Blast_Score=269, Evalue=6e-72,
Organism=Homo sapiens, GI115511026, Length=545, Percent_Identity=31.1926605504587, Blast_Score=248, Evalue=8e-66,
Organism=Homo sapiens, GI42544134, Length=371, Percent_Identity=33.4231805929919, Blast_Score=219, Evalue=6e-57,
Organism=Homo sapiens, GI195947378, Length=443, Percent_Identity=27.765237020316, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI13375727, Length=531, Percent_Identity=26.7419962335217, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI28416953, Length=576, Percent_Identity=25.6944444444444, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI253970489, Length=367, Percent_Identity=30.2452316076294, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI8923896, Length=367, Percent_Identity=30.2452316076294, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI156151445, Length=545, Percent_Identity=26.7889908256881, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1790505, Length=526, Percent_Identity=29.0874524714829, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1788107, Length=516, Percent_Identity=25.968992248062, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI221142682, Length=537, Percent_Identity=24.5810055865922, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1786529, Length=569, Percent_Identity=26.713532513181, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1786810, Length=522, Percent_Identity=26.8199233716475, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI145693145, Length=501, Percent_Identity=26.1477045908184, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1788595, Length=429, Percent_Identity=27.039627039627, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71983001, Length=529, Percent_Identity=27.9773156899811, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71982997, Length=529, Percent_Identity=27.9773156899811, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71996755, Length=470, Percent_Identity=24.8936170212766, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17559526, Length=375, Percent_Identity=26.1333333333333, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI32563687, Length=485, Percent_Identity=22.4742268041237, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17558820, Length=480, Percent_Identity=22.2916666666667, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17557194, Length=521, Percent_Identity=23.9923224568138, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71994703, Length=541, Percent_Identity=21.6266173752311, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71994694, Length=541, Percent_Identity=21.6266173752311, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71994690, Length=541, Percent_Identity=22.181146025878, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17538037, Length=523, Percent_Identity=23.3269598470363, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17560308, Length=384, Percent_Identity=24.4791666666667, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17531443, Length=501, Percent_Identity=22.9540918163673, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71985884, Length=384, Percent_Identity=22.9166666666667, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17560140, Length=161, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319264, Length=548, Percent_Identity=26.8248175182482, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6323182, Length=547, Percent_Identity=25.7769652650823, Blast_Score=120, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6319699, Length=348, Percent_Identity=27.2988505747126, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24667955, Length=367, Percent_Identity=31.0626702997275, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI62472339, Length=367, Percent_Identity=31.0626702997275, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24667959, Length=367, Percent_Identity=31.0626702997275, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI21355225, Length=531, Percent_Identity=26.7419962335217, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI21355181, Length=486, Percent_Identity=24.8971193415638, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24581924, Length=348, Percent_Identity=26.4367816091954, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI18859661, Length=400, Percent_Identity=26.5, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24648260, Length=504, Percent_Identity=24.2063492063492, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21356947, Length=491, Percent_Identity=21.9959266802444, Blast_Score=73, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.2.1.1

Molecular weight: Translated: 58083; Mature: 57952

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAFVEARDFLISNRCDYATAYRDFVFPRLTHFNWALDYFDSLPGEQLALWIVEEDGSEL
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEE
RLTFAELSARSNRTANLLRRRGVRRGDRVLVMLGNEVALWETMLAAFKLGAVVIPTTPLL
EEEHHHHHCCCCHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHCCEEEECCCCCC
GTADLQDRLARGQVRHVVAGRHIDSFADIAGDFSRISLDGASRESALFEPDGPTLASDPL
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEECCCCCCCCEECCCCCCCCCCCE
LLYFTSGTTAQPKLVQHSHESYPVGHLSTMYWLGLQPGDVHWNISSPGWAKHAWSCFFAP
EEEEECCCCCCCHHHHCCCCCCCCCHHCEEEEEECCCCCEEEECCCCCCCCCCEEEEEEE
WNAGATVFIYNYARFHAADALRVLASKPVTSLCAPPTVWRMLVLEDLAAHRVQLREVMSA
CCCCCEEEEEECHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GEPLNPEVIQRIRAEWKLTVRDGYGQTETTAMVGNPPGQPLKPGSMGRPLPGYRIELTDE
CCCCCHHHHHHHHHHEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEECCC
GEICLELAARPAGLMLGYTGVPGPADDKFYRTGDVATCDEEGYLTYVGRADDVFKSSDYR
CCEEHHHHCCCCCEEEEECCCCCCCCCCCEECCCCEEECCCCCEEEECCCCHHHCCCCCE
ISPFELESLLLRHPAVAEAAIVPCEDKARGCVPKAYITLIAGYKPSEKMARYLFSFIRQT
ECHHHHHHHHHCCCCHHHEEEECCCCCCCCCCCHHHHEEEECCCCHHHHHHHHHHHHHHH
FSPFKRIRRIEFCELPKTISGKIRRAELRTRKPLKEYRD
HHHHHHHHHHHHHCCCCHHCCCEEHHHHHHCCCHHHHCC
>Mature Secondary Structure 
SAFVEARDFLISNRCDYATAYRDFVFPRLTHFNWALDYFDSLPGEQLALWIVEEDGSEL
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEE
RLTFAELSARSNRTANLLRRRGVRRGDRVLVMLGNEVALWETMLAAFKLGAVVIPTTPLL
EEEHHHHHCCCCHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHCCEEEECCCCCC
GTADLQDRLARGQVRHVVAGRHIDSFADIAGDFSRISLDGASRESALFEPDGPTLASDPL
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEECCCCCCCCEECCCCCCCCCCCE
LLYFTSGTTAQPKLVQHSHESYPVGHLSTMYWLGLQPGDVHWNISSPGWAKHAWSCFFAP
EEEEECCCCCCCHHHHCCCCCCCCCHHCEEEEEECCCCCEEEECCCCCCCCCCEEEEEEE
WNAGATVFIYNYARFHAADALRVLASKPVTSLCAPPTVWRMLVLEDLAAHRVQLREVMSA
CCCCCEEEEEECHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GEPLNPEVIQRIRAEWKLTVRDGYGQTETTAMVGNPPGQPLKPGSMGRPLPGYRIELTDE
CCCCCHHHHHHHHHHEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEECCC
GEICLELAARPAGLMLGYTGVPGPADDKFYRTGDVATCDEEGYLTYVGRADDVFKSSDYR
CCEEHHHHCCCCCEEEEECCCCCCCCCCCEECCCCEEECCCCCEEEECCCCHHHCCCCCE
ISPFELESLLLRHPAVAEAAIVPCEDKARGCVPKAYITLIAGYKPSEKMARYLFSFIRQT
ECHHHHHHHHHCCCCHHHEEEECCCCCCCCCCCHHHHEEEECCCCHHHHHHHHHHHHHHH
FSPFKRIRRIEFCELPKTISGKIRRAELRTRKPLKEYRD
HHHHHHHHHHHHHCCCCHHCCCEEHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; acetate; CoA

Specific reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

General reaction: Acid-thiol ligation [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]