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The map label for this gene is 116625569

Identifier: 116625569

GI number: 116625569

Start: 8168931

End: 8170139

Strand: Reverse

Name: 116625569

Synonym: Acid_6516

Alternate gene names: NA

Gene position: 8170139-8168931 (Counterclockwise)

Preceding gene: 116625570

Following gene: 116625564

Centisome position: 81.98

GC content: 64.35

Gene sequence:

>1209_bases
ATGACCGATTTTCCGATTCAGAACCTCCCCTACGGCGTTTTTCGGAATGCGGCGGGACAGGTCTCCATCGGAGTCGCCAT
CGAAGACTACATTCTCGACTTGCGCGTCACCGCCGCCGCGGGACTGCTCAAAGCGCTGCCGCCGGAGACGCGCCGCGCCT
GCGCCGCCGAATCGCTGAATGCCTTGATGGCGCTCACCCCCACCCACTGGCGCGACCTGCGCGCGCGGATCACGGAGCTT
CTCTCCGGCGAACCGTTCCTGGTGGCGATGAAAGATGCGGTCATGCTCGCGCCCGCGTCGATCGGCGATTACACCGATTT
CTACGCGTCGATTTTTCACGCGACCAATGTCGGCAGCCTTTTCCGCCCGGACAATCCGCTGCTGCCCAACTATAAATACG
TCCCCATCGGCTATCACGGGCGCGCCTCCTCGATTGTGCCCAGCGGCGCCGCTATCCGAAGGCCGCAAGGGCAGGCAATG
GATCCCGGTGCCGCGGCTCCACGTTTTGGACCGACGCGCGCGCTTGATTACGAGCTCGAGGCCGGCTTCTTCATCGGACC
CGGGAATGCGCTCGGCGAGCCGGTTCCGATTGAAGCCGCGGAAGATCACGTCTTCGGCGTTTGCCTGGTGAACGATTGGT
CCGCGCGCGATATTCAGGCGTGGGAATACCAGCCGCTCGGTCCCTTTCTCGGTAAGAGCTTCGCGACAAGCATCTCGCCC
TGGGTGGTGACGATGGAGGCGCTGGCACCGTACCGCGCACCGCTCTACCAACGGCCCGAGGGCGACCCCGCGCCGCTGCC
GTATTTGCACTCCGAAGGCAATGCCGCGATTGATCTGACGCTCGAGGTGGAGATTACGAGCGCGCAGATGCGCGCGCGAG
ACATGGCGCCGATGCGGCTCAGCCGTGGGAATCTCAAGGACCTCTACTGGTCGATTGCGCAGATGGTCGCGCATCATACT
TCGAACGGCTGCAATTTGCGGCCCGGTGATTTGCTGGCGAGCGGCACGGTATCGGGCGCGACACCGGATTCGCGCGGCTG
CCTGCTGGAGATCACGCGCCGGGGCGCGGAGCCGATCGCGCTTCCTACTGGCGAACTCCGCAAGTTCCTGGAAGACGGCG
ACGAAATCACAATGCGCGGCTACTGCGAGCGCGAGGGCCTGCCGCGGATTGGCCTGGCCACATGCAGCGGCAGGGTGGAC
GCTACTTAA

Upstream 100 bases:

>100_bases
CCACGTCGCAGCTCAGCTCGGCGCGCCGCAAGTTCGCCATCAGCTTCGGCTCCTGCTCCTTCGAGGAGCCGATTCAGGAT
CTGAAGGGCCTCGGCTGGCT

Downstream 100 bases:

>100_bases
CCCAGAGGGTGCCGGCGTTGCTATCGACGCCGCCGACGGTGATGACGATCGGATACTTGCCGGGGCTCAGGTTCGGAATT
TCGAGGTTGGCCTGCGCCAG

Product: fumarylacetoacetate hydrolase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Hydroxylase; Fumarylacetoacetate Hydrolase Family Protein; Fumarylacetoacetase Hydrolase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MTDFPIQNLPYGVFRNAAGQVSIGVAIEDYILDLRVTAAAGLLKALPPETRRACAAESLNALMALTPTHWRDLRARITEL
LSGEPFLVAMKDAVMLAPASIGDYTDFYASIFHATNVGSLFRPDNPLLPNYKYVPIGYHGRASSIVPSGAAIRRPQGQAM
DPGAAAPRFGPTRALDYELEAGFFIGPGNALGEPVPIEAAEDHVFGVCLVNDWSARDIQAWEYQPLGPFLGKSFATSISP
WVVTMEALAPYRAPLYQRPEGDPAPLPYLHSEGNAAIDLTLEVEITSAQMRARDMAPMRLSRGNLKDLYWSIAQMVAHHT
SNGCNLRPGDLLASGTVSGATPDSRGCLLEITRRGAEPIALPTGELRKFLEDGDEITMRGYCEREGLPRIGLATCSGRVD
AT

Sequences:

>Translated_402_residues
MTDFPIQNLPYGVFRNAAGQVSIGVAIEDYILDLRVTAAAGLLKALPPETRRACAAESLNALMALTPTHWRDLRARITEL
LSGEPFLVAMKDAVMLAPASIGDYTDFYASIFHATNVGSLFRPDNPLLPNYKYVPIGYHGRASSIVPSGAAIRRPQGQAM
DPGAAAPRFGPTRALDYELEAGFFIGPGNALGEPVPIEAAEDHVFGVCLVNDWSARDIQAWEYQPLGPFLGKSFATSISP
WVVTMEALAPYRAPLYQRPEGDPAPLPYLHSEGNAAIDLTLEVEITSAQMRARDMAPMRLSRGNLKDLYWSIAQMVAHHT
SNGCNLRPGDLLASGTVSGATPDSRGCLLEITRRGAEPIALPTGELRKFLEDGDEITMRGYCEREGLPRIGLATCSGRVD
AT
>Mature_401_residues
TDFPIQNLPYGVFRNAAGQVSIGVAIEDYILDLRVTAAAGLLKALPPETRRACAAESLNALMALTPTHWRDLRARITELL
SGEPFLVAMKDAVMLAPASIGDYTDFYASIFHATNVGSLFRPDNPLLPNYKYVPIGYHGRASSIVPSGAAIRRPQGQAMD
PGAAAPRFGPTRALDYELEAGFFIGPGNALGEPVPIEAAEDHVFGVCLVNDWSARDIQAWEYQPLGPFLGKSFATSISPW
VVTMEALAPYRAPLYQRPEGDPAPLPYLHSEGNAAIDLTLEVEITSAQMRARDMAPMRLSRGNLKDLYWSIAQMVAHHTS
NGCNLRPGDLLASGTVSGATPDSRGCLLEITRRGAEPIALPTGELRKFLEDGDEITMRGYCEREGLPRIGLATCSGRVDA
T

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=412, Percent_Identity=47.0873786407767, Blast_Score=377, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17568863, Length=415, Percent_Identity=51.566265060241, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24657182, Length=412, Percent_Identity=47.5728155339806, Blast_Score=375, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 43467; Mature: 43336

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDFPIQNLPYGVFRNAAGQVSIGVAIEDYILDLRVTAAAGLLKALPPETRRACAAESLN
CCCCCCCCCCHHHHHCCCCCEEEEEEEEHHEEEEHHHHHHHHHHHCCCHHHHHHHHHHHH
ALMALTPTHWRDLRARITELLSGEPFLVAMKDAVMLAPASIGDYTDFYASIFHATNVGSL
HEEEECCHHHHHHHHHHHHHHCCCCEEEEECCEEEECCCCCCCHHHHHHHHHHHCCCCCC
FRPDNPLLPNYKYVPIGYHGRASSIVPSGAAIRRPQGQAMDPGAAAPRFGPTRALDYELE
CCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCEEEEEEC
AGFFIGPGNALGEPVPIEAAEDHVFGVCLVNDWSARDIQAWEYQPLGPFLGKSFATSISP
CCEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCC
WVVTMEALAPYRAPLYQRPEGDPAPLPYLHSEGNAAIDLTLEVEITSAQMRARDMAPMRL
CEEEHHHHCCCCCCCCCCCCCCCCCCCEEECCCCEEEEEEEEEEECHHHHHHHCCCCHHH
SRGNLKDLYWSIAQMVAHHTSNGCNLRPGDLLASGTVSGATPDSRGCLLEITRRGAEPIA
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEECCCCCCEE
LPTGELRKFLEDGDEITMRGYCEREGLPRIGLATCSGRVDAT
CCHHHHHHHHHCCCEEEEEEEHHHCCCCCEEEEECCCCCCCC
>Mature Secondary Structure 
TDFPIQNLPYGVFRNAAGQVSIGVAIEDYILDLRVTAAAGLLKALPPETRRACAAESLN
CCCCCCCCCHHHHHCCCCCEEEEEEEEHHEEEEHHHHHHHHHHHCCCHHHHHHHHHHHH
ALMALTPTHWRDLRARITELLSGEPFLVAMKDAVMLAPASIGDYTDFYASIFHATNVGSL
HEEEECCHHHHHHHHHHHHHHCCCCEEEEECCEEEECCCCCCCHHHHHHHHHHHCCCCCC
FRPDNPLLPNYKYVPIGYHGRASSIVPSGAAIRRPQGQAMDPGAAAPRFGPTRALDYELE
CCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCEEEEEEC
AGFFIGPGNALGEPVPIEAAEDHVFGVCLVNDWSARDIQAWEYQPLGPFLGKSFATSISP
CCEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCC
WVVTMEALAPYRAPLYQRPEGDPAPLPYLHSEGNAAIDLTLEVEITSAQMRARDMAPMRL
CEEEHHHHCCCCCCCCCCCCCCCCCCCEEECCCCEEEEEEEEEEECHHHHHHHCCCCHHH
SRGNLKDLYWSIAQMVAHHTSNGCNLRPGDLLASGTVSGATPDSRGCLLEITRRGAEPIA
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEECCCCCCEE
LPTGELRKFLEDGDEITMRGYCEREGLPRIGLATCSGRVDAT
CCHHHHHHHHHCCCEEEEEEEHHHCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA