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The map label for this gene is pheS [H]

Identifier: 116625451

GI number: 116625451

Start: 8014310

End: 8015335

Strand: Direct

Name: pheS [H]

Synonym: Acid_6396

Alternate gene names: 116625451

Gene position: 8014310-8015335 (Clockwise)

Preceding gene: 116625450

Following gene: 116625452

Centisome position: 80.42

GC content: 65.69

Gene sequence:

>1026_bases
ATGCTTGACGAATCCATACAGGAACTGGCGTCCCGTTCCCTGGCGCGCATCGCCTCCGCGCAAACGCCGGAGGAACTCGA
GGCCGTCCGCGTTGACGCCATCGGCCGCAAGGGCGCGCTCGCCGAAATCAGCAAAGGGATGGGAAAACTCGCCCCCGAGG
AACGCAAGCGCATCGGCCAGGTCCTCAACGCCGCCAAGCAGGAGCTCGAGACCGCGCTCGATGCCCGCAAGCGCGAGTTC
GACGACGCCGTCCTGCGCGCGCGCCTCGACGCCGAATGGGTCGACCTCACCCTCCCGCCCCCGCCCCCGGCGCGCGGACA
CCTCCACCCCATCACGCGTATCCAGCGCGAACTCGAAGAGCTCTTCGTCTCCCTCGGCTTCACCGTGCTCGATGGGCCCG
AGGTCGAAACCGAATATCACAACTTCGACGCCCTGAACATTCCGCCCGACCATCCGGCCCGCGACATGCAGGATACCTTC
TGGCTCGATGGCGGCAAGCTCCTCCTCCGCACCCACACCTCGCCCGTGCAGGTCCGGGGCATGGAGCGCCTCGGTCCGCC
CCTGCGCATGATCGCGCCCGGCCGCGTCTTCCGCAATGAGAGCGTGGACGCCAGCCACGAGCACACCTTCTACCAGCTCG
AAGGCATGATGATCGATCGCGATGTCAGCGTGGCGCACCTTCTGTATTTCATGAAGACGCTGCTCACCGCGATCTTCAAG
CGCGAAGTCACCGTCCGTCTGCGCCCCGGCTACTTCCCGTTCGTCGAACCGGGCTTCGAGCTCGATATCCAGTGCCTCAT
CTGCGGCGGCCCGGGCTGCCCCGTCTGCAAGCAGAGCGGCTGGGTGGAGCTGCTGCCCTGCGGCCTCGTCAACCCCAACG
TGCTGCGTAAAAGCGGCATTGACCCTGAGGAGTGGAACGGCTTCGCCTTCGGGCTCGGCCTCACCCGCCTCGTCATGATG
CGCTACGCCATCGACGATATCCGCCAGTTGCAAGGCGGCGATCTCCGTTTCCTCGAGCAGTTTTAA

Upstream 100 bases:

>100_bases
CCTAGCCTGGCGCCGGCGCTGCCGTCTTGAGCGCCGAATCCCGACATCGCTCCCAACCGCTTCCGTCTCCCTCCGCTGCT
ACAATAAAAACTTCCACGAC

Downstream 100 bases:

>100_bases
ATTGGAGCAGCTCTAACCGTGAAGTTCTCCTACAACTGGATCCGCGAATTCGTACCCGGCCTGACCCAGGCCGCCGCTCC
GCTGGAACGGCTGATCACCA

Product: phenylalanyl-tRNA synthetase subunit alpha

Products: NA

Alternate protein names: Phenylalanine--tRNA ligase alpha chain; PheRS [H]

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MLDESIQELASRSLARIASAQTPEELEAVRVDAIGRKGALAEISKGMGKLAPEERKRIGQVLNAAKQELETALDARKREF
DDAVLRARLDAEWVDLTLPPPPPARGHLHPITRIQRELEELFVSLGFTVLDGPEVETEYHNFDALNIPPDHPARDMQDTF
WLDGGKLLLRTHTSPVQVRGMERLGPPLRMIAPGRVFRNESVDASHEHTFYQLEGMMIDRDVSVAHLLYFMKTLLTAIFK
REVTVRLRPGYFPFVEPGFELDIQCLICGGPGCPVCKQSGWVELLPCGLVNPNVLRKSGIDPEEWNGFAFGLGLTRLVMM
RYAIDDIRQLQGGDLRFLEQF

Sequences:

>Translated_341_residues
MLDESIQELASRSLARIASAQTPEELEAVRVDAIGRKGALAEISKGMGKLAPEERKRIGQVLNAAKQELETALDARKREF
DDAVLRARLDAEWVDLTLPPPPPARGHLHPITRIQRELEELFVSLGFTVLDGPEVETEYHNFDALNIPPDHPARDMQDTF
WLDGGKLLLRTHTSPVQVRGMERLGPPLRMIAPGRVFRNESVDASHEHTFYQLEGMMIDRDVSVAHLLYFMKTLLTAIFK
REVTVRLRPGYFPFVEPGFELDIQCLICGGPGCPVCKQSGWVELLPCGLVNPNVLRKSGIDPEEWNGFAFGLGLTRLVMM
RYAIDDIRQLQGGDLRFLEQF
>Mature_341_residues
MLDESIQELASRSLARIASAQTPEELEAVRVDAIGRKGALAEISKGMGKLAPEERKRIGQVLNAAKQELETALDARKREF
DDAVLRARLDAEWVDLTLPPPPPARGHLHPITRIQRELEELFVSLGFTVLDGPEVETEYHNFDALNIPPDHPARDMQDTF
WLDGGKLLLRTHTSPVQVRGMERLGPPLRMIAPGRVFRNESVDASHEHTFYQLEGMMIDRDVSVAHLLYFMKTLLTAIFK
REVTVRLRPGYFPFVEPGFELDIQCLICGGPGCPVCKQSGWVELLPCGLVNPNVLRKSGIDPEEWNGFAFGLGLTRLVMM
RYAIDDIRQLQGGDLRFLEQF

Specific function: Unknown

COG id: COG0016

COG function: function code J; Phenylalanyl-tRNA synthetase alpha subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha chain type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI4758340, Length=274, Percent_Identity=31.021897810219, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI5729820, Length=278, Percent_Identity=29.8561151079137, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1788007, Length=336, Percent_Identity=46.1309523809524, Blast_Score=307, Evalue=6e-85,
Organism=Caenorhabditis elegans, GI17508957, Length=278, Percent_Identity=31.294964028777, Blast_Score=137, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI32563657, Length=278, Percent_Identity=31.294964028777, Blast_Score=137, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI32566635, Length=257, Percent_Identity=29.1828793774319, Blast_Score=98, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6321087, Length=283, Percent_Identity=30.7420494699647, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6325304, Length=101, Percent_Identity=38.6138613861386, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI18858079, Length=287, Percent_Identity=31.0104529616725, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI17137424, Length=298, Percent_Identity=26.510067114094, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006195
- InterPro:   IPR004529
- InterPro:   IPR004188
- InterPro:   IPR022911
- InterPro:   IPR002319
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02912 Phe_tRNA-synt_N; PF01409 tRNA-synt_2d [H]

EC number: =6.1.1.20 [H]

Molecular weight: Translated: 38390; Mature: 38390

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDESIQELASRSLARIASAQTPEELEAVRVDAIGRKGALAEISKGMGKLAPEERKRIGQ
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHH
VLNAAKQELETALDARKREFDDAVLRARLDAEWVDLTLPPPPPARGHLHPITRIQRELEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHH
LFVSLGFTVLDGPEVETEYHNFDALNIPPDHPARDMQDTFWLDGGKLLLRTHTSPVQVRG
HHHHHCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEECCCEEEEEECCCCCEECC
MERLGPPLRMIAPGRVFRNESVDASHEHTFYQLEGMMIDRDVSVAHLLYFMKTLLTAIFK
HHHCCCCEEEECCCHHCCCCCCCCCCCCEEEEEECEEEECCHHHHHHHHHHHHHHHHHHH
REVTVRLRPGYFPFVEPGFELDIQCLICGGPGCPVCKQSGWVELLPCGLVNPNVLRKSGI
HCEEEEECCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEEECCCCCCHHHHHCCC
DPEEWNGFAFGLGLTRLVMMRYAIDDIRQLQGGDLRFLEQF
CHHHCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCC
>Mature Secondary Structure
MLDESIQELASRSLARIASAQTPEELEAVRVDAIGRKGALAEISKGMGKLAPEERKRIGQ
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHH
VLNAAKQELETALDARKREFDDAVLRARLDAEWVDLTLPPPPPARGHLHPITRIQRELEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHH
LFVSLGFTVLDGPEVETEYHNFDALNIPPDHPARDMQDTFWLDGGKLLLRTHTSPVQVRG
HHHHHCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEECCCEEEEEECCCCCEECC
MERLGPPLRMIAPGRVFRNESVDASHEHTFYQLEGMMIDRDVSVAHLLYFMKTLLTAIFK
HHHCCCCEEEECCCHHCCCCCCCCCCCCEEEEEECEEEECCHHHHHHHHHHHHHHHHHHH
REVTVRLRPGYFPFVEPGFELDIQCLICGGPGCPVCKQSGWVELLPCGLVNPNVLRKSGI
HCEEEEECCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEEECCCCCCHHHHHCCC
DPEEWNGFAFGLGLTRLVMMRYAIDDIRQLQGGDLRFLEQF
CHHHCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA