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The map label for this gene is htrA [H]

Identifier: 116625455

GI number: 116625455

Start: 8019319

End: 8020092

Strand: Direct

Name: htrA [H]

Synonym: Acid_6400

Alternate gene names: 116625455

Gene position: 8019319-8020092 (Clockwise)

Preceding gene: 116625454

Following gene: 116625456

Centisome position: 80.47

GC content: 70.54

Gene sequence:

>774_bases
ATGCGGGGATTCGGAGAAATCGCGGAGCGCCTCAGGCGCTCCACCGTGCAGGTGCGCCTAAACAAACACGGCGGCGGCAG
CGGCATCGTCTGGAAGCCCGACGGCCTGATCCTTACCAACGCCCATGTCGCCCGCGGCTCCCAAGCGGAGATCGAACTGT
GGGACGGGCGCCGCTTCCCGGCGAAGCTCGTCTCCAAGGATGCGCGGCGCGACCTCGCGACCTTCCGCATTGCCGCGGCC
AACCTCGAGGCCGCGGTGGTCGGGGATTCCGCCGCGCTGCGCCCAGGTGAGTTGGTGATCGCGGTCGGCAATCCGCTGGG
CTTCGCCGGAGCGCTCTCCACCGGCATCGTCCATTCGAACAGCGACCGCTGGATTCACGCCGACGTCCAGCTCGCGCCCG
GCAACTCCGGCGGGCCGCTGGCCAATTCGCTTGGCCAGGTGATCGGCGTCAACACGGCGATCGTGAACGGCTTGGGCGCG
GCAGTCCCCTCCAAGGCCGCGCTCGAGTTCGTGCAGCACGGCGCGCGCCCCACGCTCGGAGTCACGATGCGTCCGGTACA
TCTCGGCCTGCAGTTGCTCGAGGTCGAGCCCGGCGGCGCCGCGGCGAATGCGAGCCTCCGCGCGGGCGACATACTCCTCA
CGCGCTTCGACGCGCTCAATGAAGCCCTCGACAGCGGCCGGCCGACGCTCCGCCTGCACTTCCTGCGCGACGACCCCAAG
CGGGTCCGCGAAGCCGTCGTGCTGCTCGCCGCGCGGGTGGAGGCCGCTGCGTGA

Upstream 100 bases:

>100_bases
GGCCACGCGGTCGGGCTAAAGGTGGAGGTGGAGGTGCTGCGCGGCGGCGAAGCGCGGCAGGTGAACGTGGTGGTCGGCGA
ACGGCCGCGGAGGAACTGAG

Downstream 100 bases:

>100_bases
TTCGTGTCCGGATCGCTGCATCGTCCGCGGTGGTGAAGGCCGGGTTGGACGCCCTGGTGGCGTCCAACCCGGCGTTGCTG
CCCACGGAGTCGTACGCCGA

Product: peptidase S1 and S6, chymotrypsin/Hap

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MRGFGEIAERLRRSTVQVRLNKHGGGSGIVWKPDGLILTNAHVARGSQAEIELWDGRRFPAKLVSKDARRDLATFRIAAA
NLEAAVVGDSAALRPGELVIAVGNPLGFAGALSTGIVHSNSDRWIHADVQLAPGNSGGPLANSLGQVIGVNTAIVNGLGA
AVPSKAALEFVQHGARPTLGVTMRPVHLGLQLLEVEPGGAAANASLRAGDILLTRFDALNEALDSGRPTLRLHFLRDDPK
RVREAVVLLAARVEAAA

Sequences:

>Translated_257_residues
MRGFGEIAERLRRSTVQVRLNKHGGGSGIVWKPDGLILTNAHVARGSQAEIELWDGRRFPAKLVSKDARRDLATFRIAAA
NLEAAVVGDSAALRPGELVIAVGNPLGFAGALSTGIVHSNSDRWIHADVQLAPGNSGGPLANSLGQVIGVNTAIVNGLGA
AVPSKAALEFVQHGARPTLGVTMRPVHLGLQLLEVEPGGAAANASLRAGDILLTRFDALNEALDSGRPTLRLHFLRDDPK
RVREAVVLLAARVEAAA
>Mature_257_residues
MRGFGEIAERLRRSTVQVRLNKHGGGSGIVWKPDGLILTNAHVARGSQAEIELWDGRRFPAKLVSKDARRDLATFRIAAA
NLEAAVVGDSAALRPGELVIAVGNPLGFAGALSTGIVHSNSDRWIHADVQLAPGNSGGPLANSLGQVIGVNTAIVNGLGA
AVPSKAALEFVQHGARPTLGVTMRPVHLGLQLLEVEPGGAAANASLRAGDILLTRFDALNEALDSGRPTLRLHFLRDDPK
RVREAVVLLAARVEAAA

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=185, Percent_Identity=34.0540540540541, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI22129776, Length=235, Percent_Identity=30.2127659574468, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI24308541, Length=216, Percent_Identity=34.2592592592593, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI7019477, Length=166, Percent_Identity=37.3493975903614, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1786356, Length=225, Percent_Identity=34.2222222222222, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1789629, Length=260, Percent_Identity=32.3076923076923, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1789630, Length=227, Percent_Identity=29.9559471365639, Blast_Score=87, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24646839, Length=194, Percent_Identity=35.5670103092784, Blast_Score=105, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 26925; Mature: 26925

Theoretical pI: Translated: 10.92; Mature: 10.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGFGEIAERLRRSTVQVRLNKHGGGSGIVWKPDGLILTNAHVARGSQAEIELWDGRRFP
CCCHHHHHHHHHHCEEEEEEECCCCCCCEEECCCCEEEECCEECCCCCCEEEEECCCCCC
AKLVSKDARRDLATFRIAAANLEAAVVGDSAALRPGELVIAVGNPLGFAGALSTGIVHSN
HHHHHHHHHHHHHHEEEEECCCEEEEECCCCCCCCCCEEEEECCCCCCHHHHHHCEEECC
SDRWIHADVQLAPGNSGGPLANSLGQVIGVNTAIVNGLGAAVPSKAALEFVQHGARPTLG
CCCEEEEEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCC
VTMRPVHLGLQLLEVEPGGAAANASLRAGDILLTRFDALNEALDSGRPTLRLHFLRDDPK
EEEEHHHHCEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCEEEEEEECCCHH
RVREAVVLLAARVEAAA
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRGFGEIAERLRRSTVQVRLNKHGGGSGIVWKPDGLILTNAHVARGSQAEIELWDGRRFP
CCCHHHHHHHHHHCEEEEEEECCCCCCCEEECCCCEEEECCEECCCCCCEEEEECCCCCC
AKLVSKDARRDLATFRIAAANLEAAVVGDSAALRPGELVIAVGNPLGFAGALSTGIVHSN
HHHHHHHHHHHHHHEEEEECCCEEEEECCCCCCCCCCEEEEECCCCCCHHHHHHCEEECC
SDRWIHADVQLAPGNSGGPLANSLGQVIGVNTAIVNGLGAAVPSKAALEFVQHGARPTLG
CCCEEEEEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCC
VTMRPVHLGLQLLEVEPGGAAANASLRAGDILLTRFDALNEALDSGRPTLRLHFLRDDPK
EEEEHHHHCEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCEEEEEEECCCHH
RVREAVVLLAARVEAAA
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]